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公开(公告)号：US09097671B2
公开(公告)日：2015-08-04
申请号：US13688606
申请日：2012-11-29
申请人： Clondiag GmbH
发明人： Torsten Schulz , Thomas Kaiser , Thomas Uhlig , Klaus Peter Möbius , Alexander von Schenk zu Schweinsberg
CPC分类号： G01N21/6454 , B01L3/50273 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/087 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones are disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.
摘要翻译： 描述了用于分析多种分析物中的每一种的样品的方法。 该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。 测试区域设置在微流体装置的通道内。 通道由至少一个柔性壁和可以是柔性的第二壁限定。 每个测试区域包含对各个目标分析物特异的探针化合物。 微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。 每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。 每个测试区域的相互作用表明样品中目标分析物的存在。
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公开(公告)号：US20140148365A1
公开(公告)日：2014-05-29
申请号：US13688606
申请日：2012-11-29
申请人： CLONDIAG GMBH
发明人： Torsten Schulz , Thomas Kaiser , Thomas Uhlig , Klaus Peter Moubius , Alexander Von Schenk Zu Schweinsberg
IPC分类号： G01N21/64
CPC分类号： G01N21/6454 , B01L3/50273 , B01L2300/0636 , B01L2300/0816 , B01L2300/0819 , B01L2300/087 , B01L2400/0481
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones are disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte.
摘要翻译： 描述了用于分析多种分析物中的每一种的样品的方法。 该方法包括使间隔开的测试区域的阵列与液体样品（例如全血）接触。 测试区域设置在微流体装置的通道内。 通道由至少一个柔性壁和可以是柔性的第二壁限定。 每个测试区域包含对各个目标分析物特异的探针化合物。 微流体装置被压缩以减小通道的厚度，其是通道内的壁的内表面之间的距离。 每个分析物的存在通过光学检测在相应位置处的内表面之间的距离减小的多个测试区域中的每一个处的相互作用来确定。 每个测试区域的相互作用表明样品中目标分析物的存在。
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公开(公告)号：US20190004054A1
公开(公告)日：2019-01-03
申请号：US15893675
申请日：2018-02-11
申请人： CLONDIAG GMBH
发明人： Eugen Ermantraut , Thomas Kaiser , Jens Tuchscheerer , Vico Beier , Torsten Schulz , Anke Wostemeyer
摘要： A method for assaying a sample for each of multiple analytes is described. The method includes contacting an array of spaced-apart test zones with a liquid sample (e.g., whole blood). The test zones disposed within a channel of a microfluidic device. The channel is defined by at least one flexible wall and a second wall which may or may not be flexible. Each test zone comprising a probe compound specific for a respective target analyte. The microfluidic device is compressed to reduce the thickness of the channel, which is the distance between the inner surfaces of the walls within the channel. The presence of each analyte is determined by optically detecting an interaction at each of multiple test zones for which the distance between the inner surfaces at the corresponding location is reduced. The interaction at each test zone is indicative of the presence in the sample of a target analyte. Capillary structures of the devices or used in the methods may comprise a matrix and the devices may comprise control elements and methods for assaying of sample may use corresponding controlling activities.
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公开(公告)号：US20150197822A1
公开(公告)日：2015-07-16
申请号：US14499221
申请日：2014-09-28
申请人： CLONDIAG GMBH
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，并用于确定指示靶分子的存在和/或量的值;微流体网络 至少互连第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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