公开(公告)号：US20060063782A1

公开(公告)日：2006-03-23

申请号：US10519922

申请日：2003-07-03

申请人： Christopher Murray ,  Michael Hartshorn ,  Martyn Frederickson ,  Miles Congreve ,  Alessandro Padova ,  Steven Woodhead ,  Adrian Gill ,  Andrew Woodhead

发明人： Christopher Murray ,  Michael Hartshorn ,  Martyn Frederickson ,  Miles Congreve ,  Alessandro Padova ,  Steven Woodhead ,  Adrian Gill ,  Andrew Woodhead

IPC分类号： A61K31/4965 ,  C07D213/63 ,  A61K31/44

CPC分类号： C07D213/73 ,  C07D213/65 ,  C07D213/74 ,  C07D213/81 ,  C07D241/18 ,  C07D241/20 ,  C07D241/24 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D417/12 ,  C07D417/14 ,  C07D513/04

摘要： Compounds of the formula (I), wherein: —X═Y— is selected from —CR =CR — and —CR ═N—; R is selected from H, halo, NRR′, NHC(═O)R, NHC(═O)NRR′, NH2SO2R, and C(═O)NRR′; R and R (where present) are independently selected from H, optionally substituted C1-7 alkyl, optionally substituted C5-20 aryl, optionally substituted C3-20 heterocyclyl, halo, amino, amido, hydroxy, ether, thio, thioether, acylamido, ureido and sulfonamino; R is an optionally substituted C5-20 aryl or C5-20 heteroaryl group; and R is selected from R , halo, NHR , C(═O)NHR , OR , SR , NHC(═O)R , NHC(═O)NHR , NHS(═O)R , wherein R is H or C1-3 alkyl (optionally substituted by halo, NH2, OH, SH) are disclosed for use in therapy and for treating diseases ameliorated by inhibiting p38 MAP kinase.

摘要翻译： 式（I）的化合物，其中：-X-Y-选自-CR 2 = CR 3 - 和-CR 2 -N-; R 1选自H，卤素，NRR'，NHC（-O）R，NHC（-O）NRR'，NH 2 SO 2 R和C（-O）NRR'; R 2和R 3（如果存在）独立地选自H，任选取代的C 1-7烷基，任选取代的C 5-20芳基，任选取代的C 3-20杂环基，卤素，氨基，酰胺基，羟基，醚， 硫代，硫醚，酰氨基，脲基和磺氨基; R 4是任选取代的C 5-20芳基或C 5-20杂芳基; R 5选自R 5，卤素，NHR 5，C（O）NHR 5，OR 5，SR 5，NHC（-O） R 5，NHC（-O）NHR 5，NHS（-O）R 5，其中R 5'是H或C 1-3烷基（任选地被卤素，NH 2，OH ，SH）被公开用于治疗和治疗通过抑制p38 MAP激酶而改善的疾病。

公开(公告)号：US20050124620A1

公开(公告)日：2005-06-09

申请号：US10962085

申请日：2004-10-08

申请人： Martyn Frederickson ,  Adrian Gill ,  Alessandro Padova ,  Miles Congreve

发明人： Martyn Frederickson ,  Adrian Gill ,  Alessandro Padova ,  Miles Congreve

IPC分类号： A61K31/404 ,  C07D209/08 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D471/02 ,  C07D487/02 ,  A61K31/53 ,  A61K31/519

CPC分类号： C07D401/06 ,  A61K31/404 ,  C07D209/08 ,  C07D401/14 ,  C07D403/06 ,  C07D403/12 ,  Y02A50/411

摘要： Compounds are disclosed of the formula (I): in which U, T, V and W are each a nitrogen atom or carbon atom. When U, T, V or W is a carbon atom, it may be substituted. The compounds are inhibitors of p38 MAP kinase and are useful for treating inflammatory diseases such as arthritis. An example of such a compound is:

摘要翻译： 公开了式（I）的化合物：其中U，T，V和W各自为氮原子或碳原子。 当U，T，V或W为碳原子时，它可以被取代。 这些化合物是p38 MAP激酶的抑制剂，可用于治疗炎性疾病如关节炎。 这种化合物的一个例子是：

