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公开(公告)号：US5858757A
公开(公告)日：1999-01-12
申请号：US140083
申请日：1993-11-11
申请人： Claus Von Der Osten , Sven Branner , Allan Svendsen , Lisbeth Hedeg.ang.rd , Nina Eriksen , Maarten Robert Egmond , Eric Casteleijn
发明人： Claus Von Der Osten , Sven Branner , Allan Svendsen , Lisbeth Hedeg.ang.rd , Nina Eriksen , Maarten Robert Egmond , Eric Casteleijn
IPC分类号： C12N1/21 , C11D3/386 , C12N1/15 , C12N1/19 , C12N5/10 , C12N9/00 , C12N9/50 , C12N9/54 , C12N9/56 , C12N15/09 , C12N15/57 , C12R1/01 , C12R1/19 , C12N15/11 , C12N15/75
摘要： The invention relates to stabilized subtilisin proteases wherein one or more prolines is substituted for a native amino acid at stabilizing positions defined both by the range of the dihedral angles in the primary structure present at the substitution site and by selected characteristics of the protease secondary structure in the vicinity of the substitution site, to nucleotide sequences that encode the stabilized proteases, and to host organisms that contain the nucleotide sequences encoding the stabilized proteases.
摘要翻译： PCT No.PCT / DK92 / 00138 Sec。 371日期：1993年11月11日 102（e）日期1993年11月11日PCT提交1992年4月30日PCT公布。 出版物WO92 / 19729 日期1992年11月12日本发明涉及稳定的枯草杆菌蛋白酶，其中一个或多个脯氨酸取代了稳定位置处的天然氨基酸，两个稳定位置由在取代部位存在的一级结构中的二面角的范围和 在取代位点附近的蛋白酶二级结构，编码稳定化蛋白酶的核苷酸序列，以及含有编码稳定化蛋白酶的核苷酸序列的生物。
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公开(公告)号：US06632646B1
公开(公告)日：2003-10-14
申请号：US09678867
申请日：2000-10-02
申请人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Nørskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
发明人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Nørskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
IPC分类号： C12N950
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38636
摘要： Enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes are well-suited for use in detergent compositions.
摘要翻译： 提出了通过突变多个枯草杆菌蛋白酶的基因并在合适的宿主中表达突变的基因产生的酶。与其野生型亲本酶相比，酶显示改善的洗涤性能。酶是良好的 - 用于洗涤剂组合物。
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公开(公告)号：US06197567B1
公开(公告)日：2001-03-06
申请号：US08815775
申请日：1997-03-12
申请人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Nørskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
发明人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Nørskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
IPC分类号： C12N954
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38636
摘要： Enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzyme exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes are well-suited for use in detergent compositions.
摘要翻译： 提出了通过突变多个枯草杆菌蛋白酶的基因并在合适的宿主中表达突变的基因产生的酶。与其野生型亲本酶相比，酶显示出改进的洗涤性能。酶非常适合用于洗涤剂组合物中。
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公开(公告)号：US5665587A
公开(公告)日：1997-09-09
申请号：US484190
申请日：1995-06-07
申请人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif N.o slashed.rskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
发明人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif N.o slashed.rskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Casteleijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38636
摘要： The present invention relates to modified subtilisins comprising a mutation in an amino acid sequence of a subtilisin at a position selected from the group consisting of 1, 2, 3, 4, 6, 9, 10, 12, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 27, 36, 37, 38, 40, 41, 43, 44, 45, 46, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 75, 76, 77, 78, 79, 87, 89, 91, 94, 97, 98, 99, 100, 101, 103, 104, 105, 106, 107, 108, 109, 112, 113, 115, 116, 117, 118, 120, 126, 128, 129, 130, 131, 133, 134, 136, 137, 140, 141, 143, 144, 145, 146, 155, 156, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 170, 171, 172, 173, 181, 182, 183, 184, 185, 186, 188, 189, 191, 192, 194, 195, 197, 204, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 259, 260, 261, 262, 263, 265, 269, 271, 272 and 275. The present invention also relates to detergent compositions comprising a modified subtilisin of the present invention.
