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公开(公告)号：US06844998B2
公开(公告)日：2005-01-18
申请号：US10103359
申请日：2002-03-20
申请人： Daigo Aoki , Kenji Honda , Kiyoshi Sato , Naoya Hasegawa , Yukie Nakazawa
发明人： Daigo Aoki , Kenji Honda , Kiyoshi Sato , Naoya Hasegawa , Yukie Nakazawa
CPC分类号： G11B5/3903 , H01L43/08
摘要： Assuming that a distance between an upper shield layer and a lower shield layer in an area, which overlaps only a first electrode layer, but does not overlap a second electrode layer, is G1s, and a distance between the upper shield layer and the lower shield layer at a position in alignment with a center of a multilayered film is G1c, a difference in value between G1s and G1c is set to be not larger than a predetermined value, whereby an effective track (read) width can be reduced.
摘要翻译： 假设在仅与第一电极层重叠但不与第二电极层重叠的区域中的上屏蔽层和下屏蔽层之间的距离为G1s，并且上屏蔽层和下屏蔽层之间的距离 在与多层膜的中心对准的位置处的层是G1c，G1s和G1c之间的值之差被设定为不大于预定值，从而可以减少有效的轨迹（读取）宽度。
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公开(公告)号：US6074707A
公开(公告)日：2000-06-13
申请号：US18919
申请日：1998-02-05
CPC分类号： B82Y25/00 , H01F10/3268 , H01F41/32 , H01L43/12
摘要： The present invention provides a method of producing a magnetoresistive element in which a laminate including a free ferromagnetic layer in which at least magnetization is freely rotated according to an external magnetic field, a non-magnetic layer, and a pinned ferromagnetic layer in which reversal of magnetization is pinned is formed, and is heat-treated for setting different directions of the easy axis of magnetization of the free ferromagnetic layer and the pinned ferromagnetic layer under different conditions. In the heat treatment, first annealing is performed at the predetermined temperature in a magnetic field applied in a first direction, and second annealing is performed in a magnetic field applied in a second direction substantially perpendicular to the first direction so that the easy axis of magnetization of the free ferromagnetic layer is substantially perpendicular to that of the pinned ferromagnetic layer.
摘要翻译： 本发明提供了一种制造磁阻元件的方法，其中包括自由铁磁层的层压体，其中至少磁化根据外部磁场自由旋转，非磁性层和固定的铁磁层，其中反转 形成磁化，并对不同条件下的自由铁磁层和被固定铁磁层的易磁化轴的不同方向进行热处理。 在热处理中，在施加于第一方向的磁场中，在规定温度下进行第一退火，在与第一方向大致正交的第二方向施加的磁场中进行第二退火，使得易磁化轴 的自由铁磁层基本上垂直于被钉扎的铁磁层。
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3.发明授权公开(公告)号：US06282069B1
公开(公告)日：2001-08-28
申请号：US09062027
申请日：1998-04-17
IPC分类号： G11B5127
CPC分类号： B82Y25/00 , B82Y10/00 , B82Y40/00 , G11B5/3903 , G11B2005/3996 , G11C11/1675 , H01F10/3268 , H01F41/304 , Y10T29/49032 , Y10T29/49034 , Y10T29/49043 , Y10T29/49044 , Y10T29/49055
摘要： A second antiferromagnetic layer formed on a free magnetic layer has a blocking temperature lower than that of a first antiferromagnetic layer. The exchange anisotropic magnetic field between the free magnetic layer and the second antiferromagnetic layer is smaller than the exchange anisotropic magnetic field between the first antiferromagnetic layer and the pinned magnetic layer. By applying an annealing treatment utilizing the blocking temperature difference between the first and second antiferromagnetic layers, the magnetization direction and the strength of the pinned magnetic layer and the free magnetic layer can be controlled appropriately.
