公开(公告)号：US20160153014A1

公开(公告)日：2016-06-02

申请号：US14784621

申请日：2014-04-16

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Hyung Joon Kim ,  Ju No Jang ,  Kyung Rim Kim ,  Keun Cheol Lee ,  Young Bin Hwang ,  Hyeong Pyo Hong

IPC: C12P13/22 ,  C12N9/10

CPC classification number: C12P13/227 ,  C12N9/1077 ,  C12Y204/02018 ,  Y02P20/52

Abstract: The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.

Abstract translation: 本发明涉及具有增强的L-色氨酸生产力的埃希氏菌属微生物，其已被修饰以表达酵母邻氨基苯甲酸酯磷酸核糖转移酶，以便能够产生高浓度的L-色氨酸，以及L-色氨酸的生产方法 包括培养微生物的步骤。 埃希氏菌属的微生物可产生L-色氨酸，因此可有利地用于制药工业和饲料工业，尤其用于动物饲料。

公开(公告)号：US10113191B2

公开(公告)日：2018-10-30

申请号：US15112855

申请日：2015-03-17

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Eun Sung Koh ,  Su Yon Kwon ,  Kwang Ho Lee ,  Ji Sun Lee ,  Juno Jang ,  Keun Cheol Lee ,  Hyeong Pyo Hong

IPC: C12P13/22 ,  C12N9/24 ,  C12N9/78 ,  C12P13/08

Abstract: Disclosed are a recombinant microorganism having enhanced L-amino acid productivity, wherein the recombinant microorganism is transformed to have removed or decreased activity of at least one of adenosine deaminase and AMP nucleosidase, and a method of producing an L-amino acid using the recombinant microorganism. The use of the recombinant microorganism may enable the production of the L-amino acid in a highly efficient manner.

公开(公告)号：US10053698B2

公开(公告)日：2018-08-21

申请号：US15112992

申请日：2014-04-25

Applicant: CJ Cheiljedang Corporation

Inventor： Hyung Joon Kim ,  Su Yon Kwon ,  Eun Sung Koh ,  Ji Sun Lee ,  Keun Cheol Lee ,  Young Bin Hwang ,  Hyeong Pyo Hong

IPC: C12N1/20 ,  C12P13/08 ,  C12N15/70 ,  C07K14/34

CPC classification number: C12N15/70 ,  C07K14/34 ,  C12N1/20 ,  C12P13/08

Abstract: The present invention relates to an E. coli mutant strain having enhanced L-threonine productivity, which is obtained by introducing the permease of Corynebacterium origin, and to method of producing L-threonine using the E. coli mutant strain.

公开(公告)号：US10815510B2

公开(公告)日：2020-10-27

申请号：US15321717

申请日：2015-06-23

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ki Yong Cheong ,  Kyung Rim Kim ,  Seok Myung Lee ,  Kwang Ho Lee ,  Keun Cheol Lee ,  Hyeong Pyo Hong

IPC: C12P13/22 ,  C12N1/21 ,  C12N9/88 ,  C12N15/52

Abstract: The present application relates to a microorganism of the genus Escherichia producing L-tryptophan and, more specifically, to a microorganism of the genus Escherichia with improved activity of producing L-tryptophan by weakening or inactivating the activity of endogenous 6-phosphogluconate dehydratase and 2-keto-3-deoxy-6-phosphogluconate aldolase.Additionally, the present application relates to a method for producing L-tryptophan using the microorganism of the genus Escherichia.

公开(公告)号：US09562246B2

公开(公告)日：2017-02-07

申请号：US14784621

申请日：2014-04-16

Applicant: CJ Cheiljedang Corporation

Inventor： Hyung Joon Kim ,  Ju No Jang ,  Kyung Rim Kim ,  Keun Cheol Lee ,  Young Bin Hwang ,  Hyeong Pyo Hong

IPC: C12P13/22 ,  C12N9/10

CPC classification number: C12P13/227 ,  C12N9/1077 ,  C12Y204/02018 ,  Y02P20/52

Abstract: The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.

Abstract translation: 本发明涉及具有增强的L-色氨酸生产力的埃希氏菌属微生物，其已被修饰以表达酵母邻氨基苯甲酸酯磷酸核糖转移酶，以便能够产生高浓度的L-色氨酸，以及L-色氨酸的生产方法 包括培养微生物的步骤。 埃希氏菌属的微生物可产生L-色氨酸，因此可有利地用于制药工业和饲料工业，尤其用于动物饲料。