公开(公告)号：US10815510B2

公开(公告)日：2020-10-27

申请号：US15321717

申请日：2015-06-23

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ki Yong Cheong ,  Kyung Rim Kim ,  Seok Myung Lee ,  Kwang Ho Lee ,  Keun Cheol Lee ,  Hyeong Pyo Hong

IPC: C12P13/22 ,  C12N1/21 ,  C12N9/88 ,  C12N15/52

Abstract: The present application relates to a microorganism of the genus Escherichia producing L-tryptophan and, more specifically, to a microorganism of the genus Escherichia with improved activity of producing L-tryptophan by weakening or inactivating the activity of endogenous 6-phosphogluconate dehydratase and 2-keto-3-deoxy-6-phosphogluconate aldolase.Additionally, the present application relates to a method for producing L-tryptophan using the microorganism of the genus Escherichia.

公开(公告)号：US10787692B2

公开(公告)日：2020-09-29

申请号：US15465881

申请日：2017-03-22

Applicant: CJ Cheiljedang Corporation

Inventor： Ki Yong Cheong ,  Seok Myung Lee ,  Young Bin Hwang ,  Keun Cheol Lee ,  Kwang Ho Lee

IPC: C12P13/22 ,  C12N9/02 ,  C07K14/245 ,  C12P13/08 ,  C12N1/20

Abstract: The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.

公开(公告)号：US20170198317A1

公开(公告)日：2017-07-13

申请号：US15465881

申请日：2017-03-22

Applicant: CJ Cheiljedang Corporation

Inventor： Ki Yong Cheong ,  Seok Myung Lee ,  Young Bin Hwang ,  Keun Cheol Lee ,  Kwang Ho Lee

IPC: C12P13/22 ,  C12N9/02 ,  C07K14/245 ,  C12N1/20 ,  C12P13/08

Abstract: The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.

公开(公告)号：US11524981B2

公开(公告)日：2022-12-13

申请号：US17268691

申请日：2020-03-20

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Moo Young Jung ,  Hyun Ah Kim ,  Chang Il Seo ,  Imsang Lee ,  Ji-won Kim ,  Tae Yeon Kim ,  Sung Kwang Son ,  Ki Yong Cheong

IPC: C12P13/22 ,  C12N1/21 ,  C12N15/74 ,  C12N15/77 ,  C07K14/195 ,  C12R1/15 ,  C12R1/19

Abstract: The present disclosure relates to a protein variant having a tryptophan-exporting activity, an L-tryptophan-producing microorganism expressing the protein variant, and a method for producing L-tryptophan using the microorganism.

公开(公告)号：US11512331B2

公开(公告)日：2022-11-29

申请号：US16644315

申请日：2019-07-25

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Ki Yong Cheong ,  Hyeryun Yoo ,  Chang Ii Seo ,  Jaemin Lee ,  Seung Hyun Cho

IPC: C12P13/08 ,  C07K14/245 ,  C12N15/70 ,  C12P13/22

Abstract: Provided are a cAMP receptor protein variant, a microorganism including the same, and a method of producing an L-amino acid using the same.

公开(公告)号：US20200248218A1

公开(公告)日：2020-08-06

申请号：US15769920

申请日：2016-10-21

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Chang Il Seo ,  Hye Min Park ,  Kwang Ho Lee ,  Sang Min Park ,  Kyung Rim Kim ,  Ki Yong Cheong

IPC: C12P13/08 ,  C12N9/88 ,  C12N9/10

Abstract: The present disclosure relates to a recombinant microorganism producing threonine, and a method for producing L-threonine using the same.

公开(公告)号：US20150050703A1

公开(公告)日：2015-02-19

申请号：US14370500

申请日：2013-01-07

Applicant: CJ Cheiljedang Corporation

Inventor： Ki Yong Cheong ,  Seok Myung Lee ,  Young Bin Hwang ,  Keun Cheol Lee ,  Kwang Ho Lee

IPC: C12N1/20 ,  C12P13/08 ,  C12P13/22

CPC classification number: C12P13/227 ,  C07K14/245 ,  C12N1/20 ,  C12N9/0053 ,  C12N9/0071 ,  C12P13/08 ,  C12Y114/11 ,  Y02P20/59

Abstract: The present invention relates to a microorganism able to produce L-threonine or L-tryptophan, and to a method for producing L-threonine or L-tryptophan by using same. More specifically, the present invention relates to: recombinant Escherichia coli which is more efficient in producing L-threonine or L-tryptophan by increasing the ability to produce ATP which is used as the most plentiful energy source in cells when producing L-threonine or L-tryptophan; and a method for producing L-threonine or L-tryptophan by using same.

Abstract translation: 本发明涉及能够产生L-苏氨酸或L-色氨酸的微生物，以及通过使用它们生产L-苏氨酸或L-色氨酸的方法。 更具体地说，本发明涉及：重组大肠杆菌，其通过增加产生L-苏氨酸或L的细胞中用作最丰富能量的ATP的能力而产生L-苏氨酸或L-色氨酸 色氨酸 以及通过使用它们生产L-苏氨酸或L-色氨酸的方法。

公开(公告)号：US11697673B2

公开(公告)日：2023-07-11

申请号：US16956799

申请日：2019-07-25

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Seok Myung Lee ,  Ki Yong Cheong ,  Chang Il Seo ,  Ji Sun Lee

IPC: C07K14/245 ,  C12N15/70 ,  C12P13/08 ,  C12P13/22 ,  C12N1/20 ,  C12R1/19

CPC classification number: C07K14/245 ,  C12N1/205 ,  C12P13/08 ,  C12P13/22 ,  C12R2001/19

Abstract: The present disclosure relates to a variant of cAMP receptor protein of Escherichia coli with alanine at position 35, a microorganism including the same, and a method of producing an L-amino acid using the same.

公开(公告)号：US11473113B2

公开(公告)日：2022-10-18

申请号：US16633461

申请日：2019-07-25

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Seok Myung Lee ,  Ki Yong Cheong ,  Chang Il Seo ,  Ji Sun Lee

IPC: C12N15/09 ,  C12P13/22 ,  C07K14/245 ,  C12N1/20 ,  C12N15/70 ,  C12P13/08

Abstract: Provided are a cAMP receptor protein variant and coding sequence, a microorganism including the same, and a method of producing a L-amino acid using the same.

公开(公告)号：US20220009973A1

公开(公告)日：2022-01-13

申请号：US17268691

申请日：2020-03-20

Applicant: CJ CHEILJEDANG CORPORATION

Inventor： Moo Young Jung ,  Hyun Ah Kim ,  Chang Il Seo ,  Imsang Lee ,  Ji-won Kim ,  Tae Yeon Kim ,  Sung Kwang Son ,  Ki Yong Cheong

IPC: C07K14/195 ,  C12P13/22

Abstract: The present disclosure relates to a protein variant having a tryptophan-exporting activity, an L-tryptophan-producing microorganism expressing the protein variant, and a method for producing L-tryptophan using the microorganism.