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公开(公告)号：US07683061B2
公开(公告)日：2010-03-23
申请号：US10580237
申请日：2004-11-22
申请人： Christopher Penney , Boulos Zacharie , Shaun D. Abbott , Jean-François Bienvenu , Alan D. Cameron , Jean-Simon Duceppe , Abdallah Ezzitouni , Daniel Fortin , Karine Houde , Nancie Moreau , Nicole Wilb , Brigitte Grouix , Lyne Gagnon
发明人： Christopher Penney , Boulos Zacharie , Shaun D. Abbott , Jean-François Bienvenu , Alan D. Cameron , Jean-Simon Duceppe , Abdallah Ezzitouni , Daniel Fortin , Karine Houde , Nancie Moreau , Nicole Wilb , Brigitte Grouix , Lyne Gagnon
IPC分类号： C07D403/12 , C07D403/14 , A61K31/53 , A61K39/395 , A61P13/12 , A61P17/06 , A61P19/02 , A61P37/00 , A61M1/36 , C07K1/22 , C07K16/24
CPC分类号： C07D401/14 , C07D251/70
摘要： Compounds containing two mono- or disubstituted triazine rings covalently linked by an organic linker, but not linked directly to each other, may be used to treat autoimmune diseases. Autoimmune diseases which are amenable to treatment with compounds of this invention include rheumatoid arthritis, systemic lupus erythematosus (SLE), idiopathic (immune) thrombocytopenia (ITP), glomerulonephritis and vasculitis. The present invention also relates to reducing drug toxicity which often accompanies traditional therapies for autoimmune diseases. The compounds may also be used to bind antibody in vitro or ex vivo.
摘要翻译： 含有通过有机接头共价连接但不直接相互连接的两个单取代或二取代的三嗪环的化合物可用于治疗自身免疫性疾病。 适合用本发明化合物治疗的自身免疫性疾病包括类风湿性关节炎，系统性红斑狼疮（SLE），特发性（免疫性）血小板减少症（ITP），肾小球性肾炎和血管炎。 本发明还涉及通常伴随着自身免疫疾病的传统疗法的药物毒性的降低。 该化合物也可用于体外或离体结合抗体。
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2.发明申请2,4,6-triamino-s-triazine-based compounds which bind to the tail (fc) portion of immunoglobulins and their use 审中-公开结合免疫球蛋白尾部（fc）部分的2,4,6-三氨基-s-三嗪类化合物及其用途公开(公告)号：US20090068169A1
公开(公告)日：2009-03-12
申请号：US11661233
申请日：2005-09-02
申请人： Christopher Penney , Boulos Zacharie , Shaun D. Abbott , Jean-Francois Bienvenu , Alan D. Cameron , Jean-Simon Duceppe , Abdallah Ezzitouni , Daniel Fortin , Karine Houde , Nancie Moreau , Nicole Wilb , Brigitte Grouix , Lyne Gagnon
发明人： Christopher Penney , Boulos Zacharie , Shaun D. Abbott , Jean-Francois Bienvenu , Alan D. Cameron , Jean-Simon Duceppe , Abdallah Ezzitouni , Daniel Fortin , Karine Houde , Nancie Moreau , Nicole Wilb , Brigitte Grouix , Lyne Gagnon
IPC分类号： A61K31/53 , C07D251/54 , A61K38/00 , A61K39/395 , A61K35/14 , A61K35/00 , C07K1/14
CPC分类号： C07D251/70 , A61M1/3679 , C07K16/00 , C07K2317/52
摘要： The present invention describes new compounds which are useful for binding to the tail or Fc portion of immunoglobulins and so have utility in those applications which require the non-covalent binding interaction of a molecule with the Fc portion of immunoglobulins. Such applications include the detection and purification of immunoglobulins as well as the treatment of certain autoimmune diseases.
摘要翻译： 本发明描述了可用于结合免疫球蛋白的尾部或Fc部分的新化合物，因此在需要分子与免疫球蛋白的Fc部分的非共价结合相互作用的那些应用中有用。 这些应用包括免疫球蛋白的检测和纯化以及某些自身免疫性疾病的治疗。
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公开(公告)号：US20070149528A1
公开(公告)日：2007-06-28
申请号：US10580237
申请日：2004-11-22
申请人： Christopher Penney , Boulos Zacharie , Shaun Abbott , Jean-Francois Bienvenu , Alan Cameron , Jean-Simon Duceppe , Abdallah Ezzitouni , Daniel Fortin , Karine Houde , Nancia Moreau , Nicole Wilb , Brigitte Grouix , Lyne Gagnon
发明人： Christopher Penney , Boulos Zacharie , Shaun Abbott , Jean-Francois Bienvenu , Alan Cameron , Jean-Simon Duceppe , Abdallah Ezzitouni , Daniel Fortin , Karine Houde , Nancia Moreau , Nicole Wilb , Brigitte Grouix , Lyne Gagnon
IPC分类号： A61K31/53 , C07D403/14 , C07D403/02
CPC分类号： C07D401/14 , C07D251/70
摘要： Compounds containing two mono- or disubstituted triazine rings covalently linked by an organic linker, but not linked directly to each other, may be used to treat autoimmune diseases. Autoimmune diseases which are amenable to treatment with compounds of this invention include rheumatoid arthritis, systemic lupus erythematosus (SLE), idiopathic (immune) thrombocytopenia (ITP), glomerulonephritis and vasculitis. The present invention also relates to reducing drug toxicity which often accompanies traditional therapies for autoimmune diseases. The compounds may also be used to bind antibody in vitro or ex vivo.
