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公开(公告)号：US20140367567A1
公开(公告)日：2014-12-18
申请号：US14338250
申请日：2014-07-22
CPC分类号： H01J49/009 , G01N27/622 , G01N30/7206 , G01N30/7233 , H01J49/0027 , H01J49/0031 , H01J49/004
摘要： The present invention relates to a parallel IMS and MS measurement method where a sample flow is split and delivered to an IMS and a MS in parallel. A parallel acquisition MS/IMS method is used to supplement LC-MS and or MS data by using a synchronized MS/IMS acquisition.
摘要翻译： 本发明涉及一种并行的IMS和MS测量方法，其中采样流被并行地分离并传送到IMS和MS。 并行采集MS / IMS方法用于通过使用同步的MS / IMS采集来补充LC-MS和/或MS数据。
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公开(公告)号：US08785848B2
公开(公告)日：2014-07-22
申请号：US13792043
申请日：2013-03-09
IPC分类号： H01J49/26
CPC分类号： H01J49/009 , G01N27/622 , G01N30/7206 , G01N30/7233 , H01J49/0027 , H01J49/0031 , H01J49/004
摘要： The present invention relates to a parallel IMS and MS measurement method where a sample flow is split and delivered to an IMS and a MS in parallel. A parallel acquisition MS/IMS method is used to supplement LC-MS and or MS data by using a synchronized MS/IMS acquisition.
摘要翻译： 本发明涉及一种并行的IMS和MS测量方法，其中采样流被并行地分离并传送到IMS和MS。 并行采集MS / IMS方法用于通过使用同步的MS / IMS采集来补充LC-MS和/或MS数据。
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公开(公告)号：US20120228491A1
公开(公告)日：2012-09-13
申请号：US13475993
申请日：2012-05-20
IPC分类号： H01J49/26
CPC分类号： G01N27/622
摘要： An ion mobility spectrometer wherein ions are separated along a drift axis while providing a drift gas flow in a direction that is substantially neither in the direction of the drift axis nor opposite to the drift axis. An ion mobility spectrometer and operation methods use a cross-directional gas flow in a drift tube and/or a segmented drift tube for pre-separation.
摘要翻译： 离子迁移谱仪，其中离子沿着漂移轴线分离，同时在基本上不是在漂移轴线的方向上也不与漂移轴线相反的方向提供漂移气流。 离子迁移谱仪和操作方法在漂移管和/或分段漂移管中使用横向气流用于预分离。
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公开(公告)号：US20180067078A1
公开(公告)日：2018-03-08
申请号：US15713684
申请日：2017-09-24
IPC分类号： G01N27/62
CPC分类号： G01N27/622
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.
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公开(公告)号：US20190285583A1
公开(公告)日：2019-09-19
申请号：US16430309
申请日：2019-06-03
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method. In addition, automation of the direct spray needle can be achieved by setting up array of the spray needles that are loaded in a manner that rotates and/or moves to the next spray needle in the ESI source region.
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6.发明申请公开(公告)号：US20120228490A1
公开(公告)日：2012-09-13
申请号：US13419425
申请日：2012-03-13
IPC分类号： H01J49/26
CPC分类号： G01N27/622 , G01N27/624 , H01J49/067 , H01J49/165
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.
摘要翻译： 本发明中描述的IMS装置和方法涉及将离子检测器设置在漂移管的最高电位并将电离源设置在接地或接地电位。 该方法允许显着简单的样品引入，而不受前端样品传送的高电位（电压）的限制。 本发明还描述了将样品直接引入离子迁移率漂移管中。 本发明还描述了通过电喷雾离子化方法使用单个注射器进行样品引入。
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公开(公告)号：US10309928B2
公开(公告)日：2019-06-04
申请号：US15713684
申请日：2017-09-24
摘要： The IMS apparatus and methods described in this invention involve setting the ion detector at the highest potential of the drift tube and setting the ionization source at ground or near ground potential. The methods allow significantly simple sample introduction without the limitation of the high potential (voltage) concern of the front end sample delivery. The invention also describes bringing samples directly into the ion mobility drift tube. The invention further describes using single syringe for sample introduction via an electrospray ionization method.
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公开(公告)号：US20160005581A1
公开(公告)日：2016-01-07
申请号：US14742653
申请日：2015-06-17
CPC分类号： H01J49/0031 , G01N27/622 , G01N30/7233 , H01J49/004
摘要： A second gate in an Ion Mobility Spectrometer is used to select or block different time windows of the ion mobility spectrum. A second gate in the Ion Mobility Mass Spectrometer is used to modulate peak intensities in the IMS spectrum, allowing each peak in the IMS spectrum to be unambiguously matched with its set of fragment ions in a subsequent MS-MS mass spectrum.
摘要翻译： 离子移动光谱仪中的第二个门用于选择或阻止离子迁移谱的不同时间窗。 离子迁移质谱仪中的第二个栅极用于调制IMS光谱中的峰值强度，允许IMS光谱中的每个峰与其随后的MS-MS质谱中的碎片离子组明确匹配。
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公开(公告)号：US20150303043A1
公开(公告)日：2015-10-22
申请号：US14703868
申请日：2015-05-04
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
CPC分类号： H01J49/004 , C07B63/00 , G01N27/622 , H01J49/0027 , H01J49/0031 , H01J49/0495 , H01J49/067
摘要： The present invention relates to improving the ability of a hyphenated instrument to analyze a sample benefiting from having the first instrument's analysis of the same sample. A fast switching mechanism can be used as the interface between an ion mobility spectrometer (IMS) and a mass spectrometer (MS) such that the obtained IMS spectrum is converted into a timing diagram that controls the vacuum inlet's size dynamically during analysis of a neutral and/or charged chemical and/or biological species such that a smaller pumping system can be used.
摘要翻译： 本发明涉及提高连字的仪器分析从具有第一仪器对相同样品的分析而受益的样品的能力。 可以将快速切换机制用作离子迁移谱仪（IMS）和质谱仪（MS）之间的界面，使得所获得的IMS光谱被转换成时序图，其在中性分析期间动态地控制真空入口的尺寸， /或带电的化学和/或生物物质，使得可以使用较小的泵送系统。
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公开(公告)号：US20100200745A1
公开(公告)日：2010-08-12
申请号：US12763092
申请日：2010-04-19
申请人： Mark A. Osgood , Ching Wu
发明人： Mark A. Osgood , Ching Wu
CPC分类号： H01J49/061 , C07B63/00 , G01N27/622 , Y10T29/49227
摘要： The present invention generally relates to systems and methods for transmitting beams of charged particles, and in particular to such systems and methods that employ defecting at least one set of grid elements into the same plane to form an ion gate. In addition, an operation method of closing a gate involving alternating voltages on the adjacent gate wires is described.
摘要翻译： 本发明一般涉及用于传送带电粒子束的系统和方法，特别涉及这样的系统和方法，该系统和方法使用将至少一组栅格元件缺陷到同一平面中以形成离子门。 此外，描述了在相邻栅极线上闭合涉及交流电压的栅极的操作方法。
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