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1.发明申请HYDROPHOBIC POLYSACCHARIDES WITH DIESTER- OR CARBONATE ESTER-CONTAINING LINKAGES HAVING ENHANCED DEGRADATION 失效具有增强降解性的含有碳酸钙或含碳酸酯的链接的疏水性多糖公开(公告)号：US20100316687A1
公开(公告)日：2010-12-16
申请号：US12814109
申请日：2010-06-11
申请人： Dale G. Swan , Emily R. Rolfes Meyering , Aleksey V. Kurdyumov , Stephen J. Chudzik , Pamela J. Reed
发明人： Dale G. Swan , Emily R. Rolfes Meyering , Aleksey V. Kurdyumov , Stephen J. Chudzik , Pamela J. Reed
CPC分类号： A61K9/0024 , A61K47/36 , C08B30/18 , C08B37/0009
摘要： Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
摘要翻译： 描述了具有增强的降解性质的疏水性α（1→4）吡喃葡萄糖聚合物。 在α（1→4）吡喃葡萄糖聚合物部分和疏水部分之间存在具有促进聚合物降解的化学物质的接头部分。 二酯和碳酸酯接头化学品被列举。 可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够以增加的速率在体内降解。 还描述了包括和能够在体内释放生物活性剂的基质。
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2.发明授权公开(公告)号：US08586731B2
公开(公告)日：2013-11-19
申请号：US12814109
申请日：2010-06-11
CPC分类号： A61K9/0024 , A61K47/36 , C08B30/18 , C08B37/0009
摘要： Hydrophobic α(1→4)glucopyranose polymers with enhanced degradation properties are described. Between the α(1→4)glucopyranose polymeric portion and the hydrophobic portion exists a linker portion having a chemistry that facilitates degradation of the polymer. Diester and carbonate ester linker chemistries are exemplified. Biodegradable matrices can be formed from these polymers, and the matrices can be used for the preparation of implantable and injectable medical devices wherein the matrix is capable of degrading in vivo at an increased rate. Matrices including and capable of releasing a bioactive agent in vivo are also described.
摘要翻译： 描述了具有增强的降解性质的疏水性α（1-> 4）吡喃葡萄糖聚合物。 在α（1-> 4）吡喃葡萄糖聚合物部分和疏水部分之间存在具有促进聚合物降解的化学物质的连接部分。 二酯和碳酸酯接头化学品被列举。 可以由这些聚合物形成可生物降解的基质，并且该基质可用于制备可植入和可注射的医疗装置，其中基质能够以增加的速率在体内降解。 还描述了包括和能够在体内释放生物活性剂的基质。
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3.发明申请SILANE-FUNCTIONALIZED HYDROPHOBIC a(1-4)GLUCOPYRANOSE POLYMERS AND POLYMERIC MATRICES FOR IMPLANTATION OR INJECTION 有权硅烷官能化的疏水性（1-4）葡聚糖聚合物和用于植入或注射的聚合物基质公开(公告)号：US20100303879A1
公开(公告)日：2010-12-02
申请号：US12792365
申请日：2010-06-02
CPC分类号： A61K39/39591 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/624 , C07K2317/55 , Y10T428/31663 , C08L71/02 , C08L67/04
摘要： Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic α(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
摘要翻译： 描述了硅烷官能化的疏水性α（1→4）吡喃葡萄糖聚合物和聚合物基质。 生物可降解基质可以由具有反应性侧挂甲硅烷基醚基团的疏水性α（1→4）吡喃葡萄糖聚合物形成。 甲硅烷基醚基团的反应通过结合到器件的器件表面，聚合物 - 聚合物交联或两者来提供改进的基质形成。 可生物降解基质可用于制备可植入和可注射的医疗器械，包括那些释放生物活性剂的医疗器械。
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4.发明授权Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices for implantation or injection 有权硅烷官能化疏水性α（1→4）吡喃葡萄糖聚合物和聚合物基质用于植入或注射公开(公告)号：US08802121B2
公开(公告)日：2014-08-12
申请号：US12792365
申请日：2010-06-02
CPC分类号： A61K39/39591 , A61L17/005 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/624 , C07K2317/55 , Y10T428/31663 , C08L71/02 , C08L67/04
摘要： Silane-functionalized hydrophobic α(1→4)glucopyranose polymers and polymeric matrices are described. Biodegradable matrices can be formed from hydrophobic α(1→4)glucopyranose polymers with reactive pendent silyl ether groups. Reaction of the silyl ether groups provides improved matrix formation through bonding to a device surface of a device, polymer-polymer crosslinking, or both. Biodegradable matrices can be used for the preparation of implantable and injectable medical devices, including those that release a bioactive agent.
