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    Antimicrobial compounds
    1.
    发明授权
    Antimicrobial compounds 失效
    抗菌化合物

    公开(公告)号：US07385086B2

    公开(公告)日：2008-06-10

    申请号：US10764451

    申请日：2004-01-27

    申请人： Craig A. Townsend ,  James D. Dick ,  Gary R. Pasternack ,  Francis P. Kuhajda ,  Nicole M. Parrish

    发明人： Craig A. Townsend ,  James D. Dick ,  Gary R. Pasternack ,  Francis P. Kuhajda ,  Nicole M. Parrish

    IPC分类号： C07C317/00 ,  C07C317/02 ,  C07C317/04 ,  C07C317/06 ,  C07C317/08

    CPC分类号： C40B40/04 ,  C07C311/06 ,  C07C317/44

    摘要： This invention provides compounds and methods for treating, with said compound, a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn-Z-CO—Y, where R is an alkyl groups having 6-20 carbon atoms, unsaturated hydrocarbon groups having 6-20 carbon atoms, or alkyl groups having 6-20 carbon atoms interrupted by at least one aromatic ring; Z is —CH2—, —CH2CH2—, —NH—NH—, —O—, ——NH—, —O—NH—, —CH2—NH—, —CH2—O—, —NH—O—, —NH—CH2—, —O—CH2—, and —CH═CH—; Y is —NH2, —O—CH2—C6H5, —CO—CO—O—CH3, and —O—CH3; and n is 1 or 2. It has been discovered that these compounds treat microbially-based infections caused by corynebacteria, nocardiae, rhodococcus, and mycobacteria. These compounds may be used to treat mycobacterial cells, such as Mycobacteria tuberculosis, drug resistant M. tuberculosis, M. avium intracellulare, M. leprae, M. paratuberculosis, and pathogenic Mycobacteria sp.

    摘要翻译： 本发明提供了通过向动物施用含有具有式R-SO n -Z-CO-Y的化合物的药物组合物，通过向所述化合物处理分枝杆菌感染的化合物和方法，其中R 是具有6-20个碳原子的烷基，具有6-20个碳原子的不饱和烃基或具有6-20个碳原子的烷基被至少一个芳环中断; Z是-CH 2 - ， - CH 2 CH 2 - ， - NH-NH-， - O - ， - NH-， -O-NH-，-CH 2 -NH-，-CH 2 -O-，-NH-O-，-NH-CH 2， -O - CH 2 - 和-CH-CH-; Y是-NH 2，-O-CH 2 -C 6 H 5，-CO-CO- O-CH 3，和-O-CH 3; 已发现这些化合物治疗由棒状杆菌，诺卡氏菌，罗红球菌和分枝杆菌引起的基于微生物的感染。 这些化合物可用于治疗分枝杆菌细胞，例如结核分枝杆菌，耐药性结核分枝杆菌，胞内分枝杆菌，麻疯病，副结核分枝杆菌和致病性分枝杆菌属。

    Antimicrobial compounds
    2.
    发明授权
    Antimicrobial compounds 失效
    抗菌化合物

    公开(公告)号：US06713654B1

    公开(公告)日：2004-03-30

    申请号：US09486550

    申请日：2000-08-28

    申请人： Craig A. Townsend ,  James D. Dick ,  Gary R. Pasternack ,  Francis P. Kuhajda ,  Nicole M. Parrish

    发明人： Craig A. Townsend ,  James D. Dick ,  Gary R. Pasternack ,  Francis P. Kuhajda ,  Nicole M. Parrish

    IPC分类号： C07C31500

    CPC分类号： C40B40/04 ,  C07C311/06 ,  C07C317/44

    摘要： This invention provides methods for treating a mycobacterial infection by administering to an animal a pharmaceutical composition containing a compound having the formula R—SOn—Z—CO—Y, where R is an alkyl group having 6-20 carbons; Z is a radical selected from —CH2—, —O—, and —NH—, two of these radicals coupled together, or —CH2═CH2—; Y is —NH2, O—CH2—C6H5, —CO—CO—O—CH3, or O—CH3; and n is 1 or 2. It has been discovered that these compounds inhibit growth of microbial cells which synthesize &agr;-substitued, &bgr;-hydroxy fatty acids, particularly corynemycolic acid, nocardic acid, and mycolic acid. These compounds may be used to inhibit growth of mycobacterial cells, such as Mycobacterium tuberculosis, drug-resistant M. tuberculosis, M. avium intracellulare, and M. leprae.

