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    Film-form preparation
    4.
    发明授权
    Film-form preparation 有权
    电影形式准备

    公开(公告)号：US08383145B2

    公开(公告)日：2013-02-26

    申请号：US13014245

    申请日：2011-01-26

    申请人： Daisuke Asari ,  Mitsuhiko Hori ,  Takuya Shishido

    发明人： Daisuke Asari ,  Mitsuhiko Hori ,  Takuya Shishido

    IPC分类号： A61K48/00

    CPC分类号： A61K9/006 ,  A61K9/1623 ,  A61K9/7007 ,  A61K47/38

    摘要： An object of the present invention is to provide a film-form preparation to be used in desensitization therapy and a method for producing the same. This film-form preparation enables the patient to self-administer an allergen and adjust the dose, has excellent portability, has no residual sensation, provides excellent protection against accidental swallowing, is easy for a caregiver to administer, and can greatly improve the QOL of both patients and caregivers. Additionally, this film-form preparation enables arbitrary control of the dissolution time in the mouth, particularly sublingually and has very little gummy sensation in the mouth and better feeling when touched by the fingers. A film-form preparation including: an allergen; an edible polymer that is soluble in both water and a polar organic solvent; and one or two or more types of particles selected from the group consisting of monosaccharide to hexasaccharide sugars and sugar alcohols thereof that have an average particle size of 0.1 to 100 μm.

    摘要翻译： 本发明的目的是提供一种用于脱敏治疗的薄膜状制剂及其制造方法。 这种胶片形式的准备使患者能够自我管理过敏原并调整剂量，具有优异的携带性，无残留感，提供极好的防止意外吞咽的保护作用，易于护理人员进行管理，可大大提高患者的生活质量 病人和护理人员。 此外，该膜形式的制备能够任意地控制口中的溶解时间，特别是舌下，并且在口中具有非常小的粘性感，并且当被手指触摸时具有更好的感觉。 一种膜形成制剂，包括：变应原; 可溶于水和极性有机溶剂的可食用聚合物; 以及选自平均粒径为0.1〜100μm的选自单糖至六糖的一种或两种以上的粒子及其糖醇。

    Oral film-form base and oral film-form preparation
    5.
    发明授权
    Oral film-form base and oral film-form preparation 有权
    口服薄膜形式基础和口服膜形式制备

    公开(公告)号：US09289386B2

    公开(公告)日：2016-03-22

    申请号：US13146829

    申请日：2009-03-06

    申请人： Daisuke Asari ,  Mitsuhiko Hori ,  Keiko Ogawa

    发明人： Daisuke Asari ,  Mitsuhiko Hori ,  Keiko Ogawa

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/26 ,  A61K47/38

    CPC分类号： A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/38

    摘要： The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a solubility parameter of 9.7 or higher, an edible polymer soluble in water and the organic solvent, and particles of one or two or more compounds selected from the group consisting of mono- to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 μm to 60 μm and are insoluble in an organic solvent. The present invention can therefore provide oral film-form base and preparation which have a rapid dissolution profile in the mouth and sufficient film strength, and provide a reduced sticky sensation attributed to the water-soluble polymer in the mouth and an improved feel when handled with the fingers.

    摘要翻译： 本发明提供一种具有分散为细颗粒的一种或多种糖或糖醇的薄膜形式的底物，并且还提供含有该基质和药物的薄膜形式的制剂。 该碱是通过在溶解度参数为9.7以上的有机溶剂中分散可溶于水和有机溶剂的可食性聚合物，以及一种或两种以上选自单 - 六 糖和糖醇，其平均粒度为0.1〜60μm，不溶于有机溶剂。 因此，本发明可以提供在口腔中具有快速溶出曲线并具有足够的膜强度的口腔膜形式的基质和制剂，并且在口腔中提供归因于水溶性聚合物的降低的粘稠感和当用 手指。

    ORAL FILM-FORM BASE AND ORAL FILM-FORM PREPARATION
    6.
    发明申请
    ORAL FILM-FORM BASE AND ORAL FILM-FORM PREPARATION 有权
    口腔膜形式和口腔膜形成准备

