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    High impedance active fixation electrode of an electrical medical lead
    2.
    发明授权
    High impedance active fixation electrode of an electrical medical lead 有权
    电气医用引线的高阻抗主动固定电极

    公开(公告)号：US08332051B2

    公开(公告)日：2012-12-11

    申请号：US12782465

    申请日：2010-05-18

    申请人： John L. Sommer ,  Daniel C. Sigg ,  James A. Coles, Jr.

    发明人： John L. Sommer ,  Daniel C. Sigg ,  James A. Coles, Jr.

    IPC分类号： A61N1/00

    CPC分类号： A61N1/0573

    摘要： Electrical medical leads having active fixation electrodes, particularly helix electrodes intended to be screwed into body tissue, e.g., the heart, are disclosed having selectively applied insulation to optimize exposed electrode surface area and dispose the exposed electrode surface area toward tissue that is less traumatized by injury caused by screwing in the fixation helix. In a preferred fabrication method, an outer helical surface is masked by contact with a masking tube while a dielectric coating is applied to the inner helical surface of the coil turns of the helix, and the masking tube is removed when the dielectric coating has set. In one variation, at least one aperture is formed through the masking tube sidewall exposing an area of the outer helical surface thereby interrupting the uninsulated outer helical electrode.

    摘要翻译： 公开了具有主动固定电极的电医疗引线，特别是旨在拧入身体组织（例如心脏）的螺旋电极，其具有选择性地施加的绝缘体以优化暴露的电极表面积，并将暴露的电极表面区域设置成较少受到创伤的组织 螺钉固定螺旋引起的损伤。 在优选的制造方法中，外部螺旋表面通过与掩蔽管的接触而被掩蔽，同时将电介质涂层施加到螺旋线圈匝的内螺旋形表面，并且当电介质涂层固化时，掩蔽管被去除。 在一个变型中，通过掩蔽管侧壁形成至少一个孔，暴露外螺旋表面的一个区域，从而中断未绝缘的外螺旋电极。

    Medical fluid delivery system
    3.
    发明授权
    Medical fluid delivery system 有权
    医疗液体输送系统

    公开(公告)号：US07274966B2

    公开(公告)日：2007-09-25

    申请号：US10754173

    申请日：2004-01-08

    申请人： John L. Sommer ,  James A. Coles, Jr. ,  Daniel C. Sigg

    发明人： John L. Sommer ,  James A. Coles, Jr. ,  Daniel C. Sigg

    IPC分类号： A61N1/00

    CPC分类号： A61M25/0082 ,  A61M25/0026 ,  A61M25/0084 ,  A61M2025/0089 ,  A61M2025/0095 ,  A61N1/05 ,  A61N1/0575 ,  A61N1/0587

    摘要： A medical fluid delivery system includes an implantable medical lead including a fixation element adapted to secure the lead to a tissue site and a fluid delivery device including a tissue piercing distal tip; the device is adapted to pass through a proximal port, a lumen and a distal port of the lead. The system further includes means for adjusting a position of the device distal tip with respect to the lead distal port.

    摘要翻译： 医疗流体递送系统包括可植入医疗引线，其包括适于将引线固定到组织部位的固定元件和包括组织穿刺远端的流体输送装置; 该装置适于穿过导线的近端口，内腔和远端口。 所述系统还包括用于调节所述装置远侧尖端相对于所述引线远端端口的位置的装置。

    Predicting chronic optimal A-V intervals for biventricular pacing via observed inter-atrial delay
    5.
    发明授权
    Predicting chronic optimal A-V intervals for biventricular pacing via observed inter-atrial delay 有权
    通过观察到的心房间延迟预测双心室起搏的慢性最佳A-V间期

    公开(公告)号：US07877144B2

    公开(公告)日：2011-01-25

    申请号：US11460144

    申请日：2006-07-26

    申请人： James A. Coles, Jr. ,  Michael R. Ujhelyi ,  Mehdi Razavi ,  Vadim Levin

    发明人： James A. Coles, Jr. ,  Michael R. Ujhelyi ,  Mehdi Razavi ,  Vadim Levin

    IPC分类号： A61N1/365 ,  A61N1/368

    CPC分类号： A61N1/056 ,  A61B5/0422 ,  A61B5/4884 ,  A61N2001/0585

    摘要： Methods for optimizing the atrio-ventricular (A-V) delay for efficacious delivery of cardiac resynchronization therapy. In CRT devices, the programmed A-V delay starts with detection of electrical activity in the right atrium (RA). Thus, a major component of the A-V delay is the time required for inter-atrial conduction time (IACT) from the RA to the LA. This IACT can be measured during implantation as the time from the atrial lead stimulation artifact to local electrograms in a coronary sinus (CS) catheter. Assuming that the beginning of LA contraction closely corresponds with the beginning of LA electrical activity, the optimal AV delay should be related to the time between the start of RA electrical activity and the start of LA electrical activity plus the duration of LA atrial contraction. Thus ‘during atrial pacing’ the IACT measured at implantation is correlated with the echocardiographically defined optimal paced AV delay (PAV).

