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公开(公告)号：US20170015736A1
公开(公告)日：2017-01-19
申请号：US15125780
申请日：2015-03-12
申请人： CERAPEDICS, INC.
CPC分类号： C07K16/18 , A61L15/40 , A61L27/227 , A61L27/3608 , A61L27/50 , A61L2430/02 , C07K14/43586 , C07K2317/34 , D01B7/00 , G01N33/53 , G01N33/6878 , G01N2333/43578
摘要： The present invention relates to antibodies that bind to a polypeptide at an epitope in the amino acid sequence of SEQ ID NO: 1 (e.g., a sericin polypeptide). The invention also provides methods and kits using the antibodies of the invention. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 2. In some embodiments, the antibody binds to a polypeptide at an epitope in the amino add sequence of SEQ ID NO: 3. In some embodiments, the polypeptide is a sericin polypeptide (e.g., a sericin isoform 1B polypeptide). In a related aspect, the invention features a method for selectively detecting sericin in a sample.
摘要翻译： 本发明涉及在SEQ ID NO：1的氨基酸序列中的表位结合多肽的抗体（例如，丝胶蛋白多肽）。 本发明还提供了使用本发明的抗体的方法和试剂盒。 在一些实施方案中，抗体结合SEQ ID NO：2的氨基酸加成序列中的表位的多肽。在一些实施方案中，抗体结合SEQ ID NO：3的氨基酸加成序列中的表位的多肽。 在一些实施方案中，多肽是丝胶蛋白多肽（例如，丝胶蛋白同种型1B多肽）。 在相关方面，本发明的特征在于一种用于选择性检测样品中丝氨酸的方法。
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公开(公告)号：US20160095955A1
公开(公告)日：2016-04-07
申请号：US14821964
申请日：2015-08-10
申请人： Cerapedics, Inc.
CPC分类号： A61L27/3608 , A61L27/20 , A61L27/28 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2430/02 , C08L1/28
摘要： A firm but pliable medical device for use as a bone graft substitute or bone graft extender retains its shape without the requirement of a containment device, such as a syringe. Because the device is solid, it is easy to locate or position in-vivo and, in the moist environment of the body, it will hold its shape well, for an extended time. Because the lyophilized pliable medical device is porous, it adsorbs blood and other beneficial cells containing body fluids, such as bone marrow, contributing to its superior bone repair efficacy in comparison to an analogous putty that has not been lyophilized. In addition these lyophilized pliable medical devices are easier to terminally steam sterilize than the analogous putty because there is no moisture present to boil and ‘blow-out’ of the containment device (syringe). The glycerin that is present in the formulation lends pliability but has a low vapor pressure.
摘要翻译： 用作骨移植物替代物或骨移植物延长剂的牢固但柔韧的医疗装置保持其形状，而不需要诸如注射器的容纳装置。 因为该装置是固体，所以很容易在体内定位或定位，并且在身体的潮湿环境中，其将保持良好的形状，长时间。 因为冻干的柔韧的医疗装置是多孔的，因此与没有被冻干的类似的腻子相比，它吸收含有体液如骨髓的血液和其它有益细胞，有助于其优异的骨修复功效。 此外，这些冻干的柔韧的医疗设备比类似的油灰更容易终止蒸汽灭菌，因为没有水分存在，以使容器（注射器）沸腾和“吹出”。 存在于制剂中的甘油具有柔韧性但具有低蒸气压。
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公开(公告)号：US20130244942A1
公开(公告)日：2013-09-19
申请号：US13724704
申请日：2012-12-21
申请人： CERAPEDICS, INC.
CPC分类号： A61L27/58 , A61K38/39 , A61L27/12 , A61L27/3608 , A61L27/427 , A61L27/46 , A61L27/52 , A61L2430/02
摘要： The invention features fiber reinforced bone repair putties and fiber reinforced pliable lyophilized implants which are useful for the treatment of bone defects. The putties and lyophilized implants include ceramic particles. The formulations of the invention can exhibit reduced migration of the ceramic particles, and are mechanically strengthened so the materials can be aggressively manipulated by a physician during an implantation procedure without tearing or puncturing.
摘要翻译： 本发明的特征在于可用于治疗骨缺损的纤维增强骨修复油灰和纤维增强的柔韧性冻干植入物。 油灰和冻干植入物包括陶瓷颗粒。 本发明的制剂可以显示出减少的陶瓷颗粒的迁移，并且被机械加强，使得材料可以在植入过程期间被医生积极地操纵而不撕裂或穿刺。
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