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公开(公告)号：US20240182876A1
公开(公告)日：2024-06-06
申请号：US18485855
申请日：2023-10-12
Applicant: Codexis, Inc.
Inventor： David Entwistle , Stephanie Forget , Michelle Li , Niusha Mahmoodi , Ryan Reeves , Ljubica Vojcic , Jonathan Vroom , David Watts , Leland Ken Wong
CPC classification number: C12N9/1264 , C12N15/63 , C12Y207/07031
Abstract: The present invention provides engineered terminal deoxynucleotidyl transferase (TdT) polypeptides useful in template-independent polynucleotide synthesis, as well as compositions, methods of utilizing these engineered polypeptides, and polynucleotides encoding the engineered terminal deoxynucleotidyl transferases.
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公开(公告)号：US20240010999A1
公开(公告)日：2024-01-11
申请号：US18364419
申请日：2023-08-02
Applicant: Codexis, Inc.
Inventor： Jonathan Vroom , Stephanie Sue Galanie , Jack Liang , Joyce Liu , Nikki Dellas , Melissa Ann Mayo , David Entwistle
IPC: C12N9/10 , C07H15/252 , C12P19/56
CPC classification number: C12N9/1062 , C12N9/1048 , C07H15/252 , C12P19/56 , C12Y204/01013
Abstract: The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US20180223264A1
公开(公告)日：2018-08-09
申请号：US15886094
申请日：2018-02-01
Applicant: Codexis, Inc.
Inventor： Jonathan Vroom , Stephanie Sue Galanie , Nikki Dellas , Jack Liang , Joyce Liu , David Entwistle , Courtney Dianne Moffett
CPC classification number: C12N9/1048 , C12N9/1051 , C12N9/88 , C12P19/18 , C12P19/56 , C12Y204/01 , C12Y204/01013
Abstract: The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US20240209406A1
公开(公告)日：2024-06-27
申请号：US18486140
申请日：2023-10-12
Applicant: Codexis, Inc.
Inventor： David Entwistle , Stephanie Marie Forget , Anders Matthew Knight , Mikayla Jianghongxia Krawczyk , Marissa Greene MacAvoy , Simon Ng , Nicholas Porter , Philip Provencher , Amani Shoubber , Leann Quertinmont Teadt , Jonathan Vroom , David Watts , Leland Ken Wong
CPC classification number: C12P19/34 , C12N9/1205 , C12N9/1217 , C12N9/1223 , C12N9/1229 , C12Y207/0102 , C12Y207/02001 , C12Y207/03002 , C12Y207/04001 , C12Y207/04003 , C12Y207/04006
Abstract: The present disclosure provides enzymatic methods for the production of 3′-phosphate-nucleoside-5′-triphosphate (NQP). The present disclosure further provides enzymatic methods for the production of nucleotide-5′-triphosphates.
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公开(公告)号：US20230159904A1
公开(公告)日：2023-05-25
申请号：US17916510
申请日：2021-04-06
Applicant: Codexis, Inc
Inventor： Rama Voladri , Jessica Anna Hurtak , Auric Anthony Sowell-Kantz , Nandhitha Subramanian , Ericka Bermudez , David Entwistle , Melissa Ann Mayo , James Nicholas Riggins
IPC: C12N9/18
CPC classification number: C12N9/18
Abstract: The present invention provides engineered carboxyesterase enzymes having improved properties as compared to a naturally occurring wild-type carboxyesterase enzymes, as well as polynucleotides encoding the engineered carboxyesterase enzymes, host cells capable of expressing the engineered carboxyesterase enzymes, and methods of using the engineered carboxyesterase enzymes in hydrolysis reactions.
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Patent Agency Ranking
公开(公告)号：US11634695B2
公开(公告)日：2023-04-25
申请号：US17072910
申请日：2020-10-16
Applicant: Codexis, Inc.
Inventor： Jovana Nazor , Robert Osborne , Jack Liang , Jonathan Vroom , Xiyun Zhang , David Entwistle , Rama Voladri , Ravi David Garcia , Jeffrey C. Moore , Shane Grosser , Birgit Kosjek , Matthew Truppo
Abstract: The present invention provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.
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公开(公告)号：US20220306998A1
公开(公告)日：2022-09-29
申请号：US17081923
申请日：2020-10-27
Applicant: Codexis, Inc.
Inventor： Jonathan Vroom , Stephanie Sue Galanie , Nikki Dellas , Jack Liang , Joyce Liu , David Entwistle , Courtney Dianne Moffett
Abstract: The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US20200347365A1
公开(公告)日：2020-11-05
申请号：US16874574
申请日：2020-05-14
Applicant: Codexis, Inc.
Inventor： Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US10696953B2
公开(公告)日：2020-06-30
申请号：US15543535
申请日：2016-02-05
Applicant: Codexis, Inc.
Inventor： Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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公开(公告)号：US20180002676A1
公开(公告)日：2018-01-04
申请号：US15543535
申请日：2016-02-05
Applicant: Codexis, Inc.
Inventor： Oscar Alvizo , Nicholas J. Agard , Xinkai Xie , David Entwistle , Birgit Kosjek
Abstract: The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of expressing the engineered ketoreductase enzymes, and methods of using the engineered ketoreductase enzymes to synthesize a variety of chiral compounds.
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