摘要翻译： 形成在自由磁性层上的第二反铁磁层的阻挡温度低于第一反铁磁性层的阻挡温度。 自由磁性层与第二反铁磁性层之间的交换各向异性磁场小于第一反铁磁性层与被钉扎磁性层之间的交换各向异性磁场。 通过利用第一和第二反铁磁层之间的阻挡温度差进行退火处理，可以适当地控制磁化方向和钉扎磁性层和自由磁性层的强度。
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公开(公告)号：US06591479B2
公开(公告)日：2003-07-15
申请号：US09538336
申请日：2000-03-29
IPC分类号： G11B5127
CPC分类号： B82Y25/00 , B82Y10/00 , B82Y40/00 , G11B5/3903 , G11B2005/3996 , G11C11/1675 , H01F10/3268 , H01F41/304 , Y10T29/49032 , Y10T29/49034 , Y10T29/49043 , Y10T29/49044 , Y10T29/49055
摘要： A production method for a spin-valve type magnetoresistive element comprising laminating an antiferromagnetic layer, a pinned magnetic layer, a non-magnetic electrically conductive layer, a free magnetic layer, and a second antiferromagnetic layer. The second antiferromagnetic layer is located on the free magnetic layer and orients the magnetization direction of the free magnetic layer. In this method, a first thermal treatment is performed at a first temperature of ordering a crystal structure of the first antiferromagnetic layer or at a second temperature lower than a second blocking temperature of the second antiferromagnetic layer. After the first thermal treatment, a second thermal treatment is performed at a third temperature lower than a first blocking temperature of the first antiferromagnetic layer but higher than said second blocking temperature of the second antiferromagnetic layer.
摘要翻译： 一种自旋阀型磁阻元件的制造方法，包括层叠反铁磁性层，钉扎磁性层，非磁性导电层，自由磁性层和第二反铁磁性层。 第二反铁磁层位于自由磁性层上并定向自由磁性层的磁化方向。 在该方法中，在排列第一反铁磁层的晶体结构的第一温度或低于第二反铁磁性层的第二阻挡温度的第二温度下进行第一热处理。 在第一热处理之后，在比第一反铁磁层的第一阻挡温度低的第三温度下进行第二热处理，但高于第二反铁磁性层的所述第二阻挡温度。
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公开(公告)号：US20080176274A1
公开(公告)日：2008-07-24
申请号：US11926918
申请日：2007-10-29
申请人： Tomohiro TSUJI , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
发明人： Tomohiro TSUJI , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
IPC分类号： C12Q1/04
CPC分类号： G01N33/52 , G01N2015/1477
摘要： 1. A method for classifying and counting leukocytes, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent, with a fluorescent dye; (2) a step of introducing the sample containing the stained cells into a flow cytometer to measure first scattered light, second scattered light different from the first scattered light and fluorescence of the respective cells; (3) a step of obtaining scattered light peak intensities and scattered light widths of the respective cells based on the measured first scattered light, obtaining scattered light intensities of the respective cells based on the measured second scattered light, and obtaining fluorescece intensities of the respective cells based on the measured fluorescence light; (4) a step of classifying the cells into a first group and a second group based on the scattered light peak intensities and the scattered light widths, the first group including leukocytes and second group including platelet clumps; (5) a step of classifying the leukocytes included in the first group into at least lymphocytes, monocytes and granulocytes based on the scattered light intensities and the fluorescence intensities; and (6) a step of counting the classified lymphocytes, the classified monocytes and the classified granulocytes.
摘要翻译： 1.一种白细胞分类和计数方法，其特征在于：（1）通过用溶血剂用荧光染料处理从血液样品获得的样品中染色细胞的步骤; （2）将含有染色细胞的样品引入流式细胞仪中以测量第一散射光，与第一散射光不同的第二散射光和各细胞的荧光的步骤; （3）基于所测量的第一散射光获得各个单元的散射光峰强度和散射光宽度的步骤，基于测量的第二散射光获得各个单元的散射光强度，并获得各个单元的荧光强度 基于测量荧光的细胞; （4）基于散射光峰强度和散射光宽度，将细胞分类为第一组和第二组的步骤，所述第一组包括白细胞，第二组包括血小板聚集; （5）基于散射光强度和荧光强度，将包含在第一组中的白细胞分类为至少淋巴细胞，单核细胞和粒细胞的步骤; 和（6）计数分类的淋巴细胞，分类的单核细胞和分类的粒细胞的步骤。
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公开(公告)号：US07625730B2
公开(公告)日：2009-12-01
申请号：US10517422
申请日：2003-06-23
申请人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
发明人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
IPC分类号： C12N13/00
CPC分类号： G01N33/52 , G01N2015/1477
摘要： There is provided a method for classifying and counting leukocytes with abnormal DNA amount, which comprises: (1) a step of staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent to lyse erythrocytes, with a fluorescent dye which can make a difference in the fluorescence intensity at least among mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes; (2) a step of introducing the sample containing the stained cells into a flow cytometer to measure scattered light and fluorescence of the respective cells; (3) a step of classifying leukocytes and coincidence cells/platelet clumps utilizing a difference in the intensity of a scattered light peak and a difference in the scattered light width; (4) a step of classifying and counting mature leukocytes, leukocytes with abnormal DNA amount and immature leukocytes, utilizing a difference in the scattered light intensity and a difference in the fluorescence intensity of leukocytes classified in the step (3).