    摘要翻译： 本发明提供了通过向动物施用含有具有式R-SOn-Z-CO-Y的化合物的药物组合物来治疗分枝杆菌感染的方法，其中R是具有6-20个碳原子的烷基; Z是选自-CH 2 - ， - O-和-NH-的基团，这些基团中的两个连接在一起，或-CH 2 = CH 2 - ; Y是-NH 2，O-CH 2 -C 6 H 5，-CO-CO-O-CH 3或O-CH 3; 已经发现，这些化合物抑制合成α-取代的β-羟基脂肪酸，特别是氯霉素酸，诺卡酸和霉菌酸的微生物细胞的生长。 这些化合物可用于抑制分枝杆菌细胞的生长，例如结核分枝杆菌，耐药性结核分枝杆菌，胞内分枝杆菌和麻疯病。

    Inhibition of fatty acid synthase as a means to reduce adipocyte mass
    3.
    发明授权
    Inhibition of fatty acid synthase as a means to reduce adipocyte mass 失效
    抑制脂肪酸合酶作为减少脂肪细胞质量的手段

    公开(公告)号：US5981575A

    公开(公告)日：1999-11-09

    申请号：US157

    申请日：1998-01-27

    申请人： Francis P. Kuhajda ,  Gary R. Pasternack ,  Craig A. Townsend ,  Neelakandha S. Mani

    发明人： Francis P. Kuhajda ,  Gary R. Pasternack ,  Craig A. Townsend ,  Neelakandha S. Mani

    IPC分类号： A61K31/00 ,  A61K31/365 ,  A61K31/381 ,  A61K31/4025 ,  A01K31/04

    CPC分类号： A61K31/4025 ,  A61K31/00 ,  A61K31/365 ,  A61K31/381

    摘要： Weight loss was noted in nude mice treated with cerulenin, a non-competitive inhibitor of FAS. Sustained reduction of adipocyte mass in humans without toxicity would significantly impact disease prevention worldwide. Aside from psychological and self-esteem improvement, weight loss via reduction of adipocyte mass may: (1) ameliorate hyperglycemia associated with non-insulin-dependent diabetes mellitus thereby reducing diabetic complications such as arterial disease, blindness, cataracts, etc., (2) reduce hypertension, (3) reduce risk of coronary artery vascular disease and stroke, and (4) reduce the risk of other complications of massive obesity such as osteoarthritis, surgical complications, etc. There is also potential use in livestock and poultry to reduce the saturated fat content of meat products. Therefore FAS inhibitors are disclosed herein as novel agents for weight reduction. A family of compounds (.gamma.-substituted-.alpha.-methylene-.beta.-carboxy-.gamma.-butyrolactones) whose synthesis was based on the cerulenin motif is shown herein to inhibit fatty acid synthesis, inhibit growth in certain susceptible tumor cells, and induce weight loss.

    摘要翻译： PCT No.PCT / US96 / 17678 Sec。 371日期：1998年1月27日 102（e）日期1998年1月27日PCT 1996年11月15日PCT PCT。 第WO97 / 18806号公报 日期1997年5月29日在使用非竞争性FAS抑制剂的木瓜素治疗的裸小鼠中观察到重度损失。 持续减少人体脂肪细胞质量无毒性将严重影响全球疾病预防。 除了心理和自尊心的改善之外，通过减少脂肪细胞质量可以减轻体重：（1）改善与非胰岛素依赖性糖尿病相关的高血糖，从而减少糖尿病并发症，如动脉疾病，失明，白内障等（2 ）降低高血压，（3）降低冠状动脉血管疾病和中风的风险，（4）降低骨质疏松，手术并发症等巨大肥胖的其他并发症的风险。畜禽养殖也有可能减少 肉制品的饱和脂肪含量。 因此，本文公开了FAS抑制剂作为减轻体重的新型药剂。 本文显示了其合成基于苏氨酸基序的化合物（γ-取代-α-亚甲基-β-羧基-γ-丁内酯）家族，以抑制脂肪酸合成，抑制某些易感的肿瘤细胞中的生长，并诱导体重减轻 。

