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公开(公告)号：US08267081B2
公开(公告)日：2012-09-18
申请号：US12389802
申请日：2009-02-20
IPC分类号： A61M15/00
CPC分类号： A61M16/104 , A61M11/04 , A61M16/0093 , A61M16/04 , A61M16/0833 , A61M16/1045 , A61M16/18 , A61M16/22 , A61M2016/1035 , A61M2202/0208 , A61M2202/03 , A61M2205/123 , A61M2205/505 , A61M2230/437 , A61M2202/0007
摘要： A therapy utilizing inhaled anesthetic agents (such as desflurane, sevoflurane, isoflurane, or xenon) for the sedation of patients outside of the immediate perioperative space such as in the medical intensive care unit (MICU) and the surgical intensive care unit (SICU). The therapy includes controlled delivery of volatile anesthetic agents to patients undergoing ventilatory support on an ICU ventilator over extended periods of time. A system which provides for the delivery of anesthetic agents includes an anesthetic agent vaporizer element, an anesthetic agent reflector, and a plug-in cassette which contains both a cartridge housing liquid phase volatile anesthetic agent and an anesthetic vapor scrubbing medium.
摘要翻译： 使用吸入麻醉剂（如地氟烷，七氟醚，异氟烷或氙气）治疗立即围手术期外的患者镇静，如医疗重症监护室（MICU）和手术重症监护病房（SICU）。 该疗法包括将挥发性麻醉剂控制递送给在ICU通气机上长时间接受通气支持的患者。 提供麻醉剂递送的系统包括麻醉剂蒸发器元件，麻醉剂反射器和插入盒，其包含容纳液相挥发性麻醉剂和麻醉蒸气洗涤介质的盒。
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公开(公告)号：US07188744B2
公开(公告)日：2007-03-13
申请号：US10268162
申请日：2002-10-10
申请人： William S. Hurst , Sidney T. Smith , Pierre Caloz , Sindhu Ramachandran , Michele M. Ulm , Jesse F. Rodriguez
发明人： William S. Hurst , Sidney T. Smith , Pierre Caloz , Sindhu Ramachandran , Michele M. Ulm , Jesse F. Rodriguez
CPC分类号： B65B69/0091 , B65D77/061 , B65D90/205
摘要： A container (10) having a plurality of panels (12–18) joined together to form a sleeve (64). The panels (12–18) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (64). The container (10) further has an end panel (20,22) connected to the panels (12–18) at the one end of the sleeve (64). The end panel (20,22) has at least one portion extending beyond the imaginary plane (P). The supporting box (100) is provided to support the container (10). A hanger system (150) is provided and is attached to the box (100). The hanger system (150) supports an upper portion of the container (10) within the box (100). The container (10) is also provided with a port closure (300) that provides both a sterile and gas permeable barrier.
摘要翻译： 具有连接在一起以形成套筒（64）的多个面板（12-18）的容器（10）。 面板（12-18）各自具有端部边缘，其协作以在套筒（64）的一端限定假想平面（P）。 容器（10）还具有在套筒（64）的一端处连接到面板（12-18）的端板（20,22）。 端面板（20,22）具有延伸超过虚平面（P）的至少一个部分。 提供支撑箱（100）以支撑容器（10）。 提供衣架系统（150）并附接到盒子（100）。 衣架系统（150）支撑箱体（100）内的容器（10）的上部。 容器（10）还设置有提供无菌和透气屏障的端口封闭件（300）。
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公开(公告)号：US06974447B2
公开(公告)日：2005-12-13
申请号：US10124599
申请日：2002-04-16
申请人： Sidney T. Smith , Larry Rosenbaum , Gregg Nebgen , William S. Hurst , William S. Hoerle , Adel M. Sadik , Melissa J. Skelnik , Steven H. Giovanetto , Bradley Buchanan
发明人： Sidney T. Smith , Larry Rosenbaum , Gregg Nebgen , William S. Hurst , William S. Hoerle , Adel M. Sadik , Melissa J. Skelnik , Steven H. Giovanetto , Bradley Buchanan
IPC分类号： B65D30/02 , A61J1/00 , A61J1/05 , A61J1/10 , B32B1/08 , B32B27/08 , B32B27/30 , B65D65/40 , A61B19/00 , A61M37/00 , B29D22/00 , B65D30/08 , B65D37/00
CPC分类号： B32B27/30 , A61J1/10 , A61M2207/00 , B32B1/08 , Y10S128/24 , Y10S128/912 , Y10S206/828 , Y10S604/905 , Y10T428/1334 , Y10T428/1341 , Y10T428/2495 , Y10T428/269 , Y10T428/31757 , Y10T428/31909 , Y10T428/31913 , Y10T428/31935
摘要： The present invention provides a receptacle for a therapeutic fluid susceptible to deterioration on exposure to a gas such as oxygen or carbon dioxide. The receptacle has walls of sheet material each including at least one layer forming a barrier essentially impermeable to such gas, and a seal sealing the walls together in a region thereof. A transfer tube is sealed in the seal having a proximal end in the receptacle, a distal end accessible from outside the receptacle, a flow passage extending between said proximal and distal ends, and a closure blocking flow through the flow passage adapted to be pierced by a tubular needle for transfer of therapeutic through the needle. The transfer tube and closure are essentially impermeable to said gas.
