公开(公告)号：US20110034378A1

公开(公告)日：2011-02-10

申请号：US12735472

申请日：2009-01-21

申请人： Chaitanya Dutt ,  Deepa Joshi ,  Ram Gupta ,  Kumarprafull Chandra

发明人： Chaitanya Dutt ,  Deepa Joshi ,  Ram Gupta ,  Kumarprafull Chandra

IPC分类号： A61K31/4425 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/4436 ,  A61K31/55 ,  A61K31/472 ,  A61K31/675 ,  A61K31/549 ,  A61K31/397 ,  A61K38/26 ,  A61K38/28 ,  A61K31/704 ,  A61P9/04 ,  A61P9/12 ,  A61P9/10 ,  A61P9/00 ,  A61P13/12 ,  A61P3/10 ,  A61P3/04 ,  A61P7/02 ,  C07D213/86 ,  C07D213/87 ,  C07D405/14 ,  C07D401/12 ,  C07D401/06 ,  C07D409/06 ,  C07D417/06

CPC分类号： A61K31/155 ,  A61K31/00 ,  A61K31/40 ,  A61K31/44 ,  A61K31/4422 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a combination, such as a combined preparation or pharmaceutical composition comprising: (a) compound of formula (I), and/or (II) or a pharmaceutically acceptable salt thereof; (b) at least one therapeutic agent selected from the group consisting of: an antihypertensive agent; an antidiabetics agent; a hypolipidemic agent; an antiplatelet agent; an antiobesity agent; an antithrombotic agent; an agent for diabetic vascular complications; and an agent for treatment of heart failure; or a pharmaceutically acceptable salts thereof, optionally in presence of a pharmaceutically acceptable carrier for separate, simultaneous or sequential use. The present invention also relates to a use of such combination for the treatment of mammal including human being. R1, R2, R3, R1, R2, R3, R4, R5, X, Y, A and B and m are as defined in the specification.

摘要翻译： 本发明涉及组合，例如组合制剂或药物组合物，其包含：（a）式（I）和/或（II）化合物或其药学上可接受的盐; （b）至少一种选自以下的治疗剂：抗高血压药; 抗糖尿病药; 降血脂药; 抗血小板药; 抗生素; 抗血栓剂; 糖尿病血管并发症的药剂; 和治疗心力衰竭的药剂; 或其药学上可接受的盐，任选地在用于分离，同时或顺序使用的药学上可接受的载体的存在下。 本发明还涉及这种组合用于治疗包括人的哺乳动物的用途。 R1，R2，R3，R1，R2，R3，R4，R5，X，Y，A和B和m如说明书中所定义。

公开(公告)号：US20120046317A1

公开(公告)日：2012-02-23

申请号：US13318740

申请日：2010-05-06

申请人： Chaitanya Dutt ,  Vijay Chauthaiwale ,  Ramesh Chandra Gupta ,  Manish Patel ,  Jignesh Kotecha ,  Sachin Latad ,  Jaya Abraham ,  Sanjay Srivastava ,  Milin Rode ,  Shailesh Deshpande ,  Anita Chaudhary ,  Amit Kumar Kesarwani

发明人： Chaitanya Dutt ,  Vijay Chauthaiwale ,  Ramesh Chandra Gupta ,  Manish Patel ,  Jignesh Kotecha ,  Sachin Latad ,  Jaya Abraham ,  Sanjay Srivastava ,  Milin Rode ,  Shailesh Deshpande ,  Anita Chaudhary ,  Amit Kumar Kesarwani

IPC分类号： A61K31/4535 ,  C07D213/54 ,  C07D211/34 ,  C07D409/02 ,  A61K31/4436 ,  A61K31/444 ,  A61K31/4439 ,  A61K31/435 ,  A61K31/445 ,  A61P25/00 ,  A61P9/12 ,  A61P9/04 ,  A61P27/02 ,  A61P9/10 ,  A61P25/28 ,  A61P13/12 ,  A61P17/00 ,  C07D409/14

CPC分类号： C07D409/06 ,  C07D211/56 ,  C07D211/60 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D417/04

摘要： The present invention relates to a new class of heterocyclic compounds and pharmaceutically acceptable salts thereof, process for preparing the same, pharmaceutical composition containing these compounds and to their use in treatment of diseases caused due to formation and accumulation of AGEs (Advanced Glycation end products). The compounds of the present invention are useful for the treatment of diabetic and aging-related complications caused by formation and accumulation of AGEs, such as neuropathy, nephropathy, microangiopathy, retinopathy, hypertension, heart failure, atherosclerosis, Alzheimer's disease & dermatological disorders.

