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公开(公告)号：US11549116B2
公开(公告)日：2023-01-10
申请号：US16534132
申请日：2019-08-07
发明人： Ji Sun Lee , Dong Eun Chang , Sang Jun Kim , So Young Kim
IPC分类号： C12N15/70
摘要： A nucleic acid molecule comprising a variant inc coding strand is disclosed as a regulator of plasmid copy number. Also disclosed is a replicon comprising the nucleic acid molecule, a promoter, and an origin of replication. Also disclosed is a vector comprising the replicon. Also disclosed is a recombinant microorganism comprising the vector.
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公开(公告)号：US10968467B2
公开(公告)日：2021-04-06
申请号：US16447814
申请日：2019-06-20
发明人： Ji Sun Lee , Kwang Ho Lee , Hyo Jin Kim , Keun Chul Lee , Young Bin Hwang
IPC分类号： C12P13/08 , C07K14/245 , C12N1/21 , C12N9/12
摘要： The present invention relates to a novel variant RNA polymerase sigma factor 70 (σ70) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing L-threonine by using the microorganism.
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公开(公告)号：US10053698B2
公开(公告)日：2018-08-21
申请号：US15112992
申请日：2014-04-25
发明人： Hyung Joon Kim , Su Yon Kwon , Eun Sung Koh , Ji Sun Lee , Keun Cheol Lee , Young Bin Hwang , Hyeong Pyo Hong
摘要： The present invention relates to an E. coli mutant strain having enhanced L-threonine productivity, which is obtained by introducing the permease of Corynebacterium origin, and to method of producing L-threonine using the E. coli mutant strain.
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公开(公告)号：US09758772B2
公开(公告)日：2017-09-12
申请号：US14899676
申请日：2014-04-24
发明人： Ji Sun Lee , Kwang Ho Lee , Eun Sung Koh , Hyung Joon Kim , Keun Cheol Lee , Young Bin Hwang
IPC分类号： C12P13/08 , C12P13/02 , C12N9/10 , C12N1/20 , C12P21/06 , C12P19/34 , C12N15/00 , C07H21/04 , C07K1/00 , C12N9/12 , C12N15/70 , C07K14/245
CPC分类号： C12N9/1247 , C07K14/245 , C12N15/70 , C12P13/08 , C12Y207/07006
摘要： The present application relates to an L-threonine-producing microorganism and a production method for L-threonine using the same, and more specifically, to a microorganism having enhanced L-threonine productivity and a method for producing L-threonine in high yield using the same.
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公开(公告)号：US11697673B2
公开(公告)日：2023-07-11
申请号：US16956799
申请日：2019-07-25
发明人： Seok Myung Lee , Ki Yong Cheong , Chang Il Seo , Ji Sun Lee
CPC分类号： C07K14/245 , C12N1/205 , C12P13/08 , C12P13/22 , C12R2001/19
摘要： The present disclosure relates to a variant of cAMP receptor protein of Escherichia coli with alanine at position 35, a microorganism including the same, and a method of producing an L-amino acid using the same.
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公开(公告)号：US11555213B2
公开(公告)日：2023-01-17
申请号：US17472028
申请日：2021-09-10
发明人： Hyo Jin Kim , Lan Huh , Sang Jo Lim , Hyun Ah Kim , Hyoung Joon Kim , Chang il Seo , Seung Bin Lee , Ji Sun Lee
摘要： The present disclosure relates to modified homoserine dehydrogenase and a method for producing a homoserine-derived L-amino acid using the same.
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7.发明授权公开(公告)号：US11473113B2
公开(公告)日：2022-10-18
申请号：US16633461
申请日：2019-07-25
发明人： Seok Myung Lee , Ki Yong Cheong , Chang Il Seo , Ji Sun Lee
摘要： Provided are a cAMP receptor protein variant and coding sequence, a microorganism including the same, and a method of producing a L-amino acid using the same.
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公开(公告)号：US10113191B2
公开(公告)日：2018-10-30
申请号：US15112855
申请日：2015-03-17
发明人： Eun Sung Koh , Su Yon Kwon , Kwang Ho Lee , Ji Sun Lee , Juno Jang , Keun Cheol Lee , Hyeong Pyo Hong
摘要： Disclosed are a recombinant microorganism having enhanced L-amino acid productivity, wherein the recombinant microorganism is transformed to have removed or decreased activity of at least one of adenosine deaminase and AMP nucleosidase, and a method of producing an L-amino acid using the recombinant microorganism. The use of the recombinant microorganism may enable the production of the L-amino acid in a highly efficient manner.
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9.发明申请L-THREONINE-PRODUCING MICROORGANISM AND PRODUCTION METHOD FOR L-THREONINE USING THE SAME 有权利用该方法生产L-噻吩的L-产生微生物和生产方法公开(公告)号：US20160281070A1
公开(公告)日：2016-09-29
申请号：US14899676
申请日：2014-04-24
发明人： Ji Sun Lee , Kwang Ho Lee , Eun Sung Koh , Hyung Joon Kim , Keun Cheol Lee , Young Bin Hwang
CPC分类号： C12N9/1247 , C07K14/245 , C12N15/70 , C12P13/08 , C12Y207/07006
摘要： The present application relates to an L-threonine-producing microorganism and a production method for L-threonine using the same, and more specifically, to a microorganism having enhanced L-threonine productivity and a method for producing L-threonine in high yield using the same.
摘要翻译： 本申请涉及L-苏氨酸生产微生物和使用其的L-苏氨酸的制备方法，更具体地说，涉及具有增强的L-苏氨酸生产力的微生物和使用该产物的高产率L-赖氨酸生产方法 相同。
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公开(公告)号：US11407983B2
公开(公告)日：2022-08-09
申请号：US16534130
申请日：2019-08-07
发明人： Ji Sun Lee , Dong Eun Chang , So Young Kim
摘要： A nucleic acid molecule comprising a variant rpoC coding sequence is disclosed. The variant rpoC coding sequence encodes a variant RpoC which regulates copy number of a plasmid. Also disclosed are a recombinant microorganism comprising the nucleic acid molecule, a method for regulating copy number of a subject vector in the recombinant microorganism, and a method for making a target product by use of the recombinant microorganism.
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