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公开(公告)号：US20150306296A1
公开(公告)日：2015-10-29
申请号：US14694628
申请日：2015-04-23
发明人： Jeffrey T. Borenstein , Ernest Kim , Joseph L. Charest , Alla Epshteyn , Abigail Spencer , James Truslow
CPC分类号： A61M1/32 , A61M1/1698 , A61M2205/0244 , B29C65/06 , B29C65/08 , B29C65/16 , B29C65/4815 , B29C65/483 , B29C66/1122 , B29C66/543 , B29L2031/756 , B32B37/06 , B32B37/12 , B32B37/182 , B32B38/0008 , B32B38/18 , B32B38/1808 , B32B38/1841 , B32B2307/724 , B32B2535/00
摘要： The present disclosure describes a blood oxygenator that includes a checkerboard layout of fluid (e.g., blood) and gas (e.g., oxygen) channels. When viewed as a cross-section through each of the channels of the oxygenator, the checkerboard configuration includes alternating gas and fluid channels in both the x-axis (e.g., in-plane) and in the y-axis (e.g., out-of-plane) directions. The oxygenator described herein reduces manufacturing complexity by using first, second, and third polymer layers that include asymmetrical channel designs. The channel designs include “open” gas channels, which are exposed to the ambient atmosphere. The oxygenator is placed within a pressure vessel to drive gas into each of the open gas channels, which in some implementations, negates the need for a gas manifold.
摘要翻译： 本公开描述了一种血液充氧器，其包括流体（例如血液）和气体（例如氧气）通道的棋盘布局。 当视为通过氧合器的每个通道的横截面时，棋盘结构包括在x轴（例如，平面内）和y轴（例如，外侧）中的交替的气体和流体通道 平面）方向。 本文所述的氧合器通过使用包括不对称通道设计的第一，第二和第三聚合物层来降低制造复杂性。 通道设计包括暴露于大气环境的“开放”气体通道。 将氧合器放置在压力容器内以将气体驱动到每个开放气体通道中，这在一些实施方式中不需要气体歧管。
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公开(公告)号：US20210154452A1
公开(公告)日：2021-05-27
申请号：US17100335
申请日：2020-11-20
发明人： Vishal Tandon , Ernest Kim , Jeffrey Borenstein
IPC分类号： A61M31/00
摘要： The present solution provides systems and methods for trans-round window membrane drug delivery. As an overview, a system can include a micropump that is connected to a flexible cannula. The cannula can be threaded through a handpiece that can be used to pierce the round window membrane of a patient. Using the handpiece, the cannula can be inserted through the round window membrane to improve the distribution of the delivered drug throughout the inner ear. The present solution can function as a small implantable or wearable device that can be used for both chronic and acute trans-round window membrane drug delivery. With this configuration, the micropump can constantly or intermittently deliver, over a period of days to months, small volumes of drugs from an internal reservoir.
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公开(公告)号：US10071193B2
公开(公告)日：2018-09-11
申请号：US15094623
申请日：2016-04-08
发明人： Christopher DiBiasio , Joseph L. Charest , Jeffrey T. Borenstein , Ernest Kim , Daniel I. Harjes
CPC分类号： A61M1/34 , A61M1/16 , A61M1/1631 , A61M1/1698 , A61M1/3403 , A61M1/36 , A61M2202/0413 , A61M2205/0244 , A61M2205/75 , B01D61/243 , B01D63/005 , B01D63/082 , B01D63/085 , B01D63/088 , B01D2313/08 , B01D2313/105 , B01D2319/04 , B01L3/5027 , B01L2300/0864 , B01L2300/0874 , F17D1/00 , Y10T137/794
摘要： A compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
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公开(公告)号：US09717835B2
公开(公告)日：2017-08-01
申请号：US14694628
申请日：2015-04-23
发明人： Jeffrey T. Borenstein , Ernest Kim , Joseph L. Charest , Alla Epshteyn , Abigail Spencer , James Truslow
IPC分类号： A61M1/00 , A61M1/32 , B32B38/18 , A61M1/16 , B32B37/06 , B32B37/12 , B32B37/18 , B32B38/00 , B29C65/08 , B29C65/16 , B29C65/48 , B29C65/00 , B29L31/00 , B29C65/06
CPC分类号： A61M1/32 , A61M1/1698 , A61M2205/0244 , B29C65/06 , B29C65/08 , B29C65/16 , B29C65/4815 , B29C65/483 , B29C66/1122 , B29C66/543 , B29L2031/756 , B32B37/06 , B32B37/12 , B32B37/182 , B32B38/0008 , B32B38/18 , B32B38/1808 , B32B38/1841 , B32B2307/724 , B32B2535/00
摘要： The present disclosure describes a blood oxygenator that includes a checkerboard layout of fluid (e.g., blood) and gas (e.g., oxygen) channels. When viewed as a cross-section through each of the channels of the oxygenator, the checkerboard configuration includes alternating gas and fluid channels in both the x-axis (e.g., in-plane) and in the y-axis (e.g., out-of-plane) directions. The oxygenator described herein reduces manufacturing complexity by using first, second, and third polymer layers that include asymmetrical channel designs. The channel designs include “open” gas channels, which are exposed to the ambient atmosphere. The oxygenator is placed within a pressure vessel to drive gas into each of the open gas channels, which in some implementations, negates the need for a gas manifold.
