公开(公告)号：US11542545B2

公开(公告)日：2023-01-03

申请号：US15524449

申请日：2015-11-05

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY ,  Talis Biomedical Corporation

Inventor： Rustem F. Ismagilov ,  Eugenia Khorosheva ,  Travis S. Schlappi ,  Matthew S. Curtis ,  Nathan G. Schoepp ,  Hedia Maamar ,  Feng Shen ,  Erik B. Jue

IPC: C12Q1/6851 ,  C12Q1/689 ,  C12Q1/6809 ,  C12Q1/18 ,  C12Q1/686 ,  B01L3/00 ,  B01L7/00

Abstract: Disclosed herein are methods and devices for rapid assessment of whether a microorganism present in a sample is susceptible or resistant to a treatment.

公开(公告)号：US10196684B2

公开(公告)日：2019-02-05

申请号：US15030202

申请日：2014-10-16

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. Ismagilov ,  Bing Sun ,  Jesus Rodriguez Manzano ,  Eugenia Khorosheva ,  Matthew S. Curtis

IPC: C12Q1/68 ,  C12Q1/6848 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q1/6865 ,  C12Q1/70

Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.

公开(公告)号：US12122996B2

公开(公告)日：2024-10-22

申请号：US16141707

申请日：2018-09-25

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. Ismagilov ,  Eugenia Khorosheva ,  Dmitriy V. Zhukov

IPC: B01L3/00 ,  C12N15/10 ,  C12Q1/6806 ,  C12Q1/6855 ,  G01N33/58 ,  G01N33/68 ,  C40B30/04 ,  C40B40/08 ,  C40B70/00

CPC classification number: C12N15/1065 ,  B01L3/502715 ,  B01L3/502738 ,  C12Q1/6806 ,  C12Q1/6855 ,  G01N33/58 ,  G01N33/68 ,  B01L2200/027 ,  B01L2200/141 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0861 ,  B01L2300/161 ,  B01L2400/065 ,  C40B30/04 ,  C40B40/08 ,  C40B70/00 ,  C12Q1/6806 ,  C12Q2523/101 ,  C12Q2525/191 ,  C12Q2565/514

Abstract: A device for allowing compartmentalized reactions with minimized cross-contamination between the compartments, utilizing a delivery of material by loading wells to pooling wells, such that the pooling wells can be additively provided with reactants while maintaining isolation between the pooling wells. The use of geometric properties is used to facilitate transmission of fluids/droplets without the need for hydrophilic surfaces.

公开(公告)号：US11434526B2

公开(公告)日：2022-09-06

申请号：US16224617

申请日：2018-12-18

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rustem F. Ismagilov ,  Bing Sun ,  Jesus Rodriguez Manzano ,  Eugenia Khorosheva ,  Matthew S. Curtis

IPC: C12Q1/68 ,  C12Q1/6848 ,  C12Q1/6844 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q1/6865 ,  C12Q1/70

Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.