公开(公告)号：US20110070206A1

公开(公告)日：2011-03-24

申请号：US12919533

申请日：2009-03-02

申请人： Clinton Rubin ,  Stefan Judex ,  Yen Kim Luu

发明人： Clinton Rubin ,  Stefan Judex ,  Yen Kim Luu

IPC分类号： C12N5/07 ,  C12N5/10 ,  C12Q1/02 ,  A61K35/12 ,  A61H1/00

CPC分类号： C12N5/0663 ,  C12N2527/00

摘要： We describe herein methods for applying physical stimuli to cells, including mesenchymal stem cells, in culture or in vivo. These methods can be applied in, and are expected to benefit subjects in, a great variety of circumstances that arise in the context of, for example, traumatic injury (including that induced by surgical procedures), wound healing (of the skin and other tissues), cancer therapies (e.g., chemotherapy or radiation therapy), tissue transplantation (e.g., bone marrow transplantation), and aging. More generally, the present methods apply where patients would benefit from an increase in the number of cells (e.g., stem cells) within a given tissue and, ex vivo, where it is desirable to increase the proliferation of cells (e.g., stem cells) for scientific study, inclusion in devices bearing cells (e.g., polymer or hydrogel-based implants), and administration to patients.

摘要翻译： 我们在这里描述了在培养或体内将物理刺激应用于包括间充质干细胞的细胞的方法。 这些方法可以在例如外伤性损伤（包括由外科手术引起的），伤口愈合（皮肤和其他组织）的情况下出现的各种各样的情况下被应用并且预期会受益于受试者 ），癌症治疗（例如化疗或放射治疗），组织移植（例如骨髓移植）和衰老。 更一般来说，本发明的方法适用于患者将受益于给定组织内细胞数量增加（例如干细胞），并且离体，其中希望增加细胞增殖（例如干细胞） 用于科学研究，包含在携带细胞的装置（例如聚合物或基于水凝胶的植入物）中，以及对患者的给药。

公开(公告)号：US20100028968A1

公开(公告)日：2010-02-04

申请号：US12300958

申请日：2007-05-17

申请人： Clinton Rubin ,  Stefan Judex ,  Jeff Pessin

发明人： Clinton Rubin ,  Stefan Judex ,  Jeff Pessin

IPC分类号： C12N13/00

CPC分类号： A61H23/02 ,  A61H1/005 ,  A61H2201/0142 ,  A61H2201/0149 ,  A61H2203/0406 ,  A61H2203/0425 ,  A61H2203/0456 ,  C12N13/00

摘要： Methods of maintaining or improving the metabolic state of a subject, e.g., a human, are disclosed. The methods can include providing to the subject a low magnitude, high frequency mechanical signal on a periodic basis and for a time sufficient to maintain or improve the subject's metabolic state. The subject can be diagnosed as having or can be at risk of developing, an obesity-related medical condition, e.g., type 2 diabetes, cardiovascular disease, hypertension, rheumatoid arthritis, and breast cancer. The methods can include a step of identifying a suitable subject by evaluating a physiological parameter that reflects the metabolic state of the subject, e.g., visceral fat content, subcutaneous fat content, body mass index, and blood pressure.

摘要翻译： 公开了维持或改善受试者例如人的代谢状态的方法。 所述方法可以包括向患者提供周期性基础上的低幅度高频机械信号，并且足以维持或改善受试者的代谢状态的时间。 可以将该受试者诊断为具有或可能处于与肥胖有关的疾病如II型糖尿病，心血管疾病，高血压，类风湿性关节炎和乳腺癌的风险中。 所述方法可以包括通过评估反映受试者的代谢状态的生理参数，例如内脏脂肪含量，皮下脂肪含量，体重指数和血压来鉴定合适受试者的步骤。

公开(公告)号：US20070219470A1

公开(公告)日：2007-09-20

申请号：US11716519

申请日：2007-03-08

申请人： Roger Talish ,  Clinton Rubin ,  Kenneth McLeod

发明人： Roger Talish ,  Clinton Rubin ,  Kenneth McLeod

IPC分类号： A61H1/02

CPC分类号： A61N7/00 ,  A61H1/005 ,  A61H23/00 ,  A61H23/0245 ,  A61H2201/10 ,  A61H2201/5007 ,  A61H2230/06 ,  A61N1/00

摘要： Systems and methods are disclosed for providing therapeutic treatment using vibrational stimulation, ultrasound stimulation and electro-stimulation. The combined therapeutic treatment allows for more flexible and effective treatment of bone-loss related and other ailments and conditions by providing one or a combination of vibrational, ultrasound and/or electro-stimulation to a patient.