摘要翻译： 本发明涉及一类新的杂环化合物及其药学上可接受的盐，其制备方法，含有这些化合物的药物组合物及其用于治疗由于AGEs的形成和积累引起的疾病（高级糖化终产物） 。 本发明的化合物可用于治疗由AGEs的形成和积累引起的糖尿病和老化相关并发症，例如神经病，肾病，微血管病变，视网膜病变，高血压，心力衰竭，动脉粥样硬化，阿尔茨海默病和皮肤病。

公开(公告)号：US20110130414A1

公开(公告)日：2011-06-02

申请号：US12877704

申请日：2010-09-08

申请人： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

发明人： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

IPC分类号： A61K31/519 ,  C07D487/04 ,  C07D471/14 ,  A61P9/00 ,  A61P13/12 ,  A61P31/00 ,  A61P35/00 ,  A61P7/06

CPC分类号： C07D513/04 ,  C07D513/14

摘要： The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

摘要翻译： 本发明涉及新化合物，其药学上可接受的盐及其异构体，立体异构体，构象异构体，互变异构体，多晶型物，水合物和溶剂合物。 本发明还包括所述化合物的药学上可接受的组合物和制备新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。

公开(公告)号：US08541430B2

公开(公告)日：2013-09-24

申请号：US12877704

申请日：2010-09-08

申请人： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

发明人： Sanjay Srivastava ,  Laxmikant Chhipa ,  Ramesh Chandra Gupta ,  Shailesh Deshpande ,  Anita Chaudhari ,  Anookh Mohanan ,  Chaitanya Dutt ,  Vijay Chauthaiwale ,  Murali Badanthadka ,  Prashant G. Jamadarkhana

IPC分类号： A01N43/54 ,  A61K31/505

CPC分类号： C07D513/04 ,  C07D513/14

摘要： The present invention relates to novel compounds, their pharmaceutically acceptable salts, and their isomers, stereoisomers, conformers, tautomers, polymorphs, hydrates and solvates. The present invention also encompasses pharmaceutically acceptable compositions of said compounds and process for preparing novel compounds. The invention further relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

摘要翻译： 本发明涉及新化合物，其药学上可接受的盐及其异构体，立体异构体，构象异构体，互变异构体，多晶型物，水合物和溶剂合物。 本发明还包括所述化合物的药学上可接受的组合物和制备新化合物的方法。 本发明还涉及上述化合物在制备用作药物的药物中的用途。

公开(公告)号：US08143424B2

公开(公告)日：2012-03-27

申请号：US12224168

申请日：2008-06-02

申请人： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  Chaitanya Dutt ,  Vijay Chauthaiwale

发明人： Laxmikant Chhipa ,  Shitalkumar Pukharaj Zambad ,  Ramesh Gupta ,  Davinder Tuli ,  Ashok Kasundra ,  Siralee Munshi ,  M. Amir Siddiqui ,  Subrat Kumar Bhattamisra ,  Chaitanya Dutt ,  Vijay Chauthaiwale

IPC分类号： A61K31/5377 ,  A61K31/415 ,  A61K31/4155 ,  A61K31/4245 ,  A61K31/506 ,  C07D231/20 ,  C07D403/06 ,  C07D403/04 ,  C07D413/04 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P3/00 ,  A61P5/14 ,  A61P17/00 ,  A61P9/00 ,  A61P25/24

CPC分类号： C07D403/06 ,  C07D231/12 ,  C07D231/14 ,  C07D231/18 ,  C07D403/10 ,  C07D403/12 ,  C07D409/04 ,  C07D413/06

摘要： A novel thyroid like compounds of formula (I), wherein R1, R2, R3, R4 and Z are as defined in the specification, method for its preparation, composition and use thereof. Further, compounds of formula (I) has significantly low binding affinity to thyroid receptors and thus considerably devoid of thyrotoxic effects. The invention also relates to the use of the compound of formula (I) for the preparation of a medicament for treating various disease conditions including obesity, dyslipidemia, metabolic syndrome and co-morbidities associated with metabolic syndrome.

摘要翻译： 一种新型甲状腺类似式（I）的化合物，其中R1，R2，R3，R4和Z如说明书中所定义，其制备方法，组合物和用途。 此外，式（I）化合物对甲状腺受体具有显着低的结合亲和力，因此显着缺乏甲状腺毒性作用。 本发明还涉及式（I）化合物在制备用于治疗各种疾病状况，包括肥胖，血脂异常，代谢综合征和与代谢综合征相关的并发症的药物中的用途。