摘要翻译： 含有通过有机接头共价连接但不直接相互连接的两个单取代或二取代的三嗪环的化合物可用于治疗自身免疫性疾病。 适合用本发明化合物治疗的自身免疫性疾病包括类风湿性关节炎，系统性红斑狼疮（SLE），特发性（免疫性）血小板减少症（ITP），肾小球性肾炎和血管炎。 本发明还涉及通常伴随着自身免疫疾病的传统疗法的药物毒性的降低。 该化合物也可用于体外或离体结合抗体。
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公开(公告)号：US20120095102A1
公开(公告)日：2012-04-19
申请号：US13318252
申请日：2010-05-03
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： A61K31/192 , C07C51/09 , A61P7/00 , A61P13/12 , A61P29/00 , A61P7/06 , A61P37/06 , A61P19/02 , A61P9/00 , A61P17/06 , A61P1/00 , A61P27/02 , A61P35/00 , A61P3/10 , A61P9/10 , A61P25/16 , A61P9/04 , A61P25/28 , A61P43/00 , C07C57/30
CPC分类号： A61K31/192 , C07C51/412 , C07C57/30 , C07C67/303 , C07C67/343 , C07C69/612 , C07C69/618
摘要： The present invention relates to salts of 3-pentylphenylacetic acid and their pharmaceutical uses. Particular aspects of the invention relate to the use of those salts in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention and treatment of (i) blood disorders, (ii) renal disorders and renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译： 本发明涉及3-戊基苯乙酸的盐及其药物用途。 本发明的特定方面涉及这些盐在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防和治疗（i）血液病症，（ii）肾脏疾病和肾脏疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。
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公开(公告)号：US09475750B2
公开(公告)日：2016-10-25
申请号：US13882363
申请日：2011-10-26
申请人： Boulos Zacharie , Christopher Penney , Shaun Abbott , Lyne Gagnon , Brigitte Grouix , Pierre Laurin , Jean-François Bienvenu
发明人： Boulos Zacharie , Christopher Penney , Shaun Abbott , Lyne Gagnon , Brigitte Grouix , Pierre Laurin , Jean-François Bienvenu
IPC分类号： C07C59/90 , C07C62/38 , C07C65/32 , C07C69/92 , C07C217/84 , C07C225/22 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C59/68 , C07C59/84
CPC分类号： C07C59/90 , A61K31/192 , A61K31/196 , A61K31/222 , A61K31/235 , C07C59/68 , C07C59/84 , C07C62/38 , C07C65/32 , C07C69/92 , C07C217/84 , C07C225/22 , C07C229/18 , C07C323/20 , C07C323/52 , C07C323/62 , C07C2602/08
摘要： Phenylketone carboxylate compounds of Formula I, wherein n=2-6; R═C(0); —OC(O)— or —CH(OH)—; A is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when B is Ft B is (CH2)mCOOH, W(CH2)mCOOH or YCH(COOH)((CH2)pCH3) when A is Ft or A and B form a 5-7 membered cycloalkyl substituted with COOFt W=0, S or NFt Y=0,S,NH or CH2; m=0-2; p=1-7; have been prepared. These compounds and their pharmaceutically acceptable salts have beneficial therapeutic effects to prevent or treat a condition related to (l) blood disorders, (ii) inflammation related diseases, (iii) renal disorders and/or renal disorders complications, or (iv) fibrosis-related organ dysfunction.
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公开(公告)号：US08927765B2
公开(公告)日：2015-01-06
申请号：US13289592
申请日：2011-11-04
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： C07C53/134 , C07C57/30 , C07C61/39 , C07D257/04 , C07C59/48 , C07D213/55 , C07C57/58 , C07C59/52
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译： 本发明涉及取代的式I的芳族化合物及其药物用途。 本发明的特定方面涉及这些化合物在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防或治疗（i）血液病症，（ii）肾病，肾病或肾脏 疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。
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公开(公告)号：US20120088784A1
公开(公告)日：2012-04-12
申请号：US13289592
申请日：2011-11-04
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Jean-François Bienvenu , Valérie Perron , Brigitte Grouix
IPC分类号： A61K31/192 , C07C57/42 , C07C59/52 , C07C57/50 , C07D213/55 , A61K31/44 , C07D257/04 , A61K31/41 , A61P7/00 , A61P13/12 , A61P29/00 , A61P9/10 , A61P7/06 , A61P37/00 , A61P19/02 , A61P19/04 , A61P17/06 , A61P1/00 , A61P27/02 , A61P9/00 , A61P35/00 , A61P3/10 , A61P25/16 , A61P9/04 , A61P25/28 , A61P25/00 , C07C57/30
CPC分类号： C07C57/58 , A61K31/19 , A61K31/192 , C07C57/30 , C07C57/42 , C07C59/48 , C07C59/52 , C07C61/39 , C07D213/55 , C07D257/04
摘要： The present invention relates to substituted aromatic compounds of Formula I and their pharmaceutical uses. Particular aspects of the invention relate to the use of those compounds in the prevention and/or treatment of various diseases and conditions in subjects, including the prevention or treatment of (i) blood disorders, (ii) renal disorders, a nephropathies, or renal disorder complications; (iii) inflammatory-related diseases; and/or (iv) oxidative stress related disorders.
