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公开(公告)号：US20210128913A1
公开(公告)日：2021-05-06
申请号：US16605026
申请日：2018-04-16
申请人： Case Western Reserve University , VANDERBILT UNIVERSITY , UNIVESITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人： Emilie H. Lothet , Kendrick M. Shaw , Eric Duco Jansen , Hillel J. Chiel , Michael W. Jenkins , Charles C. Horn
摘要： Small-diameter axons can be targeted for neuromodulation. A nerve modulating therapy can be configured to target the small diameter axons in a target area of a subject specifically. The nerve modulating therapy can be applied to the target area to modulate conduction in one or more small diameter axons within the target area to a greater degree than in large diameter axons within the target area. The nerve modulating therapy can be any therapy that affects an outer surface of the one or more small diameter axons (like a heat signal, a pressure wave, an optogenetic manipulation, and/or a pharmaceutical dosage).
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2.发明申请METHOD AND APPARATUS FOR SELECTIVELY CONTROLLING NEURAL ACTIVITIES AND APPLICATIONS OF SAME 审中-公开用于选择性控制神经活动的方法和装置及其应用公开(公告)号：US20140074176A1
公开(公告)日：2014-03-13
申请号：US14024544
申请日：2013-09-11
CPC分类号： A61N5/0622 , A61N1/32 , A61N1/36
摘要： In one aspect of the present invention, a method of transient and selective suppression of neural activities of a target of interest, such as one or more nerves, includes selectively applying at least one light to the target of interest at selected locations with predetermined radiant exposures to create a localized and selective inhibitory response therein. The localized and selective inhibitory response comprises a local temperature change.
摘要翻译： 在本发明的一个方面，瞬时和选择性抑制感兴趣的靶标（例如一个或多个神经）的神经活动的方法包括在预定辐射暴露的选定位置选择性地将至少一种光照射到感兴趣的靶 以在其中产生局部和选择性抑制反应。 局部和选择性抑制反应包括局部温度变化。
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公开(公告)号：US11786750B2
公开(公告)日：2023-10-17
申请号：US16767277
申请日：2018-11-30
发明人： Michael W. Jenkins , Stephen J. Lewis , Hillel J. Chiel , Eric Duco Jansen , Junqi Zhuo , Emilie Lothet , Gjinovefa Kola
CPC分类号： A61N5/0622 , A61N5/0601 , A61N5/067 , A61N2005/0626 , A61N2005/0659
摘要： The present disclosure relates to modulating neural activity within brainstem circuitry to evoke a certain bodily function (e.g., cardiorespiratory response) in a patient. A controller can configure a light signal (such as an infrared light signal) to deliver an amount of radiant exposure to a specific portion of the brainstem for a time. The specific portion of the brainstem can include brainstem circuitry that is the control center for the certain bodily function. The configured light signal can be delivered to the specific portion of the brainstem by an optrode for the time. During application, the light signal can deliver the amount of radiant exposure to the specific portion of the brainstem to evoke the certain bodily function.
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公开(公告)号：US12011428B2
公开(公告)日：2024-06-18
申请号：US17696204
申请日：2022-03-16
IPC分类号： A61K31/198 , A61K45/06 , A61P11/00
CPC分类号： A61K31/198 , A61K45/06 , A61P11/00
摘要： A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising an glutathione alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
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公开(公告)号：US11845955B2
公开(公告)日：2023-12-19
申请号：US17878438
申请日：2022-08-01
发明人： Michael W. Jenkins , Yehe Liu
IPC分类号： G06T7/136 , C12N5/00 , G06T7/11 , C12N5/071 , G01N21/47 , G01N21/49 , G01N33/483 , G06T5/00 , G06T5/20 , G06T5/50 , G06T7/00
CPC分类号： C12N5/0018 , C12N5/0679 , C12N5/0691 , G01N21/4795 , G01N21/49 , G01N33/4833 , G06T5/002 , G06T5/009 , G06T5/20 , G06T5/50 , G06T7/0012 , G06T7/11 , G06T7/136 , C12N2513/00 , G06T2207/10101 , G06T2207/20224 , G06T2207/30024
摘要： The present disclosure relates to a simple, fast, and low cost method for 3D microvascular imaging, termed “scatter labeled imaging of microvasculature in excised tissue” (SLIME). The method can include perfusing a contrast agent through vasculature of a tissue sample. The contrast agent can include colloids and a dispersant. After the contrast agent is perfused through the vasculature, the vasculature of the tissue sample can be treated with a molecule that cross links with at least a portion of the dispersant to form a sticky, non-Newtonian polymer that prevents leakage of the contrast agent out of the vasculature of the tissue sample. The tissue sample can then be immersed in a solution comprising a clearing agent and subsequently imaged.
