摘要:
The present disclosure is directed to methods of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs) and their use for targeted drug delivery formulations and systems and for biomedical applications. The present disclosure is also directed in part to a multilamellar or unilamellar protocell vaccine to deliver full length viral protein and/or plasmid encoded viral protein to antigen presenting cells (APCs) in order to induce an immunogenic response to a virus.
摘要:
The present disclosure is directed to methods of producing monosized protocells from monosized mesoporous silica nanoparticles (mMSNPs) and their use for targeted drug delivery formulations and systems and for biomedical applications. The present disclosure is also directed in part to a multilamellar or unilamellar protocell vaccine to deliver full length viral protein and/or plasmid encoded viral protein to antigen presenting cells (APCs) in order to induce an immunogenic response to a virus.
摘要:
The present disclosure is directed to protocells or nanoparticles, which are optionally coated with a lipid bilayer, which can be used for targeting bone tissue for the delivery of bioactive agents useful in the treatment and/or diagnosis of bone cancer, often metastatic bone cancer which often occurs secondary to a primary cancer such as prostate cancer, breast cancer, lung cancer and ovarian cancer, among numerous others. These protocells or nanoparticles target bone cancer especially metastatic bone cancer with bioactive agents including anticancer agents and/or diagnostic agents for purposes of treating, diagnosing and/or monitoring the therapy of the bone cancer. Osteotropic protocells or nanoparticles, pharmaceutical compositions comprising a population of osteotropic protocells or nanoparticles and methods of diagnosing, treating and/or monitoring therapy of bone cancer are representative aspects.
摘要:
An adaptive pulse width control power conversion device includes a pulse width adjustable pulse frequency module (PFM) control circuit, a pulse width modulation (PWM) control circuit, a PWM/PFM switching unit, a switching circuit, and a load status detection circuit. When the power conversion device is to be switched from a PWM mode to a PFM mode, pulse width of a series of PFM control signals is sequentially adjusted from a low value to a high value according to a predetermined pulse width increment until an optimum pulse width is determined and thereafter, an output voltage is supplied to a load in the PFM mode, whereby ripple of output voltage in the PFM mode can be improved and improved stability of output of the power conversion device is realized.
摘要:
A method for erasing a flash EEPROM. The flash EEROM includes a number of memory units. First, the flash EEPROM is pre-programmed. Second, the step of erasing the flash EEPROM is performed and the flash EEPROM is then soft-programmed. Subsequently, the final step is performed to determine if the erasing step succeeds.
摘要:
An integrated circuit memory array with an extra column of memory cells and a reference bit line is provided, in which the reference bit line acts as a reference for a shared precharging and clamping control on the bit lines in the array. Precharge transistors are coupled to respective bit lines in the array, and adapted to precharge voltage on the respective bit lines to near a target level. A detector has an input coupled to the reference bit line and an output coupled to the precharge transistors on the plurality of bit lines. The detector generates a precharge signal which turns off the precharge transistors when the reference bit line has a voltage near the target level, and turns on the precharge transistors when the reference bit line has a voltage below the target level.
摘要:
An integrated circuit memory array with an extra column of memory cells and a reference bit line is provided, in which the reference bit line acts as a reference for a shared precharging and clamping control on the bit lines in the array. Clamp transistors are coupled to respective bit lines in the array, and adapted to prevent voltage on the respective bit lines from exceeding a target level. A comparator has an input coupled to the reference bit line and an output coupled to the clamp transistors on the plurality of bit lines. The comparator generates a bias voltage which turns on the clamp transistors at a first bias level when the reference bit line has a voltage below the target level, and a second bias level, which is lower than the first bias level, when the reference bit line has a voltage near the target level.
摘要:
A voltage-boosting generator for reducing the effects due to operating voltage variation and temperature change. The generator comprises a delay line circuit and a voltage boosting circuit. The delay line circuit is used to perform a time delay according to an initial boosting signal and to produce a control signal. The voltage boosting circuit is used to boosted voltage according to the control signal.
摘要:
A lock device includes a locking unit, a connecting unit, and a latch. The locking unit includes a shank, a rotation knob, a control wheel, a plurality of number wheels, a plurality of locating pieces, and a plurality of snap-fit members. The shank has a first positioning hole. The rotation knob has a second positioning hole combined with the first positioning hole of the shank by a positioning member. Thus, the user has to detach the positioning member from the first positioning hole of the shank to release the rotation knob so as to rotate the rotation knob for changing the code of the number wheels, thereby preventing the user from changing the code of the number wheels freely when rotating the rotation knob unintentionally.