    Listeria monocytogenes bacteriophage and uses thereof
    9.
    发明授权
    Listeria monocytogenes bacteriophage and uses thereof 有权
    单核细胞增生利斯特氏菌噬菌体及其用途

    公开(公告)号：US07507571B2

    公开(公告)日：2009-03-24

    申请号：US11764587

    申请日：2007-06-18

    申请人： Gary R. Pasternack ,  Alexander Sulakvelidze

    发明人： Gary R. Pasternack ,  Alexander Sulakvelidze

    IPC分类号： C12N7/00

    CPC分类号： C12N7/00 ,  C12N2795/00021

    摘要： The present invention is directed to isolated Listeria monocytogenes bacteriophage, and methods of using Listeria monocytogenes bacteriophage, or polynucleotides and polypeptides derived therefrom, to control the growth or contamination of food products by Listeria monocytogenes. The present invention also contemplates the use of Listeria monocytogenes bacteriophage, and polynucleotides and polypeptides derived therefrom, for the treatment of host infections or environmental contamination by Listeria monocytogenes.

    摘要翻译： 本发明涉及分离的单核细胞增生利斯特氏菌噬菌体，以及使用单核细胞增生利斯特氏菌噬菌体或其衍生的多核苷酸和多肽控制单核细胞增生利斯特氏菌的食物生长或污染的方法。 本发明还考虑了单核细胞增生利斯特氏菌噬菌体及其衍生的多核苷酸和多肽用于治疗单核细胞增多性李斯特菌的宿主感染或环境污染的用途。

    Nucleic acid encoding a novel mammalian protein associated with uncontrolled cell division
    10.
    发明授权
    Nucleic acid encoding a novel mammalian protein associated with uncontrolled cell division 失效
    编码与不受控细胞分裂相关的新型哺乳动物蛋白的核酸

    公开(公告)号：US6040173A

    公开(公告)日：2000-03-21

    申请号：US466743

    申请日：1995-06-06

    申请人： Gary R. Pasternack

    发明人： Gary R. Pasternack

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K16/04 ,  C07K16/18 ,  C07K16/30 ,  C12Q1/68 ,  C12N15/00 ,  C07H21/04

    CPC分类号： C07K16/30 ,  C07K14/47 ,  C07K16/04 ,  C07K16/18 ,  C12Q1/68 ,  C12Q1/6886 ,  A61K38/00 ,  C12N2799/026 ,  C12Q2600/112 ,  C12Q2600/136 ,  Y10S530/828

    摘要： Three mammalian proteins are disclosed which are useful in the diagnosis and prognosis of tumors of lymphoid and epithelial origin. The three proteins are immunologically related to each other. The level of expression of the proteins correlates with the malignant potential of lymphoid and epithelial tumors. In addition, in some cases the subcellular location of the proteins is indicative of malignant potential. Antibodies reactive with the proteins are disclosed as diagnostic tools, as are nucleic acid probes and primers for quantitating the messenger RNAs encoding the proteins. Methods for preparing and purifying the proteins are also taught.

    摘要翻译： 公开了三种哺乳动物蛋白质，其可用于淋巴和上皮起源的肿瘤的诊断和预后。 三种蛋白质在免疫学上相互关联。 蛋白质的表达水平与淋巴样和上皮性肿瘤的恶性潜能相关。 此外，在一些情况下，蛋白质的亚细胞位置指示恶性潜能。 公开了与蛋白质反应的抗体作为诊断工具，核酸探针和引物用于定量编码蛋白质的信使RNA。 还教导了制备和纯化蛋白质的方法。