公开(公告)号：US20070259871A1

公开(公告)日：2007-11-08

申请号：US11680830

申请日：2007-03-01

申请人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead ,  Alison Woolford

发明人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead ,  Alison Woolford

IPC分类号： A61K31/4035 ,  A61K31/47 ,  A61K31/496 ,  A61K31/5377 ,  A61P35/00 ,  C07D209/04 ,  C07D215/00 ,  C07D217/00 ,  C07D227/00 ,  C07D241/00 ,  C07D265/30 ,  C07D401/02 ,  C07D471/00

CPC分类号： C07D401/12 ,  C07C65/21 ,  C07D209/08 ,  C07D209/44 ,  C07D215/08 ,  C07D217/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D491/10

摘要： The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

摘要翻译： 本发明提供式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R 1是羟基或氢; R 2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R 3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5 - 烃氧基; R 4选自氢; 其中n为0或1且R 7为任选取代的无环C 1 - （O）N - ， - -5个烃基或具有3〜7个环成员的单环碳环或杂环基; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。 该化合物具有作为Hsp90抑制剂的活性。

公开(公告)号：US20070259886A1

公开(公告)日：2007-11-08

申请号：US11680818

申请日：2007-03-01

申请人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead

发明人： Gianni Chessari ,  Maria Carr ,  Miles Congreve ,  Robert Downham ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Michael O'Brien ,  Theresa Phillips ,  Andrew Woodhead

IPC分类号： A61K31/497 ,  A61P35/00 ,  C07D403/00

CPC分类号： C07D209/44 ,  C07D401/04 ,  C07D401/12

摘要： Compounds having the formula (I): and in particular, those of subgenus VIIa are disclosed as inhibits or modulators of the activity of the heat shock protein Hsp90. As such they are useful for treating cancer, particularly hematopoietic tumors of lymphoid or myeloid lineage, prostate cancer, lung cancer, gastrointestinal stromal tumor, breast cancer and melanoma.

摘要翻译： 公开了具有式（I）：特别是亚属VIIa的化合物作为热休克蛋白Hsp90的活性的抑制剂或调节剂。 因此，它们可用于治疗癌症，特别是淋巴或骨髓谱系的造血肿瘤，前列腺癌，肺癌，胃肠道间质瘤，乳腺癌和黑素瘤。

公开(公告)号：US20070276026A1

公开(公告)日：2007-11-29

申请号：US11680805

申请日：2007-03-01

申请人： Gianni Chessari ,  Miles Congreve ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Alison Woolford

发明人： Gianni Chessari ,  Miles Congreve ,  Martyn Frederickson ,  Christopher Murray ,  Eva Navarro ,  Alison Woolford

IPC分类号： A61K31/40 ,  C07D209/00

CPC分类号： C07D401/12 ,  C07C65/21 ,  C07D209/08 ,  C07D209/44 ,  C07D215/08 ,  C07D217/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D491/10

摘要： The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof, wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

摘要翻译： 本发明提供式（I）化合物或其盐，互变异构体，溶剂合物和N-氧化物，其中R 1是羟基或氢; R 2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R 3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5 - 烃氧基; R 4选自氢; 其中n为0或1且R 7为任选取代的无环C 1 - （O）N - ， - -5个烃基或具有3〜7个环成员的单环碳环或杂环基; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。 该化合物具有作为Hsp90抑制剂的活性。

公开(公告)号：US20090215772A1

公开(公告)日：2009-08-27

申请号：US11911490

申请日：2006-04-13

申请人： Gianni Chessari ,  Miles Stuart Congreve ,  Eva Figueroa Navarro ,  Martyn Frederickson ,  Christopher Murray ,  Alison Jo-Anne Woolford ,  Maria Grazia Carr ,  Michael Alistair O'Brien ,  Andrew James Woodhead ,  Robert Downham ,  Theresa Rachel Phillips

发明人： Gianni Chessari ,  Miles Stuart Congreve ,  Eva Figueroa Navarro ,  Martyn Frederickson ,  Christopher Murray ,  Alison Jo-Anne Woolford ,  Maria Grazia Carr ,  Michael Alistair O'Brien ,  Andrew James Woodhead ,  Robert Downham ,  Theresa Rachel Phillips

IPC分类号： A61K31/5377 ,  C07D209/44 ,  A61K31/403 ,  A61K31/454 ,  C07D401/02 ,  C07D403/02 ,  A61K31/497 ,  C07D413/14

CPC分类号： C07D401/12 ,  C07C65/21 ,  C07D209/08 ,  C07D209/44 ,  C07D215/08 ,  C07D217/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D491/10

摘要： The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbylamino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur.The compounds have activity as Hsp90 inhibitors.