    公开(公告)号：US20110293673A1

    公开(公告)日：2011-12-01

    申请号：US13146829

    申请日：2009-03-06

    申请人： Daisuke Asari ,  Mitsuhiko Hori ,  Keiko Ogawa

    发明人： Daisuke Asari ,  Mitsuhiko Hori ,  Keiko Ogawa

    IPC分类号： A61K9/00 ,  A61P25/06 ,  A61K31/135 ,  A61P37/08 ,  A61K31/18 ,  A61P13/08 ,  A61P1/08 ,  A61K31/437 ,  A61K31/426 ,  A61P1/04 ,  A61K31/4184 ,  A61P9/12 ,  A61K31/4439 ,  A61P3/10 ,  A61K31/4418 ,  A61K31/445 ,  A61K31/422

    CPC分类号： A61K9/0056 ,  A61K9/7007 ,  A61K47/26 ,  A61K47/38

    摘要： The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a solubility parameter of 9.7 or higher, an edible polymer soluble in water and the organic solvent, and particles of one or two or more compounds selected from the group consisting of mono- to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 μm to 60 μm and are insoluble in an organic solvent. The present invention can therefore provide oral film-form base and preparation which have a rapid dissolution profile in the mouth and sufficient film strength, and provide a reduced sticky sensation attributed to the water-soluble polymer in the mouth and an improved feel when handled with the fingers.

    摘要翻译： 本发明提供一种具有分散为细颗粒的一种或多种糖或糖醇的薄膜形式的底物，并且还提供含有该基质和药物的薄膜形式的制剂。 该碱是通过在溶解度参数为9.7以上的有机溶剂中分散可溶于水和有机溶剂的可食性聚合物，以及一种或两种以上选自单 - 六 糖和糖醇，其平均粒度为0.1〜60μm，不溶于有机溶剂。 因此，本发明可以提供在口腔中具有快速溶出曲线并具有足够的膜强度的口腔膜形式的基质和制剂，并且在口腔中提供归因于水溶性聚合物的降低的粘稠感和当用 手指。

    Oral film-form base and oral film-form preparation
    7.
    发明授权
    Oral film-form base and oral film-form preparation 有权

    公开(公告)号：US09238004B2

    公开(公告)日：2016-01-19

    申请号：US13146829

    申请日：2009-03-06

    申请人： Daisuke Asari ,  Mitsuhiko Hori ,  Keiko Ogawa

    发明人： Daisuke Asari ,  Mitsuhiko Hori ,  Keiko Ogawa

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K47/26 ,  A61K47/38

    摘要： The present invention provides a film-form base having one or more sugars or sugar alcohols dispersed as fine particles therein, and also provides a film-form preparation containing the base and a drug. The base is produced by dispersing, in an organic solvent having a solubility parameter of 9.7 or higher, an edible polymer soluble in water and the organic solvent, and particles of one or two or more compounds selected from the group consisting of mono- to hexasaccharide sugars and sugar alcohols thereof which have an average particle size of 0.1 μm to 60 μm and are insoluble in an organic solvent. The present invention can therefore provide oral film-form base and preparation which have a rapid dissolution profile in the mouth and sufficient film strength, and provide a reduced sticky sensation attributed to the water-soluble polymer in the mouth and an improved feel when handled with the fingers.

    Percutaneous administration tape preparation
    8.
    发明授权
    Percutaneous administration tape preparation 失效
    经皮给药胶带制剂

    公开(公告)号：US5814032A

    公开(公告)日：1998-09-29

    申请号：US855897

    申请日：1997-05-12

    申请人： Mitsuhiko Hori ,  Katsuhiro Yamamoto ,  Tetsuo Watanabe

    发明人： Mitsuhiko Hori ,  Katsuhiro Yamamoto ,  Tetsuo Watanabe

    IPC分类号： A61K9/70 ,  A61K45/00 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61F13/02 ,  B32B9/04

    CPC分类号： A61K9/7053 ,  A61K9/7061

    摘要： There provided a percutaneous administration tape preparation which can attach well to the skin surface even in the case of the permeation of water after attaching and can be easily detached from the skin surface without giving the skin simulation such as peeling off and the injury of the horny layer. The percutaneous administration tape preparation comprises a sheet-form support, a drug-containing pressure-sensitive adhesive layer, and a separator, wherein the drug-containing pressure-sensitive adhesive layer comprises a uniform dispersed state containing from 50 to 95% by weight one or more kinds of elastomers, from 5 to 50% by weight a hygroscopic material, and a percutaneous absorption drug so that a part of the hygroscopic material contained therein remains on the applied surface at detaching the tape preparation from the applied surface.

