-
1.BENZOFURAN AND BENZOTHIOPHENE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE DISORDERS 失效
标题翻译: 用于治疗高血压疾病的苯并呋喃和苯并噻吩衍生物公开(公告)号:US20090054514A1
公开(公告)日:2009-02-26
申请号:US12059984
申请日:2008-03-31
申请人: Chengzhi ZHANG , Michael BURKE , Zhi CHEN , Jacques DUMAS , Dongping FAN , Jianmei FAN , Holia HATOUM-MOKDAD , Benjamin JONES , Gaetan LADOUCEUR , Wendy LEE , Barton PHILLIPS
发明人: Chengzhi ZHANG , Michael BURKE , Zhi CHEN , Jacques DUMAS , Dongping FAN , Jianmei FAN , Holia HATOUM-MOKDAD , Benjamin JONES , Gaetan LADOUCEUR , Wendy LEE , Barton PHILLIPS
IPC分类号: A61K31/381 , C07D307/82 , A61K31/343 , A61P35/00 , C07D333/66
CPC分类号: C07D307/82 , C07D307/92 , C07D307/93 , C07D333/66 , C07D333/74 , C07D333/78 , C07D405/04 , C07D405/06 , C07D405/10 , C07D405/14 , C07D407/06 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/06 , C07D417/04 , C07D417/06 , C07D493/04
摘要: This invention relates to novel benzofuran and benzothiophene derivatives of the general formula and their use for the treatment of hyper-proliferative disorders.
摘要翻译: 本发明涉及通式的新型苯并呋喃和苯并噻吩衍生物及其用于治疗高增殖性疾病的用途。
-
2.
公开(公告)号:US20110136809A1
公开(公告)日:2011-06-09
申请号:US12941841
申请日:2010-11-08
申请人: Wendy LEE , Gaetan LADOUCEUR , Jacques DUMAS , Roger SMITH , Shihong YING , Gan WANG , Zhi CHEN , Qingjie LIU , Holia Hatoum MOKDAD
发明人: Wendy LEE , Gaetan LADOUCEUR , Jacques DUMAS , Roger SMITH , Shihong YING , Gan WANG , Zhi CHEN , Qingjie LIU , Holia Hatoum MOKDAD
IPC分类号: A61K31/4439 , A61K31/4545 , A61K31/5377 , A61K31/444 , A61K31/496 , A61P35/00 , A61P35/04 , A61P35/02
CPC分类号: C07D401/12 , C07D405/14
摘要: The present invention relates to compounds of formula (I), pharmaceutical compositions which contain them and methods for treating cancer using compounds of formula (I).
摘要翻译: 本发明涉及式(I)化合物,含有它们的药物组合物和使用式(I)化合物治疗癌症的方法。
-
3.INHIBITION OF P38 KINASE ACTIVITY USING SUBSTITUTED HETEROCYCLIC UREAS 审中-公开
标题翻译: 使用取代的杂环类抗生素抑制P38激酶活性公开(公告)号:US20120149706A1
公开(公告)日:2012-06-14
申请号:US13401272
申请日:2012-02-21
申请人: Jacques DUMAS , Uday KHIRE , Timothy B. Lowinger , Holger PAULSEN , Bernd RIEDL , Willian J. SCOTT , Roger A. SMITH , Jill WOOD , Holia HATOUM-MOKDAD , Wendy LEE , Aniko REDMAN , Jeffrey JOHNSON , Robert SIBLEY
发明人: Jacques DUMAS , Uday KHIRE , Timothy B. Lowinger , Holger PAULSEN , Bernd RIEDL , Willian J. SCOTT , Roger A. SMITH , Jill WOOD , Holia HATOUM-MOKDAD , Wendy LEE , Aniko REDMAN , Jeffrey JOHNSON , Robert SIBLEY
IPC分类号: A61K31/42 , C07D413/12 , A61K31/4439 , A61K31/497 , A61K31/506 , A61P37/06 , A61P29/00 , A61P37/02 , A61P19/10 , A61P19/02 , A61P11/06 , A61P1/00 , C07D261/14 , A61K31/5377
CPC分类号: C07D231/40 , A61K31/381 , A61K31/415 , A61K31/4155 , A61K31/416 , A61K31/42 , A61K31/421 , A61K31/422 , A61K31/426 , A61K31/428 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/506 , C07D261/14 , Y02A50/411
摘要: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases, other than cancer and proteolytic enzyme mediated diseases, other than cancer, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲处理细胞因子介导的疾病,除了癌症以外的癌症和蛋白水解酶介导的疾病,以及用于这种治疗的药物组合物。
-
公开(公告)号:US20120129893A1
公开(公告)日:2012-05-24
申请号:US13349199
申请日:2012-01-12
申请人: Jacques DUMAS , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
发明人: Jacques DUMAS , Uday Khire , Timothy B. Lowinger , Holger Paulsen , Bernd Riedl , William J. Scott , Roger A. Smith , Jill E. Wood , Holia Hatoum-Mokdad , Jeffrey Johnson , Wendy Lee , Aniko Redman , Robert Sibley , Joel Renick
IPC分类号: A61K31/4439 , C07D401/12 , C07D417/12 , A61P35/02 , A61K31/428 , A61K31/427 , A61P35/00 , C07D231/40 , A61K31/415
CPC分类号: C07D231/40 , C07D207/34 , C07D259/00 , C07D261/14 , C07D271/113 , C07D285/135 , C07D333/36 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要: Methods of treating tumors mediated by raf kinase, with substituted urea compounds, and such compounds per se.