摘要翻译： 公开了用于使用振动刺激，超声波刺激和电刺激提供治疗性治疗的系统和方法。 组合的治疗处理允许通过向患者提供振动，超声和/或电刺激的一种或组合来更有弹性和有效地治疗与骨丢失相关的其它疾病和病症。

公开(公告)号：US20050165332A1

公开(公告)日：2005-07-28

申请号：US11087248

申请日：2005-03-23

申请人： Roger Talish ,  Kenneth McLeod ,  Clinton Rubin

发明人： Roger Talish ,  Kenneth McLeod ,  Clinton Rubin

IPC分类号： A61H1/00 ,  A61H23/02 ,  A63B21/00 ,  A63B21/06 ,  A63B22/02 ,  A63B22/08 ,  A63B69/06

CPC分类号： A63B21/00196 ,  A61H1/001 ,  A61H1/005 ,  A61H1/006 ,  A61H2201/0192 ,  A61H2201/1215 ,  A61H2201/1418 ,  A61H2201/1633 ,  A61H2201/1635 ,  A61H2201/164 ,  A63B21/06 ,  A63B22/00 ,  A63B22/0076 ,  A63B22/02 ,  A63B22/0605 ,  A63B2213/00

摘要： A therapeutic device, such as an exercise device, includes the principles of osteogenic repair by incorporating a loading mechanism into the exercise device. By doing so, the therapeutic device provides an increased osteogenic effect, thereby enhancing the benefits of the therapy. As an example, a exercise device includes a support surface for supporting all or part of the bodily tissue of an individual using the device. A linear or rotary loading mechanism associated with the frame or a rotational element of the exercise device drives the support surface at a selected load and frequency, thereby inducing mechanical loading of bodily tissue adjacent to the support surface sufficiently to facilitate the growth, development, strengthening, and/or healing of bone tissue. The loading mechanism may be incorporated into any exercise device, including standard exercise devices such as rowing machines, stair climbing machines, elliptical trainers, bicycles, cross-country ski trainers, treadmills, or weight trainers.

摘要翻译： 诸如运动装置的治疗装置包括通过将加载机构并入到运动装置中的成骨修复的原理。 通过这样做，治疗装置提供增加的成骨作用，从而增强治疗的益处。 作为示例，锻炼装置包括用于使用该装置支撑个人的身体组织的全部或部分的支撑表面。 与框架或运动装置的旋转元件相关联的线性或旋转加载机构以选定的载荷和频率驱动支撑表面，从而引起身体组织邻近支撑表面的机械负载，以促进生长，发育，强化 ，和/或骨组织愈合。 加载机构可以并入任何运动装置，包括诸如划船机，爬梯机，椭圆训练机，自行车，越野滑雪训练器，跑步机或重量训练机的标准运动装置。

公开(公告)号：US20130288260A1

公开(公告)日：2013-10-31

申请号：US13879551

申请日：2011-10-14

申请人： Clinton Rubin ,  Janet Rubin

发明人： Clinton Rubin ,  Janet Rubin

IPC分类号： A61N1/05 ,  A61M5/00 ,  C12N13/00

CPC分类号： A61N1/05 ,  A61M5/00 ,  A61M31/002 ,  A61N1/326 ,  A61N1/36 ,  A61N2/00 ,  A61N2/02 ,  A61N5/062 ,  C12N13/00

摘要： The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.

