公开(公告)号：US12129494B2

公开(公告)日：2024-10-29

申请号：US17558454

申请日：2021-12-21

Applicant: Codexis, Inc.

Inventor： Mathew G. Miller ,  Chinping Chng ,  Oscar Alvizo ,  Melissa Ann Mayo ,  James Nicholas Riggins ,  Xiang Yi ,  Jonathan S. Penfield ,  Gjalt W. Huisman ,  Jared Davis ,  Yasushi Saotome

IPC: C12N9/12 ,  C12P19/34 ,  C12N15/00

CPC classification number: C12N9/1247 ,  C12P19/34 ,  C12Y207/07006 ,  C12N15/00

Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.

公开(公告)号：US20220213518A1

公开(公告)日：2022-07-07

申请号：US17600345

申请日：2020-04-23

Applicant: Codexis, Inc.

Inventor： Xiang Yi ,  Oscar Alvizo ,  Ravi David Garcia ,  David Entwistle ,  Charlene Ching ,  James Nicholas Riggins

IPC: C12P13/04 ,  C12N9/06

Abstract: The present application provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered polypeptides, host cells capable of expressing the engineered polypeptides, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.

公开(公告)号：US20220162580A1

公开(公告)日：2022-05-26

申请号：US17592869

申请日：2022-02-04

Applicant: Codexis, Inc.

Inventor： Da Duan ,  Oscar Alvizo ,  Jovana Nazor ,  Harvinder Chagger Maniar ,  James Nicholas Riggins ,  Jonathan Vroom ,  Santhosh Sivaramakrishnan ,  Hao Yang ,  Anna Fryszkowska ,  Mark A. Huffman ,  Joshua N. Kolev ,  Iman Farasat ,  Agustina Rodriguez-Granillo ,  Deeptak Verma

IPC: C12N9/88

Abstract: The present invention provides engineered deoxyribose-phosphate aldolase polypeptides useful under industrial process conditions for the production of pharmaceutical and fine chemical compounds.

公开(公告)号：US11236311B2

公开(公告)日：2022-02-01

申请号：US16938793

申请日：2020-07-24

Applicant: Codexis, Inc.

Inventor： Mathew G. Miller ,  Chinping Chng ,  Oscar Alvizo ,  Melissa Ann Mayo ,  James Nicholas Riggins ,  Xiang Yi ,  Jonathan S. Penfield ,  Gjalt W. Huisman ,  Jared Davis ,  Yasushi Saotome

IPC: C12N9/12 ,  C12N1/20 ,  C12N15/00 ,  C12P19/34

Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.

公开(公告)号：US10745681B2

公开(公告)日：2020-08-18

申请号：US15861849

申请日：2018-01-04

Applicant: Codexis, Inc.

Inventor： Oscar Alvizo ,  David Elgart ,  Robert Kevin Orr ,  James Nicholas Riggins ,  Anna Fryszkowska ,  Katrina W. Lexa ,  Xiang Yi ,  Da Duan ,  Courtney Dianne Moffett ,  Nikki Dellas ,  Vesna Mitchell

IPC: C12N9/78 ,  C12N9/84 ,  C12N15/09 ,  C07K14/62 ,  C12P21/02

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

公开(公告)号：US20230227805A1

公开(公告)日：2023-07-20

申请号：US18158339

申请日：2023-01-23

Applicant: Codexis, Inc.

Inventor： Oscar Alvizo ,  David Elgart ,  Robert Kevin Orr ,  James Nicholas Riggins ,  Anna Fryszkowska ,  Katrina W. Lexa ,  Xiang Yi ,  Da Duan ,  Courtney Dianne Moffett ,  Nikki Dellas ,  Vesna Mitchell

IPC: C12N9/84 ,  C07K14/62 ,  C12P21/02

CPC classification number: C12N9/84 ,  C07K14/62 ,  C12P21/02 ,  C12Y305/01011 ,  C07K2319/21

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.

公开(公告)号：US20220220456A1

公开(公告)日：2022-07-14

申请号：US17705772

申请日：2022-03-28

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Jie Yang ,  Goutami Banerjee ,  Xiyun Zhang ,  James Nicholas Riggins ,  Erika M. Milczek ,  Jeffrey C. Moore

IPC: C12N9/10 ,  C07K14/62 ,  C12N15/63

Abstract: The present invention provides engineered transglutaminase enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, methods of producing these enzymes, and methods of using the engineered transglutaminase enzymes.

公开(公告)号：US20220186197A1

公开(公告)日：2022-06-16

申请号：US17558454

申请日：2021-12-21

Applicant: Codexis, Inc.

Inventor： Mathew G. Miller ,  Chinping Chng ,  Oscar Alvizo ,  Melissa Ann Mayo ,  James Nicholas Riggins ,  Xiang Yi ,  Jonathan S. Penfield ,  Gjalt W. Huisman ,  Jared Davis ,  Yasushi Saotome

IPC: C12N9/12 ,  C12P19/34

Abstract: The present invention provides engineered RNA polymerase variants and compositions comprising these variants. The present invention further provides engineered T7 RNA polymerase variants and compositions comprising these variants. These variants have been evolved for selective incorporation of the m7G(5′)ppp(5′)m7G cap analog over GTP at the initiation of in vitro transcription. The present invention also provides methods for selective capping of RNA transcripts.

公开(公告)号：US11319531B2

公开(公告)日：2022-05-03

申请号：US16652941

申请日：2018-11-02

Applicant: Codexis, Inc.

Inventor： Jovana Nazor ,  Jie Yang ,  Goutami Banerjee ,  Xiyun Zhang ,  James Nicholas Riggins ,  Erika M. Milczek ,  Jeffrey C. Moore

IPC: C12N9/10 ,  C07K14/62 ,  C12N15/63

Abstract: The present invention provides engineered transglutamirase enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, methods of producing these enzymes, and methods of using the engineered transglutaminase enzymes.

公开(公告)号：US20210054357A1

公开(公告)日：2021-02-25

申请号：US17091479

申请日：2020-11-06

Applicant: Codexis, Inc.

Inventor： Oscar Alvizo ,  David Elgart ,  Robert Kevin Orr ,  James Nicholas Riggins ,  Anna Fryszkowska ,  Katrina W. Lexa ,  Xiang Yi ,  Da Duan ,  Courtney Dianne Moffett ,  Nikki Dellas ,  Vesna Mitchell

IPC: C12N9/84 ,  C07K14/62 ,  C12P21/02

Abstract: The present invention provides engineered penicillin G acylase (PGA) enzymes, polynucleotides encoding the enzymes, compositions comprising the enzymes, and methods of using the engineered PGA enzymes.