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公开(公告)号：US20060134086A1
公开(公告)日：2006-06-22
申请号：US10881221
申请日：2004-06-30
申请人： Yiyou Chen , Anthony Day , David Estell , Christopher Murray , Scott Power , Volker Schellenberger
发明人： Yiyou Chen , Anthony Day , David Estell , Christopher Murray , Scott Power , Volker Schellenberger
CPC分类号： B82Y5/00 , A61K38/00 , A61K47/67 , A61K47/6891 , A61K48/00 , C07K2319/00 , C07K2319/01 , C12N9/00 , C12N9/50 , C12N9/86 , C12N15/1093 , C12Y305/02006
摘要： The present invention provides targeted enzymes that bind to targets better than the corresponding pre-targeted enzymes bind the target under like conditions, methods of making targeted enzymes, methods of using targeted enzymes to treat diseases, and pharmaceutical compositions comprising targeted enzymes.
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公开(公告)号：US20060088838A1
公开(公告)日：2006-04-27
申请号：US10514446
申请日：2003-06-09
CPC分类号： C40B30/04 , C12N15/1086 , C12Q1/6897 , G01N33/53 , G01N33/54306 , G01N33/581 , G01N33/6845
摘要： The present invention relates to methods for improving a binding characteristic of a molecule, e.g., a peptide, for a binding target, in which the molecule is covalently linked to a detectable moiety, e.g., an enzyme, or an active portion or derivative thereof. The present invention also relates to molecules produced by the methods of the present invention.
摘要翻译： 本发明涉及用于改善结合靶分子例如肽的结合特性的方法，其中分子共价连接到可检测部分，例如酶或其活性部分或衍生物。 本发明还涉及通过本发明的方法制备的分子。
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3.发明申请Methods and compositions for milieu-dependent binding of a targeted agent to a target 审中-公开目标药物与靶标的环境依赖性结合的方法和组合物公开(公告)号：US20060141456A1
公开(公告)日：2006-06-29
申请号：US10514516
申请日：2003-06-09
IPC分类号： C12Q1/68
CPC分类号： C07K16/3007 , C07K16/30 , C07K2299/00 , C07K2317/565 , C07K2317/622 , G01N33/53 , G01N33/574 , G01N2500/04
摘要： The present invention provides methods and compositions for milieu-dependent binding of a targeted agent to a target, for example, for the milieu-dependent binding of a diagnostic or therapeutic molecule to a diseased, injured or infected organ, tissue or cell.
摘要翻译： 本发明提供了用于目标药物与靶标的环境依赖性结合的方法和组合物，例如用于诊断或治疗分子与患病，受伤或感染的器官，组织或细胞的环境依赖性结合。
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公开(公告)号：US10421798B2
公开(公告)日：2019-09-24
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Volker Schellenberger , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755 , A61K38/00
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
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公开(公告)号：US20150158929A1
公开(公告)日：2015-06-11
申请号：US14379192
申请日：2012-07-11
申请人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
发明人： Volker Schellenberger , Pei-Yun Chang , Fatbardha Varfaj , Sheng Ding , Joshua Silverman , Chia-wei Wang , Benjamin Spink , Willem P. Stemmer , Nathan Geething , John Kulman , Tongyao Liu , Garabet G. Toby , Haiyan Jiang , Robert Peters , Deping Wang , Baisong Mei
IPC分类号： C07K14/755
摘要： The present invention relates to compositions comprising factor VIII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of factor VIII-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VIII凝血因子的组合物，编码组合物的分离的核酸和含有它们的载体和宿主细胞，以及制备和使用这些组合物治疗因子VIII相关的方法 疾病，病症和状况。
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公开(公告)号：US08957021B2
公开(公告)日：2015-02-17
申请号：US12796650
申请日：2010-06-08
申请人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-wei Wang , Nathan Geething , Jeffrey L. Cleland
发明人： Volker Schellenberger , Joshua Silverman , Willem P. Stemmer , Chia-wei Wang , Nathan Geething , Jeffrey L. Cleland
IPC分类号： A61K38/00 , C07K19/00 , A61P3/10 , C07K14/605 , C07K14/575
CPC分类号： C07K14/605 , A23V2200/328 , A61K38/00 , C07K14/575 , C07K14/57563 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N15/70 , C12P21/02 , Y10S514/866
摘要： The present invention relates to compositions comprising glucose regulating peptides linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of glucose regulating peptide-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的葡萄糖调节肽的组合物，编码组合物的分离的核酸和含有该组合物的载体和宿主细胞，以及制备和使用该组合物治疗葡萄糖调节肽相关的方法 疾病，病症和状况。
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公开(公告)号：US08728470B2
公开(公告)日：2014-05-20
申请号：US13287642
申请日：2011-11-02
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
摘要翻译： 本发明涉及CAB分子，针对CEA的ADEPT构建体及其在治疗中的用途。
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8.发明授权公开(公告)号：US08716448B2
公开(公告)日：2014-05-06
申请号：US12806005
申请日：2010-08-02
申请人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
发明人： Volker Schellenberger , Joshua Silverman , Willem Stemmer , Chia-wei Wang , Benjamin Spink , Nathan Geething , Wayne To
IPC分类号： A61K38/36 , C07K14/745
CPC分类号： C12N9/644 , A61K38/00 , C07K14/001 , C07K2319/00 , C07K2319/31 , C07K2319/50 , C12N9/6437 , C12N15/70 , C12Y304/21022
摘要： The present invention relates to compositions comprising factor VII coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
摘要翻译： 本发明涉及包含与延伸的重组多肽（XTEN）连接的因子VII凝血因子的组合物，编码组合物的分离的核酸和载体以及含有它们的宿主细胞，以及制备和使用这些组合物治疗凝血因子相关的方法 疾病，病症和状况。
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公开(公告)号：US20130039884A1
公开(公告)日：2013-02-14
申请号：US13469902
申请日：2012-05-11
申请人： Oren Bogin , Willem P. Stemmer , Volker Schellenberger , Yong Yin , Chia-wei Wang , Nathan C. Geething
发明人： Oren Bogin , Willem P. Stemmer , Volker Schellenberger , Yong Yin , Chia-wei Wang , Nathan C. Geething
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K38/00 , C07K14/00 , C07K14/535 , C07K14/56 , C07K14/61 , C07K16/2863 , C07K16/32 , C07K16/40 , C07K2317/22 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2319/00 , C07K2319/33
摘要： The present invention relates to biologically active polypeptides linked to one or more accessory polypeptides. The present invention also provides recombinant polypeptides including vectors encoding the subject proteinaceous entities, as well as host cells comprising the vectors. The subject compositions have a variety of utilities including a range of pharmaceutical applications.
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公开(公告)号：US20120107314A1
公开(公告)日：2012-05-03
申请号：US13287642
申请日：2011-11-02
IPC分类号： A61K39/395 , C07H21/04
CPC分类号： C07K16/3007 , A61K2039/505 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy.
摘要翻译： 本发明涉及CAB分子，针对CEA的ADEPT构建体及其在治疗中的用途。
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