摘要翻译： 本发明涉及包含在选自1,2,3,4,6,9,10,12,14,15,17,18中的位置的枯草杆菌蛋白酶的氨基酸序列突变的修饰的枯草杆菌蛋白酶 ，19，20，21，22，24，25，27，36，37，38，40，41，43，44，45，46，49，50，51，52，53，54，55，56，57 ，58，59，60，61，62，75，76，77，78，79，87，89，91，94，97，98，99，100，101，103，104，105，106，107，108 ，109,112,113,115,116,117,118,120,126,128,129,130,131,133,134,136,137,140,141,143,144,145,146,155,156 ，158,159,160,161,162,163,164,165,166,167,170,171,172,173,181,182,183,184,185,186,188,189,191,192,194 ，195,197,204,206,29,210,211,212,213,214,215,216,217,218,235,236,237,238,239,240,241,242,243,244,245 ，247,248,249,251,252,253,254,255,256,257,259,260,261,262,263,265,269,271,272和275.本发明还涉及洗涤剂组合物，其包含 p的修饰的枯草杆菌蛋白酶 重申发明。
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公开(公告)号：US5631217A
公开(公告)日：1997-05-20
申请号：US527734
申请日：1995-09-13
申请人： Sven Branner , Sven Hastrup , Nina Eriksen , Poul Lindegaard , Ole H. Olsen , Eric Casteleijn , Maarten R. Egmond , Johan Haverkamp , Wouter Musters , Jakob de Vlieg
发明人： Sven Branner , Sven Hastrup , Nina Eriksen , Poul Lindegaard , Ole H. Olsen , Eric Casteleijn , Maarten R. Egmond , Johan Haverkamp , Wouter Musters , Jakob de Vlieg
摘要： This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions containing them.
摘要翻译： 本发明涉及酶，适用于例如其生产的rDNA技术，可用于其生产的突变基因，载体和突变和转化的微生物以及其用途，包括例如含有它们的酶洗涤剂和清洁组合物。
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公开(公告)号：US5482849A
公开(公告)日：1996-01-09
申请号：US811502
申请日：1991-12-20
申请人： Sven Branner , Sven Hastrup , Nina Eriksen , Poul Lindegaard , Ole H. Olsen , Eric Casteleijn , Maarten R. Egmond , Johan Haverkamp , Wouter Musters , Jakob de Vlieg
发明人： Sven Branner , Sven Hastrup , Nina Eriksen , Poul Lindegaard , Ole H. Olsen , Eric Casteleijn , Maarten R. Egmond , Johan Haverkamp , Wouter Musters , Jakob de Vlieg
摘要： This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions containing them.
摘要翻译： 本发明涉及酶，适用于例如其生产的rDNA技术，可用于其生产的突变基因，载体和突变和转化的微生物以及其用途，包括例如含有它们的酶洗涤剂和清洁组合物。
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公开(公告)号：US07189553B2
公开(公告)日：2007-03-13
申请号：US10314191
申请日：2002-12-06
申请人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Norskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Castelijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
发明人： Dorrit Aaslyng , Sven Branner , Sven Hastrup , Leif Norskov-Lauritsen , Ole Hvilsted Olsen , Merete Simonsen , Eric Castelijn , Maarten Robert Egmond , Johan Haverkamp , John David Marugg , Arnoldus Theodorus Anthonius Mooren
CPC分类号： C12N9/54 , C11D3/386 , C11D3/38636
摘要： The present invention relates to enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzymes exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes are well-suited for use in detergent compositions.
摘要翻译： 本发明涉及通过突变多种枯草杆菌蛋白酶的基因并在合适的宿主中表达突变的基因而产生的酶。 与其野生型亲本酶相比，酶显示改善的洗涤性能。 酶非常适合用于洗涤剂组合物中。
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公开(公告)号：US06835821B2
公开(公告)日：2004-12-28
申请号：US10310730
申请日：2002-12-05
申请人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjorn Petersen , Leif Nørskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
发明人： Sven Hastrup , Sven Branner , Fanny Norris , Steffen Bjorn Petersen , Leif Nørskov-Lauridsen , Villy Johannes Jensen , Dorrit Aaslyng
IPC分类号： C12N1557
摘要： The present invention relates to mutations of a subtilisin gene which result in changes in the chemical characteristics of subtilisin enzymes. Mutations at specific nucleic acids of the subtilisin gene result in amino acid substitutions and consequently, altered enzyme function. Some of these mutant enzymes exhibit physical properties advantageous to industrial applications, particularly in the detergent industry, providing subtilisin which is more stable to oxidation, possesses greater protease activity, and exhibits improved washability.