摘要翻译: 治疗由raf激酶介导的肿瘤与取代的脲化合物及其化合物本身的方法。
-
5.INHIBITION OF P38 KINASE USING SYMMETRICAL AND UNSYMMETRICAL DIPHENYL UREAS 审中-公开
标题翻译: 使用对称和非对称二苯醚类尿素抑制P38激酶公开(公告)号:US20120270878A1
公开(公告)日:2012-10-25
申请号:US13539914
申请日:2012-07-02
申请人: Scott MILLER , Martin OSTERHOUT , Jacques DUMAS , Uday KHIRE , Timothy B. LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD , David E. GUNN , Holia HATOUM-MOKDAD , Marell RODRIGUEZ , Robert SIBLEY , Ming WANG , Tiffany TURNER , Catherine BRENNAN
发明人: Scott MILLER , Martin OSTERHOUT , Jacques DUMAS , Uday KHIRE , Timothy B. LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD , David E. GUNN , Holia HATOUM-MOKDAD , Marell RODRIGUEZ , Robert SIBLEY , Ming WANG , Tiffany TURNER , Catherine BRENNAN
IPC分类号: A61K31/17 , A61K31/4436 , A61K31/4409 , A61K31/428 , A61P41/00 , A61P29/00 , A61P19/02 , A61P19/10 , A61P11/00 , A61P1/00 , A61K31/5375 , A61K31/403
CPC分类号: A61K31/17 , A61K31/341 , A61K31/381 , A61K31/4035 , A61K31/44 , A61K31/5375 , Y02A50/411
摘要: This invention relates to the use of a group of aryl ureas in treating cytokine mediated diseases and proteolytic enzyme mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗细胞因子介导的疾病和蛋白水解酶介导的疾病中的用途,以及用于这种治疗的药物组合物。
-
6.SUBSTITUTED PYRIDINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISORDERS 审中-公开
标题翻译: 用于治疗癌症和其他疾病的替代吡啶衍生物公开(公告)号:US20100075971A1
公开(公告)日:2010-03-25
申请号:US12628735
申请日:2009-12-01
申请人: Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
发明人: Jacques DUMAS , Wendy Lee , Yuanwei Chen , Lila Adnane , William J. Scott , Sharad Verma , Jianqing Chen , Zhi Chen , Lin Yi
IPC分类号: A61K31/4412 , C07D211/74 , C07D405/12 , C07D401/12 , C07D413/14 , C07D401/04 , C07D417/14 , A61K31/4433 , A61K31/4709 , A61K31/4439 , A61K31/4545 , A61K31/5377
CPC分类号: C07D213/84 , C07D401/12 , C07D405/12 , C07D417/12
摘要: This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译: 本发明涉及新的二芳基脲,含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍,作为唯一试剂或与细胞毒性疗法组合的用途。
-
7.OMEGA CARBOXYARYL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS 审中-公开
标题翻译: OMEGA CARBOXYARYL替代二苯醚作为RAF激酶抑制剂公开(公告)号:US20120040986A1
公开(公告)日:2012-02-16
申请号:US13208010
申请日:2011-08-11
申请人: Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy B. LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD , Mary-Katherine MONAHAN , Reina NATERO , Joel RENICK , Robert N. SIBLEY
发明人: Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy B. LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD , Mary-Katherine MONAHAN , Reina NATERO , Joel RENICK , Robert N. SIBLEY
IPC分类号: A61K31/5377 , A61K31/17 , C07D209/44 , A61K31/4035 , C07D211/70 , A61P35/00 , C07D213/63 , C07D413/12 , C07D403/04 , A61K31/497 , C07D241/04 , A61K31/4965 , C07C275/28 , A61K31/44
CPC分类号: C07C275/40 , C07C275/30 , C07C275/34 , C07D213/81 , C07D401/12
摘要: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途,以及用于此类治疗的药物组合物。
-
8.
