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公开(公告)号：US08025688B2
公开(公告)日：2011-09-27
申请号：US10397070
申请日：2003-03-24
IPC分类号： A61F7/00
CPC分类号： A61B18/1815 , A61B18/18 , A61B18/24 , A61B90/04 , A61B2017/00092 , A61B2017/00106 , A61B2017/00274 , A61B2017/22051 , A61B2017/22065 , A61B2018/00017 , A61B2018/00547 , A61B2090/0472 , A61B2090/0481 , A61B2090/049 , A61B2090/378 , A61B2090/3925 , A61F7/12 , A61F2007/0095 , A61N5/04 , A61N7/02 , A61N7/022
摘要： An apparatus for applying thermal energy to a prostate gland, comprising a support tube having a longitudinal passageway, a power lead channeled through the longitudinal central passageway and an ultrasound crystal disposed around at least part of the support tube. The ultrasound crystal is coupled to the power lead which provides the power to energize the ultrasound crystal and generate ultrasound energy providing thermal therapy to the prostate gland. The ultrasound crystal further includes inactivated portions for reducing ultrasound energy directed to the rectal wall of the patient. A sealant is disposed in contact with the ultrasound crystal allowing vibration necessary for efficient ultrasound energy radiation for the thermal therapy of the prostate gland.
摘要翻译： 一种用于向前列腺施加热能的装置，包括具有纵向通道的支撑管，通过所述纵向中心通道引导的动力引导件和围绕所述支撑管的至少一部分设置的超声波晶体。 超声波晶体耦合到电源引线，其提供激励超声晶体的功率，并产生向前列腺提供热治疗的超声能量。 超声波晶体还包括用于减少被引导到患者直肠壁的超声能量的失活部分。 将密封剂设置成与超声波晶体接触，允许用于前列腺热疗的有效超声能量辐射所需的振动。
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2.发明授权Method of manufacture of a transurethral ultrasound applicator for prostate gland thermal therapy 失效用于前列腺热疗的经尿道超声波治疗仪的制造方法公开(公告)号：US06537306B1
公开(公告)日：2003-03-25
申请号：US08858912
申请日：1997-05-19
IPC分类号： A61N702
CPC分类号： A61B18/1815 , A61B18/18 , A61B18/24 , A61B90/04 , A61B2017/00092 , A61B2017/00106 , A61B2017/00274 , A61B2017/22051 , A61B2017/22065 , A61B2018/00017 , A61B2018/00547 , A61B2090/0472 , A61B2090/0481 , A61B2090/049 , A61B2090/378 , A61B2090/3925 , A61F7/12 , A61F2007/0095 , A61N5/04 , A61N7/02 , A61N7/022
摘要： An apparatus for applying thermal energy to a prostate gland. The apparatus to apply therapeutic treatment to the prostate includes a tube with a longitudinal passageway and wall having radial apertures, power leads threaded through the tube and out the radial apertures in the wall of the tube. Ultrasound crystals are disposed over the tube and the power leads are coupled through the apertures to the ultrasound crystals and a sealant is disposed adjacent and coupled acoustically to the ultrasound crystals. The apparatus is particularly useful to shape the ultrasound treatment fields and minimize application of energy to rectal tissue and the like.
摘要翻译： 用于向前列腺施加热能的装置。 对前列腺进行治疗治疗的装置包括具有纵向通道的管和具有径向孔的壁，电力引线穿过管并从管的壁中的径向孔排出。 超声晶体设置在管上方，并且电源引线通过孔耦合到超声晶体，并且密封剂邻近设置并声耦合到超声晶体。 该装置对于超声处理领域的成形和对于直肠组织等的能量的使用最小化是特别有用的。
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3.发明授权Method of thermal treatment of myolysis and destruction of benign uterine tumors 有权热解治疗良性子宫肿瘤的解离和破坏的方法公开(公告)号：US08790281B2
公开(公告)日：2014-07-29
申请号：US11738391
申请日：2007-04-20
CPC分类号： A61N7/022 , A61B17/2202 , A61B2017/4216 , A61N5/045 , A61N7/02 , A61N2005/1094 , A61N2007/0004 , A61N2007/0078
摘要： A high-power ultrasound heating applicator for minimally-invasive thermal treatment of uterine fibroids or myomas. High-intensity interstitial ultrasound, applied with minimally-invasive laparoscopic or hysteroscopic procedures, is used to effectively treat fibroids within the myometrium in lieu of major surgery. The applicators are configured with high-power capabilities and thermal penetration to treat large volumes of fibroid tissue (>70 cm3) in short treatment times (3-20 minutes), while maintaining three-dimensional control of energy delivery to thermally destroy the target volume.