摘要翻译： 描述了硅烷官能化的疏水性α（1→4）吡喃葡萄糖聚合物和聚合物基质。 生物可降解基质可以由具有反应性侧挂甲硅烷基醚基团的疏水性α（1→4）吡喃葡萄糖聚合物形成。 甲硅烷基醚基团的反应通过结合到器件的器件表面，聚合物 - 聚合物交联或两者来提供改进的基质形成。 可生物降解基质可用于制备可植入和可注射的医疗器械，包括那些释放生物活性剂的医疗器械。
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公开(公告)号：US20110245367A1
公开(公告)日：2011-10-06
申请号：US13074537
申请日：2011-03-29
申请人： Aleksey V. Kurdyumov , Dale G. Swan
发明人： Aleksey V. Kurdyumov , Dale G. Swan
IPC分类号： A61L27/34 , C07F7/10 , C07F7/18 , C07F9/24 , C07F9/145 , C07F9/40 , B05D3/06 , B05D3/02 , B05D7/24
CPC分类号： C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
摘要翻译： 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解的连接剂包括至少一个光反应性基团和连接基团之间的共价连接，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。
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公开(公告)号：US20130143056A1
公开(公告)日：2013-06-06
申请号：US13490994
申请日：2012-06-07
CPC分类号： C09D4/00 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , A61L2420/02 , C07F9/4078 , C08J7/16 , Y10T428/31938
摘要： Embodiments of the invention include linking agents including photo groups and vinyl groups and coatings and devices that incorporate such linking agents, along with related methods. Exemplary methods herein include methods of priming substrates and methods of coating substrates using compounds having the formula R1—X—R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Embodiments herein also include linking agents having the formula R1—X—R2, wherein R1 is a radical comprising a vinyl group, X is a radical comprising from about one to about twenty carbon atoms, and R2 is a radical comprising a photoreactive group. Other embodiments are also included herein.
摘要翻译： 本发明的实施方案包括包括光学基团和乙烯基的连接剂以及包含这种连接剂的涂层和装置以及相关方法。 本文的示例性方法包括引发底物的方法和使用具有式R1-X-R2的化合物涂覆底物的方法，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2 是包含光反应性基团的基团。 本文的实施方案还包括具有式R 1 -X-R 2的连接剂，其中R 1是包含乙烯基的基团，X是包含约1至约20个碳原子的基团，R 2是包含光反应性基团的基团。 本文还包括其它实施例。
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公开(公告)号：US08889760B2
公开(公告)日：2014-11-18
申请号：US13074537
申请日：2011-03-29
申请人： Aleksey V. Kurdyumov , Dale G. Swan
发明人： Aleksey V. Kurdyumov , Dale G. Swan
IPC分类号： C07F9/08 , C07F9/12 , C07C49/786 , C07F9/145 , C07F9/40 , A61L17/14 , A61L27/34 , A61L29/08 , A61L31/10 , C07F7/10 , C07F7/18 , C08F2/48
CPC分类号： C09D7/63 , A61L17/145 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/18 , A61L2420/02 , C07F7/10 , C07F7/1804 , C07F7/184 , C07F9/06 , C07F9/12 , C07F9/145 , C07F9/4025 , C07F9/4084 , C08F2/48 , C08K5/51 , C08K5/5419 , C08K5/544 , C09D7/1233
摘要： Described herein is a degradable linking agent of formula Photo1-LG-Photo2, wherein Photo1 and Photo2 independently represent at least one photoreactive group and LG represents a linking group comprising one or more silicon atoms or one or more phosphorous atoms. The degradable linking agent includes a covalent linkage between at least one photoreactive group and the linking group, wherein the covalent linkage between at least one photoreactive group and the linking group is interrupted by at least one heteroatom. A method for coating a support surface with the degradable linking agent, coated support surfaces and medical devices are also described.
