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公开(公告)号:US10906875B2
公开(公告)日:2021-02-02
申请号:US16427629
申请日:2019-05-31
Applicant: California Institute of Technology
Inventor: Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D207/06 , C07D207/08 , C07D207/10 , C07D201/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30 , C07D207/16
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号:US10035769B2
公开(公告)日:2018-07-31
申请号:US15366590
申请日:2016-12-01
Applicant: California Institute of Technology
Inventor: Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D207/27 , C07D207/277 , C07D211/76 , C07D211/78 , C07D211/90 , C07D211/96 , C07D223/10 , C07D265/32
CPC classification number: C07D211/78 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号:US20170137382A1
公开(公告)日:2017-05-18
申请号:US15366590
申请日:2016-12-01
Applicant: California Institute of Technology
Inventor: Brian M. Stoltz , Scott C Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D207/277 , C07D207/27 , C07D265/32 , C07D211/90 , C07D211/76 , C07D211/96 , C07D223/10
CPC classification number: C07D211/78 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号:US20210155592A1
公开(公告)日:2021-05-27
申请号:US17164204
申请日:2021-02-01
Applicant: California Institute of Technology
Inventor: Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D265/32 , C07D211/60 , C07D207/16 , C07D223/10 , C07D309/04 , C07D223/04 , C07D241/04 , C07D241/08 , C07D241/52 , C07D207/06 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D309/30 , C07D207/267 , C07D207/273 , C07D207/277 , C07D211/90
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号:US10343996B2
公开(公告)日:2019-07-09
申请号:US16049434
申请日:2018-07-30
Applicant: California Institute of Technology
Inventor: Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30 , C07D241/52
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号:US20130267699A1
公开(公告)日:2013-10-10
申请号:US13797736
申请日:2013-03-12
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor: Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D265/32 , C07D207/16 , C07D223/10 , C07D211/60
CPC classification number: C07D211/78 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
Abstract translation: 本发明提供具有季中心的杂环化合物和制备化合物的方法。 方法包括制备式(II)化合物的方法:包括用过渡金属催化剂处理式(I)化合物,并且在化合价和稳定性允许的烷基化条件下进行。
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公开(公告)号:US20230098847A1
公开(公告)日:2023-03-30
申请号:US17867233
申请日:2022-07-18
Applicant: California Institute of Technology
Inventor: Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D265/32 , C07D211/60 , C07D207/16 , C07D223/10 , C07D309/04 , C07D223/04 , C07D241/04 , C07D241/08 , C07D241/52 , C07D207/06 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D309/30 , C07D207/267 , C07D207/273 , C07D207/277 , C07D211/90
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号:US20200157049A1
公开(公告)日:2020-05-21
申请号:US16427629
申请日:2019-05-31
Applicant: California Institute of Technology
Inventor: Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D265/32 , C07D211/60 , C07D207/16 , C07D223/10 , C07D309/04 , C07D223/04 , C07D241/04 , C07D241/08 , C07D241/52 , C07D207/06 , C07D265/30 , C07D207/08 , C07D207/10 , C07D207/26 , C07D207/263 , C07D207/27 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/76 , C07D211/88 , C07D211/94 , C07D211/96 , C07D309/30 , C07D207/267 , C07D207/273 , C07D207/277 , C07D211/90
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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公开(公告)号:US20180339968A1
公开(公告)日:2018-11-29
申请号:US16049434
申请日:2018-07-30
Applicant: California Institute of Technology
Inventor: Brian M. Stoltz , Scott C. Virgil , David E. White , Taiga Yurino , Yiyang Liu , Douglas C. Behenna , Douglas Duquette , Christian Eidamshaus
IPC: C07D211/78 , C07D223/10 , C07D309/04 , C07D207/16 , C07D211/60 , C07D211/90 , C07D207/277 , C07D207/273 , C07D207/267 , C07D309/30 , C07D211/96 , C07D211/94 , C07D211/88 , C07D211/76 , C07D211/38 , C07D211/34 , C07D211/22 , C07D211/18 , C07D211/16 , C07D207/46 , C07D207/27 , C07D207/263 , C07D207/26 , C07D207/10 , C07D207/08 , C07D265/30 , C07D207/06 , C07D241/52 , C07D241/08 , C07D241/04 , C07D223/04 , C07D265/32
CPC classification number: C07D211/78 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/263 , C07D207/267 , C07D207/27 , C07D207/273 , C07D207/277 , C07D207/46 , C07D211/16 , C07D211/18 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/60 , C07D211/76 , C07D211/88 , C07D211/90 , C07D211/94 , C07D211/96 , C07D223/04 , C07D223/10 , C07D241/04 , C07D241/08 , C07D241/52 , C07D265/30 , C07D265/32 , C07D309/04 , C07D309/30
Abstract: The invention provides heterocyclic compounds with quaternary centers and methods of preparing compounds. Methods include the method for the preparation of a compound of Formula (II): comprising treating a compound of Formula (I): with a transition metal catalyst and under alkylation conditions as valence and stability permit.
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