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    Bone marrow aspiration device
    1.
    发明申请
    Bone marrow aspiration device 审中-公开
    骨髓抽吸装置

    公开(公告)号：US20070198043A1

    公开(公告)日：2007-08-23

    申请号：US11360324

    申请日：2006-02-22

    申请人： Daniel Cox ,  Eugene Michal ,  Robert Ainsworth ,  Gregory Chan ,  Jeong Lee ,  Albert Chin ,  Geoff Willis ,  Philip Yip

    发明人： Daniel Cox ,  Eugene Michal ,  Robert Ainsworth ,  Gregory Chan ,  Jeong Lee ,  Albert Chin ,  Geoff Willis ,  Philip Yip

    IPC分类号： A61B17/34 ,  A61M5/32 ,  A61B10/00

    CPC分类号： A61B10/025 ,  A61B10/0283 ,  A61B34/20 ,  A61B2010/0208 ,  A61B2010/0258

    摘要： A bone marrow aspiration device is described. In one embodiment, the bone marrow aspiration device includes a central body portion having a proximal end and a distal end, and an outer shaft portion coupled to the distal end of the central body portion. The outer shaft portion also has a distal opening. A first lumen is formed by the central body portion and the outer shaft portion, and the first lumen extends from the proximal end to the distal opening. An aspiration needle is disposed within the first lumen. The aspiration needle has a substantially linear configuration when positioned within the first lumen, and a substantially curved configuration when extended from the distal opening. The aspiration needle is adapted to aspirate liquid bone marrow from a first region of a bone cavity.

    摘要翻译： 描述骨髓抽吸装置。 在一个实施例中，骨髓抽吸装置包括具有近端和远端的中心主体部分，以及联接到中心主体部分的远端的外轴部分。 外轴部分还具有远端开口。 第一管腔由中心主体部分和外轴部分形成，并且第一内腔从近端延伸到远端开口。 抽吸针设置在第一管腔内。 当定位在第一内腔内时，抽吸针具有基本线性的构造，并且当从远端开口延伸时具有基本弯曲的构造。 抽吸针适于从骨腔的第一区域吸出液体骨髓。

    Dual needle delivery system
    3.
    发明申请
    Dual needle delivery system 有权

    公开(公告)号：US20060253088A1

    公开(公告)日：2006-11-09

    申请号：US11112546

    申请日：2005-04-22

    申请人： Mina Chow ,  Dwight Ambat ,  Jin Cheng ,  Eugene Michal

    发明人： Mina Chow ,  Dwight Ambat ,  Jin Cheng ,  Eugene Michal

    IPC分类号： A61M25/00

    CPC分类号： A61M25/06 ,  A61M25/003 ,  A61M25/0071 ,  A61M2025/0034 ,  A61M2025/0037

    摘要： An apparatus for delivering devices. The apparatus comprises a catheter with an elongated shaft having a first lumen and a second lumen extending therethrough. The apparatus further comprises a distal section with a lumen in communication with a port in a distal end of the catheter and with the first lumen and the second lumen. The first lumen is configured for a first device and the second lumen is configured for a second device to be disposed therein. The apparatus further comprises a proximal adapter coupled to the elongated shaft with a first port in communication with the first lumen and a second port in communication with the second lumen.

    METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION
    7.
    发明申请
    METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 有权
    改善心肌梗塞扩张的方法

    公开(公告)号：US20120059355A1

    公开(公告)日：2012-03-08

    申请号：US12877820

    申请日：2010-09-08

    申请人： Shubhayu Basu ,  Randolf von Oepen ,  Eugene Michal ,  Florian Ludwig

    发明人： Shubhayu Basu ,  Randolf von Oepen ,  Eugene Michal ,  Florian Ludwig

    IPC分类号： A61B17/12 ,  A61M25/00

    CPC分类号： A61M25/1011 ,  A61B17/12045 ,  A61B17/12122 ,  A61B17/12136 ,  A61B17/12186 ,  A61B17/3478 ,  A61B2017/00243 ,  A61B2017/00495 ,  A61M25/003 ,  A61M2025/0092 ,  A61M2025/1052

    摘要： A reinforcement region is formed within the myocardium by introducing a delivery device through a vessel wall to a treatment site within a myocardium. A biomaterial is then delivered to the treatment site as the delivery device is withdrawn from the treatment site to form the reinforcement regions. Formation of the reinforcement region may further include introducing a delivery device through a vessel wall to a region within a myocardium such that the delivery device is positioned within the myocardium substantially parallel to a wall of the myocardium. A biomaterial may be delivered into a space formed within the region by the delivery device. The reinforcement region may be formed around an infarct tissue region of a myocardium to reinforce the damaged tissue.

    摘要翻译： 通过将输送装置通过血管壁引导到心肌内的治疗部位，在心肌内形成增强区域。 然后当从处理部位取出输送装置以形成加强区域时，将生物材料输送到处理部位。 加强区域的形成可以进一步包括将输送装置通过血管壁引入心肌内的区域，使得输送装置位于基本上平行于心肌壁的心肌内。 生物材料可以通过输送装置输送到在该区域内形成的空间中。 加强区域可以围绕心肌的梗塞组织区域形成以加强受损组织。

    Modified two-component gelation systems, methods of use and methods of manufacture
    8.
    发明申请
    Modified two-component gelation systems, methods of use and methods of manufacture 失效
    改进的双组分凝胶化系统，使用方法和制造方法

    公开(公告)号：US20080025943A1

    公开(公告)日：2008-01-31

    申请号：US11496824

    申请日：2006-07-31

    申请人： Eugene Michal ,  Olof Mikael Trollsas ,  Shubhayu Basu

    发明人： Eugene Michal ,  Olof Mikael Trollsas ,  Shubhayu Basu

    IPC分类号： A61K38/22 ,  A61K38/19 ,  A61K38/18 ,  A61K35/14

    CPC分类号： A61K47/34 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/12 ,  A61K38/00 ,  A61L27/26 ,  A61L27/38 ,  A61L27/50 ,  A61K2300/00

    摘要： Compositions, methods of manufacture and methods of treatment for post-myocardial infarction are herein disclosed. In some embodiments, the composition includes at least two components. In one embodiment, a first component can include a first functionalized polymer and a substance having at least one cell adhesion site combined in a first buffer at a pH of approximately 6.5. A second component can include a second buffer in a pH of between about 7.5 and 9.0. A second functionalized polymer can be included in the first or second component. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition(s) of the present invention can be delivered by a dual bore injection device to a treatment area, such as a post-myocardial infarct region.

    摘要翻译： 本文公开了组合物，制造方法和心肌梗死后治疗方法。 在一些实施方案中，组合物包含至少两种组分。 在一个实施方案中，第一组分可以包括第一官能化聚合物和具有在约6.5的pH下在第一缓冲液中组合的至少一个细胞粘附位点的物质。 第二组分可以包括pH在约7.5和9.0之间的第二缓冲液。 第二官能化聚合物可以包括在第一或第二组分中。 在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。 在一些实施方案中，本发明的组合物可以通过双孔注射装置递送到治疗区域，例如心肌梗死后区域。