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公开(公告)号：US20110136682A1
公开(公告)日：2011-06-09
申请号：US12959811
申请日：2010-12-03
IPC分类号： C40B30/00 , C12Q1/02 , C12P21/00 , C07K14/00 , C12N5/071 , C12Q1/34 , C12Q1/68 , C12Q1/48 , G01N27/447 , H01J49/00 , G01J1/58 , G01J1/42 , G01N21/00 , G01R33/44
CPC分类号： G01N33/68
摘要： The present invention provides methods of evaluating CHO cells and producing recombinant glycoproteins.
摘要翻译： 本发明提供了评估CHO细胞并产生重组糖蛋白的方法。
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2.发明申请GAL ALPHA 1-3GAL-CONTAINING N-GLYCANS IN GLYCOPROTEIN PRODUCTS DERIVED FROM CHO CELLS 有权来自CHO细胞的GLYCOPROTEIN产品中的GAL ALPHA含有1GG的含N-甘氨酸公开(公告)号：US20110045496A1
公开(公告)日：2011-02-24
申请号：US12529109
申请日：2009-01-22
申请人： Carlos Bosques , Jennifer Murphy , Hetal Sarvaiya , Nathaniel Washburn , Cuihua Liu , Xiao-Jin Xu
发明人： Carlos Bosques , Jennifer Murphy , Hetal Sarvaiya , Nathaniel Washburn , Cuihua Liu , Xiao-Jin Xu
CPC分类号： C12P21/005 , C07K14/70521 , C07K2319/30 , G01N33/5308 , G01N2400/02 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The present invention provides methods of evaluating CHO cells.
摘要翻译： 本发明提供了评估CHO细胞的方法。
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3.发明授权Gal α1-3gal-containing N-glycans in glycoprotein products derived from CHO cells 有权来自CHO细胞的糖蛋白产物中含有α1α1-gal的N-聚糖公开(公告)号：US08586356B2
公开(公告)日：2013-11-19
申请号：US12529109
申请日：2009-01-22
申请人： Carlos Bosques , Jennifer Murphy , Hetal Sarvaiya , Nathaniel Washburn , Cuihua Liu , Xiao-Jin Xu
发明人： Carlos Bosques , Jennifer Murphy , Hetal Sarvaiya , Nathaniel Washburn , Cuihua Liu , Xiao-Jin Xu
CPC分类号： C12P21/005 , C07K14/70521 , C07K2319/30 , G01N33/5308 , G01N2400/02 , Y10T436/24 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： The present invention provides methods of evaluating CHO cells.
摘要翻译： 本发明提供了评价CHO细胞的方法。
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公开(公告)号：US09103821B2
公开(公告)日：2015-08-11
申请号：US13140553
申请日：2009-12-18
CPC分类号： G01N33/5308 , C12Q1/34 , G01N33/50 , G01N33/52 , G01N2400/38
摘要： Among other things, the present disclosure provides methods for enriching, identifying, and/or quantifying unusually modified glycans (e.g., phosphorylated glycans, sulfated glycans, and/or multi-acetylated glycans). In many embodiments, methods comprise providing a glycan preparation from which sialic acids have been released; subjecting the sialidase-treated glycan preparation to a separation technique that separates glycans based on charge-to-mass ratio; and quantifying the charged products using at least one quantification standard.
摘要翻译： 除其他之外，本公开提供了用于富集，鉴定和/或定量异常修饰的聚糖（例如磷酸化聚糖，硫酸化聚糖和/或多乙酰化聚糖）的方法。 在许多实施方案中，方法包括提供已经从其释放唾液酸的聚糖制剂; 将经唾液酸酶处理的聚糖制剂进行基于电荷与质量比的分离聚糖的分离技术; 并使用至少一个定量标准量化带电产物。
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公开(公告)号：US08729241B2
公开(公告)日：2014-05-20
申请号：US13140550
申请日：2009-12-18
申请人： Cuihua Liu , Xiao-Jin Xu , Shiming Dong , Guy Dellorusso
发明人： Cuihua Liu , Xiao-Jin Xu , Shiming Dong , Guy Dellorusso
CPC分类号： C08B37/00 , C08B37/006 , C12P19/28 , G01N30/72 , G01N33/5308 , G01N2030/8831 , Y10T436/143333
摘要： The present disclosure provides methods for analyzing structure and/or composition of glycoproteins and glycans of glycoproteins. Such methods can include subjecting a glycoprotein preparation to a condition that removes at least one O-linked glycan from the glycoprotein. Such methods can include subjecting a glycoprotein preparation to a condition that releases an N-glycan from the glycoprotein, e.g., prior to subjecting the glycoprotein to a condition that releases an O-glycan from the glycoprotein.
摘要翻译： 本公开提供了用于分析糖蛋白的糖蛋白和聚糖的结构和/或组成的方法。 这样的方法可以包括使糖蛋白制剂经历从糖蛋白中除去至少一个O-连接的聚糖的条件。 这样的方法可以包括使糖蛋白制剂经历糖蛋白释放N-聚糖的条件，例如在使糖蛋白从糖蛋白释放O-聚糖的条件之前。
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公开(公告)号：US08324348B1
公开(公告)日：2012-12-04
申请号：US13584309
申请日：2012-08-13
申请人： Cuihua Liu , Shiming Dong , Xiao-Jin Xu , Jonathan C. Lansing , Yanjie Jiang
发明人： Cuihua Liu , Shiming Dong , Xiao-Jin Xu , Jonathan C. Lansing , Yanjie Jiang
IPC分类号： A61K38/00
CPC分类号： G01N33/6848 , A61K38/02 , C07K2/00 , C12Q1/37
摘要： Methods of analyzing glatiramer acetate (GA) or a polymeric precursor thereof are provided. The methods can include determining a level of one or more diethylamide-modified amino acids in a sample comprising GA or a polymeric precursor thereof, and selecting at least a portion of the sample based on the assessment of the one or more diethylamide-modified amino acids in the sample.
