SSX-2 peptide analogs
    6.
    发明申请
    SSX-2 peptide analogs 有权
    SSX-2肽类似物

    公开(公告)号:US20060063913A1

    公开(公告)日:2006-03-23

    申请号:US11156253

    申请日:2005-06-17

    IPC分类号: C07K14/70

    摘要: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

    摘要翻译: 一些实施方案涉及对应于I类MHC限制性T细胞表位的肽类似物及其产生方法。 这些类似物可以在与MHC分子直接相互作用的残基处含有氨基酸取代,并且可以赋予改进的,修饰的或有用的免疫学特性。 公开了其中各种取代包含非标准残基正亮氨酸和/或正缬氨酸的类似物类别。

    SSX-2 peptide analogs
    8.
    发明授权
    SSX-2 peptide analogs 有权
    SSX-2肽类似物

    公开(公告)号:US08202841B2

    公开(公告)日:2012-06-19

    申请号:US11156253

    申请日:2005-06-17

    IPC分类号: C07K7/06 C07K7/08

    摘要: Some embodiments relate to analogs of peptides corresponding to class I MHC-restricted T cell epitopes and methods for their generation. These analogs can contain amino acid substitutions at residues that directly interact with MHC molecules, and can confer improved, modified or useful immunologic properties. Additionally classes of analogs, in which the various substitutions comprise the non-standard residues norleucine and/or norvaline, are disclosed.

    摘要翻译: 一些实施方案涉及对应于I类MHC限制性T细胞表位的肽类似物及其产生方法。 这些类似物可以在与MHC分子直接相互作用的残基处含有氨基酸取代,并且可以赋予改进的,修饰的或有用的免疫学特性。 公开了其中各种取代包含非标准残基正亮氨酸和/或正缬氨酸的类似物类别。

    METHODS AND COMPOSITIONS FOR INCREASING PLANT DISEASE RESISTANCE AND YIELD
    9.
    发明申请
    METHODS AND COMPOSITIONS FOR INCREASING PLANT DISEASE RESISTANCE AND YIELD 审中-公开
    增加植物抗病性和产量的方法和组合物

    公开(公告)号:US20110191896A1

    公开(公告)日:2011-08-04

    申请号:US12935275

    申请日:2009-04-13

    摘要: The present invention discloses novel plant homologs of the Arabidopsis peptide atPEP1. atPEP peptides in Arabidopsis are involved in the amplification of defense pathways involved in innate immunity against microbial pathogens. Homologs to atPEP1 identified in soy, corn, rice, wheat, and canola sequence databases are potential sources for transgenes to enhance crop yield through resistance to biotic and/or abiotic stresses. Chimeric genes comprising sequences from mature and precursor plant defense response polypeptides from a given species, and from different species, as well as the encoded polypeptide sequences, are also described.

    摘要翻译: 本发明公开了PEP1中拟南芥肽的新型植物同系物。 拟南芥中的atPEP肽参与了涉及针对微生物病原体的先天免疫的防御途径的扩增。 在大豆,玉米,水稻,小麦和卡诺拉序列数据库中鉴定出的atPEP1的同源物是转基因通过抵抗生物和/或非生物胁迫来提高作物产量的潜在来源。 还描述了包含来自给定物种和来自不同物种的成熟和前体植物防御反应多肽的序列的嵌合基因以及编码的多肽序列。