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1.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 审中-公开用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20150225803A1
公开(公告)日：2015-08-13
申请号：US14177194
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/70
CPC classification number: C12Q1/703 , C12Q1/6851 , C12Q1/707 , C12Q2600/158 , C12Q2561/113
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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公开(公告)号：US11434526B2
公开(公告)日：2022-09-06
申请号：US16224617
申请日：2018-12-18
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. Ismagilov , Bing Sun , Jesus Rodriguez Manzano , Eugenia Khorosheva , Matthew S. Curtis
IPC: C12Q1/68 , C12Q1/6848 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q1/6865 , C12Q1/70
Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.
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3.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 审中-公开用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20170051365A9
公开(公告)日：2017-02-23
申请号：US14177194
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/70
CPC classification number: C12Q1/703 , C12Q1/6851 , C12Q1/707 , C12Q2600/158 , C12Q2561/113
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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Patent Agency Ranking
4.发明授权Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes 有权用于定量和检测核酸和其他分析物的多体积仪器，试剂盒和相关方法公开(公告)号：US09493826B2
公开(公告)日：2016-11-15
申请号：US14177190
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
CPC classification number: C12Q1/6851 , B01F5/0085 , B01F13/0094 , B01F15/0218 , B01L3/5025 , B01L3/502738 , B01L3/50851 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/045 , B01L2300/049 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q2531/119 , C12Q2537/149 , C12Q2563/159 , C12Q2565/629
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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5.发明申请MULTIVOLUME DEVICES, KITS AND RELATED METHODS FOR QUANTIFICATION AND DETECTION OF NUCLEIC ACIDS AND OTHER ANALYTES 有权用于定量和检测核酸和其他分析物的多功能装置，试剂盒和相关方法公开(公告)号：US20140336064A1
公开(公告)日：2014-11-13
申请号：US14177190
申请日：2014-02-10
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Wenbin Du , Bing Sun
IPC: C12Q1/68
CPC classification number: C12Q1/6851 , B01F5/0085 , B01F13/0094 , B01F15/0218 , B01L3/5025 , B01L3/502738 , B01L3/50851 , B01L2200/027 , B01L2200/0605 , B01L2200/0642 , B01L2300/045 , B01L2300/049 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0644 , B01L2400/065 , C12Q2531/119 , C12Q2537/149 , C12Q2563/159 , C12Q2565/629
Abstract: Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest.
Abstract translation: 提供了包括多体积分析区域的装置，该装置能够支持放大，检测和其它过程。 还提供了检测或估计存在的核酸，病毒水平和感兴趣的其他生物标志物的相关方法。
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公开(公告)号：US10196684B2
公开(公告)日：2019-02-05
申请号：US15030202
申请日：2014-10-16
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. Ismagilov , Bing Sun , Jesus Rodriguez Manzano , Eugenia Khorosheva , Matthew S. Curtis
IPC: C12Q1/68 , C12Q1/6848 , C12Q1/6844 , C12Q1/6851 , C12Q1/686 , C12Q1/6865 , C12Q1/70
Abstract: The present invention relates to assays, including amplification assays, conducted in the presence of modulators. These assays can be used to detect the presence of particular nucleic acid sequences. In particular, these assays can allow for genotyping or other genetic analysis.
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7.发明申请ANALYSIS DEVICES, KITS, AND RELATED METHODS FOR DIGITAL QUANTIFICATION OF NUCLEIC ACIDS AND OTHER ANALYTES 审中-公开用于数字量化核酸和其他分析物的分析装置，试剂盒和相关方法公开(公告)号：US20160362734A1
公开(公告)日：2016-12-15
申请号：US15247795
申请日：2016-08-25
Applicant: California Institute of Technology , University of Chicago
Inventor： Rustem F. Ismagilov , Feng Shen , Jason E. Kreutz , Bing Sun , Wenbin Du
CPC classification number: C12Q1/6851 , B01F13/0094 , B01L3/5025 , B01L3/502715 , B01L3/502738 , B01L2200/027 , B01L2300/0864 , B01L2300/0896 , C12Q2531/119 , C12Q2537/149 , C12Q2563/159 , C12Q2565/629
Abstract: Provided are devices and methods for effecting processing of samples, including essentially isothermal amplification of nucleic acids, at multiple reaction locations in a single device. In some embodiments, the disclosed devices and methods provide for effecting parallel sample processing in several hundred locations on a single device.
Abstract translation: 提供了用于在单个装置中的多个反应位置处理样品的装置和方法，包括基本上等温的核酸扩增。 在一些实施例中，所公开的设备和方法提供了在单个设备上在几百个位置中实现并行样本处理。
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公开(公告)号：US20150247190A1
公开(公告)日：2015-09-03
申请号：US14433602
申请日：2013-10-04
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Rustem F. Ismagilov , David A. Selck , Mikhail Karymov , Bing Sun
CPC classification number: C12Q1/6851 , C12Q1/703 , C12Q2600/16 , G01N21/6428 , G01N21/6456 , G01N2021/6439 , G01N2021/6471 , G01N2201/061 , G01N2201/062 , G01N2201/12 , G16B15/00 , C12Q2527/101 , C12Q2565/619 , C12Q2565/628
Abstract: Disclosed herein are methods and devices for assessing sample for the presence of a disease or organism using images from devices such as a consumer cell phones.
Abstract translation: 本文公开了使用来自诸如消费者手机的装置的图像评估疾病或生物体存在的样品的方法和装置。
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