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公开(公告)号：US11760981B2
公开(公告)日：2023-09-19
申请号：US16514578
申请日：2019-07-17
发明人： Jonathan Vroom , Stephanie Sue Galanie , Jack Liang , Joyce Liu , Nikki Dellas , Melissa Ann Mayo , David Entwistle
IPC分类号： C12N9/10 , C07H15/252 , C12P19/56
CPC分类号： C12N9/1062 , C07H15/252 , C12N9/1048 , C12P19/56 , C12Y204/01013
摘要： The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US20200032227A1
公开(公告)日：2020-01-30
申请号：US16514578
申请日：2019-07-17
发明人： Jonathan Vroom , Stephanie Sue Galanie , Jack Liang , Joyce Liu , Nikki Dellas , Melissa Ann Mayo , David Entwistle
IPC分类号： C12N9/10 , C12P19/56 , C07H15/252
摘要： The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US20210054349A1
公开(公告)日：2021-02-25
申请号：US17081932
申请日：2020-10-27
申请人： Codexis, Inc.
发明人： Jonathan Vroom , Stephanie Sue Galanie , Nikki Dellas , Jack Liang , Joyce Liu , David Entwistle , Courtney Dianne Moffett
摘要： The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US20220306998A1
公开(公告)日：2022-09-29
申请号：US17081923
申请日：2020-10-27
申请人： Codexis, Inc.
发明人： Jonathan Vroom , Stephanie Sue Galanie , Nikki Dellas , Jack Liang , Joyce Liu , David Entwistle , Courtney Dianne Moffett
摘要： The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US11299723B2
公开(公告)日：2022-04-12
申请号：US16306029
申请日：2017-06-09
申请人： Codexis, Inc.
摘要： The present invention provides engineered β-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with β-glucose linkages.
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公开(公告)号：US20210054348A1
公开(公告)日：2021-02-25
申请号：US17081904
申请日：2020-10-27
申请人： Codexis, Inc.
发明人： Jonathan Vroom , Stephanie Sue Galanie , Nikki Dellas , Jack Liang , Joyce Liu , David Entwistle , Courtney Dianne Moffett
摘要： The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US20220195411A1
公开(公告)日：2022-06-23
申请号：US17688458
申请日：2022-03-07
申请人： Codexis, Inc.
摘要： The present invention provides engineered β-glucosidase (BGL) enzymes, polypeptides having BGL activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the enzymes, and methods of using the engineered BGL enzymes to make products with β-glucose linkages.
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公开(公告)号：US20210062168A1
公开(公告)日：2021-03-04
申请号：US17005913
申请日：2020-08-28
发明人： Chinping Chng , William Casey Hallows , Judy Victoria Antonio Viduya , Nikki Dellas , Stephanie Sue Galanie , Kristen Jean Vallieu
摘要： The present invention provides engineered lipase polypeptides and compositions thereof. The engineered lipase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH 7) conditions. The invention also relates to the use of the compositions comprising the engineered lipase polypeptides for therapeutic and/or nutritional purposes. The present invention also provides polynucleotides encoding the engineered lipase polypeptides, as well as methods for making the engineered polynucleotides and lipase polypeptides.
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公开(公告)号：US20240010999A1
公开(公告)日：2024-01-11
申请号：US18364419
申请日：2023-08-02
申请人： Codexis, Inc.
发明人： Jonathan Vroom , Stephanie Sue Galanie , Jack Liang , Joyce Liu , Nikki Dellas , Melissa Ann Mayo , David Entwistle
IPC分类号： C12N9/10 , C07H15/252 , C12P19/56
CPC分类号： C12N9/1062 , C12N9/1048 , C07H15/252 , C12P19/56 , C12Y204/01013
摘要： The present invention provides engineered glycosyltransferase (GT) enzymes, polypeptides having GT activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention provides engineered sucrose synthase (SuS) enzymes, polypeptides having SuS activity, and polynucleotides encoding these enzymes, as well as vectors and host cells comprising these polynucleotides and polypeptides. The present invention also provides compositions comprising the GT enzymes and methods of using the engineered GT enzymes to make products with β-glucose linkages. The present invention further provides compositions and methods for the production of rebaudiosides (e.g., rebaudioside M, rebaudioside A, rebaudioside I, and rebaudioside D). The present invention also provides compositions comprising the SuS enzymes and methods of using them. Methods for producing GT and SuS enzymes are also provided.
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公开(公告)号：US20220403362A1
公开(公告)日：2022-12-22
申请号：US17749034
申请日：2022-05-19
申请人： Codexis, Inc.
发明人： Kierra Aleece Franklin , Stephanie Sue Galanie , Gjalt W. Huisman , Nikki D. Kruse , Kerryn McCluskie , Vesna Mitchell , Leann Quertinmont Teadt , Kristen Jean Vallieu
摘要： The present invention provides engineered methionine gamma lyase polypeptides and compositions thereof. The engineered methionine gamma lyase polypeptides have been optimized to provide improved thermostability, protease stability, and stability under a range of pH conditions, including acidic (pH
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