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1.发明授权公开(公告)号：US08610056B2
公开(公告)日：2013-12-17
申请号：US13164617
申请日：2011-06-20
IPC分类号： B01D59/44
CPC分类号： B01D59/44 , H01J49/004 , H01J49/063 , H01J49/401
摘要： An apparatus includes an atmospheric pressure ion source; a first vacuum stage and a second vacuum stage separated from the first vacuum stage by a vacuum partition; a first ion guide positioned within a first vacuum stage and arranged to receive ions from the atmospheric pressure ion source; a second ion guide positioned within a second vacuum stage downstream of the first vacuum stage from the atmospheric pressure ion source, the second ion guide being a multipole ion guide arranged to receive ions from the first ion guide; and a time-of-flight mass analyzer that includes an orthogonal pulsing region arranged to receive ions from the second ion guide.
摘要翻译： 一种装置包括大气压离子源; 通过真空隔板与第一真空级分离的第一真空级和第二真空级; 位于第一真空级内并被布置成接收来自大气压离子源的离子的第一离子引导件; 位于第一真空级下游的第二真空级的第二离子导向器，其位于大气压离子源的下游，所述第二离子导向器是布置成接收来自第一离子导向器的离子的多极离子导向器; 以及飞行时间质量分析器，其包括布置成接收来自第二离子导向器的离子的正交脉冲区域。
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2.发明授权
公开(公告)号：US06011259A
公开(公告)日：2000-01-04
申请号：US694542
申请日：1996-08-09
CPC分类号： H01J49/40 , H01J49/004 , H01J49/063
摘要： A Time-Of-Flight (TOF) mass analyzer is configured with a multipole ion guide in the ion path between the ion source and pulsing region of the mass analyzer, and enables trapping or transmission of ions from an atmospheric pressure ion source. The mass-to-charge (m/z) range(s) of ions transmitted through or trapped in the ion guide can be selected. Ions with stable trajectories can undergo Collisional Induced Dissociation (CID). During ion fragmentation, the ion guide potentials can be set to transmit or trap fragment ions produced by CID. The parent and fragment ion population can be delivered from the ion guide to the pulsing region of the TOF mass analyzer for mass analysis. After the first fragmentation step, the ion guide potentials can again be set to select a narrow m/z range to clear the ion guide in trapping mode of all but a selected set of fragment ions. M/z selection and ion fragmentation can be repeated a number of times with mass analysis occurring at the end of all the MS/MS.sup.n steps or at various times during the MS/MS.sup.n stepwise process. Additionally, the normally stepwise MS/MS.sup.n analysis function can be merged into a single step, increasing the effective duty cycle. In all embodiments, the ion guide can reside in one vacuum pumping stage or can extend continuously into more than one vacuum pumping stage.
摘要翻译： 飞行时间质量分析仪（TOF）质量分析仪在质量分析仪的离子源和脉冲区域之间的离子路径中配置有多极离子导向器，并能够从大气压离子源捕获或传输离子。 可以选择通过或捕获在离子导向器中的离子的质量（m / z）范围（s）。 具有稳定轨迹的离子可以经历碰撞诱导解离（CID）。 在离子碎片化期间，离子导向电位可以设置为透过或捕获由CID产生的碎片离子。 母体和碎片离子群体可以从离子导向器输送到TOF质量分析器的脉冲区域进行质量分析。 在第一次碎裂步骤之后，离子导向电位可以再次被设置为选择窄的m / z范围，以便除所选择的一组碎片离子之外的所有离子导向器以捕获模式中的离子导向。 可以在MS / MSn步骤结束时或MS / MSn逐步处理过程中的不同时间进行质量分析，重复多次M / Z选择和离子碎片。 此外，正常逐步的MS / MSn分析功能可以合并成一个步骤，增加有效占空比。 在所有实施例中，离子导向器可以驻留在一个真空泵送阶段中，或者可以连续地延伸到多于一个的真空泵送阶段。
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3.发明授权公开(公告)号：US08598519B2
公开(公告)日：2013-12-03
申请号：US13164590
申请日：2011-06-20
IPC分类号： B01D59/44
CPC分类号： B01D59/44 , H01J49/0481 , H01J49/063
摘要： A method includes directing ions from an atmospheric pressure ion source to a first ion guide; directing ions in the first ion guide to a second ion guide, the second ion guide being a multipole ion guide extending along an axis; periodically directing ions along the axis; receiving at least some of the ions in a time-of-flight analyzer; accelerating the ions in the time-of-flight mass analyzer orthogonal to the axis; and detecting the accelerated ions.