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公开(公告)号：US06225329B1
公开(公告)日：2001-05-01
申请号：US09265069
申请日：1999-03-09
申请人： Lutz Stefan Richter , Henrik Sune Andersen , Josef Vagner , Claus Bekker Jeppesen , Niels Peter Hundahl Møller , Sven Branner , Jing Su , Farid Bakir , Luke Milburn Judge
发明人： Lutz Stefan Richter , Henrik Sune Andersen , Josef Vagner , Claus Bekker Jeppesen , Niels Peter Hundahl Møller , Sven Branner , Jing Su , Farid Bakir , Luke Milburn Judge
IPC分类号： A61K3141
CPC分类号： C07D213/79 , C07D213/80 , C07D239/557 , C07D241/26 , C07D261/08 , C07D271/07
摘要： The present invention provides novel compounds of Formula 1, compositions containing these compounds, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTP&agr;, LAR and HePTP or the like, wherein A, R1, R2, R3, R4, R16 and R17 are as defined in the specification. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.
摘要翻译： 本发明提供新的式1化合物，含有这些化合物的组合物，其使用方法及其制备方法，其中这些化合物是蛋白酪氨酸磷酸酶（PTPase）如PTP1B，CD45，SHP-1， SHP-2，PTPalpha，LAR和HePTP等，其中A，R1，R2，R3，R4，R16和R17如说明书中所定义。 该化合物可用于治疗I型糖尿病，II型糖尿病，葡萄糖耐量降低，胰岛素抵抗，肥胖症，免疫功能障碍，包括凝血系统功能障碍的自身免疫性疾病，包括哮喘，过度性疾病，骨质疏松症，包括癌症和牛皮癣在内的增殖性疾病 ，具有减少或增加的生长激素合成或作用的疾病，调节生长激素释放/或对生长激素的反应，包括阿尔茨海默氏病和精神分裂症的疾病以及传染病的激素或细胞因子合成减少或增加的疾病。
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公开(公告)号：US5702934A
公开(公告)日：1997-12-30
申请号：US238130
申请日：1994-05-04
申请人： Sven Hastrup , Sven Branner , Birthe Ravn J.o slashed.rgensen , Tove Christensen , Birgitte Bojer J.o slashed.rgensen , Jeffrey R. Shuster , Mark Madden , Donna L. Moyer , Claus Fuglsang
发明人： Sven Hastrup , Sven Branner , Birthe Ravn J.o slashed.rgensen , Tove Christensen , Birgitte Bojer J.o slashed.rgensen , Jeffrey R. Shuster , Mark Madden , Donna L. Moyer , Claus Fuglsang
IPC分类号： A61K39/12 , A61K39/395 , A61P31/04 , C07K14/025 , C12N20060101 , C12N9/00 , C12N9/54 , C12N9/58 , C12N15/09 , C12N15/37 , C12N15/62 , C12N15/80 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/69 , C12R1/77 , C12N1/15 , C12N9/76
CPC分类号： C12N9/58 , C07K14/005 , C12N15/80 , C12N15/86 , C12N7/00 , C12N9/54 , C12P21/06 , C07K2319/00 , C07K2319/40 , C12N2710/20022 , C12N2710/24143
摘要： The present invention is related to a process for producing an active enzyme comprising fermenting the proform of the active enzyme in the present of a proteolytic enzyme different from the active enzyme and capable of converting the proenzyme into an active enzyme as well as to host cells, recombinant expression vectors and host cells suitable for use in the process.
摘要翻译： 本发明涉及一种生产活性酶的方法，其包括在不同于活性酶的蛋白水解酶存在下发酵活性酶的形式并能够将酶转化为活性酶以及宿主细胞， 重组表达载体和适用于该过程的宿主细胞。
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