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公开(公告)号：US09986751B2
公开(公告)日：2018-06-05
申请号：US15102037
申请日：2014-12-11
Applicant: DSM IP ASSETS B.V. , NOVOZYMES A/S
Inventor： Maaike Johanna Bruins , Luppo Edens , Helena Maria Nan
IPC: A23K20/189 , A23K20/174 , A23K10/14 , A23K20/20 , A23K50/75 , A23K50/30 , A61K38/48
CPC classification number: A23K20/189 , A23K10/14 , A23K20/174 , A23K20/30 , A23K50/30 , A23K50/75 , A61K38/488 , C12Y304/23019
Abstract: This invention relates to the use of the Aspergillus niger aspergilloglutamic peptidase in a feed composition containing cereals, pulses, oilseeds, and/or tubers to improve animal performance, reduce nitrogen excretion and/or reduce intestinal inflammation. Furthermore, the present invention relates to a feed composition or a feed additive comprising the Aspergillus niger aspergilloglutamic peptidase. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of efficiently hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat, barley and related cereal species, as well as hydrolyzing trypsin inhibitors that are present in pulses, oilseeds, and tubers. Furthermore, the present invention relates to a method of improving animal performance comprising improving feed conversion ratio, and/or improving daily weight gain, and/or reducing intestinal inflammation, and/or reducing nitrogen excretion in an animal fed a feed stuff containing alpha-amylase and/or trypsin inhibitors, comprising orally administering a sufficient amount of the Aspergillus niger aspergilloglutamic peptidase. It also relates to the pretreatment of feedstuff with the Aspergillus niger aspergilloglutamic peptidase.
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2.发明授权Methods of treatment using water-soluble tryptophan-containing peptides obtained by the hydrolysis of hens eggs lysozyme 有权使用通过水解鸡蛋溶菌酶获得的含有水溶性色氨酸的肽的处理方法公开(公告)号：US09228219B2
公开(公告)日：2016-01-05
申请号：US13694103
申请日：2012-10-31
Applicant: DSM IP Assets B.V.
Inventor： Andre Leonardus De Roos , Luppo Edens , Rudolf Franciscus Van Beckhoven , Alexander Lucia Leonardus Duchateau , Joris Kloek
Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
Abstract translation: 本发明涉及一种制备包含水溶性肽并且Trp / LNAA比大于0.15的组合物的方法，其包括水解溶菌酶，优选鸡蛋溶菌酶，以制备DH为5至45的水解产物 。
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公开(公告)号：US09770493B2
公开(公告)日：2017-09-26
申请号：US14327683
申请日：2014-07-10
Applicant: DSM IP ASSETS B.V.
Inventor： Cinderella Christina Gerhardt , Luppo Edens
IPC: A61K31/405 , A61K38/47 , A23J3/34 , C12P21/06 , A23L33/18
CPC classification number: A61K38/47 , A23J3/341 , A23L33/18 , A61K31/405 , C12P21/06 , C12Y302/01017
Abstract: The present disclosure relates to a composition, and method thereof, which comprises tryptophan whereby 10 to 90%, preferably 20 to 80% of the tryptophan is present as free tryptophan or peptide-bound tryptophan and 10 to 90%, preferably 20 to 80% of the tryptophan is present as polypeptide-bound tryptophan.
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公开(公告)号：US20130231278A1
公开(公告)日：2013-09-05
申请号：US13694103
申请日：2012-10-31
Applicant: DSM IP ASSETS B.V.
Inventor： Andre Leonardus De Roos , Luppo Edens , Rudolf Franciscus Van Beckhoven , Alexander Lucia Leonardus Duchateau , Joris Kloek
Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
Abstract translation: 本发明涉及一种制备包含水溶性肽并且Trp / LNAA比大于0.15的组合物的方法，其包括水解溶菌酶，优选鸡蛋溶菌酶，以制备DH为5至45的水解产物 。
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公开(公告)号：US10196630B2
公开(公告)日：2019-02-05
申请号：US14893186
申请日：2014-06-02
Applicant: DSM IP ASSETS B.V.
Inventor： Aida Hiseni , Igor Galaev , Luppo Edens
Abstract: The present invention relates to immobilized proline-specific endoprotease, wherein the proline-specific endoprotease is immobilized on a carrier comprising methacrylate which has been functionalized with amino dimethylene, and wherein the carrier has a particle size range of 100 to 400 μm. The invention also relates to a process for producing beer comprising the steps of preparing a mash, fermenting the beer, and stabilizing the beer, wherein the beer is incubated with the immobilized proline-specific endoprotease.