摘要翻译： 本发明提供式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R1是羟基或氢; R2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5烃氧基; R4选自氢; 其中n为0或1，R7为任选取代的无环C 1-5烃基或具有3至7个环成员的单环碳环或杂环基团 - （O）n -R 7基团; 卤素; 氰基; 羟基; 氨基; 和任选取代的一或二-C 1-5烃基氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。 该化合物具有作为Hsp90抑制剂的活性。

公开(公告)号：US20080306054A1

公开(公告)日：2008-12-11

申请号：US11911447

申请日：2006-04-13

申请人： Gianni Chessari ,  Miles Stuart Congreve ,  Eva Figueroa Navarro ,  Martyn Frederickson ,  Christopher Murray ,  Alison Jo-Anne Woolford ,  Maria Grazia Carr ,  Michael Alistair O'Brien ,  Andrew James Woodhead

发明人： Gianni Chessari ,  Miles Stuart Congreve ,  Eva Figueroa Navarro ,  Martyn Frederickson ,  Christopher Murray ,  Alison Jo-Anne Woolford ,  Maria Grazia Carr ,  Michael Alistair O'Brien ,  Andrew James Woodhead

IPC分类号： A61K31/54 ,  C07D241/04 ,  A61K31/495 ,  A61K31/5375 ,  A61K31/435 ,  C07D211/06 ,  C07D265/30 ,  C07D279/12

CPC分类号： C07D401/12 ,  C07C65/21 ,  C07D209/08 ,  C07D209/44 ,  C07D215/08 ,  C07D217/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D491/10

摘要： The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; C1-5 hydrocarbyl and C1-5 hydrocarbyloxy; wherein the C1-5 hydrocarbyl and C1-5 hydrocarbyloxy moieties are each optionally substituted by one or more substituents selected from hydroxy, halogen, C1-2 alkoxy, amino, mono- and di-C1-2 alkylamino, and aryl and heteroaryl groups of 5 to 12 ring members; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and mono- or di-C1-5 hydrocarbyl-amino, wherein the acyclic C1-5 hydrocarbyl group and the mono and di-C1-5 hydrocarbylamino moieties in each instance are optionally substituted by one or more substituents selected from hydroxy, halogen, C1-2 alkoxy, amino, mono- and di-C1-2 alkylamino, and aryl and heteroaryl groups of 5 to 12 ring members; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and R5 and R6 are as defined in the claims.

摘要翻译： 本发明提供用作Hsp90抑制剂的化合物，具有式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R1是羟基或氢; R2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R3选自氢; 卤素; 氰基; C 1-5烃基和C 1-5烃氧基; 其中C 1-5烃基和C 1-5烃氧基部分各自任选被一个或多个选自羟基，卤素，C 1-2烷氧基，氨基，单和二-C 1-2烷基氨基，和芳基和杂芳基的取代基取代 5至12名成员; R4选自氢; 基团 - （O）n -R 7，其中n为0或1，R 7为无环C 1-5烃基或具有3〜7个环成员的单环碳环或杂环基; 卤素; 氰基 羟基; 氨基; 和单 - 或二-C1-5烃基 - 氨基，其中无规C 1〜5烃基和单-C 1〜C 5烃基氨基部分任选被一个或多个选自羟基，卤素，C1 -2-烷氧基，氨基，单和二-C 1-2烷基氨基，以及5至12个环成员的芳基和杂芳基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且R 5和R 6如权利要求中所定义。

公开(公告)号：US08101648B2

公开(公告)日：2012-01-24

申请号：US11911490

申请日：2006-04-13

申请人： Gianni Chessari ,  Miles Stuart Congreve ,  Eva Figueroa Navarro ,  Martyn Frederickson ,  Christopher Murray ,  Alison Jo-Anne Woolford ,  Maria Grazia Carr ,  Michael Alistair O'Brien ,  Andrew James Woodhead ,  Robert Downham ,  Theresa Rachel Phillips

