公开(公告)号：US10968467B2

公开(公告)日：2021-04-06

申请号：US16447814

申请日：2019-06-20

申请人： CJ CHEILJEDANG CORPORATION

发明人： Ji Sun Lee ,  Kwang Ho Lee ,  Hyo Jin Kim ,  Keun Chul Lee ,  Young Bin Hwang

IPC分类号： C12P13/08 ,  C07K14/245 ,  C12N1/21 ,  C12N9/12

摘要： The present invention relates to a novel variant RNA polymerase sigma factor 70 (σ70) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing L-threonine by using the microorganism.

公开(公告)号：US09562246B2

公开(公告)日：2017-02-07

申请号：US14784621

申请日：2014-04-16

申请人： CJ Cheiljedang Corporation

发明人： Hyung Joon Kim ,  Ju No Jang ,  Kyung Rim Kim ,  Keun Cheol Lee ,  Young Bin Hwang ,  Hyeong Pyo Hong

IPC分类号： C12P13/22 ,  C12N9/10

CPC分类号： C12P13/227 ,  C12N9/1077 ,  C12Y204/02018 ,  Y02P20/52

摘要： The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.

摘要翻译： 本发明涉及具有增强的L-色氨酸生产力的埃希氏菌属微生物，其已被修饰以表达酵母邻氨基苯甲酸酯磷酸核糖转移酶，以便能够产生高浓度的L-色氨酸，以及L-色氨酸的生产方法 包括培养微生物的步骤。 埃希氏菌属的微生物可产生L-色氨酸，因此可有利地用于制药工业和饲料工业，尤其用于动物饲料。

公开(公告)号：US10053698B2

公开(公告)日：2018-08-21

申请号：US15112992

申请日：2014-04-25

申请人： CJ Cheiljedang Corporation

发明人： Hyung Joon Kim ,  Su Yon Kwon ,  Eun Sung Koh ,  Ji Sun Lee ,  Keun Cheol Lee ,  Young Bin Hwang ,  Hyeong Pyo Hong

IPC分类号： C12N1/20 ,  C12P13/08 ,  C12N15/70 ,  C07K14/34

CPC分类号： C12N15/70 ,  C07K14/34 ,  C12N1/20 ,  C12P13/08

摘要： The present invention relates to an E. coli mutant strain having enhanced L-threonine productivity, which is obtained by introducing the permease of Corynebacterium origin, and to method of producing L-threonine using the E. coli mutant strain.

公开(公告)号：US09758772B2

公开(公告)日：2017-09-12

申请号：US14899676

申请日：2014-04-24

申请人： CJ Cheiljedang Corporation

发明人： Ji Sun Lee ,  Kwang Ho Lee ,  Eun Sung Koh ,  Hyung Joon Kim ,  Keun Cheol Lee ,  Young Bin Hwang

IPC分类号： C12P13/08 ,  C12P13/02 ,  C12N9/10 ,  C12N1/20 ,  C12P21/06 ,  C12P19/34 ,  C12N15/00 ,  C07H21/04 ,  C07K1/00 ,  C12N9/12 ,  C12N15/70 ,  C07K14/245

CPC分类号： C12N9/1247 ,  C07K14/245 ,  C12N15/70 ,  C12P13/08 ,  C12Y207/07006

摘要： The present application relates to an L-threonine-producing microorganism and a production method for L-threonine using the same, and more specifically, to a microorganism having enhanced L-threonine productivity and a method for producing L-threonine in high yield using the same.

公开(公告)号：US09587261B2

公开(公告)日：2017-03-07

申请号：US14371465

申请日：2013-01-10

申请人： CJ Cheiljedang Corporation

发明人： Kwang Ho Lee ,  Hye Min Park ,  Hyo Hyoung Lee ,  Young Bin Hwang ,  Seok Myung Lee

IPC分类号： C12P13/22 ,  C12N1/20 ,  C07K14/245 ,  C12N15/71 ,  H01L27/32 ,  H01L51/52

CPC分类号： C12P13/227 ,  C07K14/245 ,  C12N15/71 ,  H01L27/3276 ,  H01L51/5231

摘要： The present invention relates to microorganisms of Escherichia coli having enhanced L-tryptophan productivity and to a method for producing L-tryptophan using the same. More particularly, the present invention relates to an Escherichia coli variant in which repression and attenuation control of the tryptophan operon is released and accumulation of anthranilate is reduced and thereby enhancing L-tryptophan productivity. The present invention also relates to a method for producing L-tryptophan using the Escherichia coli variant.