摘要翻译： 提供了一种用于对异常DNA量进行白细胞分类和计数的方法，其包括：（1）通过用溶血剂处理从血液样品获得的样品中的细胞染色红细胞裂解红细胞的步骤，可以使用荧光染料 至少在成熟白细胞，具有异常DNA量的白细胞和未成熟白细胞之间的荧光强度差异; （2）将含有染色细胞的样品引入流式细胞仪中以测量各细胞的散射光和荧光的步骤; （3）利用散射光峰的强度和散射光宽度的差异来分类白细胞和符合细胞/血小板结块的步骤; （4）利用步骤（3）中分类的散射光强度和白细胞的荧光强度差异，对成熟白细胞，具有异常DNA量的白细胞和未成熟白细胞进行分类和计数的步骤。
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公开(公告)号：US07923229B2
公开(公告)日：2011-04-12
申请号：US11926918
申请日：2007-10-29
申请人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
发明人： Tomohiro Tsuji , Toshihiro Mizukami , Aya Konishi , Yusuke Mori , Yukie Nakazawa
IPC分类号： C12N13/00
CPC分类号： G01N33/52 , G01N2015/1477
摘要： A method for classifying and counting leukocytes, which comprises steps of: staining cells in a sample obtained from a hematological sample by treatment with a hemolytic agent, with a fluorescent dye; introducing the sample containing the stained cells into a flow cytometer to measure first scattered light, second scattered light different from the first scattered light and fluorescence of the respective cells; obtaining scattered light peak intensities and scattered light widths of the respective cells based on the measured first scattered light, obtaining scattered light intensities of the respective cells based on the measured second scattered light, and obtaining fluorescence intensities of the respective cells based on the measured fluorescence light; classifying the cells into a first group and a second group based on the scattered light peak intensities and the scattered light widths, the first group including leukocytes and second group including platelet clumps; classifying the leukocytes included in the first group into at least lymphocytes, monocytes and granulocytes based on the scattered light intensities and the fluorescence intensities; and counting the classified lymphocytes, the classified monocytes and the classified granulocytes.
摘要翻译： 一种白细胞分类和计数方法，其特征在于包括以下步骤：用溶血剂用荧光染料染色从血液样品中获得的样品中的细胞; 将含有染色细胞的样品引入流式细胞仪中以测量第一散射光，与第一散射光不同的第二散射光和各细胞的荧光; 基于所测量的第一散射光获得各个单元的散射光峰强度和散射光宽度，基于测量的第二散射光获得各个单元的散射光强度，并且基于测量的荧光获得各个单元的荧光强度 光; 基于散射光峰强度和散射光宽度将细胞分类为第一组和第二组，第一组包括白细胞和第二组包括血小板聚集; 基于散射光强度和荧光强度，将第一组中包含的白细胞分类为至少淋巴细胞，单核细胞和粒细胞; 并对分类的淋巴细胞，分类的单核细胞和分类的粒细胞进行计数。
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8.发明申请公开(公告)号：US20060089810A1
公开(公告)日：2006-04-27
申请号：US11255576
申请日：2005-10-21
申请人： Teruya Matsumoto , Yukie Nakazawa
发明人： Teruya Matsumoto , Yukie Nakazawa
CPC分类号： G01N35/00603 , G01N15/0205 , G01N35/028 , G01N2015/0092 , G01N2015/0693
摘要： In a biological sample analyzing apparatus and method, an assay sample is prepared by mixing a reagent with a biological sample which may contain assay material. Then, a first information relating to the assay material is collected from the assay sample, and when the first information satisfies predetermined condition, the assay material is analyzed based on the first information. However, when the first information does not satisfy the predetermined condition, a second information related to the assay material is collected from the assay sample, and the assay material is analyzed based on the second information.
