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公开(公告)号：US20150284785A1
公开(公告)日：2015-10-08
申请号：US14474274
申请日：2014-09-01
申请人： CLONDIAG GMBH
发明人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
摘要翻译： 本发明涉及用于检测分析物的装置和方法。 特别地，本发明涉及用于定性和/或定量检测分析物的方法，其包括在基底上的微阵列，探针分子固定在阵列元件上，所述微阵列设置在装置的第一表面上; 以及检测室，形成在包括设置在其上的微阵列的第一表面和第二表面之间，其中微阵列和第二表面之间的距离是可变的，并且其中第二表面具有位移结构。
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公开(公告)号：US20180088115A1
公开(公告)日：2018-03-29
申请号：US15719522
申请日：2017-09-28
申请人： CLONDIAG GMBH
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.
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公开(公告)号：US20180135116A1
公开(公告)日：2018-05-17
申请号：US15443759
申请日：2017-02-27
申请人： CLONDIAG GMBH
发明人： Eugen Emantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
IPC分类号： C12Q1/6837 , B01F11/00 , G01N21/64
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
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公开(公告)号：US09791441B2
公开(公告)日：2017-10-17
申请号：US13919524
申请日：2013-06-17
申请人： CLONDIAG GMBH
IPC分类号： G01N21/00 , G01N33/569 , B01F11/00 , B01F11/02 , B01F13/00 , B01L3/00 , G01N21/03 , G01N35/00
CPC分类号： G01N33/56966 , B01F11/0045 , B01F11/0266 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0825 , B01L2400/0481 , G01N21/03 , G01N35/0099 , G01N2021/0346 , G01N2035/00346
摘要： The present invention relates to devices and methods for the qualitative and/or quantitative detection of particles. In particular, the invention relates to devices for the detection of particles, comprising a reaction chamber formed within a chamber body between a first surface and a second surface, wherein the second surface is located opposite to the first surface, and one or more displacers, wherein the distance between the first surface and the second surface is variable via the one or more displacers at least in one or more parts of the surface area of the first surface and/or second surface. The invention also relates to corresponding methods for the detection of particles.
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公开(公告)号：US09580745B2
公开(公告)日：2017-02-28
申请号：US14474274
申请日：2014-09-01
申请人： CLONDIAG GMBH
发明人： Eugen Ermantraut , Ralf Bickel , Torsten Schulz , Thomas Ullrich
CPC分类号： C12Q1/6837 , B01F11/0045 , B01L3/5027 , B01L3/502746 , B01L7/52 , B01L7/525 , B01L2200/027 , B01L2300/044 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0864 , B01L2300/0877 , B01L2300/1827 , B01L2300/1838 , B01L2400/0481 , G01N21/6452 , G01N21/6458
摘要： The present invention relates to devices and methods for the detection of analytes. In particular, the invention relates to methods for the qualitative and/or quantitative detection of analytes, comprising a microarray on a substrate, onto which probe molecules are immobilized on array elements, said microarray being disposed on a first surface of the device; and a detection chamber formed between the first surface including the microarray disposed thereon and a second surface, wherein the distance between the microarray and the second surface is variable, and wherein the second surface has a displacement structure.
摘要翻译： 本发明涉及用于检测分析物的装置和方法。 特别地，本发明涉及用于定性和/或定量检测分析物的方法，其包括在基底上的微阵列，探针分子固定在阵列元件上，所述微阵列设置在装置的第一表面上; 以及检测室，形成在包括设置在其上的微阵列的第一表面和第二表面之间，其中微阵列和第二表面之间的距离是可变的，并且其中第二表面具有位移结构。
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公开(公告)号：US20150197822A1
公开(公告)日：2015-07-16
申请号：US14499221
申请日：2014-09-28
申请人： CLONDIAG GMBH
CPC分类号： C12Q1/703 , B01J19/0046 , B01J2219/00527 , B01J2219/00576 , B01J2219/00605 , B01J2219/00659 , B01J2219/00695 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01L3/502738 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L7/52 , B01L9/527 , B01L2200/0647 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , C12Q1/6813 , C12Q1/6825 , C12Q1/6837 , C12Q1/701 , C12Q2600/158
摘要： A device comprising a rigid substrate, a flexible cover element at least partially covering the substrate, a first structure formed in the substrate, adapted for accommodating liquids and adapted for releasing contents of one or more cells, spores, or viruses, the contents including the target molecules, a second structure formed in the substrate, adapted for accommodating liquids and comprising at least one binding member adapted for capturing the target molecules and for determining a value indicative of the presence and/or amount of the target molecules, a micro fluidic network interconnecting at least the first structure and the second structure, and an actuator member adapted for effecting a fluid flow between the first structure and the second structure by pressing the flexible cover element against the substrate to selectively close a portion of the micro fluidic network.
摘要翻译： 一种包括刚性基底的装置，至少部分地覆盖基底的柔性覆盖元件，形成在基底中的适于容纳液体并适于释放一个或多个细胞，孢子或病毒的内容物的第一结构，所述内容物包括 目标分子，形成在基底中的第二结构，适于容纳液体，并且包括适于捕获靶分子的至少一个结合成分，并用于确定指示靶分子的存在和/或量的值;微流体网络 至少互连第一结构和第二结构，以及致动器构件，其适于通过将柔性覆盖元件压靠在衬底上来选择性地关闭微流体网络的一部分来实现第一结构和第二结构之间的流体流动。
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