公开(公告)号：US20020138075A1

公开(公告)日：2002-09-26

申请号：US10156505

申请日：2002-05-28

Applicant: Curon Medical, Inc.

Inventor： Stuart D. Edwards ,  John W. Gaiser ,  David S. Utley

IPC: A61B018/18

CPC classification number: A61B18/1233 ,  A61B18/1477 ,  A61B18/1492 ,  A61B90/39 ,  A61B2017/00039 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00077 ,  A61B2018/00142 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00702 ,  A61B2018/00738 ,  A61B2018/00791 ,  A61B2018/00821 ,  A61B2018/00839 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00982 ,  A61B2018/0237 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1467 ,  A61B2090/064 ,  A61B2090/3782 ,  A61B2218/002 ,  A61N1/06

Abstract: The present invention comprises a method of treating a sphincter that provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. Bioelectric activity causing a relaxation of the sphincter is detected and energy is delivered from either the mapping electrode or the treatment electrode to treat the bioelectric activity. In another embodiment of the method of the invention, a method of treating a sphincter that provides a sphincter electropotential mapping device with at least one of a mapping electrode or a treatment electrode. The sphincter electropotential mapping device is introduced into at least a portion of the sphincter, the lower esophageal sphincter, stomach, the cardia or the fundus. The sphincter, lower esophageal sphincter, stomach, cardia or fundus is stimulated to produce a transient relaxation of the sphincter. The portion of the sphincter, lower esophageal sphincter, stomach, cardia or fundus causing a relaxation of the sphincter is indentified. Energy is delivered from the sphincter electropotential mapping device to treat the portion the sphincter, lower esophageal sphincter, stomach, cardia or fundus causing the transient relaxation of the sphincter.

Abstract translation: 本发明包括一种治疗括约肌的方法，所述括约肌具有至少一个映射电极或治疗电极提供括约肌电位映射装置。 括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。 检测到引起松弛括约肌的生物电活性，并从映射电极或治疗电极传递能量以处理生物电活性。 在本发明方法的另一个实施方案中，一种治疗括约肌的方法，所述括约肌提供具有映射电极或治疗电极中的至少一个的括约肌电位映射装置。 括约肌电位映射装置被引入至少一部分括约肌，食管下括约肌，胃，贲门或眼底。 括约肌，食管下括约肌，胃，贲门或眼底被刺激以产生括约肌的短暂松弛。 括约肌部分，食管下括约肌，胃，贲门或眼底引起松弛的括约肌是确定的。 能量从括约肌电位测绘装置输送到治疗括约肌，下食道括约肌，胃，贲门或眼底的部分，导致括约肌的暂时松弛。

公开(公告)号：US20020198519A1

公开(公告)日：2002-12-26

申请号：US10212311

申请日：2002-08-05

Applicant: Curon Medical, Inc.

Inventor： Jay Qin ,  Robin Bek ,  John Gaiser ,  Rachel Croft ,  Peter Muller ,  David S. Utley

IPC: A61B018/04

CPC classification number: A61B18/00 ,  A61B18/12 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2017/00017 ,  A61B2017/00199 ,  A61B2017/00482 ,  A61B2018/00011 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00267 ,  A61B2018/00273 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00494 ,  A61B2018/0066 ,  A61B2018/00898 ,  A61B2018/1475 ,  A61B2218/002 ,  G06F19/00 ,  G06Q50/22

Abstract: Unified systems and methods enable control of the use and operation of a family of different treatment devices, to treat dysfunction in different regions of the body.

Abstract translation: 统一的系统和方法能够控制一系列不同治疗装置的使用和操作，以治疗身体不同区域的功能障碍。

公开(公告)号：US20010034518A1

公开(公告)日：2001-10-25

申请号：US09776140

申请日：2001-02-02

Applicant: Curon Medical, Inc.

Inventor： Stuart D. Edwards ,  John W. Gaiser ,  David S. Utley ,  Jay J. Qin

IPC: A61B018/18

CPC classification number: A61B18/1477 ,  A61B17/32 ,  A61B18/1206 ,  A61B18/148 ,  A61B18/1485 ,  A61B18/1492 ,  A61B18/18 ,  A61B18/1815 ,  A61B2017/00084 ,  A61B2017/00106 ,  A61B2017/003 ,  A61B2017/22061 ,  A61B2017/4216 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00029 ,  A61B2018/00065 ,  A61B2018/00077 ,  A61B2018/00083 ,  A61B2018/00113 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00654 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00755 ,  A61B2018/00761 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00815 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00869 ,  A61B2018/00875 ,  A61B2018/00886 ,  A61B2018/00892 ,  A61B2018/00898 ,  A61B2018/0091 ,  A61B2018/00916 ,  A61B2018/00982 ,  A61B2018/0262 ,  A61B2018/046 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1273 ,  A61B2018/1425 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2018/183 ,  A61B2090/3614 ,  A61B2090/3782 ,  A61B2218/002 ,  A61M3/0279 ,  A61M16/0438 ,  A61M16/0481 ,  A61M25/1002 ,  A61M2025/1052 ,  A61M2025/1086 ,  A61N1/056 ,  A61N1/06 ,  A61N1/08 ,  A61N1/40