摘要翻译： 在生物样品分析装置和方法中，通过将试剂与可能含有测定材料的生物样品混合来制备测定样品。 然后，从测定样品收集与测定材料有关的第一信息，并且当第一信息满足预定条件时，基于第一信息分析测定材料。 然而，当第一信息不满足预定条件时，从测定样品收集与测定材料相关的第二信息，并且基于第二信息分析测定材料。
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9.发明授权Method of manufacturing spin-valve type thin film element having remagnetized bias layer 有权制造具有再磁化偏置层的自旋阀型薄膜元件的方法
公开(公告)号：US6157524A
公开(公告)日：2000-12-05
申请号：US191088
申请日：1998-11-12
申请人： Yukie Nakazawa , Masamichi Saito
发明人： Yukie Nakazawa , Masamichi Saito
CPC分类号： B82Y25/00 , B82Y10/00 , B82Y40/00 , G11B5/3903 , H01F10/3268 , H01F41/304 , G11B2005/3996 , G11B5/31 , G11B5/3967
摘要： A spin-valve type thin film element includes an antiferromagnetic layer; a fixed magnetic layer formed so as to be in contact with the antiferromagnetic layer, the magnetization direction of the fixed magnetic layer being fixed by the exchange anisotropic magnetic field between the fixed magnetic layer and the antiferromagnetic layer; a free magnetic layer formed on the fixed magnetic layer with a nonmagnetic conductive layer therebetween; a bias layer for setting the magnetization direction of the free magnetic layer in the direction perpendicular to the magnetization direction of the fixed magnetic layer; and a conductive layer for applying a sensing current into the fixed magnetic layer, the nonmagnetic conductive layer, and the free magnetic layer. The magnetization of the fixed magnetic layer in the central region is fixed in the height direction, and the magnetization of the fixed magnetic layer in the end regions is fixed in the direction inclined in relation to the height direction. A method of manufacturing such a spin-valve type thin film element is also disclosed.
摘要翻译： 自旋阀型薄膜元件包括反铁磁层; 形成为与反铁磁层接触的固定磁性层，固定磁性层的磁化方向由固定磁性层和反铁磁层之间的交换各向异性磁场固定; 形成在固定磁性层上的自由磁性层，其间具有非磁性导电层; 偏置层，用于在与固定磁性层的磁化方向垂直的方向上设定自由磁性层的磁化方向; 以及用于将感测电流施加到固定磁性层，非磁性导电层和自由磁性层中的导电层。 中心区域中的固定磁性层的磁化在高度方向上固定，并且端部区域中的固定磁性层的磁化在相对于高度方向倾斜的方向上是固定的。 还公开了制造这种自旋阀型薄膜元件的方法。
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公开(公告)号：US09568488B2
公开(公告)日：2017-02-14
申请号：US11255576
申请日：2005-10-21
申请人： Teruya Matsumoto , Yukie Nakazawa
发明人： Teruya Matsumoto , Yukie Nakazawa
CPC分类号： G01N35/00603 , G01N15/0205 , G01N35/028 , G01N2015/0092 , G01N2015/0693
摘要： In a biological sample analyzing apparatus and method, an assay sample is prepared by mixing a reagent with a biological sample which may contain assay material. Then, a first information relating to the assay material is collected from the assay sample, and when the first information satisfies predetermined condition, the assay material is analyzed based on the first information. However, when the first information does not satisfy the predetermined condition, a second information related to the assay material is collected from the assay sample, and the assay material is analyzed based on the second information.
摘要翻译： 在生物样品分析装置和方法中，通过将试剂与可能含有测定材料的生物样品混合来制备测定样品。 然后，从测定样品收集与测定材料有关的第一信息，并且当第一信息满足预定条件时，基于第一信息分析测定材料。 然而，当第一信息不满足预定条件时，从测定样品收集与测定材料相关的第二信息，并且基于第二信息分析测定材料。
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