公开(公告)号：US12179198B2

公开(公告)日：2024-12-31

申请号：US16475901

申请日：2018-01-05

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Vincent Agache ,  Fabrice Casset ,  Stephane Fanget ,  Yves Fouillet ,  Arnaud Millet

IPC: C12Q1/04 ,  B01L3/00 ,  C12M1/26 ,  G01N15/01 ,  G01N15/10

Abstract: A system for handling biological cells includes a main channel having an inlet end and an outlet end, and, at least over a first portion from the inlet end, including a cross section such that a cell circulating in the portion undergoes mechanical stresses. The system further includes first means for detecting the presence of a cell at the inlet end of the main channel and at least one access zone opening into the main channel between its inlet end and its outlet end in the first portion, in order to make it possible to exert an action on the cell. The system also includes means for displacing the cell in order to control the displacement of the cell between the inlet end and the outlet end.

公开(公告)号：US11693481B2

公开(公告)日：2023-07-04

申请号：US17538883

申请日：2021-11-30

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Emmanuel Ollier ,  Tristan Caroff ,  Fabrice Casset

IPC: G06F3/01 ,  G06F3/02

CPC classification number: G06F3/016 ,  G06F3/0202

Abstract: A multimodal haptic device includes a matrix incorporating at least one cell, each cell comprising: at least one thermal element capable of generating a cooling and a heating; at least one vibratory element capable of generating a vibration; and at least one encapsulation layer made of an electrically insulating material; the at least one vibratory element and the at least one thermal element being anchored in at least one part in the at least one encapsulation layer; each cell being adapted to be in contact directly or indirectly with the skin of a person so as to transmit thermal and/or vibratory sensations to that person, the cell having a thickness less than or equal to ten millimetres.

公开(公告)号：US10968422B2

公开(公告)日：2021-04-06

申请号：US15335702

申请日：2016-10-27

Applicant: Commissariat A L'Energie Atomique et aux Energies Alternatives ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

Inventor： Fabrice Casset ,  Arnaud Millet

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/42 ,  C12N13/00

Abstract: A device for treating at least one biological cell includes at least one treatment support comprising a receiving surface enabling the adhesion of the at least one biological cell, at least one actuator capable of deforming said support in order to apply a stress to said at least one cell, and means of controlling said at least one actuator such that the actuator deforms the treatment support according to a given amplitude of deformation and for a given duration so as to generate at least one transitory pore in a membrane of the biological cell.

公开(公告)号：US10149054B2

公开(公告)日：2018-12-04

申请号：US15057708

申请日：2016-03-01

Applicant: Commissariat A L'Energie Atomique et aux Energies Alternatives

Inventor： Fabrice Casset

IPC: H04R3/12 ,  F04B43/02 ,  H04R1/00 ,  H04R1/24 ,  H04R1/22 ,  B81B3/00 ,  B06B1/02 ,  B81C1/00 ,  H04R17/00 ,  H04R31/00

Abstract: An operable membrane device is provided, including a plate, a plurality of membranes suspended from the plate and being a seat of residual mechanical constraints, at least a first actuator configured to deform the plate outside its plane, second actuators, each second actuator being configured to deform a membrane outside its plane, and control electronics configured to generate second control signals at the second actuators in order to vibrate the membranes and configured to generate first control signals at the first actuator to cause a deformation of the plate so that the plate is found in the deformed state, wherein a mechanical constraint is applied to the membranes that at least reduces the residual constraints of the membranes.

公开(公告)号：US12168229B2

公开(公告)日：2024-12-17

申请号：US16953601

申请日：2020-11-20

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  Institut National de la Sante et de la recherche Medicale

Inventor： Fabrice Casset ,  Arnaud Millet ,  Baptiste Neff

IPC: B01L3/00 ,  G01N15/14 ,  G01N15/149

Abstract: Device for locating biological cells of at least one size, including a fluid cavity (3), fluid connection means (6.1, 6.2) configured to allow the introduction of liquid and cells into the fluid cavity, a plate (4) provided with an accommodating surface (8) having properties of adhesion vis-à-vis cells, said plate (4) being suspended in the fluid cavity (3), means (10) for vibrating the plate (4) in at least one stationary mode including at least one actuator (16) intended to act on the plate (4) and a control unit (UC) configured to control the at least one actuator so as to actuate the vibrating plate in a stationary mode at a wavelength greater than the size of the cells.

