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    Mutated adenovirus E1A gene for E1A promoter stimulation
    1.
    发明授权
    Mutated adenovirus E1A gene for E1A promoter stimulation 失效
    用于E1A启动子刺激的突变腺病毒E1A基因

    公开(公告)号：US4920211A

    公开(公告)日：1990-04-24

    申请号：US140625

    申请日：1988-01-04

    申请人： Clark Tibbetts ,  Pamela L. Larsen

    发明人： Clark Tibbetts ,  Pamela L. Larsen

    IPC分类号： C07K14/075

    CPC分类号： C07K14/005 ,  C12N2710/10322

    摘要： A functional mutated E1A gene of human adenovirus subgroup B:1 is provided which has a modified autorepression functional domain that is effective to express E1A products that stimulate without net repression of promoters controlling an E1A mutated gene.

    摘要翻译： 提供人腺病毒亚组B：1的功能性突变E1A基因，其具有修饰的自抗体功能结构域，其有效表达刺激而没有抑制E1A突变基因的启动子的净抑制的E1A产物。

    MICROARRAY IMAGING SYSTEM AND ASSOCIATED METHODOLOGY
    2.
    发明申请
    MICROARRAY IMAGING SYSTEM AND ASSOCIATED METHODOLOGY 失效
    微型成像系统及相关方法

    公开(公告)号：US20070263914A1

    公开(公告)日：2007-11-15

    申请号：US11684484

    申请日：2007-03-09

    申请人： Clark Tibbetts

    发明人： Clark Tibbetts

    IPC分类号： G06K9/00

    CPC分类号： G01J3/02 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/2846 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/0626 ,  G01N2201/0631

    摘要： An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CCD having an imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire micro array.

    摘要翻译： 提供了一种用于创建微阵列图像的装置和方法。 该装置包括被配置为将光引向微阵列的至少一个光源。 该装置包括被配置为将光过滤到朝向二色镜的第一频带的激励滤波器。 二色镜将光反射到微阵列上，导致微阵列发射电磁能。 该装置包括被配置为过滤第二频带内的电磁能的发射滤波器。 该装置还包括具有电荷耦合器件（CCD）的成像单元，该CCD具有被针孔掩蔽的成像表面，使得当针孔盲孔从发射滤光片接收电磁能时，产生整个微阵列的图像 。

    Microarray imaging system and associated methodology
    3.
    发明授权
    Microarray imaging system and associated methodology 失效
    微阵列成像系统及相关方法

    公开(公告)号：US07961323B2

    公开(公告)日：2011-06-14

    申请号：US11684484

    申请日：2007-03-09

    申请人： Clark Tibbetts

    发明人： Clark Tibbetts

    IPC分类号： G01N21/25

    CPC分类号： G01J3/02 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/2846 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/0626 ,  G01N2201/0631

    摘要： An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CCD having an imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire microarray.

    摘要翻译： 提供了一种用于创建微阵列图像的装置和方法。 该装置包括被配置为将光引向微阵列的至少一个光源。 该装置包括被配置为将光过滤到朝向二色镜的第一频带的激励滤波器。 二色镜将光反射到微阵列上，导致微阵列发射电磁能。 该装置包括被配置为过滤第二频带内的电磁能的发射滤波器。 该装置还包括具有电荷耦合器件（CCD）的成像单元，该CCD具有由针孔掩蔽的成像表面，使得当针孔盲孔从发射滤光片接收电磁能时，产生整个微阵列的图像。

    Method and apparatus for automated processing of DNA sequence data
    5.
    发明授权
    Method and apparatus for automated processing of DNA sequence data 失效
    用于自动处理DNA序列数据的方法和装置

    公开(公告)号：US5502773A

    公开(公告)日：1996-03-26

    申请号：US88208

    申请日：1993-07-06

    申请人： Clark Tibbetts ,  James B. Golden, III ,  Deborah L. Torgersen

    发明人： Clark Tibbetts ,  James B. Golden, III ,  Deborah L. Torgersen

    IPC分类号： G01N27/447 ,  G06F17/00 ,  G06F19/00 ,  G06K9/00 ,  G06F15/18

    CPC分类号： G01N27/447

    摘要： A method and apparatus for the processing of DNA sequence image data in real time is implemented using a series of linked neural network processors. As raw image data is received from a sequencing machine, it is buffered and then separately transformed in real time in the processors to enhance the signals indicative of the unknown DNA sequence. A fourth processor receives the transformed data and determines and reports the sequence indicating events.

    摘要翻译： 使用一系列链接的神经网络处理器来实现用于处理DNA序列图像数据的实时方法和装置。 当从测序机接收到原始图像数据时，将其缓冲，然后在处理器中实时地单独变换，以增强指示未知DNA序列的信号。 第四处理器接收变换的数据并确定并报告指示事件的序列。

    Method and apparatus for automatic nucleic acid sequence determination
    8.
    发明授权
    Method and apparatus for automatic nucleic acid sequence determination 失效
    自动核酸序列测定的方法和装置

    公开(公告)号：US5365455A

    公开(公告)日：1994-11-15

    申请号：US763457

    申请日：1991-09-20

    申请人： Clark Tibbetts ,  John M. Bowling

    发明人： Clark Tibbetts ,  John M. Bowling

    IPC分类号： G01N27/447 ,  G06F17/00 ,  G06F19/00 ,  G06G7/58

    CPC分类号： G01N27/447 ,  Y10S706/924

    摘要： A method and system for automated nucleic acid sequence determination of a polynucleotide, wherein a nucleic acid sequencing ladder comprises signals corresponding to oligonucleotides formed from the polynucleotide, comprising the step of correlating, particularly in a trained neural network or a scatter plot, an intensity variable for each signal in the nucleic acid sequencing ladder with an informative variable for that signal, wherein the informative variable comprises information from at least two adjacent signals in the nucleic acid sequencing ladder, such that each signal in the nucleic acid sequencing ladder identified so as to determine the nucleic acid sequence corresponding to the polynucleotide. In particular, the relative separation between consecutive signals, the relative intensities between consecutive signals, and a pattern recognition factor, which incorporates a comparison of relative separations and intensities of at least two adjacent signals with pattern recognition templates, can be used as informative variables. Furthermore, this invention relates to a method and system for the on-the-fly resolution and extraction of information of signals contained in a digitized data stream involving calculation of the smoothed second derivative of a data point from the smoothed first derivative of the data point.

    摘要翻译： 一种用于多核苷酸的自动化核酸序列测定的方法和系统，其中核酸测序梯度包括对应于由所述多核苷酸形成的寡核苷酸的信号，包括特别是在经过训练的神经网络或散点图中的强度变量 对于核酸测序梯度中的每个信号具有用于该信号的信息变量，其中所述信息变量包含来自所述核酸测序梯级中的至少两个相邻信号的信息，使得所述核酸测序梯中的每个信号被识别为 确定对应于多核苷酸的核酸序列。 特别地，可以使用连续信号之间的相对间隔（连续信号之间的相对强度）和模式识别因子（其包含具有模式识别模板的至少两个相邻信号的相对间隔和强度的比较）作为信息变量。 此外，本发明涉及一种用于即时分辨和提取包含在数字化数据流中的信号的信息的方法和系统，包括从数据点的平滑一阶导数计算数据点的平滑二阶导数 。