Abstract: A sphincter treatment apparatus includes an elongated member having at least one lumen including an inflation lumen and a basket assembly with first and second arms. The basket assembly is coupled to the elongated member and has deployed and non-deployed configurations. An inflatable member is coupled to the elongated member and positioned in an interior of the basket assembly. The inflatable member has deployed and non-deployed states and is coupled to the inflation lumen. In the deployed state, the inflatable member expands the basket assembly to its deployed configuration. A first energy delivery device is positionable in the first arm and advanceable from the first arm to a selected treatment site. A second energy delivery device is positionable in the second arm and advanceable from the second arm to a selected treatment site.

公开(公告)号：US20040204708A1

公开(公告)日：2004-10-14

申请号：US10838292

申请日：2004-05-04

Applicant: Curon Medical, Inc.

Inventor： Stuart D. Edwards ,  David S. Utley

IPC: A61B018/18

CPC classification number: A61B18/1477 ,  A61B5/4233 ,  A61B18/0218 ,  A61B18/1492 ,  A61B2017/3445 ,  A61B2017/345 ,  A61B2018/00267 ,  A61B2018/00488 ,  A61B2018/00553 ,  A61B2018/00589 ,  A61B2018/00648 ,  A61B2018/00702 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/0262 ,  A61B2018/0293 ,  A61B2018/046 ,  A61B2018/1861 ,  A61B2018/1869

Abstract: A sphincter treatment apparatus has an introducer means including a distal portion means. An expandable device means includes a plurality of arm means. Each arm means of the plurality has a distal section means and a proximal section means. Each of distal sections means of the arm means are coupled and each of the proximal sections means of the arm means are coupled to the introducer means distal portion means. The expandable device means is configured to at least partially dilate a sphincter in a deployed state. An energy delivery device means is introduceable from the introducer means into a selected site of the sphincter. The energy delivery device means is configured to deliver sufficient energy to reduce a frequency of relaxation of the sphincter.

公开(公告)号：US20040147921A1

公开(公告)日：2004-07-29

申请号：US10405746

申请日：2003-04-02

Applicant: Curon Medical, Inc.

Inventor： Stuart D. Edwards ,  David S. Utley ,  Ronald G. Lax ,  Theodore R. Kucklick ,  Peter H. Muller

IPC: A61B018/18

CPC classification number: A61B18/14 ,  A61B17/32 ,  A61B18/1477 ,  A61B18/1492 ,  A61B18/1815 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00577 ,  A61B2018/00702 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00916 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1472 ,  A61B2018/183 ,  A61B2090/3614 ,  A61B2090/3782

Abstract: A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.

公开(公告)号：US20030024538A1

公开(公告)日：2003-02-06

申请号：US10254471

申请日：2002-09-25

Applicant: Curon Medical, Inc.

Inventor： Stuart D. Edwards ,  David S. Utley ,  Ronald G. Lax ,  John Gaiser

IPC: A61B019/00

CPC classification number: A61B18/1492 ,  A61B18/1206 ,  A61B18/1477 ,  A61B18/18 ,  A61B2018/00011 ,  A61B2018/00029 ,  A61B2018/00047 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/00666 ,  A61B2018/00678 ,  A61B2018/00684 ,  A61B2018/00702 ,  A61B2018/00708 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1425 ,  A61B2218/002

Abstract: A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.

公开(公告)号：US20020123748A1

公开(公告)日：2002-09-05

申请号：US09971085

申请日：2001-10-04

Applicant: Curon Medical, Inc.

Inventor： Stuart D. Edwards ,  David S. Utley

IPC: A61B018/18

CPC classification number: A61B18/1477 ,  A61B5/4233 ,  A61B18/0218 ,  A61B18/1492 ,  A61B2017/3445 ,  A61B2017/345 ,  A61B2018/00267 ,  A61B2018/00488 ,  A61B2018/00553 ,  A61B2018/00589 ,  A61B2018/00648 ,  A61B2018/00702 ,  A61B2018/00821 ,  A61B2018/00827 ,  A61B2018/00875 ,  A61B2018/00892 ,  A61B2018/00994 ,  A61B2018/0262 ,  A61B2018/0293 ,  A61B2018/046 ,  A61B2018/1861 ,  A61B2018/1869

Abstract: A sphincter treatment apparatus has an introducer means including a distal portion means. An expandable device means includes a plurality of arm means. Each arm means of the plurality has a distal section means and a proximal section means. Each of distal sections means of the arm means are coupled and each of the proximal sections means of the arm means are coupled to the introducer means distal portion means. The expandable device means is configured to at least partially dilate a sphincter in a deployed state. An energy delivery device means is introduceable from the introducer means into a selected site of the sphincter. The energy delivery device means is configured to deliver sufficient energy to reduce a frequency of relaxation of the sphincter.