    摘要翻译： 提供了经皮给药胶带制剂，即使在附着后水渗透的情况下也能很好地附着于皮肤表面，并且可以容易地从皮肤表面脱离，而不会产生皮肤模拟，例如剥离和角质的损伤 层。 经皮给药带制剂包括片状载体，含药物的压敏粘合剂层和隔膜，其中含药物的压敏粘合剂层包含均匀的分散状态，其含有50至95重量％的一种 或更多种类的弹性体，5至50重量％的吸湿材料和经皮吸收药物，使得其中包含的部分吸湿材料残留在施用的表面上，以将带制剂从施用的表面上分离。

    Preparation for transdermal drug administration
    9.
    发明授权
    Preparation for transdermal drug administration 失效
    透皮给药制剂

    公开(公告)号：US5368860A

    公开(公告)日：1994-11-29

    申请号：US798149

    申请日：1991-11-26

    申请人： Masaki Sunami ,  Koji Maruyama ,  Mitsuhiko Hori ,  Shoichi Tokuda ,  Kenichiro Saito ,  Ikuo Kishi

    发明人： Masaki Sunami ,  Koji Maruyama ,  Mitsuhiko Hori ,  Shoichi Tokuda ,  Kenichiro Saito ,  Ikuo Kishi

    IPC分类号： A61K9/70 ,  A61K31/165 ,  A61K31/245 ,  A61K31/46 ,  A61K31/47 ,  A61K45/00 ,  A61P23/02 ,  A61P25/02 ,  A61P25/04 ,  A61F13/02

    CPC分类号： A61K9/7061 ,  A61K31/165

    摘要： A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.

    摘要翻译： 用于经皮给药的制剂包括柔性背衬层和含有40-65重量％比例的局部麻醉剂的压敏粘合剂层。 由于粘合剂层中未溶解的局部麻醉剂（Ac）与溶解的局部麻醉剂（As）Ac / As的比例确定为0.1-1.8，所以制剂 对于本发明的透皮给药，自身粘合性优异，从皮肤上除去时没有粘合剂。 此外，在施用于皮肤之后立即从压敏粘合剂层中爆发出的未溶解药物的释放允许快速出现麻醉效果，这使得本发明的制剂能够广泛的临床应用。

    Adhesive preparation containing fentanyl
    10.
    发明授权
    Adhesive preparation containing fentanyl 有权
    含芬太尼的粘合剂

    公开(公告)号：US08591939B2

    公开(公告)日：2013-11-26

    申请号：US11196935

    申请日：2005-08-04

    申请人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

    发明人： Yuji Saeki ,  Masato Nishimura ,  Kensuke Matsuoka ,  Takateru Muraoka ,  Yoshifumi Hosaka ,  Mitsuhiko Hori ,  Kazuhisa Ninomiya ,  Hitoshi Akemi ,  Hidetoshi Kuroda

    IPC分类号： A61K31/445 ,  A61F13/02

    CPC分类号： A61K9/7053 ,  A61K31/4468

    摘要： The present invention provides a Fentanyl-containing percutaneously absorbable adhesive preparation, which is obtained from economic starting materials, has a constitution simpler than that of conventional ones, has sufficient skin permeability, and which permits control of skin permeability by changing the mixing ratio of two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid. Specifically, the present invention provides a percutaneously absorbable adhesive preparation comprising a support and an adhesive layer laminated on one surface thereof, wherein the adhesive layer comprises Fentanyl, two kinds of polyisobutylene having different molecular weights, a tackifier and an organic liquid compatible with the aforementioned two kinds of polyisobutylene and the aforementioned tackifier.

    摘要翻译： 本发明提供了一种经济起始材料得到的含有芬太尼的经皮吸收性粘合剂制剂，其结构比以往更简单，具有足够的皮肤渗透性，并且通过改变两者的混合比可以控制皮肤渗透性 种类具有不同分子量的聚异丁烯，增粘剂和有机液体。 具体地说，本发明提供了一种经皮吸收性粘合剂制剂，其包含在其一个表面上层叠的载体和粘合剂层，其中所述粘合剂层包括芬太尼，两种具有不同分子量的聚异丁烯，增粘剂和与上述相容的有机液体 两种聚异丁烯和上述增粘剂。