摘要翻译： 本发明涉及构造成将刺激（例如治疗剂或治疗有益的信号）递送至细胞，组织，器官或生物体的组合物和方法。 刺激施加至少两次，并且第一和第二应用分开休止期，其中不再进一步刺激。 休息时间具有足以引起对第二刺激的增强的响应的持续时间（例如，约1-6小时）。

公开(公告)号：US20050283072A1

公开(公告)日：2005-12-22

申请号：US10522452

申请日：2002-02-28

申请人： Yixian Qin ,  Clinton Rubin ,  Wei Lin

发明人： Yixian Qin ,  Clinton Rubin ,  Wei Lin

IPC分类号： A61B8/00 ,  A61B8/08

CPC分类号： A61B8/4483 ,  A61B8/0875 ,  A61B8/485

摘要： The invention comprises a system and method for determining at least one material property of a material sample (such as a bone sample) at at least one point. The system includes a transmitting ultrasonic transducer and a receiving ultrasonic transducer, both transducers being confocal transducers. The transducers are configured to receive the material sample therebetween such that the confocal point of the transducers are located at the at least one point in the material sample. A processor initiates an ultrasonic signal from the transmitting transducers that is transmitted trough the at least one point of the material sample when positioned between the transducers. The ultrasonic signal is received by the receiving transducing and the processor in turn receives a signal reflecting one or more measures of the received ultrasonic signal. The processor determines at least one ultrasonic parameter for the at least one point of the material sample based upon the transmitted and received ultrasonic signals. The processor further determines the at least one material property at the point of the sample based upon the at least one ultrasonic parameter.

摘要翻译： 本发明包括用于在至少一个点处确定材料样品（例如骨样品）的至少一种材料性质的系统和方法。 该系统包括发射超声波换能器和接收超声换能器，两个换能器是共聚焦换能器。 换能器被配置为在其间接收材料样品，使得换能器的共焦点位于材料样品中的至少一个点处。 处理器启动来自发射换能器的超声信号，其在定位在换能器之间时通过材料样品的至少一个点传输。 超声信号由接收转换接收，并且处理器又接收反映接收的超声信号的一个或多个测量的信号。 处理器基于所发送和接收的超声波信号来确定材料样品的至少一个点的至少一个超声参数。 处理器还基于至少一个超声参数确定样品点处的至少一种材料性质。

公开(公告)号：US10029089B2

公开(公告)日：2018-07-24

申请号：US13879551

申请日：2011-10-14

申请人： Clinton Rubin ,  Janet Rubin

发明人： Clinton Rubin ,  Janet Rubin

IPC分类号： A61N1/05 ,  A61N1/36 ,  A61N2/02 ,  A61M5/00 ,  C12N13/00 ,  A61M31/00 ,  A61N2/00 ,  A61N5/06 ,  A61N1/32

摘要： The present invention relates to compositions and methods configured to deliver a stimulus (e.g., a therapeutic agent or a therapeutically beneficial signal) to a cell, tissue, organ, or organism. The stimulus is applied at least twice, and the first and second applications are separated by a rest period in which no further stimulus is actively applied. The rest period is of a duration (e.g., about 1-6 hours) sufficient to provoke an enhanced response to the second stimulus.

公开(公告)号：US07727152B2

公开(公告)日：2010-06-01

申请号：US10522452

申请日：2002-02-28

申请人： Yixian Qin ,  Clinton Rubin ,  Wei Lin

发明人： Yixian Qin ,  Clinton Rubin ,  Wei Lin

IPC分类号： A61B8/00 ,  G01H15/00

CPC分类号： A61B8/4483 ,  A61B8/0875 ,  A61B8/485

摘要： The invention comprises a system and method for determining at least one material property of a material sample (such as a bone sample) at at least one point. The system includes a transmitting ultrasonic transducer and a receiving ultrasonic transducer, both transducers being confocal transducers. The transducers are configured to receive the material sample therebetween such that the confocal point of the transducers are located at the at least one point in the material sample. A processor initiates an ultrasonic signal from the transmitting transducers that is transmitted trough the at least one point of the material sample when positioned between the transducers. The ultrasonic signal is received by the receiving transducing and the processor in turn receives a signal reflecting one or more measures of the received ultrasonic signal. The processor determines at least one ultrasonic parameter for the at least one point of the material sample based upon the transmitted and received ultrasonic signals. The processor further determines the at least one material property at the point of the sample based upon the at least one ultrasonic parameter.

