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    Medical Devices and Coatings with Non-Leaching Antimicrobial Peptides
    3.
    发明申请
    Medical Devices and Coatings with Non-Leaching Antimicrobial Peptides 审中-公开
    具有非浸出性抗菌肽的医疗器械和涂料

    公开(公告)号：US20070254006A1

    公开(公告)日：2007-11-01

    申请号：US11675500

    申请日：2007-02-15

    申请人： Christopher Loose ,  William O'Shaughnessy ,  LinO Ferreira ,  Andreas Zumbuehl ,  Robert Langer ,  Gregory Stephanopoulos

    发明人： Christopher Loose ,  William O'Shaughnessy ,  LinO Ferreira ,  Andreas Zumbuehl ,  Robert Langer ,  Gregory Stephanopoulos

    IPC分类号： A61K9/70 ,  A61F2/00 ,  A61K38/00

    CPC分类号： A61L27/54 ,  A61K38/10 ,  A61L2/16 ,  A61L2/232 ,  A61L15/46 ,  A61L27/227 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/25 ,  A61L2300/404

    摘要： Antimicrobial peptides enable an alternate approach to developing antimicrobial coatings due to their targeting of the membranes of the bacteria. High specific activity is achieved by orienting the peptides so that the antimicrobial ends of the peptides maximally contact the bacteria. In one embodiment, one end of the peptide is covalently attached directly to the substrate. In another embodiment, the peptides are immobilized on the substrate using a coupling agent or tether. Non-covalent methods include coating the peptide onto the substrate or physiochemically immobilizing the peptides on the substrate using highly specific interactions, such as the biotin/avidin or streptavidin system. The compositions are substantially non-leaching, antifouling, and non-hemolytic. The immobilized peptides retain sufficient flexibility and mobility to interact with and de endocytosed by the bacteria, viruses, and/or fungi upon exposure. Immobilizing the peptides to the substrate reduces concerns regarding toxicity of the peptides and the development of antimicrobial resistance, while presenting substantially all of the peptide at the site of action at the surface of the substrate.

    摘要翻译： 由于抗菌肽靶向细菌膜，抗微生物肽能够开发抗微生物涂层。 通过使肽定向以使肽的抗微生物末端最大程度地接触细菌来实现高比活性。 在一个实施方案中，肽的一端直接共价连接到底物上。 在另一个实施方案中，使用偶联剂或系链将肽固定在底物上。 非共价方法包括将肽涂覆到底物上或者使用高度特异性相互作用如生物素/抗生物素蛋白或链霉亲和素系统在肽上生理化学地固定在底物上。 组合物基本上是非浸出，防污和非溶血性的。 固定的肽保持足够的灵活性和移动性，以在暴露时与细菌，病毒和/或真菌相互作用和内吞。 将肽固定到底物可减少对肽的毒性和抗微生物耐药性的发展的担忧，同时在基底表面的作用部位呈现基本上所有的肽。