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公开(公告)号：US20230338319A1
公开(公告)日：2023-10-26
申请号：US17696204
申请日：2022-03-16
IPC分类号： A61K45/06 , A61K31/198 , A61P11/00
CPC分类号： A61K31/198 , A61K45/06 , A61P11/00
摘要： A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising an glutathione alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
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公开(公告)号：US11427801B2
公开(公告)日：2022-08-30
申请号：US16761278
申请日：2018-11-09
发明人： Michael W. Jenkins , Yehe Liu
IPC分类号： G06T7/136 , C12N5/00 , G06T7/11 , C12N5/071 , G01N21/47 , G01N21/49 , G01N33/483 , G06T5/00 , G06T5/20 , G06T5/50 , G06T7/00
摘要： The present disclosure relates to a simple, fast, and low cost method for 3D microvascular imaging, termed “scatter labeled imaging of microvasculature in excised tissue” (SLIME). The method can include perfusing a contrast agent through vasculature of a tissue sample with a contrast perfusing unit (22). The contrast agent can include colloids and a dispersant. After the contrast agent is perfused through the vasculature, the vasculature of the tissue sample can be treated with a cross-linking agent delivery unit (24) providing a molecule that cross links with at least a portion of the dispersant to form a sticky, non-Newtonian polymer that prevents leakage of the contrast agent out of the vasculature of the tissue sample. The tissue sample can then be immersed in a solution comprising a clearing agent with an optical clearing unit (26) and subsequently imaged.
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公开(公告)号：US20150313460A1
公开(公告)日：2015-11-05
申请号：US14700711
申请日：2015-04-30
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/14 , A61B3/16 , A61B5/0048 , A61B5/0066 , A61B2576/00
摘要： Systems and method are provided for evaluating a biomechanical property of tissue. A shear wave generator is configured to induce a shear wave in the tissue. An optical coherence tomography (OCT) imager is configured to capture a B-scan frame of the tissue. An image processing component is configured to determine a frequency of the shear wave in the tissue from the B-scan frame of the tissue at each of a plurality of locations within the B-scan. A parameter calculation component is configured to calculate a value for the biomechanical property for a plural subset of the plurality of locations within the B-scan frame of the tissue from the determined frequency of the shear wave at each of the plural subset of the plurality of locations.
摘要翻译： 提供系统和方法来评估组织的生物力学性质。 剪切波发生器被配置为在组织中引起剪切波。 光学相干断层摄影（OCT）成像仪配置成捕获组织的B扫描帧。 图像处理部件被配置为在B扫描内的多个位置的每个位置处确定来自组织的B扫描帧的组织中的剪切波的频率。 参数计算部件被配置为从多个子集的多个子集中的剪切波的确定的频率来计算组织的B扫描帧内的多个位置的多个子集的生物力学性质的值 位置。
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公开(公告)号：US20240335410A1
公开(公告)日：2024-10-10
申请号：US18746681
申请日：2024-06-18
IPC分类号： A61K31/198 , A61K45/06 , A61P11/00
CPC分类号： A61K31/198 , A61K45/06 , A61P11/00
摘要： A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising an glutathione alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
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公开(公告)号：US09854964B2
公开(公告)日：2018-01-02
申请号：US14700711
申请日：2015-04-30
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/14 , A61B3/16 , A61B5/0048 , A61B5/0066 , A61B2576/00
摘要： Systems and method are provided for evaluating a biomechanical property of tissue. A shear wave generator is configured to induce a shear wave in the tissue. An optical coherence tomography (OCT) imager is configured to capture a B-scan frame of the tissue. An image processing component is configured to determine a frequency of the shear wave in the tissue from the B-scan frame of the tissue at each of a plurality of locations within the B-scan. A parameter calculation component is configured to calculate a value for the biomechanical property for a plural subset of the plurality of locations within the B-scan frame of the tissue from the determined frequency of the shear wave at each of the plural subset of the plurality of locations.
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