摘要翻译： 一种方法包括将离子从大气压离子源引导到第一离子导向器; 将所述第一离子导向器中的离子引导到第二离子引导件，所述第二离子引导件是沿着轴线延伸的多极离子引导件; 沿着轴定期引导离子; 在飞行时间分析仪中接收至少一些离子; 加速与轴垂直的飞行时间质量分析仪中的离子; 并检测加速离子。
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公开(公告)号：US07019285B2
公开(公告)日：2006-03-28
申请号：US09808468
申请日：2001-03-14
IPC分类号： H01J49/40
CPC分类号： H01J49/401
摘要： A method and an apparatus which combines at least one linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.
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5.发明授权Apparatus for analysis of sample chemical species featuring multiple sample placement locations 有权用于分析具有多个样品放置位置的样品化学物质的装置公开(公告)号：US09240311B2
公开(公告)日：2016-01-19
申请号：US13487037
申请日：2012-06-01
申请人： Craig M. Whitehouse , Thomas Dresch
发明人： Craig M. Whitehouse , Thomas Dresch
CPC分类号： H01J49/145 , H01J49/0413 , H01J49/0431 , H01J49/0459 , H01J49/24
摘要： A Direct Sample Analysis (DSA) ion source system operating at essentially atmospheric pressure is configured to facilitate the ionization, or desorption and ionization, of sample species from a wide variety of gaseous, liquid, and/or solid samples, for chemical analysis by mass spectrometry or other gas phase ion detectors. The DSA system includes one or more means of ionizing samples and includes a sealed enclosure which provides protection from high voltages and hazardous vapors, and in which the local background gas environment may be monitored and well-controlled. The DSA system is configured to accommodate single or multiple samples at any one time, and provide external control of individual sample positioning, sample conditioning, sample heating, positional sensing, and temperature measurement.
摘要翻译： 以基本上大气压力运行的直接样品分析（DSA）离子源系统被配置为促进来自各种气态，液体和/或固体样品的样品物质的电离或解吸和电离，用于通过质量进行化学分析 光谱仪或其他气相离子检测器。 DSA系统包括一种或多种离子化样品的方法，并且包括密封的外壳，其提供对高电压和危险蒸汽的保护，并且其中可以监测和良好控制本地背景气体环境。 DSA系统配置为可以随时容纳单个或多个样品，并提供单独样品定位，样品调节，样品加热，位置检测和温度测量的外部控制。
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公开(公告)号：US20110309244A1
公开(公告)日：2011-12-22
申请号：US13164617
申请日：2011-06-20
IPC分类号： H01J49/40
CPC分类号： B01D59/44 , H01J49/004 , H01J49/063 , H01J49/401
摘要： A Time-Of-Flight mass analyzer includes a multipole ion guide located in the ion flight path between the ion source and the flight tube of the Time-Of-Flight mass analyzer. In one preferred embodiment, a Time-Of-Flight (TOF) mass analyzer is configured such that a multipole ion guide is positioned in the ion path between the ion source and the ion pulsing region of the TOF mass analyzer. The multipole ion guide electronics and the ion guide entrance and exit electrostatic lenses are configured to enable the trapping or passing through of ions delivered from an atmospheric pressure ion source. The ion guide electronics can be set to select the mass to charge (m/z) range of ions which can be successfully transmitted or trapped in the ion guide. More than one set of m/z values can be selected using techniques such as notch filtering with resonant frequency ion ejection of unwanted m/z values. All or a portion of the ions with stable ion guide trajectories in transmission or trapping mode can then undergo Collisional Induced Dissociation (CID) using one of at least three techniques. During the ion fragmentation step the multipole ion guide AC and DC electric potentials are set to transmit or trap all or a portion of the fragment ions produced by the CID process. All or a portion of the parent and fragment ion population are delivered from the multipole ion guide to the pulsing region of Time-OF-Flight mass analyzer for mass analysis. After the first ion fragmentation step, the multipole ion guide AC and DC electric potentials can again be set to select a narrow m/z range to clear the ion guide in trapping mode of all but a selected set of fragment ions. The m/z selection and ion fragmentation step can be repeated a number of times with mass analysis occurring at the end of all the MS/MSn steps or at various times during the MS/MSn stepwise process. A technique is also described where the normally stepwise MS/MSn analysis function can be merged into a single step, increasing the effective duty cycle. The multipole ion guide used for ion transmission, trapping and fragmentation can reside in one vacuum pumping stage or can extend continuously into more than one vacuum pumping stage.
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7.发明申请公开(公告)号：US20110303840A1
公开(公告)日：2011-12-15
申请号：US13164590
申请日：2011-06-20
IPC分类号： H01J49/40
CPC分类号： B01D59/44 , H01J49/0481 , H01J49/063
摘要： A method includes directing ions from an atmospheric pressure ion source to a first ion guide; directing ions in the first ion guide to a second ion guide, the second ion guide being a multipole ion guide extending along an axis; periodically directing ions along the axis; receiving at least some of the ions in a time-of-flight analyzer; accelerating the ions in the time-of-flight mass analyzer orthogonal to the axis; and detecting the accelerated ions.
