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    Modified variant Bowman Birk protease inhibitors
    7.
    发明授权
    Modified variant Bowman Birk protease inhibitors 有权
    改良型Bowman Birk蛋白酶抑制剂

    公开(公告)号：US08962796B2

    公开(公告)日：2015-02-24

    申请号：US13756337

    申请日：2013-01-31

    Applicant: Danisco US Inc.

    Inventor： Neelam S. Amin ,  Katherine D. Collier ,  Melodie Estabrook ,  David A. Estell ,  Bryan P. Fox ,  Scott D. Power ,  Brian F. Schmidt ,  Gudrun Vogentanz

    IPC: C07K14/00 ,  C07K14/81 ,  A61K8/64

    CPC classification number: C07K14/811 ,  A61K8/64 ,  A61Q7/02

    Abstract: The present invention relates to modified variant Bowman Birk Protease Inhibitor proteins (BBPIs) that comprise peptides that bind target proteins, and that are further modified to have greater protease inhibitory activity and/or be produced at greater yields than the unmodified BBPIs. The invention encompasses polynucleotide constructs and expression vectors containing polynucleotide sequences that encode the modified variant BBPIs, the transformed host cells that express and produce the modified variant BBPIs, the modified variant BBPI proteins, the compositions comprising the modified variant BBPIs, and the methods for making and using the modified variant BBPIs in personal care.

    Abstract translation: 本发明涉及包含结合靶蛋白的肽的修饰变体Bowman Birk蛋白酶抑制剂蛋白（BBPI），并且被进一步修饰以具有比未修饰的BBPI更大的蛋白酶抑制活性和/或以更高的产量产生。 本发明包括多核苷酸构建体和含有编码修饰变体BBPI的多核苷酸序列的表达载体，表达和产生修饰变体BBPI的转化宿主细胞，修饰变体BBPI蛋白，包含修饰变体BBPI的组合物和制备方法 并在个人护理中使用修改后的变体BBPI。

    Alpha-amylase variants
    9.
    发明授权
    Alpha-amylase variants 有权
    α-淀粉酶变体

    公开(公告)号：US09334466B2

    公开(公告)日：2016-05-10

    申请号：US13975048

    申请日：2013-08-23

    Applicant: Danisco US Inc.

    Inventor： Wolfgang Aehle ,  Neelam S. Amin

    IPC: C11D3/386 ,  C12N9/28 ,  C12P21/02 ,  A21D8/04

    CPC classification number: C11D3/38618 ,  A21D8/042 ,  C11D3/386 ,  C12N9/2417 ,  C12P21/02 ,  Y02P20/52

    Abstract: Variants of Bacillus sp. no. 707 alpha-amylase are provided that are produced more efficiently and thus more economically. Higher fermentation yields are achieved through introducing amino acid variations that promote solubility of the variant in a fermentation broth. Increased solubility allows more enzyme to remain in solution after expression in a host cell. This in turn increases the efficiency with which the expressed variant enzyme can be recovered from the fermentation broth.

    Abstract translation: 芽孢杆菌的变种 没有。 提供707α-淀粉酶，其更有效地产生，因此更经济地产生。 通过引入促进变体在发酵液中的溶解度的氨基酸变异来实现更高的发酵产率。 增加的溶解度允许在宿主细胞中表达后更多的酶保留在溶液中。 这又提高了从发酵液中回收表达的变体酶的效率。

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