    摘要翻译： 用于优化心房再同步治疗有效递送的心房（A-V）延迟的方法。 在CRT设备中，编程的A-V延迟开始于右心房（RA）的电活动检测。 因此，A-V延迟的主要部分是从RA到LA的心房间传导时间（IACT）所需的时间。 这个IACT可以在植入期间被测量为从冠状窦（CS）导管中的心房引导刺激假象到局部电描记图的时间。 假设LA收缩的开始与LA电活动的开始密切相关，最佳AV延迟应与RA电活动开始与LA电活动开始加LA心房收缩持续时间之间的时间有关。 因此，在心房起搏期间，植入时测量的IACT与超声心动图定义的最佳起搏AV延迟（PAV）相关。

    Method for fabrication of low-polarization implantable stimulation electrode
    6.
    发明授权
    Method for fabrication of low-polarization implantable stimulation electrode 有权
    低极化可植入刺激电极的制造方法

    公开(公告)号：US08155754B2

    公开(公告)日：2012-04-10

    申请号：US11042649

    申请日：2005-01-25

    申请人： Lea A. Nygren ,  James A. Coles, Jr. ,  Scott J. Brabec ,  Randy G. Rose

    发明人： Lea A. Nygren ,  James A. Coles, Jr. ,  Scott J. Brabec ,  Randy G. Rose

    IPC分类号： A61N1/04

    CPC分类号： A61N1/05 ,  C23C28/32 ,  Y10T29/49204

    摘要： A method for fabricating an implantable medical electrode includes roughening the electrode substrate, applying an adhesion layer, and depositing a valve metal oxide coating over the adhesion layer under conditions optimized to minimize electrode impedance and post-pulse polarization. The electrode substrate may be a variety of electrode metals or alloys including titanium, platinum, platinum-iridium, or niobium. The adhesion layer may be formed of titanium or zirconium. The valve metal oxide coating is a ruthenium oxide coating sputtered onto the adhesion layer under controlled target power, sputtering pressure, and sputter gas ratio setting optimized to minimize electrode impedance and post-pulse polarization.

    摘要翻译： 一种用于制造可植入医疗电极的方法包括使电极基板粗糙化，施加粘合层，以及在优化以最小化电极阻抗和脉冲后极化的条件下，在粘附层上沉积阀金属氧化物涂层。 电极基板可以是各种电极金属或包括钛，铂，铂 - 铱或铌的合金。 粘合层可以由钛或锆形成。 阀金属氧化物涂层是在受控目标功率，溅射压力和溅射气体比设置下溅射到粘附层上的氧化钌涂层，其被优化以最小化电极阻抗和后脉冲极化。

    Medical devices incorporating carbon nanotube material and methods of fabricating same
    8.
    发明授权
    Medical devices incorporating carbon nanotube material and methods of fabricating same 有权
    纳入碳纳米管材料的医疗器械及其制造方法

    公开(公告)号：US07596415B2

    公开(公告)日：2009-09-29

    申请号：US11038731

    申请日：2005-01-20

    申请人： Scott J. Brabec ,  Kenneth C. Gardeski ,  Suping Lyu ,  James A. Coles, Jr. ,  Christopher M. Hobot

    发明人： Scott J. Brabec ,  Kenneth C. Gardeski ,  Suping Lyu ,  James A. Coles, Jr. ,  Christopher M. Hobot

    IPC分类号： A61N1/18 ,  A61N1/05

    CPC分类号： A61N1/056 ,  A61N1/0565 ,  Y10S977/905 ,  Y10S977/925 ,  Y10S977/931

    摘要： The present invention relates generally to medical devices; in particular and without limitation, to unique electrodes and/or electrical lead assemblies for stimulating cardiac tissue, muscle tissue, neurological tissue, brain tissue and/or organ tissue; to electrophysiology mapping and ablation catheters for monitoring and selectively altering physiologic conduction pathways; and, wherein said electrodes, lead assemblies and catheters optionally include fluid irrigation conduit(s) for providing therapeutic and/or performance enhancing materials to adjacent biological tissue, and wherein each said device is coupled to or incorporates nanostructure or materials therein. The present invention also provides methods for fabricating, deploying, and operating such medical devices.

    摘要翻译： 本发明一般涉及医疗器械; 特别是但不限于用于刺激心脏组织，肌肉组织，神经组织，脑组织和/或器官组织的独特电极和/或电引线组件; 用于电生理测绘和消融导管，用于监测和选择性地改变生理传导途径; 并且其中所述电极，引线组件和导管可选地包括用于向相邻生物组织提供治疗和/或性能增强材料的流体冲洗导管，并且其中每个所述装置与其中的纳米结构或材料耦合或结合。 本发明还提供了制造，部署和操作这种医疗装置的方法。