公开(公告)号：US5304479A

公开(公告)日：1994-04-19

申请号：US803057

申请日：1991-12-06

申请人： Cheng-I Lin ,  Yuh-geng Tsay

发明人： Cheng-I Lin ,  Yuh-geng Tsay

IPC分类号： C07D295/135 ,  C07D295/155 ,  C12N9/96 ,  G01N33/94 ,  C07D211/06 ,  C07K17/06

CPC分类号： C07D295/135 ,  C07D295/155 ,  C12N9/96 ,  G01N33/9486 ,  C07C2101/14 ,  Y10S436/816 ,  Y10S436/901 ,  Y10S530/807

摘要： Novel derivatives of phencyclidine are provided as precursors for conjugating to antigenic proteins for the preparation of antibodies which bind to phencyclidine or conjugation to enzymes for use as reagents in immunoassays. The combination of the antibodies and enzyme conjugates provide a sensitive and rapid assay for phencyclidine.

摘要翻译： 提供苯环利定的新型衍生物作为与抗原蛋白偶联的前体，用于制备结合苯环利定或与酶结合的抗体，用作免疫测定中的试剂。 抗体和酶结合物的组合为苯环利定敏敏和快速测定。

公开(公告)号：US5595867A

公开(公告)日：1997-01-21

申请号：US452171

申请日：1995-05-26

申请人： Cheng-I Lin ,  Yuh-Geng Tsay

发明人： Cheng-I Lin ,  Yuh-Geng Tsay

IPC分类号： C12Q1/00 ,  C12Q1/58 ,  C12Q1/62

CPC分类号： C12Q1/62 ,  C12Q1/00 ,  C12Q1/58

摘要： The present invention concerns a method of enzymatically determining the pH of a specimen (e.g., a solution or a biological fluid) and a kit for conducting the method. The present method involves mixing (1) a specimen with (2) an enzyme and (3) one or more substrates for the enzyme in a buffered solution having a pH effective to provide a direct proportional relationship between the activity of the enzyme and the pH of the specimen; determining the activity of the enzyme; and correlating the activity of the enzyme to the pH of the specimen. Each of the sample, the enzyme, the substrate and the buffered solution is present in an amount effective to provide the direct proportional relationship between the activity of the enzyme and the pH of the specimen. The present kit contains an enzyme, one or more substrates for the enzyme present in an amount effective to determine the enzyme activity, and a buffered solution having a pH effective to provide a direct proportional relationship between the activity of the enzyme and the pH of the specimen. The present invention is particularly applicable to detecting adulteration of a urine specimen.

摘要翻译： 本发明涉及一种酶法测定样品（例如溶液或生物流体）的pH值的方法和用于进行该方法的试剂盒。 本发明的方法包括将样品与（2）酶和（3）酶的一种或多种底物混合（1）在具有pH的缓冲溶液中，以提供酶的活性与pH之间的直接比例关系 的样本; 测定酶的活性; 并将酶的活性与样品的pH相关联。 每个样品，酶，底物和缓冲溶液以有效提供酶的活性和样品的pH之间的直接比例关系的量存在。 本试剂盒包含一种酶，一种或多种用于确定酶活性的量存在的酶的底物，以及具有有效提供酶的活性和pH的直接比例关系的pH的缓冲溶液 标本。 本发明特别适用于检测尿标本的掺假。

公开(公告)号：US5567581A

公开(公告)日：1996-10-22

申请号：US398693

申请日：1995-03-06

申请人： Cheng-I Lin ,  Yuh-Geng Tsay

发明人： Cheng-I Lin ,  Yuh-Geng Tsay

IPC分类号： C12Q1/00 ,  C12Q1/58 ,  C12Q1/62 ,  C12Q1/26 ,  C12Q1/54

CPC分类号： C12Q1/62 ,  C12Q1/00 ,  C12Q1/58

摘要： The present invention concerns a method of enzymatically determining the pH of a specimen (e.g., a solution or a biological fluid) and a kit for conducting the method. The present method involves mixing (1) a specimen with (2) an enzyme and (3) one or more substrates for the enzyme in a buffered solution having a pH effective to provide a direct proportional relationship between the activity of the enzyme and the pH of the specimen; determining the activity of the enzyme; and correlating the activity of the enzyme to the pH of the specimen. Each of the sample, the enzyme, the substrate and the buffered solution is present in an amount effective to provide the direct proportional relationship between the activity of the enzyme and the pH of the specimen. The present kit contains an enzyme, one or more substrates for the enzyme present in an amount effective to determine the enzyme activity, and a buffered solution having a pH effective to provide a direct proportional relationship between the activity of the enzyme and the pH of the specimen. The present invention is particularly applicable to detecting adulteration of a urine specimen.

