专利检索 ap:("Robin Burgis" OR "Michael Paul Capparelli" OR "Lucian Dipietro" OR "Gabriel G. Gamber" OR "Charles Francis Jewell, JR." OR "Erik Meredith" OR "Karl Miranda" OR "Lauren G. Monovich" OR "Chang Rao" OR "Nicolas Soldermann" OR "Taeyoung Yoon" OR "Qingming Zhu") AND inv:"Michael Paul Capparelli" 第 1 页

1.

发明申请
ORGANIC COMPOUNDS 审中-公开

公开(公告)号：US20110092505A1

公开(公告)日：2011-04-21

申请号：US12996901

申请日：2009-06-12

申请人： Robin Burgis , Michael Paul Capparelli , Lucian Dipietro , Gabriel G. Gamber , Charles Francis Jewell, JR. , Erik Meredith , Karl Miranda , Lauren G. Monovich , Chang Rao , Nicolas Soldermann , Taeyoung Yoon , Qingming Zhu

发明人： Robin Burgis , Michael Paul Capparelli , Lucian Dipietro , Gabriel G. Gamber , Charles Francis Jewell, JR. , Erik Meredith , Karl Miranda , Lauren G. Monovich , Chang Rao , Nicolas Soldermann , Taeyoung Yoon , Qingming Zhu

IPC分类号： A61K31/535 , A61K31/4985 , A61K31/501 , A61K31/497 , A61K31/437 , A61K31/4545 , C07D417/14 , C07D487/04 , C07D413/14 , C07D471/04 , C07D401/14 , A61P17/00 , A61P9/00 , A61P35/00 , A61P37/00

CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D519/00

摘要： The present invention provides novel organic compounds of Formula I: methods of use, and pharmaceutical compositions thereof.

2.

发明申请
ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物

公开(公告)号：US20120142685A1

公开(公告)日：2012-06-07

申请号：US12594728

申请日：2008-04-04

申请人： Markus Rolf Dobler , Charles Francis Jewell, JR. , Erik Meredith , Lauren G. Monovich , Sarah Siska , Anette Von Matt , Maurice Van Eis , Taeyoung Yoon , Christoph Gaul , Michael Paul Capparelli

发明人： Markus Rolf Dobler , Charles Francis Jewell, JR. , Erik Meredith , Lauren G. Monovich , Sarah Siska , Anette Von Matt , Maurice Van Eis , Taeyoung Yoon , Christoph Gaul , Michael Paul Capparelli

IPC分类号： A61K31/5377 , C07D471/10 , A61K31/444 , A61P7/10 , A61P9/04 , A61P35/00 , A61P3/04 , A61P3/10 , C07D471/04 , A61K31/496

CPC分类号： C07D471/04

摘要： The present invention provides a compound formula I: (formula I) said compound is inhibitor of selective subset of kinases belonging to the AGC or calmodulin kinase family, such as for example MARK1/2/3, PKD-1/2/3, PKN-1/2, CDK-9, CaMKII, ROCK-I/II, inhibitors of histone deacetylase (HDAC) phosphorylation, or inhibitors of other kinases. Finally, the present invention also provides a pharmaceutical composition.

摘要翻译： 本发明提供式I化合物：（式I）所述化合物是属于AGC或钙调蛋白激酶家族的激酶选择性亚型的抑制剂，例如MARK1 / 2/3，PKD-1/2/3，PKN -1/2，CDK-9，CaMKII，ROCK-I / II，组蛋白脱乙酰酶（HDAC）磷酸化抑制剂或其他激酶抑制剂。最后，本发明还提供药物组合物。

3.

发明授权
Indane and indoline derivatives and the use thereof as soluble guanylate cyclase activators 有权

公开(公告)号：US10208018B2

公开(公告)日：2019-02-19

申请号：US15320810

申请日：2015-07-02

申请人： Christopher M. Adams , Doug Bevan , Michael Paul Capparelli , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Nello Mainolfi , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna

发明人： Christopher M. Adams , Doug Bevan , Michael Paul Capparelli , Takeru Ehara , Luciana Ferrara , Nan Ji , Mitsunori Kato , Nello Mainolfi , Erik Meredith , Muneto Mogi , James J. Powers , Ganesh Prasanna

IPC分类号： C07D401/04 , C07D401/14 , C07D413/14 , C07D401/10 , C07D401/12 , A61K9/00 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/4725 , C07D405/14

摘要： The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

4.

发明申请
Piperidinyl-Indole Derivatives Complement Factor B Inhibitors and Uses Thereof 有权
标题翻译：哌啶基 - 吲哚衍生物补体因子B抑制剂及其用途

公开(公告)号：US20160152605A1

公开(公告)日：2016-06-02

申请号：US14904694

申请日：2014-07-14

申请人： Christopher ADAMS , Michael Paul CAPPARELLI , Takeru EHARA , Rajeshri Ganesh KARKI , Nello MAINOLFI , Chun ZHANG

发明人： Christopher Michael Adams , Michael Paul Capparelli , Takeru Ehara , Rajeshri Ganesh Karki , Nello Mainolfi , Chun Zhang

IPC分类号： C07D413/06 , A61K31/454 , C07D403/06 , A61K31/438 , C07D401/14 , A61K31/4439 , A61K31/5377 , A61K31/55 , C07D401/06 , A61K31/404

CPC分类号： C07D413/06 , A61K31/404 , A61K31/438 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K31/55 , C07D401/06 , C07D401/14 , C07D403/06 , C07D413/14 , C07D417/14

摘要： The present invention provides a compound of formula I: (I) a method for manufacturing the compounds of the invention, and its therapeutic uses as inhibitors of the complement alternative pathway, in particular of Factor B. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

摘要翻译： 本发明提供式I化合物：（I）制备本发明化合物的方法及其作为补体替代途径抑制剂，特别是因子B的治疗用途。本发明进一步提供了药理学上的组合活性剂和药物组合物。

5.

发明授权
Complement factor B inhibitors and uses there of 有权
标题翻译：补体因子B抑制剂及其用途

公开(公告)号：US09475806B2

公开(公告)日：2016-10-25

申请号：US14774430

申请日：2014-03-13

申请人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang

发明人： Christopher Michael Adams , Charles Babu , Michael Paul Capparelli , Jian Ding , Takeru Ehara , Keith Jendza , Nan Ji , Rajeshri Ganesh Karki , Toshio Kawanami , Liang Xue , Nello Mainolfi , James J. Powers , Michael H. Serrano-Wu , Chun Zhang

IPC分类号： C07D401/14 , A61K31/4353 , A61K31/437 , C07D471/04

CPC分类号： C07D471/04

摘要： The present invention provides a compound of formula (I): wherein X is N or CH, Y is NH, O or S, methods for manufacturing these compounds, and their uses as Factor B inhibitors for the treatment of conditions and diseases associated with complement alternative pathway activation such as age-related macular degeneration, diabetic retinopathy and related ophthalmic diseases. The present invention further provides pharmaceutical compositions and combinations of pharmacologically active agents.