摘要翻译： 本发明涉及取代的式I的芳族化合物及其药物用途。 本发明的特定方面涉及这些化合物在预防和/或治疗受试者的各种疾病和病症中的用途，包括预防或治疗（i）血液病症，（ii）肾病，肾病或肾脏 疾病并发症; （iii）炎性相关疾病; 和/或（iv）氧化应激相关疾病。
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8.发明申请Triazine Derivatives, Compositions Containing Such Derivatives, and Methods of Treatment of Cancer and Autoimmune Diseases Using Such Derivatives 有权三嗪衍生物，含有此类衍生物的组合物，以及使用此类衍生物治疗癌症和自身免疫性疾病的方法公开(公告)号：US20100129350A1
公开(公告)日：2010-05-27
申请号：US12598273
申请日：2008-04-25
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Shaun D. Abbott
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Shaun D. Abbott
IPC分类号： A61K31/53 , C07D251/54 , A61K31/704 , A61K31/675 , A61K38/00 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K39/395 , A61P35/00 , A61P37/00
CPC分类号： C07D251/18 , C07D251/70
摘要： We describe compounds of the following general formula (I): wherein X is fluorine or chlorine; Y is oxygen, sulfur, or an amino group; R is an amino, hydroxyl, sulfonamide, or carboxamide group or an N-monomethyl or N-dimethyl analog thereof; m is an integer from 2 to 6, and n is an integer from 0 to 2. The compounds may be used for treating certain cancers and autoimmune diseases.
摘要翻译： 我们描述以下通式（I）的化合物：其中X是氟或氯; Y是氧，硫或氨基; R是氨基，羟基，磺酰胺或羧酰胺基团或其N-甲基或N-二甲基类似物; m为2〜6的整数，n为0〜2的整数。化合物可用于治疗某些癌症和自身免疫性疾病。
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9.发明授权Triazine derivatives, compositions containing such derivatives, and methods of treatment of cancer and autoimmune diseases using such derivatives 有权三嗪衍生物，含有这些衍生物的组合物，以及使用这些衍生物治疗癌症和自身免疫性疾病的方法公开(公告)号：US08258295B2
公开(公告)日：2012-09-04
申请号：US12598273
申请日：2008-04-25
申请人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Shaun D. Abbott
发明人： Boulos Zacharie , Christopher Penney , Lyne Gagnon , Brigitte Grouix , Lilianne Geerts , Shaun D. Abbott
CPC分类号： C07D251/18 , C07D251/70
摘要： We describe compounds of the following general formula (I): wherein X is fluorine or chlorine; Y is oxygen, sulfur, or an amino group; R is an amino, hydroxyl, sulfonamide, or carboxamide group or an N-monomethyl or N-dimethyl analog thereof; m is an integer from 2 to 6, and n is an integer from 0 to 2. The compounds may be used for treating certain cancers and autoimmune diseases.
摘要翻译： 我们描述以下通式（I）的化合物：其中X是氟或氯; Y是氧，硫或氨基; R是氨基，羟基，磺酰胺或羧酰胺基团或其N-甲基或N-二甲基类似物; m为2〜6的整数，n为0〜2的整数。化合物可用于治疗某些癌症和自身免疫性疾病。
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公开(公告)号：US20070027343A1
公开(公告)日：2007-02-01
申请号：US10565762
申请日：2004-07-23
IPC分类号： C07C53/126
CPC分类号： C07C51/412 , C07C53/126
摘要： A process for the preparation of metal salts of a medium-chain length monocarboxylic fatty acid comprises reacting the precursor free fatty acid, dissolved in a suitable solvent, with the appropriate metal salt. The process uses a relatively high concentration of free fatty acid as a soluble reactant and produces metal fatty acid salts at high purity and high yield at a reasonable cost.
摘要翻译： 制备中链长度单羧酸脂肪酸的金属盐的方法包括使溶解在合适溶剂中的前体游离脂肪酸与合适的金属盐反应。 该方法使用相对高浓度的游离脂肪酸作为可溶性反应物，以合理的成本产生高纯度和高收率的金属脂肪酸盐。
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