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    Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors
    2.
    发明授权
    Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors 有权
    吡唑并（3,4-B）吡啶衍生物作为磷酸二酯酶抑制剂

    公开(公告)号：US08420666B2

    公开(公告)日：2013-04-16

    申请号：US12531043

    申请日：2008-03-14

    申请人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Vinayak Vasantrao Khairnar ,  Mandadapu Raghu Ramaiah ,  Venkata P. Palle ,  Sarala Balachandran ,  Atul Kondaskar ,  Manohar Salla ,  Abhijit Ray ,  Sunanda G. Dastidar ,  Lalitha Vijaykrishnan

    发明人： Sonali Rudra ,  Nidhi Gupta ,  Lalit Kumar Baregama ,  Ritu Agarwal ,  Vinayak Vasantrao Khairnar ,  Mandadapu Raghu Ramaiah ,  Venkata P. Palle ,  Sarala Balachandran ,  Atul Kondaskar ,  Manohar Salla ,  Abhijit Ray ,  Sunanda G. Dastidar ,  Lalitha Vijaykrishnan

    IPC分类号： C07D513/02 ,  C07D515/02 ,  A01N43/42 ,  A61K31/44

    CPC分类号： C07D471/04 ,  C07D519/00

    摘要： The present invention relates to phosphodiesterase (PDE) type 4, phosphodiesterase (PDE) type 7 and dual PDE type 4/PDE type 7 inhibitors. Compounds disclosed herein having the structure of Formula 1: can be useful in the treatment, prevention, inhibition or suppression of CNS diseases, for example, multiple sclerosis; various pathological conditions such as diseases affecting the immune system, including AIDS, rejection of transplant, auto-immune disorders such as T-cell related diseases, for example, rheumatoid arthritis; inflammatory diseases such as respiratory inflammation diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchitis, allergic rhinitis, adult respiratory distress syndrome (ARDS) and other inflammatory diseases including but not limited to psoriasis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis; gastrointestinal inflammation diseases such as Crohn's disease, colitis, pancreatitis as well as different types of cancers including leukaemia; especially in humans. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as PDE type 4, PDE type 7 and dual PDE type 4/PDE type 7 inhibitors are provided.

    摘要翻译： 本发明涉及磷酸二酯酶（PDE）4型，磷酸二酯酶（PDE）7型和双重PDE型4 / PDE型7型抑制剂。 本文公开的具有式1结构的化合物可用于治疗，预防，抑制或抑制CNS疾病，例如多发性硬化; 各种病理状况如影响免疫系统的疾病，包括艾滋病，移植排斥反应，自身免疫性疾病如T细胞相关疾病，例如类风湿性关节炎; 炎性疾病如呼吸道炎症疾病，包括慢性阻塞性肺疾病（COPD），哮喘，支气管炎，过敏性鼻炎，成人呼吸窘迫综合征（ARDS）和其他炎性疾病，包括但不限于银屑病，休克，特应性皮炎，嗜酸性肉芽肿，过敏性 结膜炎，骨关节炎; 胃肠道炎症性疾病如克罗恩病，结肠炎，胰腺炎以及不同类型的癌症，包括白血病; 特别是在人类。 提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为PDE 4型，PDE型7和双重PDE型4 / PDE 7型抑制剂的用途。

    Current-limited output buffer
    4.
    发明授权
    Current-limited output buffer 失效
    限流输出缓冲器

    公开(公告)号：US07741882B1

    公开(公告)日：2010-06-22

    申请号：US12173405

    申请日：2008-07-15

    申请人： Abhijit Ray

    发明人： Abhijit Ray

    IPC分类号： H03K3/00

    CPC分类号： H03K19/018521

    摘要： An output buffer circuit includes a first output transistor having a source terminal connected to a voltage supply and a drain terminal connected to an output node. The first output transistor is capable of coupling the output node to the voltage supply when the input signal is at a high voltage in the input voltage range. The circuit also includes a second output transistor having a drain terminal connected to the output node and a source terminal connected to ground. The second output transistor is capable of coupling the output node to ground when the input signal is at a low voltage in the input voltage range. The circuit further includes a current-limiting circuit coupled to a gate terminal of the first output transistor and capable of limiting a current flowing through the gate terminal when the first output transistor is turned on. The output node outputs an output signal in an output voltage range, wherein a high voltage of the output voltage range exceeds the high voltage of the input voltage range.