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公开(公告)号：US20160220961A1
公开(公告)日：2016-08-04
申请号：US15094623
申请日：2016-04-08
发明人： Christopher DiBiasio , Joseph L. Charest , Jeffrey T. Borenstein , Ernest Kim , Daniel I. Harjes
CPC分类号： A61M1/34 , A61M1/16 , A61M1/1631 , A61M1/1698 , A61M1/3403 , A61M1/36 , A61M2202/0413 , A61M2205/0244 , A61M2205/75 , B01D61/243 , B01D63/005 , B01D63/082 , B01D63/085 , B01D63/088 , B01D2313/08 , B01D2313/105 , B01D2319/04 , B01L3/5027 , B01L2300/0864 , B01L2300/0874 , F17D1/00 , Y10T137/794
摘要： A compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device.
摘要翻译： 提供用于输送剪切敏感流体的紧凑型液压歧管。 信道网络可以包括耦合到分叉架构的中继线和分支架构。 可以使用诸如锥形通道壁，通道的曲率和通道角度以及低流体压力的区域来减小尺寸，同时将壁剪切速率保持在窄范围内。 液压歧管可以连接到一系列微流体层以构造紧凑的微流体装置。
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公开(公告)号：US20240002919A1
公开(公告)日：2024-01-04
申请号：US18141553
申请日：2023-05-01
发明人： Charles A. LISSANDRELLO , Aditi R. NAIK , Diana J. LEWIS , Erin ROSENBERGER , Joseph Neil URBAN , Jason FIERING , Caleb R. Bell , Cait Ni Chleirigh , Ernest Kim
IPC分类号： C12Q1/6851 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/6851 , B01L3/502715 , B01L7/52 , C12Q1/6806
摘要： A removable cartridge to be used in a system for extracting and detecting nucleic acids from heterogeneous samples includes a plurality of reservoirs defining at least a first wash buffer reservoir for holding a first wash buffer and a microfluidic assembly configured to attach to the plurality of reservoirs. The microfluidic assembly includes at least one sample reservoir and a nucleic acid extraction matrix in fluid communication to an automated sample preparation (ASP) reservoir through a first flow channel defined by the microfluidic assembly. An assay chamber is in fluid communication with a third flow channel and with the waste reservoir through a fourth flow channel such that a labeled nucleic acid-containing sample flows through the assay chamber and then to the waste reservoir, wherein vibration-driven mixing agitates fluids while present in the assay chamber. Finally, a nucleic acid-detecting microarray module is positioned in the assay chamber.
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公开(公告)号：US20210154379A1
公开(公告)日：2021-05-27
申请号：US17100309
申请日：2020-11-20
发明人： Vishal Tandon , Ernest Kim , Jeffrey Borenstein
摘要： The present disclosure provides a handpiece for trans-canal delivery of a therapeutic substance to the inner ear. The handpiece can be inserted into the middle ear via a surgical tympanotomy approach. The handpiece can be integrated with a micropump and a fluid reservoir. The handpiece can enable a controlled injection of a therapeutic substance directly through the round window membrane and into the inner ear. The direct delivery of the therapeutic substance to the inner ear can enable the delivery of a precise amount of therapeutic substance into the inner ear. The micropump can include a self-contained fluid reservoir that can provide predetermined volumes of fluid to precise areas of the patient.
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