公开(公告)号:US20100152251A1
公开(公告)日:2010-06-17
申请号:US12692845
申请日:2010-01-25
申请人: Jacques DUMAS , William J. Scott , Bernd Riedl
发明人: Jacques DUMAS , William J. Scott , Bernd Riedl
CPC分类号: C07D213/89 , C07D215/60 , C07D217/08
摘要: This invention relates to urea compounds containing a pyridine, quinoline, or isoquinoline functionality which is oxidized at the nitrogen heteroatom and which are useful in the treatment of (i) raf mediated diseases, for example, cancer, (ii) p38 mediated diseases such as inflammation and osteoporosis, and (iii) VEGF mediated diseases such as angiogenesis disorders.
摘要翻译: 本发明涉及含有吡啶,喹啉或异喹啉官能团的脲化合物,其在氮杂原子处被氧化并且可用于治疗(i)raf介导的疾病,例如癌症,(ii)p38介导的疾病,例如 炎症和骨质疏松症,和(iii)VEGF介导的疾病如血管生成障碍。
-
9.OMEGA-CARBOXYARL SUBSTITUTED DIPHENYL UREAS AS RAF KINASE INHIBITORS 审中-公开
标题翻译: 作为RAF激酶抑制剂的OMEGA-CARBOXYARL替代二苯醚公开(公告)号:US20140329866A1
公开(公告)日:2014-11-06
申请号:US14333533
申请日:2014-07-17
申请人: Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD
发明人: Bernd RIEDL , Jacques DUMAS , Uday KHIRE , Timothy LOWINGER , William J. SCOTT , Roger A. SMITH , Jill E. WOOD
IPC分类号: C07C275/36 , C07D209/46 , C07D213/82 , C07D213/81 , C07D413/12 , C07D209/48 , C07D213/75
CPC分类号: C07C275/36 , C07C275/28 , C07C275/30 , C07C275/32 , C07C275/40 , C07C311/29 , C07C317/22 , C07D209/46 , C07D209/48 , C07D213/75 , C07D213/81 , C07D213/82 , C07D295/13 , C07D295/135 , C07D295/192 , C07D413/12
摘要: This invention relates to the use of a group of aryl ureas in treating raf mediated diseases, and pharmaceutical compositions for use in such therapy.
摘要翻译: 本发明涉及一组芳基脲在治疗raf介导的疾病中的用途,以及用于此类治疗的药物组合物。
-
公开(公告)号:US20120289552A1
公开(公告)日:2012-11-15
申请号:US13551884
申请日:2012-07-18
IPC分类号: A61K31/44 , A61P29/00 , A61P19/08 , A61P19/10 , A61P31/00 , A61P1/00 , A61P11/06 , A61P11/00 , A61P1/16 , A61P33/06 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/00 , A61P25/28 , A61P25/00 , A61P1/18 , A61P7/00 , A61P37/00 , A61P39/00 , A61P37/06 , A61P31/06 , A61P31/04 , A61P31/16 , A61P31/18 , A61P31/22 , A61P31/14 , A61P35/00
CPC分类号: A61K31/5377 , A61K31/17 , A61K31/40 , A61K31/421 , A61K31/426 , A61K31/44 , A61K31/4436 , A61K31/445 , A61K31/454 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/54 , Y02A50/401 , Y02A50/411 , Y02A50/414 , Y02A50/473
摘要: This invention relates to methods of using aryl ureas to treat diseases mediated by the VEGF induced signal transduction pathway characterized by abnormal angiogenesis or hyperpermeability processes.
摘要翻译: 本发明涉及使用芳基脲来治疗由VEGF诱导的信号转导途径介导的疾病的方法,其特征在于异常血管生成或高渗透性过程。
-
-
-
-
-
-
-
-
-