摘要翻译： 一种用于子宫肌瘤或肌瘤的微创热治疗的大功率超声加热器。 高强度间质超声，应用微创腹腔镜或宫腔镜手术，用于有效治疗子宫肌层内的子宫肌瘤，代替大手术。 施用器配置有大功率能力和热穿透，以在短时间内（3-20分钟）处理大量的纤维组织（> 70厘米3），同时保持能量传递的三维控制以热破坏目标体积 。
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4.发明授权Method of manufacture of a transurethral ultrasound applicator for prostate gland thermal therapy 失效用于前列腺热疗的经尿道超声波治疗仪的制造方法
公开(公告)号：US5733315A
公开(公告)日：1998-03-31
申请号：US332997
申请日：1994-11-01
摘要： An apparatus for applying thermal therapy to a prostate gland, comprising a support tube having a longitudinal central passageway, a power lead channeled through the longitudinal central passageway and an ultrasound crystal disposed around at least part of the support tube. The ultrasound crystal is coupled to the power lead which provides the power to energize the ultrasound crystal and generate ultrasound energy providing thermal therapy to the prostate gland. The ultrasound crystal further includes inactivated portions for reducing ultrasound energy directed to the rectal wall of the patient. A sealant is disposed in contact with the ultrasound crystal allowing vibration necessary for efficient ultrasound energy radiation for the thermal therapy to the prostate gland.
摘要翻译： 一种用于向前列腺施加热疗的装置，包括具有纵向中心通道的支撑管，通过所述纵向中心通道引导的动力引导件和围绕所述支撑管的至少一部分设置的超声波晶体。 超声波晶体耦合到电源引线，其提供激励超声晶体的功率，并产生向前列腺提供热治疗的超声能量。 超声波晶体还包括用于减少被引导到患者直肠壁的超声能量的失活部分。 将密封剂设置成与超声波晶体接触，允许有效的超声能量辐射所需的振动用于前列腺的热治疗。
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5.发明申请公开(公告)号：US20090171157A1
公开(公告)日：2009-07-02
申请号：US12341867
申请日：2008-12-22
申请人： Chris J. Diederich , Dana Deardorff
发明人： Chris J. Diederich , Dana Deardorff
CPC分类号： A61M29/02 , A61B2017/00092 , A61B2017/00274 , A61B2017/00557 , A61B2018/005 , A61B2018/00547 , A61B2090/0436 , A61M25/10 , A61M25/1011 , A61M2025/0037 , A61M2025/1013 , A61N5/1027 , A61N2005/1094
摘要： An apparatus and method for shielding non-target tissues and organs during thermotherapy, brachytherapy or other treatment of a diseased target tissue. The apparatus includes a catheter shaft having input and output lumens and at least one inflatable balloon. A plurality of input lumens within the catheter shaft allows the passage of liquid or gas through an input port and into the interior of the balloon thereby inflating the balloon. The gas or liquid can then be cycled through the inflated balloon through an output port and output lumen and out of the catheter shaft. Temperature sensors or other sensors may be attached to the balloon or catheter to monitor temperature or other conditions at the treatment site. The catheter is positioned between the target tissue or organ and sensitive non-target tissues in proximity to the target tissue and inflated causing a physical separation of tissues as well as a physical shield.
摘要翻译： 一种用于在热疗，近距离放射治疗或患病目标组织的其他治疗期间屏蔽非靶组织和器官的装置和方法。 该装置包括具有输入和输出腔和至少一个可充气气囊的导管轴。 导管轴内的多个输入管腔允许液体或气体通过输入端口进入球囊的内部，从而使球囊膨胀。 然后，气体或液体可以通过输出口和输出腔循环穿过膨胀的球囊并离开导管轴。 温度传感器或其他传感器可附接到球囊或导管，以监测治疗部位的温度或其他状况。 导管位于目标组织或器官与目标组织附近的敏感非目标组织之间并充气，导致组织的物理分离以及物理屏蔽。
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6.发明授权System and method providing directional ultrasound therapy to skeletal joints 有权向骨骼关节提供定向超声治疗的系统和方法公开(公告)号：US07211055B2
公开(公告)日：2007-05-01
申请号：US10347164
申请日：2003-01-15
IPC分类号： A61F7/00
CPC分类号： A61N7/02 , A61B18/04 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2090/374 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0056 , A61N2007/0078
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译： 提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。
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公开(公告)号：US20110087314A1
公开(公告)日：2011-04-14
申请号：US12898401
申请日：2010-10-05
IPC分类号： A61F7/12
CPC分类号： A61B18/04 , A61B8/56 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2018/00339 , A61B2090/374 , A61N7/00 , A61N7/02 , A61N7/022 , A61N2007/0078
摘要： A long-term implantable ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses without appreciable remodeling.