摘要翻译： 本发明涉及一种酶法测定样品（例如溶液或生物流体）的pH值的方法和用于进行该方法的试剂盒。 本发明的方法包括将样品与（2）酶和（3）酶的一种或多种底物混合（1）在具有pH的缓冲溶液中，以提供酶的活性与pH之间的直接比例关系 的样本; 测定酶的活性; 并将酶的活性与样品的pH相关联。 每个样品，酶，底物和缓冲溶液以有效提供酶的活性和样品的pH之间的直接比例关系的量存在。 本试剂盒包含一种酶，一种或多种用于确定酶活性的量存在的酶的底物，以及具有有效提供酶的活性和pH的直接比例关系的pH的缓冲溶液 标本。 本发明特别适用于检测尿标本的掺假。

公开(公告)号：US07816243B2

公开(公告)日：2010-10-19

申请号：US12372908

申请日：2009-02-18

申请人： Chun-Fei Chuang ,  Chien-Ting Lin ,  Che-Hua Hsu ,  Shao-Hua Hsu ,  Cheng-I Lin

发明人： Chun-Fei Chuang ,  Chien-Ting Lin ,  Che-Hua Hsu ,  Shao-Hua Hsu ,  Cheng-I Lin

IPC分类号： H01L21/4763

CPC分类号： H01L21/823842 ,  H01L21/28088 ,  H01L21/823807 ,  H01L21/823814 ,  H01L29/165 ,  H01L29/4966 ,  H01L29/517 ,  H01L29/66636 ,  H01L29/7843 ,  H01L29/7848

摘要： A semiconductor device and a method of fabricating the same are described. A substrate having a PMOS area and an NMOS area is provided. A high-k layer is formed on the substrate. A first cap layer is formed on the high-k layer in the PMOS area, and a second cap layer is formed on the high-k layer in the NMOS area, wherein the first cap layer is different from the second cap layer. A metal layer and a polysilicon layer are sequentially formed on the first and second cap layers. The polysilicon layer, the metal layer, the first cap layer, the second cap layer and the high-k layer are patterned to form first and second gate structures respectively in the PMOS and NMOS areas. First source/drain regions are formed in the substrate beside the first gate structure. Second source/drain regions are formed in the substrate beside the second gate structure.

摘要翻译： 对半导体器件及其制造方法进行说明。 提供具有PMOS区域和NMOS区域的衬底。 在基板上形成高k层。 在PMOS区域的高k层上形成第一覆盖层，在NMOS区域的高k层上形成第二覆盖层，其中第一覆盖层与第二覆盖层不同。 在第一和第二盖层上依次形成金属层和多晶硅层。 图案化多晶硅层，金属层，第一覆盖层，第二覆盖层和高k层，以在PMOS和NMOS区域中分别形成第一和第二栅极结构。 在第一栅极结构旁边的基板中形成第一源极/漏极区域。 第二源极/漏极区域形成在第二栅极结构旁边的衬底中。

公开(公告)号：US20080007910A1

公开(公告)日：2008-01-10

申请号：US11482741

申请日：2006-07-10

申请人： Cheng-I Lin

发明人： Cheng-I Lin

IPC分类号： G06F1/20

CPC分类号： G06F1/1632

摘要： A storage-type heat-dissipating pad of a notebook computer comprises a storage body and a heat-dissipating body. The storage body comprises a cover and a storage base for storing computer peripherals. The storage body is coupled with the heat-dissipating body. The heat-dissipating body comprises a shell and a fan unit. When in use, the notebook computer is disposed on the heat-dissipating body for heat dissipation. As a result, the storage-type heat-dissipating pad is easy to store and convenient to carry and complies with human engineering.

摘要翻译： 笔记本电脑的存储式散热垫包括存储体和散热体。 存储体包括盖和用于存储计算机外围设备的存储基座。 储存体与散热体联接。 散热体包括外壳和风扇单元。 在使用时，将笔记本电脑设置在散热体上用于散热。 因此，存储式散热垫易于存放，方便携带，符合人体工程学。

