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1.发明申请RECOMBINANT FC-FUSION PROTEIN OF THE FIFTH FIBRONECTIN TYPE III DOMAIN OF DCC 审中-公开DCC第五类FIBRONECTIN III型域的重组FC融合蛋白公开(公告)号：US20130336972A1
公开(公告)日：2013-12-19
申请号：US13818465
申请日：2011-08-26
申请人： Christian Klein , Erhard Kopetzki , Gerhard Niederfellner , Agnes Bernet , Celine Delloye-Bourgeois , Patrick Mehlen
发明人： Christian Klein , Erhard Kopetzki , Gerhard Niederfellner , Agnes Bernet , Celine Delloye-Bourgeois , Patrick Mehlen
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K14/70503 , C07K2319/30
摘要： The present invention relates to DCC-fusion proteins, nucleic acid molecules encoding the DCC-fusion proteins, as well as methods for their production and their use in treatment of cancer such as colorectal cancer, NSCLC and metastatic breast cancer. The present invention also relates to methods of treating cancer such as colorectal cancer, NSCLC and metastatic breast cancer by administering DCC-fusion proteins.
摘要翻译： 本发明涉及DCC融合蛋白，编码DCC-融合蛋白的核酸分子及其生产方法及其在治疗癌症如结肠直肠癌，NSCLC和转移性乳腺癌中的应用。 本发明还涉及通过施用DCC-融合蛋白来治疗癌症如结肠直肠癌，NSCLC和转移性乳腺癌的方法。
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公开(公告)号：US20100254988A1
公开(公告)日：2010-10-07
申请号：US12753141
申请日：2010-04-02
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-2 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-2和针对人c-Met的双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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公开(公告)号：US10106600B2
公开(公告)日：2018-10-23
申请号：US13070582
申请日：2011-03-24
申请人： Ulrich Brinkmann , Rebecca Croasdale , Harald Duerr , Christian Klein , Erhard Kopetzki , Wilma Lau , Joerg Thomas Regula , Juergen Michael Schanzer , Pablo Umana , Katharina Wartha
发明人： Ulrich Brinkmann , Rebecca Croasdale , Harald Duerr , Christian Klein , Erhard Kopetzki , Wilma Lau , Joerg Thomas Regula , Juergen Michael Schanzer , Pablo Umana , Katharina Wartha
摘要： The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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4.发明授权Multispecific antibodies comprising full length antibodies and single chain fab fragments 有权包含全长抗体和单链Fab片段的多特异性抗体公开(公告)号：US09382323B2
公开(公告)日：2016-07-05
申请号：US12750748
申请日：2010-03-31
申请人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pablo Umana
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及包含全长抗体和单链Fab片段的多特异性，特别是双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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5.发明申请公开(公告)号：US20100256338A1
公开(公告)日：2010-10-07
申请号：US12750748
申请日：2010-03-31
申请人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pabio Umana
发明人： Ulrich Brinkmann , Peter Bruenker , Rebecca Croasdale , Christian Klein , Erhard Kopetzki , Ekkehard Moessner , Joerg Thomas Regula , Juergen Michael Schanzer , Jan Olaf Stracke , Pabio Umana
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/00 , C07K16/468 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2319/00
摘要： The present invention relates to multispecific, especially bispecific antibodies comprising full length antibodies and single chain Fab fragments, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及包含全长抗体和单链Fab片段的多特异性，特别是双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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公开(公告)号：US09080183B2
公开(公告)日：2015-07-14
申请号：US12664399
申请日：2008-06-25
申请人： Christian Klein , Erhard Kopetzki
发明人： Christian Klein , Erhard Kopetzki
CPC分类号： C12N15/63 , C07K14/43595 , C07K14/4702 , C12N15/85
摘要： The current invention reports a promoter having the nucleic acid sequence of SEQ ID NO: 02, or SEQ ID NO: 03, or SEQ ID NO: 04, or SEQ ID NO: 06, which is a 5′ shortened SV40 promoter with reduced promoter strength especially useful for the limited expression of heterologous polypeptides or selectable markers.
