公开(公告)号：US20050186209A1

公开(公告)日：2005-08-25

申请号：US11041636

申请日：2005-01-24

申请人： Claire Ashman ,  James Crowe ,  Jonathan Ellis ,  Alan Lewis

发明人： Claire Ashman ,  James Crowe ,  Jonathan Ellis ,  Alan Lewis

IPC分类号： C12N15/09 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P11/06 ,  A61P43/00 ,  C07K14/54 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/24 ,  C12P21/02 ,  A61K39/395 ,  C07K14/52 ,  C07K14/74

CPC分类号： C07K14/5406 ,  A61K39/00 ,  A61K2039/55561 ,  C07K14/5437 ,  C07K2319/00

摘要： The present invention relates to an isolated polypeptide useful for immunisation against self-antigens. In particular the invention relates to a self-protein that is capable of raising auto-antibodies when administered in vivo. The invention particularly relates to rendering human cytokines immunogenic in humans. The invention further relates to pharmaceutical compositions comprising such compounds and their use in medicine and to methods for their production.

摘要翻译： 本发明涉及用于免疫抗自身抗原的分离的多肽。 特别地，本发明涉及当在体内施用时能够引发自身抗体的自身蛋白质。 本发明特别涉及在人体中呈递免疫原性的人类细胞因子。 本发明还涉及包含这些化合物的药物组合物及其在医药中的用途及其生产方法。

公开(公告)号：US20050260216A1

公开(公告)日：2005-11-24

申请号：US10469561

申请日：2002-03-01

申请人： Claire Ashman ,  James Crowe ,  Jonathan Ellis ,  Alan Lewis

发明人： Claire Ashman ,  James Crowe ,  Jonathan Ellis ,  Alan Lewis

IPC分类号： C12N15/09 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K48/00 ,  A61P11/06 ,  A61P43/00 ,  C07K14/54 ,  C07K19/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/24 ,  C12P21/02 ,  A61K39/38

CPC分类号： C07K14/5406 ,  A61K39/00 ,  A61K2039/55561 ,  C07K14/5437 ,  C07K2319/00

摘要： The present invention relates to an isolated polypeptide useful for immunisation against self-antigens. In particular the invention relates to a self-protein that is capable of raising auto-antibodies when administered in vivo. The invention particularly relates to rendering human cytokines immunogenic in humans. The invention further relates to pharmaceutical compositions comprising such compounds and their use in medicine and to methods for their production.

公开(公告)号：US20070269451A1

公开(公告)日：2007-11-22

申请号：US11555793

申请日：2006-11-02

申请人： James Crowe ,  Jonathan Ellis

发明人： James Crowe ,  Jonathan Ellis

IPC分类号： A61K39/385 ,  A61P35/00 ,  A61P5/00 ,  C12N15/63

CPC分类号： A61K39/0011 ,  A61K2039/53

摘要： A nucleic acid vaccine construct comprising an isolated polynucleotide which encodes a polypeptide comprising at least five consecutive amino acid residues from the VNTR monomer of Muc1 wherein one or more of said amino acids is a glycosylation site, characterised in that when said isolated polynucleotide is expressed in a mammalian cell, glycosylation of the resulting polypeptide is altered or prevented at at least one of said glycosylation sites.

摘要翻译： 一种核酸疫苗构建体，其包含分离的多核苷酸，其编码包含来自Muc1的VNTR单体的至少五个连续氨基酸残基的多肽，其中一个或多个所述氨基酸是糖基化位点，其特征在于当所述分离的多核苷酸以 在所述糖基化位点中的至少一个上改变或预防所得多肽的糖基化，哺乳动物细胞的糖基化。

公开(公告)号：US20060173765A1

公开(公告)日：2006-08-03

申请号：US11384460

申请日：2006-03-20

申请人： James Crowe ,  Russell Rushmeier ,  Indraneel Das ,  Paul Koster ,  Jose Alvarez ,  Mark Reynolds ,  Lorraine Lotosky

发明人： James Crowe ,  Russell Rushmeier ,  Indraneel Das ,  Paul Koster ,  Jose Alvarez ,  Mark Reynolds ,  Lorraine Lotosky

IPC分类号： G06Q40/00

CPC分类号： G06Q40/02 ,  G06Q20/108 ,  G06Q20/1085 ,  G06Q40/00

摘要： A method and computer program product are presented for selecting and arranging an appropriate combination of network components, or elements, in a communications network. The selection of network components is done in a manner that maximizes the net present value of cash flow resulting from the provision of communications services between nodes of the network. The method comprises the steps of receiving information that constrains network design and price establishment, and then using the constraint information to select a combination of network components for each link in the communications network. According to the invention, the selection of network components is performed for each of several successive time periods, effectively planning the evolution of the network. The selections are made so that the network components satisfy demand over time while maximizing the net present value of the cash flow that results from the provision of communications services.

公开(公告)号：US20070286873A1

公开(公告)日：2007-12-13

申请号：US11752742

申请日：2007-05-23

申请人： John Williams ,  James Crowe

发明人： John Williams ,  James Crowe

IPC分类号： A61K39/00 ,  A61P43/00 ,  C07K14/00 ,  C12N15/00 ,  C12N15/11 ,  C12P21/04 ,  G01N33/53

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K2039/53 ,  C07K2319/21 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/18322 ,  C12N2760/18334 ,  G01N33/56983 ,  G01N2333/11

摘要： The present invention provides an improved form of a nucleic acid encoding for the influenza hemagluttinin H5N1. The optimized gene sequence permits production via recombinant means, of the H5N1 HA protein for use in diagnostic assays and vaccines.

摘要翻译： 本发明提供编码流感血凝素H5N1的核酸的改进形式。 优化的基因序列允许通过重组方式生产H5N1HA蛋白，用于诊断测定和疫苗。

公开(公告)号：US20110135645A1

公开(公告)日：2011-06-09

申请号：US12311587

申请日：2007-10-04

申请人： R. Anthony Williamson ,  Zhifeng Chen ,  Pietro Paolo Sanna ,  Dennis R. Burton ,  James Crowe ,  John V. Williams

发明人： R. Anthony Williamson ,  Zhifeng Chen ,  Pietro Paolo Sanna ,  Dennis R. Burton ,  James Crowe ,  John V. Williams

IPC分类号： A61K39/395 ,  C07K16/10 ,  G01N33/68 ,  C12Q1/70 ,  A61P31/14 ,  A61P37/04

CPC分类号： C07K16/1027 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention discloses methods for generating antibodies to human metapneumovirus (HMPV) polypeptides, including antibodies that immunospecifically bind to a HMPV F-protein. The invention also discloses methods for preventing, treating, or ameliorating symptoms associated with HMPV infection.

摘要翻译： 本发明公开了产生针对人类偏肺病毒（HMPV）多肽的抗体的方法，包括免疫特异性结合HMPV F蛋白的抗体。 本发明还公开了用于预防，治疗或改善与HMPV感染相关的症状的方法。