发明人： Gianni Chessari ,  Miles Stuart Congreve ,  Eva Figueroa Navarro ,  Martyn Frederickson ,  Christopher Murray ,  Alison Jo-Anne Woolford ,  Maria Grazia Carr ,  Michael Alistair O'Brien ,  Andrew James Woodhead ,  Robert Downham ,  Theresa Rachel Phillips

IPC分类号： A01N43/38 ,  A61K31/40 ,  C07D209/44

CPC分类号： C07D401/12 ,  C07C65/21 ,  C07D209/08 ,  C07D209/44 ,  C07D215/08 ,  C07D217/06 ,  C07D401/04 ,  C07D401/10 ,  C07D401/14 ,  C07D403/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C07D471/04 ,  C07D471/10 ,  C07D491/08 ,  C07D491/10

摘要： The invention provides compounds of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydrogen; R2 is hydroxy or methoxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The compounds have activity as Hsp90 inhibitors.

摘要翻译： 本发明提供式（I）的化合物：或其盐，互变异构体，溶剂合物和N-氧化物; 其中R1是氢; R2是羟基或甲氧基; R3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5烃氧基; R4选自氢; 其中n为0或1，R7为任选取代的无环C 1-5烃基或具有3至7个环成员的单环碳环或杂环基团 - （O）n -R 7基团; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基，其中多达5个环成员是选自氧，氮和硫的杂原子。 该化合物具有作为Hsp90抑制剂的活性。

公开(公告)号：US08796244B2

公开(公告)日：2014-08-05

申请号：US12997754

申请日：2009-06-12

申请人： Valerio Berdini ,  Maria Grazia Carr ,  Miles Stuart Congreve ,  Martyn Frederickson ,  Charlotte Mary Griffiths-Jones ,  Christopher Charles Frederick Hamlett ,  Andrew Madin ,  Christopher William Murray ,  Rajdeep Kaur Benning ,  Gordon Saxty ,  Emma Vickerstaffe ,  Andrew James Woodhead ,  Steven John Woodhead ,  Eddy Jean Edgard Freyne ,  Tom Cornelis Hortense Govaerts ,  Patrick René Angibaud ,  Marian Williams

发明人： Valerio Berdini ,  Maria Grazia Carr ,  Miles Stuart Congreve ,  Martyn Frederickson ,  Charlotte Mary Griffiths-Jones ,  Christopher Charles Frederick Hamlett ,  Andrew Madin ,  Christopher William Murray ,  Rajdeep Kaur Benning ,  Gordon Saxty ,  Emma Vickerstaffe ,  Brian John Williams ,  Andrew James Woodhead ,  Steven John Woodhead ,  Eddy Jean Edgard Freyne ,  Tom Cornelis Hortense Govaerts ,  Patrick René Angibaud

IPC分类号： A61K31/5025 ,  C07D413/02

CPC分类号： C07D471/04 ,  C07D513/04

摘要： The invention relates to new bicyclic heterocyclic derivative compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of diseases, e.g. cancer.

摘要翻译： 本发明涉及新的双环杂环衍生物化合物，包含该化合物的药物组合物和该化合物在治疗疾病中的用途。 癌症。

公开(公告)号：US08653084B2

公开(公告)日：2014-02-18

申请号：US12445130

申请日：2007-10-12

申请人： Martyn Frederickson ,  Mladen Vinkovic ,  Andrew James Woodhead ,  Alison Jo-Anne Woolford ,  Marian Williams

发明人： Martyn Frederickson ,  Mladen Vinkovic ,  Brian John Williams ,  Andrew James Woodhead ,  Alison Jo-Anne Woolford

IPC分类号： A61K31/497 ,  C07D403/00

CPC分类号： C07C67/317 ,  C07C59/08 ,  C07C67/313 ,  C07C69/92 ,  C07C235/60 ,  C07D209/44

摘要： The invention provides an acid addition salt of a compound of the formula (1) Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogues thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analogue.

摘要翻译： 本发明提供式（1）化合物的酸加成盐本发明还提供了制备式（1）化合物及其烷基类似物的方法，用于该方法的新中间体和制备中间体的方法 。 本发明还提供式（1）化合物及其乙基类似物的新的医学用途。