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Patent Agency Ranking
公开(公告)号：US20150147365A1
公开(公告)日：2015-05-28
申请号：US14402143
申请日：2013-05-13
Applicant: DSM IP ASSETS B.V.
Inventor： Luppo Edens , Evert Tjeerd Van Rij , Marco Jan Lambertus De Groot
CPC classification number: A61K8/66 , A23G1/423 , A23G3/366 , A23G4/123 , A61K8/0216 , A61K8/23 , A61K8/36 , A61K2800/92 , A61Q11/00 , C12N9/0051 , C12Y108/03004
Abstract: The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host. The invention also provides a polypeptide having methyl mercaptan oxidase activity, wherein said polypeptide is: (a) a polypeptide comprising an amino acid sequence as set out in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence having at least 50% sequence identity with the amino acid sequence of SEQ ID NO: 2; (c) a polypeptide encoded by a polynucleotide comprising the polynucleotide sequence as set out in SEQ ID NO: 1 or SEQ ID NO: 3; or (d) a fragment of a polypeptide as defined in (a), (b) or (c).
Abstract translation: 本发明涉及包含挥发性硫化合物呼吸气味控制量的甲硫醇氧化酶的口服组合物。 口服组合物可用于控制宿主呼吸气味的方法，该方法包括将该组合物施用于该宿主的口腔。 本发明还提供了具有甲硫醇氧化酶活性的多肽，其中所述多肽是：（a）包含SEQ ID NO：2所示氨基酸序列的多肽; （b）包含与SEQ ID NO：2的氨基酸序列具有至少50％序列同一性的氨基酸序列的多肽; （c）由包含SEQ ID NO：1或SEQ ID NO：3所示的多核苷酸序列的多核苷酸编码的多肽; 或（d）（a），（b）或（c）中定义的多肽的片段。
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公开(公告)号：US11576394B2
公开(公告)日：2023-02-14
申请号：US15889952
申请日：2018-02-06
Applicant: DSM IP ASSETS B.V.
Inventor： Petrus Jacobus Theodorus Dekker , Luppo Edens , Maximiliaan Peter Marie De Swaaf , Albertus Alard Van Dijk
Abstract: The present invention describes a intracellular produced lactase, which comprises less than 40 units arylsulfatase activity per NLU of lactase activity. The invention also provides a process comprising treating a substrate with an enzyme preparation, wherein the enzyme preparation is substantially free from arylsulfatase.
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公开(公告)号：US10413599B2
公开(公告)日：2019-09-17
申请号：US15101630
申请日：2014-12-11
Applicant: DSM IP ASSETS B.V.
Inventor： Maaike Johanna Bruins , Luppo Edens , Helena Maria Nan
Abstract: This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed. It also relates to an enzyme composition comprising the Aspergillus niger aspergilloglutamic peptidase and an additional enzyme, and to foodstuff comprising the Aspergillus niger aspergilloglutamic peptidase.
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公开(公告)号：US09993515B2
公开(公告)日：2018-06-12
申请号：US14955287
申请日：2015-12-01
Applicant: DSM IP ASSETS B.V.
Inventor： Andre Leonardus De Roos , Luppo Edens , Rudolf Franciscus Van Beckhoven , Alexander Lucia Leonardus Duchateau , Joris Kloek
Abstract: The present invention relates to a process to produce a composition comprising water-soluble peptides and having a Trp/LNAA ratio of more than 0.15, which comprises hydrolyzing lysozyme, preferably hen eggs lysozyme, to prepare a hydrolysate having a DH of between 5 and 45.
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公开(公告)号：US20150201663A1
公开(公告)日：2015-07-23
申请号：US14420757
申请日：2013-08-13
Applicant: DSM IP ASSETS B.V.
Inventor： Andre Leonardus De Roos , Jing Shi , Luppo Edens
IPC: A23L1/305 , C07K14/805 , A23K1/00
CPC classification number: C07K14/805 , A23J3/34 , A23K10/12 , A23L33/18
Abstract: The present invention relates to a protein hydrolysate, wherein the hydrolysate has a percentage of peptides having a histidine residue at the C-terminal end of at least 10 wt % of the total peptide content of the protein hydrolysate and a process for preparing the protein hydrolysate. The invention further relates to a food or feed product comprising the protein hydrolysate.
Abstract translation: 本发明涉及蛋白质水解产物，其中所述水解产物具有在C-末端具有至少10重量％的蛋白质水解产物的肽含量的至少10重量％的组氨酸残基的肽百分比和制备蛋白质水解产物的方法 。 本发明还涉及包含蛋白质水解产物的食品或饲料产品。
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