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    Device for franmenting molecules in a sample by ultrasound
    1.
    发明授权
    Device for franmenting molecules in a sample by ultrasound 有权
    用于通过超声波使样品中的分子残留的装置

    公开(公告)号：US09108220B2

    公开(公告)日：2015-08-18

    申请号：US14117378

    申请日：2012-06-05

    申请人： Cristian Bogdan Craus ,  Jacob Marinus Jan Den Toonder ,  Roel Penterman ,  Pieter Jan Van Der Zaag

    发明人： Cristian Bogdan Craus ,  Jacob Marinus Jan Den Toonder ,  Roel Penterman ,  Pieter Jan Van Der Zaag

    IPC分类号： G01N15/06 ,  G01N33/00 ,  G01N33/48 ,  B06B3/00 ,  B02C19/18 ,  C12M1/00 ,  G01N1/28

    CPC分类号： B06B3/00 ,  B02C19/18 ,  C12M47/06 ,  G01N1/286 ,  Y10T29/49826

    摘要： According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.

    摘要翻译： 根据本发明的一个方面，提供了一种通过超声将碎片分子分解的装置。 该装置包括具有容器状形状的平面形状的盒和碎片装置。 通过在破碎仪器中施加低压力，将药筒拉向碎裂仪器，因此空间上封闭由碎裂仪器组成的流体隔室。 之后，可以处理包含在药筒的样品室中的样品的超声处理。 密封层设置在药筒和碎裂仪器之间，以便牢固地保持药筒的固定，以便防止流体隔室泄漏。

    DEVICE FOR FRANMENTING MOLECULES IN A SAMPLE BY ULTRASOUND
    2.
    发明申请
    DEVICE FOR FRANMENTING MOLECULES IN A SAMPLE BY ULTRASOUND 有权
    用超声波法分离样品中的分子的装置

    公开(公告)号：US20140193305A1

    公开(公告)日：2014-07-10

    申请号：US14117378

    申请日：2012-06-05

    申请人： Cristian Bogdan Craus ,  Jacob Marinus Jan Den Toonder ,  Roel Penterman ,  Pieter Jan Van Der Zaag

    发明人： Cristian Bogdan Craus ,  Jacob Marinus Jan Den Toonder ,  Roel Penterman ,  Pieter Jan Van Der Zaag

    IPC分类号： B06B3/00

    CPC分类号： B06B3/00 ,  B02C19/18 ,  C12M47/06 ,  G01N1/286 ,  Y10T29/49826

    摘要： According to an aspect of the present invention, a device for fragmenting molecules in a sample by ultrasound is provided. The device comprises a planar-shaped cartridge and a fragmentation instrument that has a vessel-like shape. By means of applying under-pressure in the fragmentation instrument the cartridge is pulled towards the fragmentation instrument and therefore spatially closes a fluid compartment that is comprised by the fragmentation instrument. Afterwards, an ultrasound treatment of the sample, which is comprised in a sample compartment of the cartridge, may be processed. A sealing layer is provided in between the cartridge and the fragmentation instrument in order to hold the fixation of the cartridge tightly and in order to provide for leakage prevention out of the fluid compartment.

    摘要翻译： 根据本发明的一个方面，提供了一种通过超声将碎片分子分解的装置。 该装置包括具有容器状形状的平面形状的盒和碎片装置。 通过在破碎仪器中施加低压力，将药筒拉向破碎仪器，因此空间上封闭由碎裂仪器组成的流体隔室。 之后，可以处理包含在药筒的样品室中的样品的超声处理。 密封层设置在药筒和碎裂仪器之间，以便牢固地保持药筒的固定，以便防止流体隔室泄漏。

    Patterned cell sheets and a method for production of the same
    4.
    发明授权
    Patterned cell sheets and a method for production of the same 有权
    图案化电池片及其制造方法

    公开(公告)号：US09267109B2

    公开(公告)日：2016-02-23

    申请号：US12746767

    申请日：2008-12-05

    申请人： Emiel Peeters ,  Roel Penterman ,  Ralph Kurt ,  Dirk Jan Wilfred Broer

    发明人： Emiel Peeters ,  Roel Penterman ,  Ralph Kurt ,  Dirk Jan Wilfred Broer

    IPC分类号： C12N5/00

    CPC分类号： C12N5/0068 ,  C12N2535/10 ,  C12N2539/10

    摘要： The present invention is related to a method for the production of cell sheets comprising at least two different cell types, said method comprising the steps of providing a continuous cell sheet which is disposed on a substrate comprising shape transition properties and/or alterable surface characteristics; exposing said continuous cell sheet to a releasing agent in a patterned fashion; washing the cell sheet after exposure to the releasing agent in order to remove cells which have been affected by the releasing agent, and repopulating the gaps remaining after the cells which have been affected by the releasing agent have been removed with a second cell type.

    摘要翻译： 本发明涉及生产包含至少两种不同细胞类型的细胞片的方法，所述方法包括以下步骤：提供设置在包含形状转变特性和/或可变表面特性的基底上的连续细胞片; 以图案方式将所述连续细胞片暴露于脱模剂; 在暴露于脱模剂之后洗涤细胞片以除去已经被脱模剂影响的细胞，并且在第二细胞类型已经去除了已经被脱模剂影响的细胞之后剩余的间隙。

    PROCESS FOR TREATING CULTURED CELLS
    6.
    发明申请
    PROCESS FOR TREATING CULTURED CELLS 审中-公开
    处理培养细胞的方法

    公开(公告)号：US20100124775A1

    公开(公告)日：2010-05-20

    申请号：US12523540

    申请日：2008-01-18

    申请人： Emiel Peeters ,  Dirk Jan Broer ,  Roel Penterman ,  Ralf Kurt ,  Steven Van Lierop

    发明人： Emiel Peeters ,  Dirk Jan Broer ,  Roel Penterman ,  Ralf Kurt ,  Steven Van Lierop

    IPC分类号： C12N13/00 ,  C12N11/00 ,  C12N5/00 ,  B29C39/02

    CPC分类号： C12N5/0068 ,  C12N2533/30 ,  C12N2533/40

    摘要： According to the present invention, a process for treating cultured cells is provided, which comprises the steps of: a) providing planar, two-dimensional objects (“flakes”), wherein these objects comprise a material which, upon application of an extrinsic stimulus, is transferred from the planar state into a rolled state, b) providing cells on said flakes, and c) transferring the flakes from the planar state into a rolled state by application of said extrinsic stimulus.

    摘要翻译： 根据本发明，提供了一种处理培养细胞的方法，其包括以下步骤：a）提供平面的二维物体（“薄片”），其中这些物体包括在施加外在刺激物 从平面状态转移到轧制状态，b）在所述薄片上提供细胞，以及c）通过施加所述外部刺激将薄片从平面状态转移到滚动状态。