摘要翻译： 本文描述了分子式为Photo1-LG-Photo2的可降解连接剂，其中Photo1和Photo2独立地表示至少一个光反应性基团，LG代表包含一个或多个硅原子或一个或多个磷原子的连接基团。 可降解交联剂包括至少一个光反应基团和连接基团之间的共价键，其中至少一个光反应基团和连接基团之间的共价键被至少一个杂原子中断。 还描述了用可降解的连接剂，涂覆的支撑表面和医疗装置涂覆支撑表面的方法。
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公开(公告)号：US20110144373A1
公开(公告)日：2011-06-16
申请号：US12965020
申请日：2010-12-10
申请人： Dale G. Swan , Emily Rose Rolfes Meyering , Aleksey V. Kurdyumov , Peter H. Duquette , Robert W. Hergenrother , Toni M. Heyer
发明人： Dale G. Swan , Emily Rose Rolfes Meyering , Aleksey V. Kurdyumov , Peter H. Duquette , Robert W. Hergenrother , Toni M. Heyer
IPC分类号： C07C271/58 , C07C309/61 , C07C69/78 , C07C327/48
CPC分类号： G03F7/031 , C07C309/42 , C07C333/08 , C08F2/50 , G03F7/165
摘要： Described herein is a degradable linking agent that includes a core molecule with one or more charged groups; and one or more photoreactive groups covalently attached to the core molecule by one or more degradable linkers.
摘要翻译： 本文描述的是可降解的连接剂，其包括具有一个或多个带电基团的核心分子; 和一个或多个可通过一个或多个可降解接头与核心分子共价连接的光反应基团。
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9.发明申请公开(公告)号：US20110076337A1
公开(公告)日：2011-03-31
申请号：US12894983
申请日：2010-09-30
申请人： Joram Slager , Aleksey V. Kurdyumov , Dale G. Swan
发明人： Joram Slager , Aleksey V. Kurdyumov , Dale G. Swan
CPC分类号： A61K9/107 , A61K9/0019 , A61K9/0024 , A61K9/113 , A61K9/5036
摘要： The invention provides emulsion compositions that include a hydrophobic compound and an arylboronic acid. An exemplary emulsion comprises a hydrophobic polymer and a halogenated arylboronic acid. Use of an arylboronic acid provides the emulsion with exceptional stability. The stability provides advantages for the formation of articles formed from the emulsion, including microparticles, as well as other implantable or injectable medical articles having polymeric matrices.
摘要翻译： 本发明提供了包含疏水化合物和芳基硼酸的乳液组合物。 示例性的乳液包含疏水性聚合物和卤代芳基硼酸。 使用芳基硼酸提供了非常稳定的乳液。 稳定性为形成由乳液形成的制品提供了优点，包括微粒，以及具有聚合物基质的其它可植入或可注射的医疗制品。
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10.发明授权公开(公告)号：US08709489B2
公开(公告)日：2014-04-29
申请号：US12894983
申请日：2010-09-30
申请人： Joram Slager , Aleksey V. Kurdyumov , Dale G. Swan
发明人： Joram Slager , Aleksey V. Kurdyumov , Dale G. Swan
CPC分类号： A61K9/107 , A61K9/0019 , A61K9/0024 , A61K9/113 , A61K9/5036
摘要： The invention provides emulsion compositions that include a hydrophobic compound and an arylboronic acid. An exemplary emulsion comprises a hydrophobic polymer and a halogenated arylboronic acid. Use of an arylboronic acid provides the emulsion with exceptional stability. The stability provides advantages for the formation of articles formed from the emulsion, including microparticles, as well as other implantable or injectable medical articles having polymeric matrices.
摘要翻译： 本发明提供了包含疏水化合物和芳基硼酸的乳液组合物。 示例性的乳液包含疏水性聚合物和卤代芳基硼酸。 使用芳基硼酸提供了非常稳定的乳液。 稳定性为形成由乳液形成的制品提供了优点，包括微粒，以及具有聚合物基质的其它可植入或可注射的医疗制品。
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