摘要翻译： 本发明包括用于在至少一个点处确定材料样品（例如骨样品）的至少一种材料性质的系统和方法。 该系统包括发射超声波换能器和接收超声换能器，两个换能器是共聚焦换能器。 换能器被配置为在其间接收材料样品，使得换能器的共焦点位于材料样品中的至少一个点处。 处理器启动来自发射换能器的超声信号，其在定位在换能器之间时通过材料样品的至少一个点传输。 超声信号由接收转换接收，并且处理器又接收反映接收的超声信号的一个或多个测量的信号。 处理器基于所发送和接收的超声波信号来确定材料样品的至少一个点的至少一个超声参数。 处理器还基于至少一个超声参数确定样品点处的至少一种材料性质。

公开(公告)号：US20070219473A1

公开(公告)日：2007-09-20

申请号：US11715222

申请日：2007-03-07

申请人： Roger Talish ,  Clinton Rubin

发明人： Roger Talish ,  Clinton Rubin

IPC分类号： A61H1/00

CPC分类号： A61H1/001 ,  A61B5/1036 ,  A61B5/1116 ,  A61H1/005 ,  A61H2203/0406

摘要： A non-invasive apparatus for dynamic motion therapy in a weightless environment include a vibration table having a non-rigidly supported platform for generating resonant vibration and for externally transferring vibrations to the musculoskeletal system, and ankle belts or other securing means to secure a person to the vibration table. The method of providing dynamic motion therapy to a person in a weightless environment includes the steps of (a) providing a vibration table having a non-rigidly supported platform; (b) securing the person to the non-rigidly supported platform; (c) subjecting the person to resonant vibrations generated by the non-rigidly supported platform; and (d) repeating steps (b) and (c) during a predetermined treatment duration. The predetermined treatment duration is at least the duration of the weightless environment.

摘要翻译： 在无重量环境中用于动态运动治疗的非侵入性装置包括振动台，其具有用于产生共振振动的非刚性支撑平台和用于将振动从外部传递到肌肉骨骼系统的振动台，以及用于将人固定的踝带或其他固定装置 振动台。 在失重环境中为人提供动态运动治疗的方法包括以下步骤：（a）提供具有非刚性支撑平台的振动台; （b）将该人员固定在非刚性支援的平台上; （c）使人受到由非刚性支撑的平台产生的共振振动; 和（d）在预定的治疗期间重复步骤（b）和（c）。 预定的治疗持续时间至少是无重量的环境的持续时间。

公开(公告)号：US20070185419A1

公开(公告)日：2007-08-09

申请号：US11724108

申请日：2007-03-14

申请人： Roger Talish ,  Kenneth McLeod ,  Clinton Rubin

发明人： Roger Talish ,  Kenneth McLeod ,  Clinton Rubin

IPC分类号： A61H1/02 ,  A61H1/00

CPC分类号： A63B21/00196 ,  A61H1/001 ,  A61H1/005 ,  A61H1/006 ,  A61H2201/0192 ,  A61H2201/1215 ,  A61H2201/1418 ,  A61H2201/1633 ,  A61H2201/1635 ,  A61H2201/164 ,  A63B21/06 ,  A63B22/00 ,  A63B22/0076 ,  A63B22/02 ,  A63B22/0605 ,  A63B2213/00

摘要： A therapeutic device, such as an exercise device, includes the principles of osteogenic repair by incorporating a loading mechanism into the exercise device. By doing so, the therapeutic device provides an increased osteogenic effect, thereby enhancing the benefits of the therapy. As an example, a exercise device includes a support surface for supporting all or part of the bodily tissue of an individual using the device. A linear or rotary loading mechanism associated with the frame or a rotational element of the exercise device drives the support surface at a selected load and frequency, thereby inducing mechanical loading of bodily tissue adjacent to the support surface sufficiently to facilitate the growth, development, strengthening, and/or healing of bone tissue. The loading mechanism may be incorporated into any exercise device, including standard exercise devices such as rowing machines, stair climbing machines, elliptical trainers, bicycles, cross-country ski trainers, treadmills, or weight trainers.

摘要翻译： 诸如运动装置的治疗装置包括通过将加载机构并入到运动装置中的成骨修复的原理。 通过这样做，治疗装置提供增加的成骨作用，从而增强治疗的益处。 作为示例，锻炼装置包括用于使用该装置支撑个人的身体组织的全部或部分的支撑表面。 与框架或运动装置的旋转元件相关联的线性或旋转加载机构以选定的载荷和频率驱动支撑表面，从而引起身体组织邻近支撑表面的机械负载，以促进生长，发育，强化 ，和/或骨组织愈合。 加载机构可以并入任何运动装置，包括诸如划船机，爬梯机，椭圆训练机，自行车，越野滑雪训练器，跑步机或重量训练机的标准运动装置。