摘要翻译： 本发明提供了一种用于暴露于诸如氧气或二氧化碳等气体的劣化的治疗性流体的容器。 容器具有片状材料壁，每个层包括至少一层形成对这种气体基本上不可渗透的阻挡层，以及将壁密封在一起的区域中。 输送管被密封在密封件中，该密封件具有在容器中的近端，可从容器外部接近的远端，在所述近端和远端之间延伸的流动通道，以及封闭流经所述流动通道的流体，其适于被 用于通过针转运治疗的管状针。 转移管和封闭物基本上不透气于所述气体。
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4.发明授权Port tube and closure composition, structure and assembly for a flowable material container 有权端口管和封闭组件，可流动材料容器的结构和组装公开(公告)号：US07550185B2
公开(公告)日：2009-06-23
申请号：US11042651
申请日：2005-01-24
申请人： Michael T. K. Ling , William S. Hurst , Lecon Woo , Algirdas Bindokas , Patrick T. Ryan , Scott D. Edwards , Henk P. Blom , Atul R. Khare
发明人： Michael T. K. Ling , William S. Hurst , Lecon Woo , Algirdas Bindokas , Patrick T. Ryan , Scott D. Edwards , Henk P. Blom , Atul R. Khare
CPC分类号： C08L23/12 , A61L29/126 , B29C65/04 , B29C66/1122 , B29C66/53262 , B29C66/71 , B29C66/7234 , B29C2035/0861 , B32B1/08 , B32B27/08 , B32B27/32 , C08L23/0815 , C08L23/0869 , C08L23/142 , C08L51/00 , C08L53/02 , C08L75/04 , C08L77/00 , C08L101/00 , C08L2314/06 , Y10T428/1352 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , Y10T428/31746 , Y10T428/31913 , Y10T428/31924 , Y10T428/31931 , C08L2666/24 , C08L2666/04 , B29C65/00 , B29K2079/08 , B29K2077/00 , B29K2075/02 , B29K2075/00 , B29K2067/00 , B29K2033/12 , B29K2033/08 , B29K2023/18 , B29K2023/14 , B29K2023/12 , B29K2023/086 , B29K2023/083 , B29K2023/08 , B29K2021/003 , B29K2009/00
摘要： The present invention provides a flowable material container assembly having a membrane tube disposed coaxially within a port tube. The membrane tube has an outer layer, a core layer, and an inner layer. The outer layer is a blend of a polyolefin and a thermoplastic elastomer. The core layer is a blend of a polyolefin and a thermoplastic elastomer. The inner layer is a blend of a polyolefin, a radio frequency susceptible polymer, and a thermoplastic elastomer.
摘要翻译： 本发明提供了一种可流动的材料容器组件，其具有同轴地设置在端口管内的膜管。 膜管具有外层，芯层和内层。 外层是聚烯烃和热塑性弹性体的共混物。 芯层是聚烯烃和热塑性弹性体的共混物。 内层是聚烯烃，射频敏感聚合物和热塑性弹性体的混合物。
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公开(公告)号：US07025318B2
公开(公告)日：2006-04-11
申请号：US09812235
申请日：2001-03-19
申请人： William S. Hurst , Sidney T. Smith , Pierre Caloz , Sindhu Ramachandran , Michele M. Ulm , Jesse F. Rodriguez
发明人： William S. Hurst , Sidney T. Smith , Pierre Caloz , Sindhu Ramachandran , Michele M. Ulm , Jesse F. Rodriguez
IPC分类号： A47H1/10
CPC分类号： B65B69/0091 , B65D77/061 , B65D90/205
摘要： A container (10) having a plurality of panels (12–18) joined together to form a sleeve (64). The panels (12–18) each have an end edge that cooperate to define an imaginary plane (P) at one end of the sleeve (64). The container (10) further has an end panel (20,22) connected to the panels (12–18) at the one end of the sleeve (64). The end panel (20,22) has at least one portion extending beyond the imaginary plane (P). The supporting box (100) is provided to support the container (10). A hanger system (150) is provided and is attached to the box (100). The hanger system (150) supports an upper portion of the container (10) within the box (100). The container (10) is also provided with a port closure (300) that provides both a sterile and gas permeable barrier.