    摘要翻译： 输出缓冲电路包括具有连接到电压源的源极端子和连接到输出节点的漏极端子的第一输出晶体管。 当输入信号在输入电压范围内处于高电压时，第一输出晶体管能够将输出节点耦合到电压源。 电路还包括具有连接到输出节点的漏极端子和连接到地的源极端子的第二输出晶体管。 当输入信号在输入电压范围内处于低电压时，第二输出晶体管能够将输出节点耦合到地。 电路还包括限流电路，其耦合到第一输出晶体管的栅极端子，并且当第一输出晶体管导通时能够限制流过栅极端子的电流。 输出节点输出输出电压范围内的输出信号，其中输出电压范围的高电压超过输入电压范围的高电压。

    5-lipoxygenase inhibitors
    5.
    发明授权
    5-lipoxygenase inhibitors 失效
    5-脂氧合酶抑制剂

    公开(公告)号：US07674811B2

    公开(公告)日：2010-03-09

    申请号：US11685892

    申请日：2007-03-14

    申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Abhijit Ray ,  Shirumalla Raj Kumar

    发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Abhijit Ray ,  Shirumalla Raj Kumar

    IPC分类号： C07D249/08 ,  A61K31/4196

    CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D413/14

    摘要： The present invention relates to 5-lipoxygenase inhibitors. Compounds disclosed herein can be useful in the treatment of bronchial asthma, chronic obstructive pulmonary disorder, arthritis, type I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, cancer, pruritis, urticaria, atopic dermatitis, allergic rhinitis, other inflammatory, and autoimmune diseases. Processes for the preparation of disclosed compounds, pharmaceutical compositions containing the disclosed compounds and their use as 5-lipoxygenase inhibitors are also provided.

    摘要翻译： 本发明涉及5-脂氧合酶抑制剂。 本文公开的化合物可用于治疗支气管哮喘，慢性阻塞性肺病，关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，癌症，瘙痒症，荨麻疹，特应性 皮炎，过敏性鼻炎，其他炎症和自身免疫性疾病。 还提供了制备所公开的化合物的方法，含有所公开的化合物的药物组合物及其作为5-脂氧合酶抑制剂的用途。

    INHIBITORS OF PHOSPHODIESTERASE TYPE-IV
    6.
    发明申请
    INHIBITORS OF PHOSPHODIESTERASE TYPE-IV 审中-公开
    磷酸酯酶类型IV的抑制剂

    公开(公告)号：US20090221566A1

    公开(公告)日：2009-09-03

    申请号：US12090790

    申请日：2006-10-05

    申请人： Venkata P. Palle ,  Sarala Balachandran ,  Sarika Ramnani ,  Abhijit Ray ,  Sunanda G. Dastidar

    发明人： Venkata P. Palle ,  Sarala Balachandran ,  Sarika Ramnani ,  Abhijit Ray ,  Sunanda G. Dastidar

    IPC分类号： A61K31/537 ,  C07D265/02 ,  A61K31/535 ,  A61P25/00 ,  A61P11/06 ,  A61P11/08 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/10

    CPC分类号： C07D265/02

    摘要： The present invention relates to oxazine derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. Compounds disclosed herein can be useful in the treatment of CMS disorders, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type IV inhibitors.

    摘要翻译： 本发明涉及恶嗪衍生物，其可用作IV型磷酸二酯酶（PDE）的选择性抑制剂。 本文公开的化合物可用于治疗CMS疾病，AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS） 嗜酸粒细胞性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎和其他炎性疾病，特别是人类。 提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为磷酸二酯酶（PDE）IV型抑制剂的用途。

    MONOSACCHARIDE DERIVATIVES
    9.
    发明申请
    MONOSACCHARIDE DERIVATIVES 审中-公开
    单糖衍生物

    公开(公告)号：US20080300196A1

    公开(公告)日：2008-12-04

    申请号：US11866542

    申请日：2007-10-03

    申请人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Rajkumar Shirumalla ,  Abhijit Ray

    发明人： Ashwani Kumar Verma ,  Sanjay Malhotra ,  Sankaranarayanan Dharmarajan ,  Rajkumar Shirumalla ,  Abhijit Ray

    IPC分类号： A61K31/7052 ,  C07H17/02 ,  A61K31/70 ,  A61P9/00 ,  A61P37/00 ,  A61P35/00 ,  A61P29/00 ,  C07H15/00

    CPC分类号： C07H3/02 ,  C07H9/04 ,  C07H15/00

    摘要： The present invention relates to monosaccharide derivatives as anti-inflammatory agents. The compounds disclosed herein can be useful for inhibition and prevention of inflammation and associated pathologies including inflammatory, cancer, cardiovascular and autoimmune diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis. Pharmacological compositions containing compounds disclosed herein and the methods of treating diseases such as bronchial asthma, rheumatoid arthritis, type-I diabetes, multiple sclerosis, cancer, cardiovascular diseases, allograft rejection, psoriasis, inflammatory bowel disease, ulcerative colitis, acne, atherosclerosis, pruritis or allergic rhinitis and other inflammatory and/or autoimmune disorders, using the compounds are also provided.

    摘要翻译： 本发明涉及作为抗炎剂的单糖衍生物。 本文公开的化合物可用于抑制和预防炎症和相关病理，包括炎症，癌症，心血管和自身免疫性疾病如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化，同种异体移植排斥，牛皮癣，炎性肠病， 溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒或过敏性鼻炎。 包含本文公开的化合物的药理学组合物和治疗诸如支气管哮喘，类风湿性关节炎，I型糖尿病，多发性硬化症，癌症，心血管疾病，同种异体移植排斥，牛皮癣，炎性肠病，溃疡性结肠炎，痤疮，动脉粥样硬化，瘙痒症 或使用该化合物的过敏性鼻炎和其它炎症和/或自身免疫性疾病。