摘要翻译： 提供了一种长期植入式超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，这些范围通过诸如体内椎间盘的预应力组织显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现了其他响应而没有明显的重塑。
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公开(公告)号：US06383151B1
公开(公告)日：2002-05-07
申请号：US09659477
申请日：2000-09-11
IPC分类号： A61B100
CPC分类号： A61B18/1492 , A61B18/00 , A61B2017/00243 , A61B2018/00083 , A61B2018/00148 , A61B2018/00214 , A61M25/1002 , A61M2210/125 , A61N7/02 , A61N7/022
摘要： This invention is a circumferential ablation device assembly which is adapted to forming a circumferential conduction block in a pulmonary vein. The assembly includes a circumferential ablation element which is adapted to ablate a circumferential region of tissue along a pulmonary vein wall which circumscribes the pulmonary vein lumen, thereby transecting the electrical conductivity of the pulmonary vein against conduction along its longitudinal axis and into the left atrium. The circumferential ablation element includes an expandable member with a working length that is adjustable from a radially collapsed position to a radially expanded position. An equatorial band circumscribes the outer surface of the working length and is adapted to ablate tissue adjacent thereto when actuated by an ablation actuator. The equatorial band has a length relative to the longitudinal axis of the expandable member that is narrow relative to the working length, and is also substantially shorter than its circumference when the working length is in the radially expanded position. A pattern of insulators may be included over an ablation element which otherwise spans the working length in order to form the equatorial band described. The expandable member is also adapted to conform to the pulmonary vein in the region of its ostium, such as by providing a great deal of radial compliance or by providing a taper along the working length which has a distally reducing outer diameter. A linear ablation element is provided adjacent to the circumferential ablation element in a combination assembly which is adapted for use in a less-invasive “maze”-type procedure in the region of the pulmonary vein ostia in the left ventricle. A cylindrical ultrasound transducer is provided on an inner member within the balloon and forms the circumferential ablation member by emitting a radial ultrasound signal which is circumferential to the transducer and highly collimated to the transducer's length. The circumferential ultrasound signal sonically couples to the balloon's outer skin to form the circumferential ablation element that is adapted to ablate a circumferential path of tissue engaged to the balloon.
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公开(公告)号：US08915949B2
公开(公告)日：2014-12-23
申请号：US12781689
申请日：2010-05-17
CPC分类号： A61N7/02 , A61B18/04 , A61B2017/00092 , A61B2017/00101 , A61B2017/00261 , A61B2090/374 , A61N7/022 , A61N2007/0021 , A61N2007/003 , A61N2007/0056 , A61N2007/0078
摘要： An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly affected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieve other responses without appreciable remodeling.
摘要翻译： 提供超声治疗系统和方法，其向身体关节内诸如脊椎关节之间的组织的局部区域提供定向的聚焦超声。 将超声发射器或换能器输送到与关节相关联的身体内的位置，并从该位置加热与关节相关联的组织的目标区域。 用于超声换能器放置的这种位置可以包括例如在椎间盘内或周围，或骨结构，例如椎体或后椎体元件，例如小关节。 各种操作模式提供在不同温度范围内的选择性控制加热，以在目标组织中提供不同的预期结果，该范围受到诸如体内椎间盘之类的预应力组织的显着影响。 特别地，高于70摄氏度，特别是75摄氏度的处理被用于结构重塑，而较低的温度实现其他响应而没有明显的重塑。
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10.发明授权公开(公告)号：US07476235B2
公开(公告)日：2009-01-13
申请号：US10756588
申请日：2004-01-12
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61B2017/00092 , A61B2017/00274 , A61B2017/00557 , A61B2018/005 , A61B2018/00547 , A61B2090/0436 , A61M25/10 , A61M25/1011 , A61M2025/0037 , A61M2025/1013 , A61N5/1027 , A61N2005/1094
摘要： An apparatus and method for shielding non-target tissues and organs during thermotherapy, brachytherapy or other treatment of a diseased target tissue. The apparatus includes a catheter shaft having input and output lumens and at least one inflatable balloon. A plurality of input lumens within the catheter shaft allows the passage of liquid or gas through an input port and into the interior of the balloon thereby inflating the balloon. The gas or liquid can then be cycled through the inflated balloon through an output port and output lumen and out of the catheter shaft. Temperature sensors or other sensors may be attached to the balloon or catheter to monitor temperature or other conditions at the treatment site. The catheter is positioned between the target tissue or organ and sensitive non-target tissues in proximity to the target tissue and inflated causing a physical separation of tissues as well as a physical shield.
摘要翻译： 一种用于在热疗，近距离放射治疗或患病目标组织的其他治疗期间屏蔽非靶组织和器官的装置和方法。 该装置包括具有输入和输出腔和至少一个可充气气囊的导管轴。 导管轴内的多个输入管腔允许液体或气体通过输入端口进入球囊的内部，从而使球囊膨胀。 然后，气体或液体可以通过输出口和输出腔循环穿过膨胀的球囊并离开导管轴。 温度传感器或其他传感器可附接到球囊或导管，以监测治疗部位的温度或其他状况。 导管位于目标组织或器官与目标组织附近的敏感非目标组织之间并充气，导致组织的物理分离以及物理屏蔽。
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