摘要翻译： 本发明涉及具有增强的L-色氨酸生产力的大肠杆菌的微生物以及使用其的生产L-色氨酸的方法。 更具体地，本发明涉及其中释放色氨酸操纵子的抑制和衰减控制并降低邻氨基苯甲酸盐的积聚并从而提高L-色氨酸生产力的大肠杆菌变体。 本发明还涉及使用大肠杆菌变体产生L-色氨酸的方法。

公开(公告)号：US10041099B2

公开(公告)日：2018-08-07

申请号：US14370500

申请日：2013-01-07

申请人： CJ Cheiljedang Corporation

发明人： Ki Yong Cheong ,  Seok Myung Lee ,  Young Bin Hwang ,  Keun Cheol Lee ,  Kwang Ho Lee

IPC分类号： C12P13/22 ,  C12N9/02 ,  C07K14/245 ,  C12P13/08 ,  C12N1/20

摘要： The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.

公开(公告)号：US20160281070A1

公开(公告)日：2016-09-29

申请号：US14899676

申请日：2014-04-24

申请人： CJ Cheiljedang Corporation

发明人： Ji Sun Lee ,  Kwang Ho Lee ,  Eun Sung Koh ,  Hyung Joon Kim ,  Keun Cheol Lee ,  Young Bin Hwang

IPC分类号： C12N9/12 ,  C12P13/08

CPC分类号： C12N9/1247 ,  C07K14/245 ,  C12N15/70 ,  C12P13/08 ,  C12Y207/07006

摘要： The present application relates to an L-threonine-producing microorganism and a production method for L-threonine using the same, and more specifically, to a microorganism having enhanced L-threonine productivity and a method for producing L-threonine in high yield using the same.

摘要翻译： 本申请涉及L-苏氨酸生产微生物和使用其的L-苏氨酸的制备方法，更具体地说，涉及具有增强的L-苏氨酸生产力的微生物和使用该产物的高产率L-赖氨酸生产方法 相同。

公开(公告)号：US11312982B2

公开(公告)日：2022-04-26

申请号：US16930082

申请日：2020-07-15

申请人： CJ CHEILJEDANG CORPORATION

发明人： Ji Sun Lee ,  Kwang Ho Lee ,  Hyo Jin Kim ,  Keun Chul Lee ,  Young Bin Hwang

IPC分类号： C12P13/08 ,  C12N15/31 ,  C07K14/245 ,  C12N9/12

摘要： The present invention relates to a novel variant RNA polymerase sigma factor 70 (δ70) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing L-threonine by using the microorganism.

公开(公告)号：US10760108B2

公开(公告)日：2020-09-01

申请号：US15117437

申请日：2015-09-04

申请人： CJ CHEILJEDANG CORPORATION

发明人： Ji Sun Lee ,  Kwang Ho Lee ,  Hyo Jin Kim ,  Keun Chul Lee ,  Young Bin Hwang

IPC分类号： C12P13/08 ,  C07K14/245 ,  C12N1/21 ,  C12N9/12

摘要： The present invention relates to a novel variant RNA polymerase sigma factor 70 (π70) polypeptide, a polynucleotide encoding the same, a microorganism containing the polypeptide, and a method for producing L-threonine by using the microorganism.

公开(公告)号：US20160153014A1

公开(公告)日：2016-06-02

申请号：US14784621

申请日：2014-04-16

申请人： CJ CHEILJEDANG CORPORATION

发明人： Hyung Joon Kim ,  Ju No Jang ,  Kyung Rim Kim ,  Keun Cheol Lee ,  Young Bin Hwang ,  Hyeong Pyo Hong

IPC分类号： C12P13/22 ,  C12N9/10

CPC分类号： C12P13/227 ,  C12N9/1077 ,  C12Y204/02018 ,  Y02P20/52

摘要： The present invention relates to a microorganism of the genus Escherichia having enhanced L-tryptophan productivity, which has been modified to express yeast anthranilate phosphoribosyltransferase in order to be able to produce L-tryptophan at high concentration, and to a method for producing L-tryptophan, comprising a step of culturing the microorganism. The microorganism of the genus Escherichia can produce L-tryptophan, and thus can be advantageously used in the pharmaceutical industry and the feed industry, particularly for animal feed.

摘要翻译： 本发明涉及具有增强的L-色氨酸生产力的埃希氏菌属微生物，其已被修饰以表达酵母邻氨基苯甲酸酯磷酸核糖转移酶，以便能够产生高浓度的L-色氨酸，以及L-色氨酸的生产方法 包括培养微生物的步骤。 埃希氏菌属的微生物可产生L-色氨酸，因此可有利地用于制药工业和饲料工业，尤其用于动物饲料。