公开(公告)号：US11852906B2

公开(公告)日：2023-12-26

申请号：US17353183

申请日：2021-06-21

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Fabrice Casset

IPC: G02F1/01 ,  G01S7/481 ,  G01S17/89

CPC classification number: G02F1/011 ,  G01S7/4818 ,  G01S17/89 ,  G02F1/0134 ,  G02F2203/05

Abstract: A phase modulator for a light beam comprising a waveguide having a longitudinal axis, and a piezoelectric actuator to apply a mechanical stress within said waveguide in response to an electrical bias, said actuator comprising a first part covering a first side of the waveguide and having a first axis of symmetry essentially parallel to the longitudinal axis. The actuator comprises a second part covering a second side of the waveguide, said second part having a second axis of symmetry essentially parallel to the longitudinal axis.

公开(公告)号：US11592904B2

公开(公告)日：2023-02-28

申请号：US17694874

申请日：2022-03-15

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Fabrice Casset

IPC: G06F3/01 ,  G06F3/041

Abstract: Flexible haptic interface including a chamber containing a non-newtonian fluid and bounded at least partially by a flexible wall the exterior face of which defines a touch surface capable of being touched by a user; a plurality of actuators borne by a flexible carrier and placed so as to transmit a local mechanical excitation to the fluid; and a control circuit connected to the actuators and configured to modulate the signals sent to the actuators in order to mechanically induce a modification of the rheology of the fluid and to generate a haptic sensation perceptible by the user on the touch surface.

公开(公告)号：US10532379B2

公开(公告)日：2020-01-14

申请号：US15515856

申请日：2015-09-30

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  STMicroelectronics (Crolles 2) SAS ,  UNIVERSITE GRENOBLE ALPES

Inventor： Fabrice Casset ,  Skandar Basrour ,  Cédrick Chappaz ,  Jean-Sébastien Danel

IPC: H01L41/09 ,  B06B3/00 ,  B81B3/00 ,  B06B1/04 ,  B06B1/06 ,  H01L41/18 ,  H01L41/25

Abstract: A mechanical structure comprising a stack including an active substrate and at least one actuator designed to generate vibrations at the active substrate, the stack comprises an elementary structure for amplifying the vibrations: positioned between the actuator and the active substrate, the structure designed to transmit and amplify the vibrations; and comprising at least one trench, located between the actuator and the active substrate. A method for manufacturing the structure comprising the use of a temporary substrate is provided.

公开(公告)号：US11972679B2

公开(公告)日：2024-04-30

申请号：US18049342

申请日：2022-10-25

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Fabrice Casset ,  Romain Le Magueresse

IPC: G08B6/00 ,  G06F3/01

CPC classification number: G08B6/00 ,  G06F3/016

Abstract: A flexible haptic interface defining a tactile surface able to be contacted by a user, the interface including a plurality of rigid tactile elements connected by a flexible support forming at least one hinge extending between at least two adjacent elements, and in contact with each element, at least one actuator, the actuators being arranged to transmit a mechanical excitation to the rigid tactile elements in order to drive in vibration the hinge situated between them with a vibration amplitude detectable by touch.

公开(公告)号：US11921958B2

公开(公告)日：2024-03-05

申请号：US17456602

申请日：2021-11-26

Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

Inventor： Fabrice Casset ,  Angélique Rascle

IPC: G06F3/043 ,  G06F3/041

CPC classification number: G06F3/043 ,  G06F3/0416 ,  G06F2203/04103

Abstract: A haptic interface of the ‘mid-air’ type, including a control circuit, a plurality of ultrasonic transducers connected to the circuit, which includes a first set of transducers emitting at a first ultrasound carrier frequency and at least a second set of transducers emitting at a second ultrasound carrier frequency different from the first; the control circuit being configured for modulating the signals sent to the transducers in order to generate, with the ultrasound waves emitted by at least a part of the transducers of the first set, an acoustic pressure detectable by touch within at least a first focal region, and generate, with the ultrasound waves emitted by at least a part of the transducers of the second set, an acoustic pressure detectable by touch within at least a second focal region.