Antigen detection
    1.
    发明授权
    Antigen detection 有权
    抗原检测

    公开(公告)号:US08748355B2

    公开(公告)日:2014-06-10

    申请号:US11886245

    申请日:2006-03-23

    IPC分类号: C40B30/06

    摘要: The present invention relates to methods of detecting specific cell surface antigens present in a sample of cells being tested and in particular blood group antigens, which methods do not employ the addition of extrinsic labels to detect said cell surface antigens. Typically detection is carried out using an intrinsic fluorescence capability of the cells being tested.

    摘要翻译: 本发明涉及检测存在于待测细胞样品中,特别是血型抗原的特异性细胞表面抗原的方法,该方法不使用外来标记物的添加来检测所述细胞表面抗原。 通常使用被测细胞的固有荧光能力进行检测。

    BLOOD GROUP ANTIBODY SCREENING
    3.
    发明申请
    BLOOD GROUP ANTIBODY SCREENING 审中-公开
    血液组织抗体筛选

    公开(公告)号:US20100256005A1

    公开(公告)日:2010-10-07

    申请号:US12595084

    申请日:2008-04-08

    IPC分类号: C40B30/04 C40B40/10 C40B40/14

    CPC分类号: G01N33/80 G01N33/54393

    摘要: An assay for the detection of antibodies to blood group antigens is provide and includes a solid substrate having immobilised thereon a fragment of cell membrane which presents a blood group antigen capable of binding to a blood group antibody. The cell fragments are preferably from red blood cells. The antigens may be immobilised in the form of an array of spots.

    摘要翻译: 提供了检测血型抗原抗体的检测方法,其中包括固定有细胞膜片段的固体底物,其具有能够结合血型抗体的血型抗原。 细胞碎片优选来自红细胞。 抗原可以以斑点阵列的形式固定。

    Blood typing
    5.
    发明授权
    Blood typing 有权
    血型打字

    公开(公告)号:US08030006B2

    公开(公告)日:2011-10-04

    申请号:US12441784

    申请日:2007-09-16

    IPC分类号: G01N33/53

    CPC分类号: G01N33/80

    摘要: A blood testing method for use in the detection of a disease, wherein at least one characteristic antibody or complement factor is bound to a subject's red blood cells, comprises providing a microarray wherein a plurality of binding agents therefor are immobilized on a substrate at discrete pre-defined positions; and contacting a blood sample therewith. The presence of bound red blood cells is then detected.

    摘要翻译: 一种用于检测疾病的血液检测方法,其中至少一种特征性抗体或补体因子与受试者的红细胞结合,包括提供微阵列,其中多个粘附剂以分散的预先固定在基质上 定义的位置 并使血液样品与其接触。 然后检测到结合的红细胞的存在。

    BLOOD TYPING
    6.
    发明申请
    BLOOD TYPING 有权
    血液型

    公开(公告)号:US20100041565A1

    公开(公告)日:2010-02-18

    申请号:US12441784

    申请日:2007-09-16

    IPC分类号: C40B30/04 C40B40/10

    CPC分类号: G01N33/80

    摘要: A blood testing method for use in the detection of a disease, wherein at least one characteristic antibody or complement factor is bound to a subject's red blood cells, comprises providing a microarray wherein a plurality of binding agents therefor are immobilised on a substrate at discrete pre-defined positions; and contacting a blood sample therewith. The presence of bound red blood cells is then detected.

    摘要翻译: 一种用于检测疾病的血液检测方法,其中至少一种特征性抗体或补体因子与受试者的红细胞结合,包括提供微阵列,其中多个粘附剂以分散的预先固定在基质上 定义的位置 并使血液样品与其接触。 然后检测结合的红细胞的存在。

    Recombinant therapeutic fusion proteins
    7.
    发明授权
    Recombinant therapeutic fusion proteins 失效
    重组治疗融合蛋白

    公开(公告)号:US07390881B2

    公开(公告)日:2008-06-24

    申请号:US11124971

    申请日:2005-05-09

    申请人: Juraj Petrik

    发明人: Juraj Petrik

    IPC分类号: C07K1/00 C07H21/00

    摘要: A recombinant bifunctional fusion protein comprises a first component which is the antigenic ectodomain of measles virus hemagglutinin protein (MeaH) genetically modified not to bind to human cells; and a second component fused thereto which is capable of binding to the surface structure of genetically variable viruses such as HCV or HIV or other therapeutic targets. The second component binds to the target and the first component is recognised by anti-measles antibodies present in the majority of the population. The protein may be used therapeutically to treat HCV or HIV infection or against other therapeutic targets.

    摘要翻译: 重组双功能融合蛋白包含第一组分,其是遗传修饰为不与人细胞结合的麻疹病毒血凝素蛋白(MeaH)的抗原性胞外域; 和与其融合的第二组分,其能够结合基因可变病毒如HCV或HIV或其它治疗靶标的表面结构。 第二组分与靶标结合,第一组分被存在于大多数群体中的抗麻疹抗体所识别。 该蛋白质可用于治疗HCV或HIV感染或其它治疗靶点。

    Systematic extraction, amplification and detection of retroviral
sequences, and oligonucleotides for use therein
    8.
    发明授权
    Systematic extraction, amplification and detection of retroviral sequences, and oligonucleotides for use therein 失效
    逆转录病毒序列的系统提取,扩增和检测以及用于其中的寡核苷酸

    公开(公告)号:US6083685A

    公开(公告)日:2000-07-04

    申请号:US43085

    申请日:1998-03-06

    申请人: Juraj Petrik

    发明人: Juraj Petrik

    CPC分类号: C12Q1/702

    摘要: A method for determining the presence of retroviral RNA or DNA in a sample comprises using one or more detectable oligonucleotides that each hybridise with the primer binding site of a retroviral genome or its complement.

    摘要翻译: PCT No.PCT / GB96 / 02196 Sec。 371日期1998年3月6日 102(e)1998年3月6日PCT PCT 1996年9月6日PCT公布。 公开号WO97 / 09452 日期1997年3月13日用于测定样品中逆转录病毒RNA或DNA的存在的方法包括使用每个与逆转录病毒基因组或其补体的引物结合位点杂交的一个或多个可检测的寡核苷酸。