摘要翻译： 提供了分析醋酸格拉醋酸（GA）或其聚合物前体的方法。 所述方法可以包括确定包含GA或其聚合物前体的样品中一种或多种二乙酰胺修饰的氨基酸的水平，并且基于一种或多种二乙基酰胺修饰的氨基酸的评估来选择至少一部分样品 在样品中。
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公开(公告)号：US20110287465A1
公开(公告)日：2011-11-24
申请号：US13140550
申请日：2009-12-18
申请人： Cuihua Liu , Xiao-Jin Xu , Shiming Dong , Guy Dellorusso
发明人： Cuihua Liu , Xiao-Jin Xu , Shiming Dong , Guy Dellorusso
CPC分类号： C08B37/00 , C08B37/006 , C12P19/28 , G01N30/72 , G01N33/5308 , G01N2030/8831 , Y10T436/143333
摘要： The present disclosure provides methods for analyzing structure and/or composition of glycoproteins and glycans of glycoproteins. Such methods can include subjecting a glycoprotein preparation to a condition that removes at least one O-linked glycan from the glycoprotein. Such methods can include subjecting a glycoprotein preparation to a condition that releases an N-glycan from the glycoprotein, e.g., prior to subjecting the glycoprotein to a condition that releases an O-glycan from the glycoprotein.
摘要翻译： 本公开提供了用于分析糖蛋白的糖蛋白和聚糖的结构和/或组成的方法。 这样的方法可以包括使糖蛋白制剂经历从糖蛋白中除去至少一个O-连接的聚糖的条件。 这样的方法可以包括使糖蛋白制剂经历糖蛋白释放N-聚糖的条件，例如在使糖蛋白从糖蛋白释放O-聚糖的条件之前。
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公开(公告)号：US09212192B2
公开(公告)日：2015-12-15
申请号：US13979387
申请日：2012-01-20
申请人： Anil Vasudevan , Thomas Dale Penning , Huanming Chen , Bo Liang , Shaohui Wang , Fengchun Wu , Yan Shen , Cuihua Liu , Zhenguang Zou , Marina Pliushchev
发明人： Anil Vasudevan , Thomas Dale Penning , Huanming Chen , Bo Liang , Shaohui Wang , Fengchun Wu , Yan Shen , Cuihua Liu , Zhenguang Zou , Marina Pliushchev
IPC分类号： C07D487/04 , A61K31/4353 , A61P35/00 , C07D519/00 , C07D471/04
CPC分类号： C07D519/00 , A61K31/4353 , C07D471/04 , C07D487/04
摘要： Compounds of formula (I) or pharmaceutical acceptable salts are provided, wherein X1˜X5, R1˜R3, A, B, Z and n are defined in the description. And compositions containing said compounds, and the uses for inhibitors of kinases such as ALK, and the uses for treating cancer thereof are provided.
摘要翻译： 提供式（I）化合物或药学上可接受的盐，其中X 1，X 5，R 1〜R 3，A，B，Z和n在说明书中定义。 并提供含有所述化合物的组合物，以及用于激酶例如ALK的用途及其用于治疗癌症的用途。
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公开(公告)号：US08101733B1
公开(公告)日：2012-01-24
申请号：US11426765
申请日：2006-06-27
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： A61K31/727 , C08B37/0075
摘要： Methods for analyzing mixtures of polysaccharides, for example heparin or a LMWH, using reduce end labeling are described. In general, the mixture of polysaccharides includes polysaccharides having a desired structural moiety. In some instances, one or more polysaccharides in the mixture are chemically modified prior to analysis.
摘要翻译： 描述了使用减少末端标记来分析多糖混合物的方法，例如肝素或LMWH。 通常，多糖的混合物包括具有所需结构部分的多糖。 在一些情况下，混合物中的一种或多种多糖在分析之前被化学修饰。
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公开(公告)号：US20070287683A1
公开(公告)日：2007-12-13
申请号：US11805829
申请日：2007-05-24
申请人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Mamuwala , Ian Fier , Yiwei Qi , Ishan Capila , Nur Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
发明人： Zachary Shriver , Mallikarjun Sundaram , Ganesh Venkataraman , Pat Oliver-Shaffer , Yiming Yao , Zainab Mamuwala , Ian Fier , Yiwei Qi , Ishan Capila , Nur Gunay , Daniela Beccati , Cuihua Liu , Corinne Bauer , Ying Li
IPC分类号： A61K31/727 , C08B37/10
CPC分类号： C08B37/0078
摘要： Preparations of low molecular weight heparins (LMWHs) having improved properties, e.g., properties that provide a clinical advantage, are provided herein. Methods of making and using such preparations as well as methods of analyzing starting materials, processing, intermediates and final products in the production of such LMWH preparations are provided.
摘要翻译： 本文提供具有改善性能的低分子量肝素（LMWH）的制备，例如提供临床优势的性质。 提供了制备和使用这些制剂的方法以及在生产这种LMWH制剂中分析原料，加工，中间体和最终产品的方法。
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