摘要翻译： 一种方法包括将离子从大气压离子源引导到第一离子导向器; 将所述第一离子导向器中的离子引导到第二离子引导件，所述第二离子引导件是沿着轴线延伸的多极离子引导件; 沿着轴定期引导离子; 在飞行时间分析仪中接收至少一些离子; 加速与轴垂直的飞行时间质量分析仪中的离子; 并检测加速离子。
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8.发明授权Time-of-flight mass spectrometer with first and second order longitudinal focusing 有权飞行时间质谱仪具有一阶和二阶纵向聚焦公开(公告)号：US06621073B1
公开(公告)日：2003-09-16
申请号：US09689309
申请日：2000-10-12
申请人： Thomas Dresch
发明人： Thomas Dresch
IPC分类号： H01J4940
CPC分类号： H01J49/405 , H01J49/40 , H01J49/403
摘要： A Time-of-Flight Mass Spectrometer (TOF-MS) is configured to improve resolution and sensitivity performance. The TOF-MS includes an arrangement of electrodes comprising an ion accelerator with two stages of homogeneous electric fields, an ion reflector with a single stage of a homogeneous electric field, accelerator and reflector being separated by a first drift space, and an ion detector which is separated from the reflector by a second drift space. Contrary to known TOF-MS of similar configuration, the set of electric potentials which must be applied to said electrodes is predetermined for a given geometry in such a way that a spatial distribution of ions initially at rest in the first gap of the said accelerator is compressed at the location of the detector in the longitudinal direction to a focus of first and second order in the initial axial coordinate. Therefore, mass resolution is enhanced over a TOF-MS that provides only for longitudinal focusing of first order, while the number of passages through grid electrodes along the flight path is reduced, and hence ion transmission and instrument sensitivity are improved.
摘要翻译： 飞行时间质谱仪（TOF-MS）被配置为提高分辨率和灵敏度性能。 TOF-MS包括电极的布置，其包括具有两级均匀电场的离子加速器，具有均匀电场的单级的离子反射器，由第一漂移空间分隔的加速器和反射器;以及离子检测器， 通过第二漂移空间与反射器分离。 与已知的类似配置的TOF-MS相反，必须施加到所述电极的电势集合对于给定的几何形状是预定的，使得最初在所述加速器的第一间隙中静止的离子的空间分布是 在检测器的纵向方向上的位置被压缩成在初始轴向坐标中的第一和第二级的焦点。 因此，仅提供一阶纵向聚焦的TOF-MS的质量分辨率提高，而沿着飞行路径的通过网格电极的通道数量减少，因此提高了离子传播和仪器灵敏度。
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公开(公告)号：US6020586A
公开(公告)日：2000-02-01
申请号：US971521
申请日：1997-11-17
CPC分类号： H01J49/401 , H01J49/004 , H01J49/063
摘要： A method and an apparatus which combines at least one linear two dimensional ion guide or a two dimensional ion storage device in tandem with a time-of-flight mass analyzer to analyze ionic chemical species generated by an ion source. The method improves the duty cycle, and therefore, the overall instrument sensitivity with respect to the analyzed chemical species.
摘要翻译： 将至少一个线性二维离子导向器或二维离子存储装置与飞行时间质量分析器串联组合以分析由离子源产生的离子化学物质的方法和装置。 该方法提高了相对于分析的化学物质的占空比，因此提高了仪器的整体灵敏度。
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公开(公告)号：US5869829A
公开(公告)日：1999-02-09
申请号：US887615
申请日：1997-07-03
申请人： Thomas Dresch
发明人： Thomas Dresch
CPC分类号： H01J49/405 , H01J49/40 , H01J49/403
摘要： A Time-of-Flight Mass Spectrometer (TOF-MS) is configured to improve resolution and sensitivity performance. The TOF-MS includes an arrangement of electrodes comprising an ion accelerator with two stages of homogeneous electric fields, an ion reflector with a single stage of a homogeneous electric field, accelerator and reflector being separated by a first drift space, and an ion detector which is separated from the reflector by a second drift space. Contrary to known TOF-MS of similar configuration, the set of electric potentials which must be applied to said electrodes is predetermined for a given geometry in such a way that a spatial distribution of ions initially at rest in the first gap of the said accelerator is compressed at the location of the detector in the longitudinal direction to a focus of first and second order in the initial axial coordinate. Therefore, mass resolution is enhanced over a TOF-MS that provides only for longitudinal focusing of first order, while the number of passages through grid electrodes along the flight path is reduced, and hence ion transmission and instrument sensitivity are improved.
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