公开(公告)号：US5256575A

公开(公告)日：1993-10-26

申请号：US755203

申请日：1991-09-04

申请人： Mae W. Hu ,  Kirk Schulkamp ,  Cheng-I Lin ,  Edwin F. Ullman

发明人： Mae W. Hu ,  Kirk Schulkamp ,  Cheng-I Lin ,  Edwin F. Ullman

IPC分类号： C07C235/34 ,  C07C235/52 ,  C07C259/10 ,  C07C309/15 ,  G01N33/53 ,  G01N33/78 ,  G01N33/94 ,  G01N33/566

CPC分类号： C07C309/15 ,  C07C235/34 ,  C07C235/52 ,  C07C259/10 ,  G01N33/5306 ,  G01N33/78 ,  G01N33/94 ,  Y10S435/962 ,  Y10S435/975 ,  Y10S436/825

摘要： A kit for inactivating interfering binding proteins in a immunoassay for a member of a specific binding pair (sbp). The method comprises including in an assay medium containing a sample suspected of containing an sbp member and an interfering binding protein an effective amount of a water soluble compound having two substituted or unsubstituted phenyl groups linked to a common atom. When the sbp member or its sbp partner has two phenyl groups linked to a common atom, the compound has a number of-groups other than hydrogen attached to the phenyl groups and the atom that differs by at least two from the number of such groups on the sbp member. When the sbp member or its sbp partner has two phenyl groups linked to a common atom and the binding protein is not an antibody, the compound has only one group other than hydrogen attached to a phenyl group or the common atom. The methods have particular application in avoiding-cross-reactivity of non-analyte materials in a sample with immunachemical reagents used in such assay. The methods-have application also in disrupting complexer between an analyte to be determined and other materials to that one can accurately determine the amount of an analyte in a sample.

摘要翻译： 用于在特异性结合对（sbp）的成员的免疫测定中灭活干扰结合蛋白的试剂盒。 该方法包括在含有疑似含有sbp成员和干扰结合蛋白的样品的测定培养基中包含有效量的具有两个与常见原子连接的取代或未取代的苯基的水溶性化合物。 当sbp成员或其sbp伴侣具有连接到共同原子的两个苯基时，该化合物具有与苯基连接的氢以外的多个基团，并且与该基团的数目不同的至少两个的原子在 sbp成员。 当sbp成员或其sbp伴侣具有连接到共同原子的两个苯基并且结合蛋白不是抗体时，该化合物除了连接到苯基或共同原子上的氢以外仅具有一个基团。 该方法特别适用于避免样品中非分析物质与这种测定中使用的免疫化学试剂的交叉反应。 所述方法还应用于破坏要测定的待分析物与其他材料之间的复合物，以使得可以准确地确定样品中分析物的量。

公开(公告)号：US5207985A

公开(公告)日：1993-05-04

申请号：US718067

申请日：1991-06-20

申请人： Cheng-I Lin ,  Marcel Pirio

发明人： Cheng-I Lin ,  Marcel Pirio

IPC分类号： C07D273/00 ,  G01N31/22 ,  G01N33/84

CPC分类号： C07D273/00 ,  G01N31/22 ,  G01N33/84

摘要： Novel compounds and assay methods are provided for determining the presence of lithium in serum, plasma, urine or other sample without deproteinization. The novel compounds are water soluble derivatives of TMC-crownformazans and provide signal enhancement by increased absorbance of the dye-lithium complex over the dye anion.

摘要翻译： 提供了新的化合物和测定方法，用于确定血清，血浆，尿液或其他样品中锂的存在，而无需脱蛋白。 这些新型化合物是TMC-冠状表面活性剂的水溶性衍生物，并通过增加染料 - 锂络合物在染料阴离子上的吸光度而提供信号增强。

公开(公告)号：US5136095A

公开(公告)日：1992-08-04

申请号：US278870

申请日：1988-12-01

申请人： Thomas L. Tarnowski ,  Cheng-I Lin ,  Edwin F. Ullman

发明人： Thomas L. Tarnowski ,  Cheng-I Lin ,  Edwin F. Ullman

IPC分类号： G01N33/543

CPC分类号： G01N33/54333 ,  G01N33/54313 ,  G01N33/54393 ,  Y10S436/808 ,  Y10S436/829

摘要： Compounds and methods are disclosed for reversibly aggregating particles suspended in a liquid medium. The method comprises combining the liquid medium containing the particles with a polyionic polymer capable of aggregating the particles under conditions suitable for such aggregation. Thereafter, the particles are contacted with a chemical reagent capable of cleaving the polyionic polymer under conditions sufficient to reverse the aggregation. Optionally, magnetic particles are added to the liquid medium in the present method under conditions for non-specific binding and the medium including the aggregates is subjected to a magnetic field gradient to separate the aggregates from the medium. The compounds of the present invention are polyions. The aggregation of the particles is reversible upon contact with chemical agents which cleave at least some of the bonds within the polyionic polymer.