摘要翻译： 本发明报告了具有SEQ ID NO：02或SEQ ID NO：03或SEQ ID NO：04或SEQ ID NO：06的核酸序列的启动子，其是具有降低的启动子的5'缩短的SV40启动子 对于异源多肽或选择性标记的有限表达特别有用的强度。
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公开(公告)号：US20100159489A1
公开(公告)日：2010-06-24
申请号：US12664399
申请日：2008-06-25
申请人： Christian Klein , Erhard Kopetzki
发明人： Christian Klein , Erhard Kopetzki
CPC分类号： C12N15/63 , C07K14/43595 , C07K14/4702 , C12N15/85
摘要： The current invention reports a promoter having the nucleic acid sequence of SEQ ID NO: 02, or SEQ ID NO: 03, or SEQ ID NO: 04, or SEQ ID NO: 06, which is a 5′ shortened SV40 promoter with reduced promoter strength especially useful for the limited expression of heterologous polypeptides or selectable markers.
摘要翻译： 本发明报告了具有SEQ ID NO：02或SEQ ID NO：03或SEQ ID NO：04或SEQ ID NO：06的核酸序列的启动子，其是具有降低的启动子的5'缩短的SV40启动子 对于异源多肽或选择性标记的有限表达特别有用的强度。
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8.发明授权Peptides with a characteristic antigenic determinant of .alpha.1-microglobulin 失效具有α1-微球蛋白特征抗原决定簇的肽
公开(公告)号：US6153192A
公开(公告)日：2000-11-28
申请号：US96044
申请日：1993-07-22
IPC分类号： A61K39/395 , C07K7/06 , C07K7/08 , C07K14/00 , C07K16/00 , C07K16/06 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N31/22 , G01N33/53 , A61K39/00 , A61K38/00 , G01N33/566
CPC分类号： C07K16/18 , C07K16/06 , Y10S530/81 , Y10S530/812
摘要： A peptide according to the present invention is not more than 40 amino acids long and contains a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 144 and 183 of human .alpha.1-microglobulin or/and a sequence which is at least 6 amino acids long from the amino acid partial sequence between the amino acids 1 and 20 of human .alpha.1-microglobulin.An antibody according to the present invention is capable of specific binding to a peptide according to the present invention as well as to human .alpha.1-microglobulin.In order to determine human .alpha.1-microglobulin in a sample liquid by an immunoassay, the sample liquid is brought into contact simultaneously or sequentially with defined amounts of the components antibody and peptide whereby one of the components is labelled and the determination is carried out by means of this label.
摘要翻译： 根据本发明的肽不超过40个氨基酸长，并且含有与人α1-微球蛋白的氨基酸144和183之间的氨基酸部分序列至少6个氨基酸长的序列或/和 该序列与人α1-微球蛋白的氨基酸1和20之间的氨基酸部分序列至少6个氨基酸长。 根据本发明的抗体能够与根据本发明的肽以及人α1-微球蛋白特异性结合。 为了通过免疫测定法在样品液体中测定人α1-微球蛋白，将样品液体与定义量的组分抗体和肽同时或依次接触，由此其中一种组分被标记，并且测定由 该标签的手段。
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公开(公告)号：US20100254989A1
公开(公告)日：2010-10-07
申请号：US12753145
申请日：2010-04-02
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Christian Klein , Gerhard Niederfellner , Wolfgang Schaefer , Juergen Michael Schanzer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C07K16/28 , C07H21/04 , A61P35/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-1 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-1和针对人c-Met的双特异性抗体，其制备方法，含有抗体的药物组合物及其用途。
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公开(公告)号：US20100256339A1
公开(公告)日：2010-10-07
申请号：US12752196
申请日：2010-04-01
申请人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
发明人： Birgit Bossenmaier , Ulrich Brinkmann , Wilma Dormeyer , Eike Hoffmann , Christian Klein , Gerhard Niederfellner , Juergen Michael Schanzer , Jan Olaf Stracke , Claudio Sustmann , Pablo Umana
CPC分类号： C07K16/468 , C07K16/2863 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/41 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/00
摘要： The present invention relates to bispecific antibodies against human ErbB-3 and against human c-Met, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人ErbB-3和针对人c-Met的双特异性抗体，其制备方法，含有该抗体的药物组合物及其用途。
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