Abstract translation: 括约肌治疗装置具有包括远端部分装置的导引装置。 可扩张装置包括多个臂装置。 多个臂的每个臂装置具有远端部分装置和近端部分装置。 臂装置的每个远端部分装置联接，并且臂装置的每个近端部分装置联接到导引装置远端部分装置。 可扩张装置装置构造成在展开状态下至少部分地扩张括约肌。 能量输送装置装置可从导引器装置引入括约肌的选定部位。 能量递送装置装置被配置为递送足够的能量以减少括约肌的松弛频率。

公开(公告)号：US20020107515A1

公开(公告)日：2002-08-08

申请号：US10046637

申请日：2002-01-14

Applicant: Curon Medical, Inc.

Inventor： Stuart D. Edwards ,  John Gaiser ,  David S. Utley ,  Scott H. West ,  Jay Qin

IPC: A61B018/18

CPC classification number: A61B18/1485 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2017/00867 ,  A61B2018/00148 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00267 ,  A61B2018/00553 ,  A61B2018/00738 ,  A61B2018/046 ,  A61B2018/1425 ,  A61B2090/036 ,  C08L2201/12

Abstract: Improved electrode assemblies for treating a tissue region at or near a sphincter comprise a support structure and an electrode carried by the support structure for advancement in a path to penetrate the tissue region. In one arrangement, the electrode has a non-cylindrical cross section selected to resist deflection when advanced to penetrate the tissue region. In another arrangement, the electrode includes a tissue stop to resist tissue penetration beyond a selected depth. In another arrangement, the electrode includes a proximal portion formed from a first material and a distal tissue penetrating portion formed of a second material different than the first material. The first material can comprise, e.g., stainless steel, and the second material can comprise, e.g., nickel titanium.

Abstract translation: 用于治疗括约肌处或附近的组织区域的改进的电极组件包括支撑结构和由支撑结构承载的电极，用于在穿过组织区域的路径中前进。 在一种布置中，电极具有非圆柱形横截面，其被选择为当前进以穿透组织区域时抵抗偏转。 在另一种布置中，电极包括用于抵抗组织穿透超过选定深度的组织止挡件。 在另一种布置中，电极包括由第一材料形成的近端部分和由不同于第一材料的第二材料形成的远侧组织穿透部分。 第一材料可以包括例如不锈钢，并且第二材料可以包括例如镍钛。

公开(公告)号：US20040089313A1

公开(公告)日：2004-05-13

申请号：US10291862

申请日：2002-11-08

Applicant: Curon Medical, Inc.

Inventor： David S. Utley ,  Rachel E. Croft ,  John W. Gaiser

IPC: A61B019/00

CPC classification number: A61F5/005 ,  A61B18/1477 ,  A61B18/1492 ,  A61B2017/00818 ,  A61B2018/00214 ,  A61B2018/00494 ,  A61B2018/00553 ,  A61B2018/1425 ,  A61B2018/143 ,  A61B2218/002 ,  A61F5/0079 ,  A61F5/0089

Abstract: Systems and methods affect tightening of the pyloric sphincter and/or serve to mediate or moderate receptive relaxation of muscles in the stomach, to treat or mitigate various physiologic conditions, such as obesity, biliary reflex, GERD, and/or Barrett's esophagus. The systems and methods may be used as either a primary treatment modality, or applied as a supplementary treatment before, during or after a primary intervention.

Abstract translation: 系统和方法影响幽门括约肌的收缩和/或用于介导或调节胃中肌肉的接受松弛，治疗或减轻各种生理条件，例如肥胖，胆汁反射，GERD和/或巴雷特食管。 系统和方法可以用作主要治疗方式，或者在主要干预之前，期间或之后作为补充治疗使用。

公开(公告)号：US20030009165A1

公开(公告)日：2003-01-09

申请号：US10230655

申请日：2002-08-29

Applicant: Curon Medical, Inc.

Inventor： Stuart D. Edwards ,  David S. Utley

IPC: A61B018/18

CPC classification number: A61B18/1492 ,  A61B18/1206 ,  A61B18/1477 ,  A61B2017/003 ,  A61B2017/22061 ,  A61B2018/00011 ,  A61B2018/00077 ,  A61B2018/00148 ,  A61B2018/0016 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00553 ,  A61B2018/00654 ,  A61B2018/00726 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/00797 ,  A61B2018/00875 ,  A61B2018/124 ,  A61B2018/1253 ,  A61B2018/126 ,  A61B2018/1467 ,  A61B2018/1472 ,  A61B2090/3782

Abstract: An apparatus to treat a sphincter includes an energy delivery device support member. An energy delivery device is coupled to the energy delivery support member. The energy delivery device has a configuration that controllably produces lesions of a sufficient size and number in the sphincter to create a selectable tightening of the sphincter.

Abstract translation: 治疗括约肌的装置包括能量输送装置支撑构件。 能量输送装置联接到能量输送支撑构件。 能量输送装置具有可控制地产生足够尺寸和数量的括约肌中的损伤以构成括约肌的可选择紧固的构造。