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    Method to measure a t cell response and its uses to qualify antigen-presenting cells
    3.
    发明申请
    Method to measure a t cell response and its uses to qualify antigen-presenting cells 审中-公开
    测量t细胞应答的方法及其用于鉴定抗原呈递细胞的方法

    公开(公告)号：US20060160153A1

    公开(公告)日：2006-07-20

    申请号：US10537500

    申请日：2003-12-02

    申请人： Jean-Pierre Abastado ,  Nadege Bercovici ,  Marc Ernstoff ,  Alice Givan ,  Alessandra Nardin ,  Margarita Magguilli born Salcedo ,  Paul Wallace

    发明人： Jean-Pierre Abastado ,  Nadege Bercovici ,  Marc Ernstoff ,  Alice Givan ,  Alessandra Nardin ,  Margarita Magguilli born Salcedo ,  Paul Wallace

    IPC分类号： G01N33/567

    CPC分类号： G01N33/5094 ,  G01N33/505 ,  G01N33/56972

    摘要： A method to characterize a T-cell response of a final population of T-lymphocytes resulting from the co-incubation of an initial population of T lymphocytes with a composition of antigen-presenting cells (APCs), said method comprising the steps of a) simultaneous measuring on a single cell basis at least two parameters: (i) proliferation of T lymphocytes and (ii) presence of a T cell antigen receptor on the surface of T lymphocytes and/or presence of at least one biological molecule produced by T lymphocytes, and the attribution of a positive or a negative value to each of these parameters, and b) classification of the final T-lymphocytes population into 2n different subsets of T lymphocytes, n being the number of parameters, each subset being characterized by a positive or a negative value respectively to each parameter and the determination of the proportion of T lymphocytes present in each subset with respect to the number of T lymphocytes in the final population, with said proportion being characteristic of the T-cell response. Use of the method for batch release assay and potency assay.

    摘要翻译： 表征由初始T淋巴细胞群与抗原呈递细胞（APC）的组合共孵育的最终T淋巴细胞群的T细胞应答的方法，所述方法包括以下步骤：a） 在单细胞基础上同时测量至少两个参数：（i）T淋巴细胞的增殖和（ii）T淋巴细胞表面上存在T细胞抗原受体和/或由T淋巴细胞产生的至少一种生物分子的存在 ，以及对这些参数中的每一个的正值或负值的归属，以及b）将最终T淋巴细胞群分类为T淋巴细胞的2个不同子集，n是参数的数目 每个子集分别以每个参数的正值或负值表示，并确定每个子集中存在的T淋巴细胞相对于最终群体中T淋巴细胞数目的比例，其中sa id比例是T细胞应答的特征。 使用批次释放测定法和效力测定法。

    Methods for the prevention and treatment of cancer using anti-C3b(i) antibodies
    6.
    发明授权
    Methods for the prevention and treatment of cancer using anti-C3b(i) antibodies 失效
    使用抗C3b（i）抗体预防和治疗癌症的方法

    公开(公告)号：US06572856B1

    公开(公告)日：2003-06-03

    申请号：US09724620

    申请日：2000-11-28

    申请人： Ronald Taylor ,  Alessandra Nardin ,  William M. Sutherland ,  Mitchell H. Sokoloff ,  Leland Chung

    发明人： Ronald Taylor ,  Alessandra Nardin ,  William M. Sutherland ,  Mitchell H. Sokoloff ,  Leland Chung

    IPC分类号： A61K39395

    CPC分类号： A61K39/395 ,  A61K38/00 ,  A61K48/00 ,  A61K51/1072 ,  C07K16/18 ,  C07K16/2896 ,  C07K16/3069 ,  C07K16/44 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2319/00 ,  A61K2300/00

    摘要： The present invention relates to the treatment and prevention of cancer, viral infections and microbial infections by the administration of anti-C3b(i) antibodies. The present invention also relates to methods of treating and preventing cancer, viral infection, or microbial infection in an animal comprising administering to said animal IgG antibodies, IgM antibodies and/or complement components in combination with antibodies specific for C3b(i). The present invention also relates methods of treating and preventing cancer, viral infection or microbial infection in an animal comprising administrating said animal antibodies that immunospecifically bind to one or more cancer cell antigens, viral antigens or microbial antigens, respectively, in combination with antibodies immunospecific for C3b(i). The present invention further relates to the detection, imaging, diagnosis and monitoring of cancer utilizing C3b(i) specific antibodies.

    摘要翻译： 本发明涉及通过施用抗C3b（i）抗体来治疗和预防癌症，病毒感染和微生物感染。 本发明还涉及治疗和预防动物中的癌症，病毒感染或微生物感染的方法，包括向所述动物IgG抗体，IgM抗体和/或补体成分与C3b（i）特异的抗体组合施用。 本发明还涉及治疗和预防动物中的癌症，病毒感染或微生物感染的方法，其包括分别将免疫特异性结合一种或多种癌细胞抗原，病毒抗原或微生物抗原的所述动物抗体与免疫特异性抗体 C3b（i）。 本发明还涉及使用C3b（i）特异性抗体的癌症的检测，成像，诊断和监测。