摘要翻译： 公开了用于可逆地聚集悬浮在液体介质中的颗粒的化合物和方法。 该方法包括将含有颗粒的液体介质与能够在适于这种聚集的条件下聚集颗粒的聚离子聚合物组合。 此后，使颗粒与能够在足以反向聚集的条件下裂解聚离子聚合物的化学试剂接触。 任选地，在本方法中，在非特异性结合的条件下，将磁性颗粒加入到液体介质中，并且将包含聚集体的介质进行磁场梯度以将聚集体与介质分离。 本发明的化合物是聚阴离子。 当与化学试剂接触时，颗粒的聚集是可逆的，其切割聚离子聚合物内的至少一些键。

公开(公告)号：US08836316B2

公开(公告)日：2014-09-16

申请号：US13325009

申请日：2011-12-13

申请人： Fang-Ta Tai ,  Chen-Hsiang Lin ,  Jen-Fan Sun ,  Cheng-I Lin

发明人： Fang-Ta Tai ,  Chen-Hsiang Lin ,  Jen-Fan Sun ,  Cheng-I Lin

IPC分类号： H02M3/157 ,  H02M3/158 ,  G06F1/26 ,  H02M3/156

CPC分类号： H02M3/1584 ,  H02M2003/1566 ,  H02M2003/1586

摘要： A power supply system to provide power for a central processing unit (CPU) includes a bridge circuit, a pulse width modulation (PWM) controller and a pulse adjusting driver circuit. The bridge circuit detects a work state of the PWM controller to obtain a feedback signal output from the PWM controller, and provides the feedback signal to the CPU. The CPU outputs a control signal to the bridge circuit according to a work state of the CPU and the feedback signal, and the bridge circuit outputs a PWM signal to the pulse adjusting driver circuit according to the control signal. The pulse adjusting driver circuit receives a first driving signal provided by an external circuit, and adjusts the first driving signal according to the PWM signal to generate at least one second driving signal to drive the CPU.

摘要翻译： 为中央处理单元（CPU）提供电力的电源系统包括桥接电路，脉宽调制（PWM）控制器和脉冲调整驱动器电路。 桥接电路检测PWM控制器的工作状态，以获得从PWM控制器输出的反馈信号，并向CPU提供反馈信号。 CPU根据CPU的工作状态和反馈信号向桥式电路输出控制信号，桥式电路根据控制信号向脉冲调整驱动电路输出PWM信号。 脉冲调整驱动电路接收由外部电路提供的第一驱动信号，并根据PWM信号调整第一驱动信号，以生成至少一个第二驱动信号来驱动CPU。

公开(公告)号：US5370993A

公开(公告)日：1994-12-06

申请号：US881987

申请日：1992-05-12

申请人： Thomas L. Tarnowski ,  Cheng-I Lin ,  Edwin F. Ullman

发明人： Thomas L. Tarnowski ,  Cheng-I Lin ,  Edwin F. Ullman

IPC分类号： G01N33/543 ,  G01N33/53

CPC分类号： G01N33/54333 ,  G01N33/54313 ,  G01N33/54393 ,  Y10S436/808 ,  Y10S436/829

摘要： Compounds and methods are disclosed for reversibly aggregating particles suspended in a liquid medium. The method comprises combining the liquid medium containing the particles with a polyionic polymer capable of aggregating the particles under conditions suitable for such aggregation. Thereafter, the particles are contacted with a chemical reagent capable of cleaving the polyionic polymer under conditions sufficient to reverse the aggregation. Optionally, magnetic particles are added to the liquid medium in the present method under conditions for non-specific binding and the medium including the aggregates is subjected to a magnetic field gradient to separate the aggregates from the medium. The compounds of the present invention are polyions. The aggregation of the particles is reversible upon contact with chemical agents which cleave at least some of the bonds within the polyionic polymer.

摘要翻译： 公开了用于可逆地聚集悬浮在液体介质中的颗粒的化合物和方法。 该方法包括将含有颗粒的液体介质与能够在适于这种聚集的条件下聚集颗粒的聚离子聚合物组合。 此后，使颗粒与能够在足以反向聚集的条件下裂解聚离子聚合物的化学试剂接触。 任选地，在本方法中，在非特异性结合的条件下，将磁性颗粒加入到液体介质中，并且将包含聚集体的介质进行磁场梯度以将聚集体与介质分离。 本发明的化合物是聚阴离子。 当与化学试剂接触时，颗粒的聚集是可逆的，其切割聚离子聚合物内的至少一些键。