摘要翻译： 具有连接在一起以形成套筒（64）的多个面板（12-18）的容器（10）。 面板（12-18）各自具有端部边缘，其协作以在套筒（64）的一端限定假想平面（P）。 容器（10）还具有在套筒（64）的一端处连接到面板（12-18）的端板（20,22）。 端面板（20,22）具有延伸超过虚平面（P）的至少一个部分。 提供支撑箱（100）以支撑容器（10）。 提供衣架系统（150）并附接到盒子（100）。 衣架系统（150）支撑箱体（100）内的容器（10）的上部。 容器（10）还设置有提供无菌和透气屏障的端口封闭件（300）。
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6.发明授权Optimization of nucleation and crystallization for lyophilization using gap freezing 有权使用间隙冷冻优化冷冻干燥的成核和结晶公开(公告)号：US08966782B2
公开(公告)日：2015-03-03
申请号：US13432498
申请日：2012-03-28
摘要： This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.
摘要翻译： 本申请公开了用于生产溶质的冻干蛋糕的装置，制品和方法。 所述装置和制品提供了通过溶液的顶部和底部同时并以大致相同的速率冷冻溶质的溶液的方法。 然后，冷冻溶液可以提供具有大且均匀孔的溶质的冻干饼。
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7.发明申请OPTIMIZATION OF NUCLEATION AND CRYSTALLIZATION FOR LYOPHILIZATION USING GAP FREEZING 有权使用GAP冷冻优化LYOPHILIZATION的核化和结晶公开(公告)号：US20120192448A1
公开(公告)日：2012-08-02
申请号：US13432498
申请日：2012-03-28
IPC分类号： F26B5/06
摘要： This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.
摘要翻译： 本申请公开了用于生产溶质的冻干蛋糕的装置，制品和方法。 所述装置和制品提供了通过溶液的顶部和底部同时并以大致相同的速率冷冻溶质的溶液的方法。 然后，冷冻溶液可以提供具有大且均匀孔的溶质的冻干饼。
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公开(公告)号：US06869653B2
公开(公告)日：2005-03-22
申请号：US09756490
申请日：2001-01-08
申请人： Michael T. K. Ling , William S. Hurst , Lecon Woo , Algirdas Bindokas , Patrick T. Ryan , Scott D. Edwards , Henk P. Blom , Atul R. Khare
发明人： Michael T. K. Ling , William S. Hurst , Lecon Woo , Algirdas Bindokas , Patrick T. Ryan , Scott D. Edwards , Henk P. Blom , Atul R. Khare
IPC分类号： F16L11/04 , A61J1/10 , A61J1/14 , A61L29/12 , A61L31/00 , B29C35/08 , B29C65/04 , B32B1/08 , B32B25/08 , B32B27/08 , B32B27/32 , C08L23/08 , C08L23/12 , C08L23/14 , C08L51/00 , C08L53/02 , C08L75/04 , C08L77/00 , C08L101/00 , C08L47/00
CPC分类号： C08L23/12 , A61L29/126 , B29C65/04 , B29C66/1122 , B29C66/53262 , B29C66/71 , B29C66/7234 , B29C2035/0861 , B32B1/08 , B32B27/08 , B32B27/32 , C08L23/0815 , C08L23/0869 , C08L23/142 , C08L51/00 , C08L53/02 , C08L75/04 , C08L77/00 , C08L101/00 , C08L2314/06 , Y10T428/1352 , Y10T428/1386 , Y10T428/139 , Y10T428/1393 , Y10T428/31746 , Y10T428/31913 , Y10T428/31924 , Y10T428/31931 , C08L2666/24 , C08L2666/04 , B29C65/00 , B29K2079/08 , B29K2077/00 , B29K2075/02 , B29K2075/00 , B29K2067/00 , B29K2033/12 , B29K2033/08 , B29K2023/18 , B29K2023/14 , B29K2023/12 , B29K2023/086 , B29K2023/083 , B29K2023/08 , B29K2021/003 , B29K2009/00
摘要： The present invention provides a flowable material container closure assembly having a port tube and a membrane tube. The port tube (I) has a first layer and a second layer, (A) the first layer is a polymer blend and (B) the second layer is disposed coaxially within the first layer; and the membrane tube (II) is disposed coaxially within the port tube, the membrane tube has an outer layer, a core layer and an inner layer.
摘要翻译： 本发明提供一种具有端口管和膜管的可流动材料容器封闭组件。 端口管（I）具有第一层和第二层，（A）第一层是聚合物共混物，（B）第二层同轴地设置在第一层内; 并且膜管（II）同轴地设置在端口管内，膜管具有外层，芯层和内层。
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