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公开(公告)号：US20210128913A1
公开(公告)日：2021-05-06
申请号：US16605026
申请日：2018-04-16
申请人： Case Western Reserve University , VANDERBILT UNIVERSITY , UNIVESITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： Emilie H. Lothet , Kendrick M. Shaw , Eric Duco Jansen , Hillel J. Chiel , Michael W. Jenkins , Charles C. Horn
摘要： Small-diameter axons can be targeted for neuromodulation. A nerve modulating therapy can be configured to target the small diameter axons in a target area of a subject specifically. The nerve modulating therapy can be applied to the target area to modulate conduction in one or more small diameter axons within the target area to a greater degree than in large diameter axons within the target area. The nerve modulating therapy can be any therapy that affects an outer surface of the one or more small diameter axons (like a heat signal, a pressure wave, an optogenetic manipulation, and/or a pharmaceutical dosage).
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公开(公告)号：US11786750B2
公开(公告)日：2023-10-17
申请号：US16767277
申请日：2018-11-30
发明人： Michael W. Jenkins , Stephen J. Lewis , Hillel J. Chiel , Eric Duco Jansen , Junqi Zhuo , Emilie Lothet , Gjinovefa Kola
CPC分类号： A61N5/0622 , A61N5/0601 , A61N5/067 , A61N2005/0626 , A61N2005/0659
摘要： The present disclosure relates to modulating neural activity within brainstem circuitry to evoke a certain bodily function (e.g., cardiorespiratory response) in a patient. A controller can configure a light signal (such as an infrared light signal) to deliver an amount of radiant exposure to a specific portion of the brainstem for a time. The specific portion of the brainstem can include brainstem circuitry that is the control center for the certain bodily function. The configured light signal can be delivered to the specific portion of the brainstem by an optrode for the time. During application, the light signal can deliver the amount of radiant exposure to the specific portion of the brainstem to evoke the certain bodily function.
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公开(公告)号：US11065467B2
公开(公告)日：2021-07-20
申请号：US16296617
申请日：2019-03-08
发明人： Hillel Chiel , Niloy Bhadra , Mike Jenkins , Emilie Lothet , Tina Vrabec , Kevin Kilgore , Narendra Bhadra , Eric Duco Jansen
IPC分类号： A61N1/40 , A61N5/06 , A61N7/02 , A61N1/06 , A61N1/28 , A61N1/36 , A61F7/00 , A61N5/067 , A61N7/00
摘要： One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.
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公开(公告)号：US10758738B2
公开(公告)日：2020-09-01
申请号：US15126610
申请日：2015-03-17
发明人： Hillel Chiel , Niloy Bhadra , Mike Jenkins , Emilie Lothet , Tina Vrabec , Kevin Kilgore , Narendra Bhadra , Eric Duco Jansen
IPC分类号： A61N1/40 , A61N5/06 , A61N7/02 , A61N1/06 , A61N1/28 , A61N1/36 , A61F7/00 , A61N5/067 , A61N7/00
摘要： One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.
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公开(公告)号：US20190201703A1
公开(公告)日：2019-07-04
申请号：US16296617
申请日：2019-03-08
发明人： Hillel Chiel , Niloy Bhadra , Mike Jenkins , Emilie Lothet , Tina Vrabec , Kevin Kilgore , Narendra Bhadra , Eric Duco Jansen
CPC分类号： A61N1/403 , A61F7/007 , A61F2007/0071 , A61N1/06 , A61N1/28 , A61N1/36067 , A61N1/36071 , A61N5/0622 , A61N5/0625 , A61N7/02 , A61N2005/0659 , A61N2005/067 , A61N2007/0021
摘要： One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.
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公开(公告)号：US10322293B2
公开(公告)日：2019-06-18
申请号：US16159748
申请日：2018-10-15
发明人： Hillel Chiel , Niloy Bhadra , Mike Jenkins , Emilie Lothet , Tina Vrabec , Kevin Kilgore , Narendra Bhadra , Eric Duco Jansen
IPC分类号： A61N1/40 , A61N5/06 , A61F7/00 , A61N1/36 , A61N1/28 , A61N1/06 , A61N7/02 , A61N7/00 , A61N5/067
摘要： One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal.
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公开(公告)号：US20240023872A1
公开(公告)日：2024-01-25
申请号：US18223785
申请日：2023-07-19
摘要： Aspects of this invention relate to a system and method of neural stimulation for intraoperative nerve monitoring for a living subject. The system includes an optical source configured to generate light; a delivering means coupled to the optical source to deliver the generated light to a target nerve of the living subject for stimulating the target nerve; and a detector coupled to the target nerve to record evoked signals responsive to the stimulation for intraoperatively monitoring of the target nerve.
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